Bernardino Ghetti

  • 31980 Citations
  • 87 h-Index
1967 …2021

Research output per year

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Publications

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Article
2001

Biochemical characterization of a neuroserpin variant associated with hereditary dementia

Yazaki, M., Liepnieks, J. J., Murrell, J. R., Takao, M., Guenther, B., Piccardo, P., Farlow, M. R., Ghetti, B. & Benson, M. D., Jan 1 2001, In : American Journal of Pathology. 158, 1, p. 227-233 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Codeposition of cystatin C with amyloid-β protein in the brain of alzheimer disease patients

Levy, E., Sastre, M., Kumar, A., Gallo, G., Piccardo, P., Ghetti, B. & Tagliavini, F., Jan 1 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

Open Access
135 Scopus citations

Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures

Takao, M., Ghetti, B., Murrell, J. R., Unverzagt, F. W., Giaccone, G., Tagliavini, F., Bugiani, O., Piccardo, P., Hulette, C. M., Crain, B. J., Farlow, M. R. & Heyman, A., Jan 1 2001, In : Journal of Neuropathology and Experimental Neurology. 60, 12, p. 1137-1152 16 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders

Cataldo, A., William Rebeck, G., Ghetti, B., Hulette, C., Lippa, C., Van Broeckhoven, C., Van Duijn, C., Cras, P., Bogdanovic, N., Bird, T., Peterhoff, C. & Nixon, R., Nov 12 2001, In : Annals of Neurology. 50, 5, p. 661-665 5 p.

Research output: Contribution to journalArticle

63 Scopus citations

Evidence that the loss of Purkinje cells and deep cerebellar nuclei neurons in homozygous weaver is not related to neurogenetic patterns

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Oct 9 2001, In : International Journal of Developmental Neuroscience. 19, 6, p. 599-610 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Primary myopathy and accumulation of PRPSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation

Chiesa, R., Pestronk, A., Schmidt, R. E., Tourtellotte, W. G., Ghetti, B., Piccardo, P. & Harris, R. E., Jan 1 2001, In : Neurobiology of Disease. 8, 2, p. 279-288 10 p., 90400.

Research output: Contribution to journalArticle

35 Scopus citations

Prion proteins with different conformations accumulate in Gerstmann-Sträussler-Scheinker disease caused by A117V and F198S mutations

Piccardo, P., Liepnieks, J. J., William, A., Dlouhy, S. R., Farlow, M. R., Young, K., Nochlin, D., Bird, T. D., Nixon, R. R., Ball, M. J., DeCarli, C., Bugiani, O., Tagliavini, F., Benson, M. D. & Ghetti, B., Jan 1 2001, In : American Journal of Pathology. 158, 6, p. 2201-2207 7 p.

Research output: Contribution to journalArticle

64 Scopus citations
2002

Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301s tau protein

Allen, B., Ingram, E., Takao, M., Smith, M. J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P. C., Atzori, C., Migheli, A., Anthony Crowther, R., Ghetti, B., Spillantini, M. G. & Goedert, M., Nov 1 2002, In : Journal of Neuroscience. 22, 21, p. 9340-9351 12 p.

Research output: Contribution to journalArticle

422 Scopus citations

A combined immunohistochemical and autoradiographic method to detect midbrain dopaminergic neurons and determine their time of origin

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Jul 22 2002, In : Brain Research Protocols. 9, 3, p. 197-205 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

A novel mutation (G217D) in the Presenilin 1 gene (PSEN1) in a Japanese family: Presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum

Takao, M., Ghetti, B., Hayakawa, I., Ikeda, E., Fukuuchi, Y., Miravalle, L., Piccardo, P., Murell, J. R., Glazier, B. S. & Koto, A., Dec 1 2002, In : Acta Neuropathologica. 104, 2, p. 155-170 16 p.

Research output: Contribution to journalArticle

56 Scopus citations

Association between conformational mutations in neuroserpin and onset and severity of dementia

Davis, R. L., Shrimpton, A. E., Carrell, R. W., Lomas, D. A., Gerhard, L., Baumann, B., Lawrence, D. A., Yepes, M., Kim, T. S., Ghetti, B., Piccardo, P., Takao, M., Lacbawan, F., Muenke, M., Sifers, R. N., Bradshaw, C. B., Kent, P. F., Collins, G. H., Larocca, D. & Holohan, P. D., Jun 29 2002, In : Lancet. 359, 9325, p. 2242-2247 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Clinical and genetic studies of families with the tau N279K mutation (FTDP-17)

Tsuboi, Y., Baker, M., Hutton, M. L., Uitti, R. J., Rascol, O., Delisle, M. B., Soulages, X., Murrell, J. R., Ghetti, B., Yasuda, M., Komure, O., Kuno, S., Arima, K., Sunohara, N., Kobayashi, T., Mizuno, Y. & Wszolek, Z. K., Dec 10 2002, In : Neurology. 59, 11, p. 1791-1793 3 p.

Research output: Contribution to journalArticle

35 Scopus citations

Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: A comparison of the pallidopontonigral degeneration kindred and a French family

Tsuboi, Y., Uitti, R. J., Delisle, M. B., Ferreira, J. J., Brefel-Courbon, C., Rascol, O., Ghetti, B., Murrell, J. R., Hutton, M., Baker, M. & Wszolek, Z. K., Jan 1 2002, In : Archives of Neurology. 59, 6, p. 943-950 8 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Dementia with Lewy bodies in a Nigerian: A case report

Ogunniyi, A., Akang, E. E. U., Gureje, O., Takao, M., Piccardo, P., Baiyewu, O., Hall, K. S., Ghetti, B. & Hendrie, H. C., Jun 1 2002, In : International Psychogeriatrics. 14, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
22 Scopus citations

Insomnia associated with thalamic involvement in E200K Creutzfeldt-Jakob disease

Taratuto, A. L., Piccardo, P., Reich, E. G., Chen, S. G., Sevlever, G., Schultz, M., Luzzi, A. A., Rugiero, M., Abecasis, G., Endelman, M., Garcia, A. M., Capellari, S., Xie, Z., Lugaresi, E., Gambetti, P., Dlouhy, S. R. & Ghetti, B., Feb 12 2002, In : Neurology. 58, 3, p. 362-367 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

P301L tauopathyconfocal immunofluorescence study of perinuclear aggregation of the mutated protein

Adamec, E., Murrell, J. R., Takao, M., Hobbs, W., Nixon, R. A., Ghetti, B. & Vonsattel, J. P., Aug 15 2002, In : Journal of the Neurological Sciences. 200, 1-2, p. 85-93 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production

Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C. & Steiner, H., Jun 11 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 12, p. 8025-8030 6 p.

Research output: Contribution to journalArticle

220 Scopus citations

Regional differences in the Purkinje cells settled pattern: A comparative autoradiographic study in control and homozygous weaver mice

Marti, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Jan 1 2002, In : Experimental Neurology. 175, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2003

A novel leukoencephalopathy associated with tau deposits primarily in white matter glia

Powers, J. M., Byrne, N. P., Ito, M., Takao, M., Yankopoulou, D., Spillantini, M. G. & Ghetti, B., Aug 2 2003, In : Acta Neuropathologica. 106, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Hereditary ferritinopathy

Vidal, R., Delisle, M. B., Rascol, O. & Ghetti, B., Mar 15 2003, In : Journal of the Neurological Sciences. 207, 1-2, p. 110-111 2 p.

Research output: Contribution to journalArticle

32 Scopus citations

Molecular distinction between pathogenic and infectious properties of the prion protein

Chiesa, R., Piccardo, P., Quaglio, E., Drisaldi, B., Si-Hoe, S. L., Takao, M., Ghetti, B. & Harris, D. A., Jul 1 2003, In : Journal of virology. 77, 13, p. 7611-7622 12 p.

Research output: Contribution to journalArticle

115 Scopus citations

Ubiquitination of α-Synuclein in Lewy Bodies Is a Pathological Event Not Associated with Impairment of Proteasome Function

Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K. S. & Spillantini, M. G., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 44405-44411 7 p.

Research output: Contribution to journalArticle

252 Scopus citations

Variable phenotype in a P102L Gerstmann-Sträussler-Scheinker Italian family

De Michele, G., Pocchiari, M., Petraroli, R., Manfredi, M., Caneve, G., Coppola, G., Casali, C., Saccà, F., Piccardo, P., Salvatore, E., Berardelli, A., Orio, M., Barbieri, F., Ghetti, B. & Filla, A., Aug 1 2003, In : Canadian Journal of Neurological Sciences. 30, 3, p. 233-236 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
2004

Early-onset dementia with Lewy bodies

Takao, M., Ghetti, B., Yoshida, H., Piccardo, P., Narain, Y., Murrell, J. R., Vidal, R., Glazier, B. S., Jakes, R., Tsutsui, M., Spillantini, M. G., Crowther, R. A., Goedert, M. & Koto, A., Apr 2004, In : Brain Pathology. 14, 2, p. 137-147 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Effects of different experimental conditions on the PrPSc core generated by protease digestion: Implications for strain typing and molecular classification of CJD

Notari, S., Capellari, S., Giese, A., Westner, I., Baruzzi, A., Ghetti, B., Gambetti, P., Kretzschmar, H. A. & Parchi, P., Apr 16 2004, In : Journal of Biological Chemistry. 279, 16, p. 16797-16804 8 p.

Research output: Contribution to journalArticle

111 Scopus citations

GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice

Barmada, S., Piccardo, P., Yamaguchi, K., Ghetti, B. & Harris, D. A., Aug 1 2004, In : Neurobiology of Disease. 16, 3, p. 527-537 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Intracellular Ferritin Accumulation in Neural and Extraneural Tissue Characterizes A Neurodegenerative Disease Associated with A Mutation in the Ferritin Light Polypeptide Gene

Vidal, R., Ghetti, B., Takao, M., Brefel-Courbon, C., Uro-Coste, E., Glazier, B. S., Siani, V., Benson, M. D., Calvas, P., Miravalle, L., Rascol, O. & Delisle, M. B., Apr 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 4, p. 363-380 18 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Soluble amyloid β-protein is increased in frontotemporal dementia with tau gene mutations

Vitali, A., Piccini, A., Borghi, R., Fornaro, P., Siedlak, S. L., Smith, M. A., Gambetti, P., Ghetti, B. & Tabaton, M., Feb 2004, In : Journal of Alzheimer's Disease. 6, 1, p. 45-51 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Human Amyloid-β Precursor Protein770 Mutation V717F Generates Peptides Longer Than Amyloid-β-(40-42) and Flocculent Amyloid Aggregates

Roher, A. E., Kokjohn, T. A., Esh, C., Weiss, N., Childress, J., Kalback, W., Luehrs, D. C., Lopez, J., Brune, D., Kuo, Y. M., Farlow, M., Murrell, J., Vidal, R. & Ghetti, B., Feb 13 2004, In : Journal of Biological Chemistry. 279, 7, p. 5829-5836 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
2005

Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the α-synuclein gene

Yamaguchi, K., Cochran, E. J., Murrell, J. R., Polymeropoulos, M. H., Shannon, K. M., Crowther, R. A., Goedert, M. & Ghetti, B., Sep 1 2005, In : Acta Neuropathologica. 110, 3, p. 298-305 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Altered APP processing in PDAPP (Val717 → Phe) transgenic mice yields extended-length Aβ peptides

Esh, C., Patton, L., Kalback, W., Kokjohn, T. A., Lopez, J., Brune, D., Newell, A. J., Beach, T., Schenk, D., Games, D., Paul, S., Bales, K., Ghetti, B., Castaño, E. M. & Roher, A. E., Oct 25 2005, In : Biochemistry. 44, 42, p. 13807-13819 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Amino-terminally truncated Aβ peptide species are the main component of cotton wool plaques

Miravalle, L., Calero, M., Takao, M., Roher, A. E., Ghetti, B. & Vidal, R., Aug 16 2005, In : Biochemistry. 44, 32, p. 10810-10821 12 p.

Research output: Contribution to journalArticle

113 Scopus citations

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease

Chiesa, R., Piccardo, P., Dossena, S., Nowoslawski, L., Roth, K. A., Ghetti, B. & Harris, D. A., Jan 4 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 1, p. 238-243 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Characterization of the F198S prion protein mutation: Enhanced glycosylation and defective refolding

Zaidi, S. I. A., Richardson, S. L., Capellari, S., Song, L., Smith, M. A., Ghetti, B., Sy, M. S., Gambetti, P. & Petersen, R. B., Jan 1 2005, In : Journal of Alzheimer's Disease. 7, 2, p. 159-171 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Chitin-like polysaccharides in Alzheimer's disease brains

Castellani, R. J., Siedlak, S. L., Fortino, A. E., Perry, G., Ghetti, B. & Smith, M. A., Oct 1 2005, In : Current Alzheimer research. 2, 4, p. 419-423 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Longitudinal characterization of two siblings with frontotemporal dementia and parkinsonism linked to chromosome 17 associated with the S305N tau mutation

Boeve, B. F., Tremont-Lukats, I. W., Waclawik, A. J., Murrell, J. R., Hermann, B., Jack, C. R., Shiung, M. M., Smith, G. E., Nair, A. R., Lindor, N., Koppikar, V. & Ghetti, B., Apr 2005, In : Brain. 128, 4, p. 752-772 21 p.

Research output: Contribution to journalArticle

48 Scopus citations

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein

Stewart, R. S., Piccardo, P., Ghetti, B. & Harris, D. A., Mar 30 2005, In : Journal of Neuroscience. 25, 13, p. 3469-3477 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Neuropsychological function in nondemented carriers of presenilin-1 mutations

Ringman, J. M., Diaz-Olavarrieta, C., Rodriguez, Y., Chavez, M., Fairbanks, L., Paz, F., Varpetian, A., Maldonado, H. C., Macias-Islas, M. A., Murrell, J., Ghetti, B. & Kawas, C., Aug 23 2005, In : Neurology. 65, 4, p. 552-558 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Recognition: Robert Terry

Ghetti, B., Jul 1 2005, In : Alzheimer's and Dementia. 1, 1, 1 p.

Research output: Contribution to journalArticle

Redox metals and oxidative abnormalities in human prion diseases

Petersen, R. B., Siedlak, S. L., Lee, H. G., Kim, Y. S., Nunomura, A., Tagliavini, F., Ghetti, B., Cras, P., Moreira, P. I., Castellani, R. J., Guentchev, M., Budka, H., Ironside, J. W., Gambetti, P., Smith, M. A. & Perry, G., Sep 1 2005, In : Acta Neuropathologica. 110, 3, p. 232-238 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Slow wave and REM sleep mechanisms are differently altered in hereditary pick disease associated with the Tau G389R mutation

Gemignani, A., Pietrini, P., Murrell, J. R., Glazier, B. S., Zolo, P., Guazzelli, M. & Ghetti, B., Feb 1 2005, In : Archives Italiennes de Biologie. 143, 1, p. 65-79 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

The Effect of tau genotype on clinical features in FTDP-17

Baba, Y., Tsuboi, Y., Baker, M. C., Uitti, R. J., Hutton, M. L., Dickson, D. W., Farrer, M., Putzke, J. D., Woodruff, B. K., Ghetti, B., Murrell, J. R., Boeve, B. F., Petersen, R. C., Verpillat, P., Brice, A., Delisle, M. B., Rascol, O., Arima, K., Dysken, M. W., Yasuda, M. & 11 others, Kobayashi, T., Sunohara, N., Komure, O., Kuno, S., Sperfeld, A. D., Stoppe, G., Kohlhase, J., Pickering-Brown, S., Neary, D., Bugiani, O. & Wszolek, Z. K., Jun 1 2005, In : Parkinsonism and Related Disorders. 11, 4, p. 205-208 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
2006

Aberrantly regulated proteins in frontotemporal dementia

Schweitzer, K., Decker, E., Zhu, L., Miller, R. E., Mirra, S. S., Spina, S., Ghetti, B., Wang, M. & Murrell, J., Sep 22 2006, In : Biochemical and Biophysical Research Communications. 348, 2, p. 465-472 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Aβ42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

Radde, R., Bolmont, T., Kaeser, S. A., Coomaraswamy, J., Lindau, D., Stoltze, L., Calhoun, M. E., Jäggi, F., Wolburg, H., Gengler, S., Haass, C., Ghetti, B., Czech, C., Hölscher, C., Mathews, P. M. & Jucker, M., Sep 1 2006, In : EMBO Reports. 7, 9, p. 940-946 7 p.

Research output: Contribution to journalArticle

443 Scopus citations

Cell-cycle markers in a transgenic mouse model of human tauopathy: Increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1

Delobel, P., Lavenir, I., Ghetti, B., Holzer, M. & Goedert, M., Mar 2006, In : American Journal of Pathology. 168, 3, p. 878-887 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Characteristics of frontotemporal dementia patients with a Progranulin mutation

Huey, E. D., Grafman, J., Wassermann, E. M., Pietrini, P., Tierney, M. C., Ghetti, B., Spina, S., Baker, M., Hutton, M., Elder, J. W., Berger, S. L., Heflin, K. A., Hardy, J. & Momeni, P., Sep 1 2006, In : Annals of Neurology. 60, 3, p. 374-380 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease

Shiarli, A. M., Jennings, R., Shi, J., Bailey, K., Davidson, Y., Tian, J., Bigio, E. H., Ghetti, B., Murrell, J. R., Delisle, M. B., Mirra, S., Crain, B., Zolo, P., Arima, K., Iseki, E., Murayama, S., Kretzschmar, H., Neumann, M., Lippa, C., Halliday, G. & 8 others, MacKenzie, J., Khan, N., Ravid, R., Dickson, D., Wszolek, Z., Iwatsubo, T., Pickering-Brown, S. M. & Mann, D. M. A., Aug 1 2006, In : Neuropathology and Applied Neurobiology. 32, 4, p. 374-387 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Gerstmann-Sträussler-Scheinker: A new phenotype with 'curly' PrP deposits

Colucci, M., Moleres, F. J., Xie, Z. L., Ray-Chaudhury, A., Gutti, S., Butefisch, C. M., Cervenakova, L., Wang, W., Goldfarb, L. G., Kong, Q., Ghetti, B., Chen, S. G. & Gambetti, P., Jul 1 2006, In : Journal of Neuropathology and Experimental Neurology. 65, 7, p. 642-651 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hereditary diffuse leukoencephalopathy with spheroids: Clinical, pathologic and genetic studies of a new kindred

Baba, Y., Ghetti, B., Baker, M. C., Uitti, R. J., Hutton, M. L., Yamaguchi, K., Bird, T., Lin, W., DeLucia, M. W., Dickson, D. W. & Wszolek, Z. K., Apr 1 2006, In : Acta Neuropathologica. 111, 4, p. 300-311 12 p.

Research output: Contribution to journalArticle

70 Scopus citations