Bernardino Ghetti

  • 33316 Citations
  • 90 h-Index
1967 …2020

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Publications

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Article
2000

The weaver gene continues to target late-generated dopaminergic neurons in midbrain areas at P90

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Aug 30 2000, In : Developmental Brain Research. 122, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons

Martí, J., Wills, K. V., Ghetti, B. & Bayer, S. A., Aug 30 2000, In : Developmental Brain Research. 122, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum

Migheli, A., Piva, R., Casolino, S., Atzori, C., Dlouhy, S. R. & Ghetti, B., Aug 1999, In : American Journal of Pathology. 155, 2, p. 365-373 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Alteration of IGF system gene expression during the postnatal development of pcd mice

Zhang, W., Ghetti, B., Yang, X. L. & Lee, W. H., 1999, In : Journal of Endocrinology. 163, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy

Delisle, M. B., Murrell, J. R., Richardson, R., Trofatter, J. A., Rascol, O., Soulages, X., Mohr, M., Calvas, P. & Ghetti, B., Jul 1 1999, In : Acta Neuropathologica. 98, 1, p. 62-77 16 p.

Research output: Contribution to journalArticle

140 Scopus citations

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., Delong, C. A., Piccardo, P., Petegnief, V., Ghetti, B. & Paul, S. M., Dec 21 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 26, p. 15233-15238 6 p.

Research output: Contribution to journalArticle

388 Scopus citations

Chapter 5 Human Prion Diseases

Ghetti, B. & Gambetti, P., Dec 1 1999, In : Advances in Cell Aging and Gerontology. 3, C, p. 135-187 53 p.

Research output: Contribution to journalArticle

6 Scopus citations

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., Poser, S., Rojiani, A., Streichemberger, N., Julien, J., Vital, C., Ghetti, B., Gambetti, P. & Kretzschmar, H., 1999, In : Annals of neurology. 46, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

1055 Scopus citations

Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau

Bugiani, O., Murrell, J. R., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., Grisoli, M., Savoiardo, M., Spillantini, M. G., Tagliavini, F., Goedert, M. & Ghetti, B., Jun 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 6, p. 667-677 11 p.

Research output: Contribution to journalArticle

Open Access
306 Scopus citations

Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: A quantitative immunocytochemical study

Broome, J. D., Wills, K. V., Lapchak, P. A., Ghetti, B., Camp, L. L. & Bayer, S. A., Aug 5 1999, In : Developmental Brain Research. 116, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

Varani, L., Hasegawa, M., Spillantini, M. G., Smith, M. J., Murrell, J. R., Ghetti, B., Klug, A., Goedert, M. & Varani, G., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 8229-8234 6 p.

Research output: Contribution to journalArticle

187 Scopus citations

Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits

Murrell, J. R., Spillantini, M. G., Zolo, P., Guazzelli, M., Smith, M. J., Hasegawa, M., Redi, F., Crowther, R. A., Pietrini, P., Ghetti, B. & Goedert, M., Dec 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 12, p. 1207-1226 20 p.

Research output: Contribution to journalArticle

Open Access
191 Scopus citations

Tau pathology in a family with dementia and a P301L mutation in tau

Mirra, S. S., Murrell, J. R., Gearing, M., Spillantini, M. G., Goedert, M., Crowther, R. A., Levey, A. I., Jones, R., Green, J., Shoffner, J. M., Wainer, B. H., Schmidt, M. L., Trojanowski, J. Q. & Ghetti, B., Apr 1999, In : Journal of Neuropathology and Experimental Neurology. 58, 4, p. 335-345 11 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations
1998

Altered responses to potassium in cerebellar neurons from weaver heterozygote mice

Fox, A. P., Dlouhy, S., Ghetti, B., Hurley, J. H., Nucifora, P. G. P., Nelson, D. J., Won, L. & Heller, A., Nov 30 1998, In : Experimental Brain Research. 123, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy

Piccardo, P., Langeveld, J. P. M., Hill, A. F., Dlouhy, S. R., Young, K., Giaccone, G., Rossi, G., Bugiani, M., Bugiani, O., Meloen, R. H., Collinge, J., Tagliavini, F. & Ghetti, B., Jun 1998, In : American Journal of Pathology. 152, 6, p. 1415-1420 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Characterization of murine Girk2 transcript isoforms: Structure and differential expression

Wei, J., Hodes, M. E., Piva, R., Feng, Y., Wang, Y., Ghetti, B. & Dlouhy, S. R., Aug 1 1998, In : Genomics. 51, 3, p. 379-390 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Creutzfeldt-Jakob disease in a husband and wife

Brown, P., Cervenáková, L., McShane, L., Goldfarb, L. G., Bishop, K., Bastian, F., Kirkpatrick, J., Piccardo, P., Ghetti, B. & Gajdusek, D. C., Mar 1998, In : Neurology. 50, 3, p. 684-688 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues

Jiménez-Huete, A., Lievens, P. M. J., Vidal, R., Piccardo, P., Ghetti, B., Tagliavini, F., Frangione, B. & Prelli, F., Nov 1998, In : American Journal of Pathology. 153, 5, p. 1561-1572 12 p.

Research output: Contribution to journalArticle

147 Scopus citations

FDG-PET and MRI in temporal lobe epilepsy: Relationship to febrile seizures, hippocampal sclerosis and outcome

Salanova, V., Markand, O., Worth, R., Smith, R., Wellman, H., Hutchins, G., Park, H., Ghetti, B. & Azzarelli, B., Jun 15 1998, In : Acta Neurologica Scandinavica. 97, 3, p. 146-153 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies

Spillantini, M. G., Bird, T. D. & Ghetti, B., 1998, In : Brain Pathology. 8, 2, p. 387-402 16 p.

Research output: Contribution to journalArticle

359 Scopus citations

Hypothalamic-pituitary-gonadal axis in the mutant weaver mouse

Schwartz, N. B., Szabo, M., Verina, T., Wei, J., Dlouhy, S. R., Won, L., Heller, A., Hodes, M. E. & Ghetti, B., 1998, In : Neuroendocrinology. 68, 6, p. 374-385 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., Ghetti, B., Nochlin, D., Bird, T. D., Cairns, N. J., Lee, V. M. Y., Iwatsubo, T. & Trojanowski, J. Q., Nov 1998, In : American Journal of Pathology. 153, 5, p. 1365-1370 6 p.

Research output: Contribution to journalArticle

403 Scopus citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A. & Ghetti, B., Jun 23 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 13, p. 7737-7741 5 p.

Research output: Contribution to journalArticle

1213 Scopus citations

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation

Chiesa, R., Piccardo, P., Ghetti, B. & Harris, D. A., Dec 1998, In : Neuron. 21, 6, p. 1339-1351 13 p.

Research output: Contribution to journalArticle

263 Scopus citations

Phenotypic variability of Gerstmann-Straussler-Scheinker disease is associated with prion protein heterogeneity

Piccardo, P., Dlouhy, S. R., Lievens, P. M. J., Young, K., Bird, T. D., Nochlin, D., Dickson, D. W., Vinters, H. V., Zimmerman, T. R., Mackenzie, I. R. A., Kish, S. J., Ang, L. C., De Carli, C., Pocchiari, M., Brown, P., Gibbs, C. J., Gajdusek, D. C., Bugiani, O., Ironside, J., Tagliavini, F. & 1 others, Ghetti, B., Oct 1998, In : Journal of Neuropathology and Experimental Neurology. 57, 10, p. 979-988 10 p.

Research output: Contribution to journalArticle

Open Access
170 Scopus citations
1997

A possible role for tyrosine kinases in the regulation of the neuronal dopamine transporter in mouse striatum

Simon, J. R., Bare, D. J., Ghetti, B. & Richter, J. A., Apr 10 1997, In : Neuroscience Letters. 224, 3, p. 201-205 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice

Verina, T., Norton, J. A., Sorbel, J. J., Triarhou, L. C., Laferty, D., Richter, J. A., Simon, J. R. & Ghetti, B., Jan 30 1997, In : Experimental Brain Research. 113, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice

Zhang, W., Ghetti, B. & Lee, W. H., Feb 20 1997, In : Developmental Brain Research. 98, 2, p. 164-176 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Diverse cell death pathways result from a single missense mutation in weaver mouse

Migheli, A., Piva, R., Wei, J., Attanasio, A., Casolino, S., Hodes, M. E., Dlouhy, S. R., Bayer, S. A. & Ghetti, B., Dec 1997, In : American Journal of Pathology. 151, 6, p. 1629-1638 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments

Spillantini, M. G., Goedert, M., Crowther, R. A., Murrell, J. R., Farlow, M. R. & Ghetti, B., Apr 15 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 8, p. 4113-4118 6 p.

Research output: Contribution to journalArticle

269 Scopus citations

Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17

Murrell, J. R., Koller, D., Foroud, T., Goedert, M., Spillantini, M. G., Edenberg, H. J., Farlow, M. R. & Ghetti, B., Nov 1997, In : American Journal of Human Genetics. 61, 5, p. 1131-1138 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Gerstmann-Straussler-Scheinker disease with the PRNP P102L mutation and valine at codon 129

Young, K., Clark, H. B., Piccardo, P., Dlouhy, S. R. & Ghetti, B., Feb 1 1997, In : Molecular Brain Research. 44, 1, p. 147-150 4 p.

Research output: Contribution to journalArticle

47 Scopus citations
7 Scopus citations
16 Scopus citations

Subacute sclerosing panencephalitis manifesting as viral retinitis: Clinical and histopathologic findings

Park, D. W., Boldt, H. C., Massicotte, S. J., Akang, E. E. U., Roos, K. L., Bodnar, A., Pless, J., Ghetti, B. & Pascuzzi, R. M., 1997, In : American Journal of Ophthalmology. 123, 4, p. 533-542 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
1996

Cloning a cDNA for carbonyl reductase (Cbr) from mouse cerebellum: Murine genes that express Cbr map to chromosomes 16 and 11

Jianjun, W., Dlouhy, S. R., Hara, A., Ghetti, B. & Hodes, M. E., May 15 1996, In : Genomics. 34, 1, p. 147-148 2 p.

Research output: Contribution to journalArticle

18 Scopus citations

Direct cDNA selection with DNA microdissected from mouse chromosome 16: Isolation of novel clones and construction of a partial transcription map of the C3-C4 region

Wei, J., Hodes, M. E., Wang, Y., Feng, Y., Ghetti, B. & Dlouhy, S. R., Aug 1996, In : Genome research. 6, 8, p. 678-687 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway

Lippa, C. F., Saunders, A. M., Smith, T. W., Swearer, J. M., Drachman, D. A., Ghetti, B., Nee, L., Pulaski-Salo, D., Dickson, D., Robitaille, Y., Bergeron, C., Crain, B., Benson, M. D., Farlow, M., Hyman, B. T., St. George-Hyslop, P., Roses, A. D. & Pollen, D. A., Feb 1996, In : Neurology. 46, 2, p. 406-412 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Linkage mapping of microdissected clones from distal mouse chromosome 16

Wei, J., Dlouhy, S. R., Wang, Y., Zhu, J., Fitzpatrick, L., Ghetti, B. & Hodes, M. E., May 1996, In : Somatic Cell and Molecular Genetics. 22, 3, p. 227-232 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease

Parchi, P., Castellani, R., Capellari, S., Ghetti, B., Young, K., Chen, S. G., Farlow, M., Dickson, D. W., Sima, A. A. F., Trojanowski, J. Q., Petersen, R. B. & Gambetti, P., Jun 1996, In : Annals of neurology. 39, 6, p. 767-778 12 p.

Research output: Contribution to journalArticle

666 Scopus citations

Phenotypic effects of the weaver gene are evident in the embryonic cerebellum but not in the ventral midbrain

Bayer, S. A., Wills, K. V., Wei, J., Feng, Y., Dlouhy, S. R., Hodes, M. E., Verina, T. & Ghetti, B., Oct 23 1996, In : Developmental Brain Research. 96, 1-2, p. 130-137 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Proteinase-K-resistant prion protein isoforms in Gerstmann-Straussler- Scheinker disease (Indiana kindred)

Piccardo, P., Seiler, C., Dlouhy, S. R., Young, K., Farlow, M. R., Prelli, F., Frangione, B., Bugiani, O., Tagliavini, F. & Ghetti, B., Nov 1996, In : Journal of Neuropathology and Experimental Neurology. 55, 11, p. 1157-1163 7 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

PRP27-30 is a normal soluble prion protein fragment released by human platelets

Perini, F., Vidal, R., Ghetti, B., Tagliavini, F., Frangione, B. & Prelli, F., Jun 25 1996, In : Biochemical and Biophysical Research Communications. 223, 3, p. 572-577 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2

Tong, Y., Wei, J., Zhang, S., Strong, J. A., Dlouhy, S. R., Hodes, M. E., Ghetti, B. & Yu, L., Jul 15 1996, In : FEBS Letters. 390, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Vascular variant of prion protein cerebral amyloidosis with τ-positive neurofibrillary tangles: The phenotype of the stop codon 145 mutation in PRNP

Ghetti, B., Piccardo, P., Spillantini, M. G., Ichimiya, Y., Porro, M., Perini, F., Kitamoto, T., Tateishi, J., Seiler, C., Frangione, B., Bugiani, O., Giaccone, G., Prelli, F., Goedert, M., Dlouhy, S. R. & Tagliavini, F., Jan 23 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 2, p. 744-748 5 p.

Research output: Contribution to journalArticle

233 Scopus citations
1995

Altered IGFBP5 gene expression in the cerebellar external germinal layer of weaver mutant mice

Lee, W. H., Wang, G. M., Lo, T., Triarhou, L. C. & Ghetti, B., Jun 1995, In : Molecular Brain Research. 30, 2, p. 259-268 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Degeneration of sertoli and spermatogenic cells in homozygous and heterozygous weaver mice

Verina, T., Tang, X., Fitzpatrick, L., Norton, J., Vogelweid, C. & Ghetti, B., 1995, In : Journal of Neurogenetics. 9, 4, p. 251-265 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

Detection of apoptosis in weaver cerebellum by electron microscopic in situ end-labeling of fragmented DNA

Migheli, A., Attanasio, A., Lee, W. H., Bayer, S. A. & Ghetti, B., Oct 13 1995, In : Neuroscience Letters. 199, 1, p. 53-56 4 p.

Research output: Contribution to journalArticle

51 Scopus citations

Dopaminergic parameters in the striatum and substantia nigra of seven strains of mice: Higher density in striatum of CAST compared to BALB mice

Richter, J. A., Brenneman, M. G., Dlouhy, S. R. & Ghetti, B., Apr 1 1995, In : Neurochemical Research. 20, 4, p. 395-400 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dopamine Transporter‐Dependent and ‐Independent Endogenous Dopamine Release from Weaver Mouse Striatum In Vitro

Richter, J. A., Bare, D. J., Yu, H., Ghetti, B. & Simon, J. R., Jan 1995, In : Journal of Neurochemistry. 64, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

11 Scopus citations