Bernardino Ghetti

  • 29265 Citations
  • 81 h-Index
1967 …2021
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Publications 1967 2019

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1996
9 Citations (Scopus)

Prion protein hereditary amyloidosis: Parenchymal and vascular

Ghetti, B., Piccardo, P., Frangione, B., Bugiani, O., Giaccone, G., Young, K., Prelli, F., Farlow, M., Dlouhy, S. & Tagliavini, F., Jun 1996, In : Seminars in Virology. 7, 3, p. 189-200 12 p.

Research output: Contribution to journalArticle

Familial Amyloidosis
Gerstmann-Straussler-Scheinker Disease
Blood Vessels
Amyloid
Spastic Paraparesis
44 Citations (Scopus)

Proteinase-K-resistant prion protein isoforms in Gerstmann-Straussler- Scheinker disease (Indiana kindred)

Piccardo, P., Seiler, C., Dlouhy, S., Young, K., Farlow, M., Prelli, F., Frangione, B., Bugiani, O., Tagliavini, F. & Ghetti, B., Nov 1996, In : Journal of Neuropathology and Experimental Neurology. 55, 11, p. 1157-1163 7 p.

Research output: Contribution to journalArticle

Gerstmann-Straussler-Scheinker Disease
Endopeptidase K
Protein Isoforms
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Amyloidogenic Proteins
68 Citations (Scopus)

PRP27-30 is a normal soluble prion protein fragment released by human platelets

Perini, F., Vidal, R., Ghetti, B., Tagliavini, F., Frangione, B. & Prelli, F., Jun 25 1996, In : Biochemical and Biophysical Research Communications. 223, 3, p. 572-577 6 p.

Research output: Contribution to journalArticle

Platelets
Protein Isoforms
Blood Platelets
Scrapie
Peptide Hydrolases
46 Citations (Scopus)

The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2

Tong, Y., Wei, J., Zhang, S., Strong, J. A., Dlouhy, S., Hodes, M. E., Ghetti, B. & Yu, L., Jul 15 1996, In : FEBS Letters. 390, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Depolarization
Ions
Mutation
mu Opioid Receptor
223 Citations (Scopus)

Vascular variant of prion protein cerebral amyloidosis with τ-positive neurofibrillary tangles: The phenotype of the stop codon 145 mutation in PRNP

Ghetti, B., Piccardo, P., Spillantini, M. G., Ichimiya, Y., Porro, M., Perini, F., Kitamoto, T., Tateishi, J., Seiler, C., Frangione, B., Bugiani, O., Giaccone, G., Prelli, F., Goedert, M., Dlouhy, S. & Tagliavini, F., Jan 23 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 2, p. 744-748 5 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Terminator Codon
Blood Vessels
Phenotype
Amyloid
1995
20 Citations (Scopus)

Altered IGFBP5 gene expression in the cerebellar external germinal layer of weaver mutant mice

Lee, W. H., Wang, G. M., Lo, T., Triarhou, L. C. & Ghetti, B., 1995, In : Molecular Brain Research. 30, 2, p. 259-268 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Gene Expression
Messenger RNA
Insulin-Like Growth Factor I
Cerebellum
17 Citations (Scopus)

Degeneration of sertoli and spermatogenic cells in homozygous and heterozygous weaver mice

Verina, T., Tang, X., Fitzpatrick, L., Norton, J., Vogelweid, C. & Ghetti, B., 1995, In : Journal of Neurogenetics. 9, 4, p. 251-265 15 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Sertoli Cells
Sperm Count
Seminiferous Epithelium
Oligospermia
51 Citations (Scopus)

Detection of apoptosis in weaver cerebellum by electron microscopic in situ end-labeling of fragmented DNA

Migheli, A., Attanasio, A., Lee, W. H., Bayer, S. A. & Ghetti, B., Oct 13 1995, In : Neuroscience Letters. 199, 1, p. 53-56 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Cerebellum
Electrons
Apoptosis
DNA
1 Citation (Scopus)

Dopaminergic parameters in the striatum and substantia nigra of seven strains of mice: Higher density in striatum of CAST compared to BALB mice

Richter, J. A., Brenneman, M. G., Dlouhy, S. & Ghetti, B., Apr 1995, In : Neurochemical Research. 20, 4, p. 395-400 6 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Substantia Nigra
Dopamine
Inbred CBA Mouse
Glutamate Decarboxylase
10 Citations (Scopus)

Dopamine transporter-dependent and -independent endogenous dopamine release from weaver mouse striatum in vitro

Richter, J. A., Bare, D. J., Yu, H., Ghetti, B. & Simon, J. R., 1995, In : Journal of Neurochemistry. 64, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine Plasma Membrane Transport Proteins
Nomifensine
Dopamine
Serotonin
1 Citation (Scopus)

Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouse

Stotz-Potter, E. H., Ghetti, B. & Simon, J. R., Jul 1995, In : Neurochemical Research. 20, 7, p. 821-826 6 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Serotonin
Fenfluramine
Corpus Striatum
36 Citations (Scopus)

Gerstmann-straussler-scheinker disease (Prnp p102l): Amyloid deposits are best recognized by antibodies directed to epitopes in prp region 90-165

Piccardo, P., Ghetti, B., Dickson, D. W., Vinters, H. V., Giaccone, G., Bugiani, O., Tagliavini, F., Young, K., Dlouhy, S., Seiler, C., Jones, C. K., Lazzarini, A., Golbe, L. I., Zimmerman, T. R., Perlman, S. L., McLachlan, D. C., George-Hyslop, P. H. S. & Lennox, A., 1995, In : Journal of Neuropathology and Experimental Neurology. 54, 6, p. 790-801 12 p.

Research output: Contribution to journalArticle

Gerstmann-Straussler-Scheinker Disease
Amyloid Plaques
Epitopes
Antibodies
Amyloid
141 Citations (Scopus)

Gerstmann-Sträussler-Scheinker disease and the Indiana kindred

Ghetti, B., Dlouhy, S., Giaccone, G., Bugiani, O., Frangione, B., Farlow, M. & Tagliavini, F., 1995, In : Brain Pathology. 5, 1, p. 61-75 15 p.

Research output: Contribution to journalArticle

Codon
Mutation
Amyloidosis
Spastic Paraparesis
Prion Diseases
43 Citations (Scopus)

Gerstmann-sträussler-scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients

Young, K., Jones, C. K., Piccardo, P., Lazzarini, A., Golbe, L. I., Zimmerman, T. R., Dickson, D. W., McLachlan, D. C., St. George-Hyslop, P., Lennox, A., Perlman, S., Vinters, H. V., Hodes, M. E., Dlouhy, S. & Ghetti, B., Jun 1995, In : Neurology. 45, 6, p. 1127-1134 8 p.

Research output: Contribution to journalArticle

Codon
Methionine
Mutation
Genes
Thymine
147 Citations (Scopus)

Neurofibrillary tangles in Niemann-Pick disease type C

Suzuki, K., Parker, C. C., Pentchev, P. G., Katz, D., Ghetti, B., D'Agostino, A. N. & Carstea, E. D., Mar 1995, In : Acta Neuropathologica. 89, 3, p. 227-238 12 p.

Research output: Contribution to journalArticle

Type C Niemann-Pick Disease
Neurofibrillary Tangles
Neurons
Amyloid Plaques
Cholesterol
38 Citations (Scopus)

Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice

Bayer, S. A., Wills, K. V., Triarhou, L. C., Verina, T., Thomas, J. D. & Ghetti, B., Sep 26 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 20, p. 9137-9140 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopaminergic Neurons
Substantia Nigra
Parturition
Neurons
22 Citations (Scopus)

Systematic differences in time of dopaminergic neuron origin between normal mice and homozygous weaver mutants

Bayer, S. A., Wills, K. V., Triarhou, L. C., Thomas, J. D. & Ghetti, B., Aug 1995, In : Experimental Brain Research. 105, 2, p. 200-208 9 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopaminergic Neurons
Neurons
Ventral Tegmental Area
Raphe Nuclei
6 Citations (Scopus)

The tyrosine kinase inhibitor genistein increases endogenous dopamine release from normal and weaver mutant mouse striatal slices

Bare, D. J., Ghetti, B. & Richter, J. A., 1995, In : Journal of Neurochemistry. 65, 5, p. 2096-2104 9 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
Genistein
Protein-Tyrosine Kinases
Dopamine
126 Citations (Scopus)

Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse

Bayer, S. A., Wills, K. V., Triarhou, L. C. & Ghetti, B., Aug 1995, In : Experimental Brain Research. 105, 2, p. 191-199 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Dopaminergic Neurons
Neurogenesis
Mesencephalon
Thymidine
4 Citations (Scopus)

Ventral mesencephalic grafts in the neostriatum of the weaver mutant mouse: Structural molecule and receptor studies

Triarhou, L. C., Solà, C., Mengod, G., Garcia-Ladona, F. J., Landwehrmeyer, B., Ghetti, B. & Palacios, J. M., 1995, In : Cell Transplantation. 4, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Neostriatum
Grafts
Transplants
Molecules
1994
19 Citations (Scopus)

Age-dependent alterations in dopamine content, tyrosine hydroxylase activity, and dopamine uptake in the striatum of the weaver mutant mouse

Simon, J. R., Richter, J. A. & Ghetti, B., Feb 1994, In : Journal of Neurochemistry. 62, 2, p. 543-548 6 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Tyrosine 3-Monooxygenase
Dopamine
Corpus Striatum
Genes
16 Citations (Scopus)

Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse

Stotz, E. H., Palacios, J. M., Landwehrmeyer, B., Norton, J., Ghetti, B., Simon, J. R. & Triarhou, L. C., Feb 1994, In : Journal of Neural Transmission. 97, 1, p. 51-64 14 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Serotonin
Citalopram
Mazindol
129 Citations (Scopus)

Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish Kindreds) express only PrP peptides encoded by the mutant allele

Tagliavini, F., Prelli, F., Porro, M., Rossi, G., Giaccone, G., Farlow, M., Dlouhy, S., Ghetti, B., Bugiani, O. & Frangione, B., Nov 18 1994, In : Cell. 79, 4, p. 695-703 9 p.

Research output: Contribution to journalArticle

Amyloid
Amyloidogenic Proteins
Alleles
Peptides
Codon
8 Citations (Scopus)
Chromosomes, Human, Pair 16
Libraries
Clone Cells
Genes
Cricetinae
1 Citation (Scopus)

cDNA approaches to isolation of the mouse mutant weaver gene

Hodes, M. E., Dlouhy, S., Wei, J. J., Wang, Y., Sangameswaran, L., Lazar, V., Triarhou, L. C. & Ghetti, B., Nov 1994, In : Neurochemical Research. 19, 11, p. 1359-1362 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Gene Library
Complementary DNA
Genes
Recessive Genes
3 Citations (Scopus)

Cerebrospinal fluid levels of amyloid β-protein precursor are low in gerstmann-sträussler-scheinker disease, Indiana kindred

Farlow, M., Ghetti, B., Dlouhy, S., Giaccone, G., Bugiani, O., Tagliavini, F. & Wagner, S., 1994, In : Neurology. 44, 8, p. 1508-1510 3 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Protein Precursors
Cerebrospinal Fluid
Asymptomatic Diseases
Amyloid Plaques
25 Citations (Scopus)
Amyloid beta-Protein Precursor
Alzheimer Disease
Genes
Lod Score
Neurofibrillary Tangles
18 Citations (Scopus)

Correlated quantitative studies of the neostriatum, nucleus accumbens, substantia nigra, and ventral tegmental area in normal and weaver mutant mice

Bayer, S. A., Triarhou, L. C., Thomas, J. D. & Ghetti, B., 1994, In : Journal of Neuroscience. 14, 11 II, p. 6901-6910 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Neostriatum
Ventral Tegmental Area
Nucleus Accumbens
Substantia Nigra
62 Citations (Scopus)

Familial Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles

Ghetti, B., Tagliavini, F., Giaccone, G., Bugiani, O., Frangione, B., Farlow, M. & Dlouhy, S., Feb 1994, In : Molecular Neurobiology. 8, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Codon
Cerebellar Ataxia
Microtubule-Associated Proteins
Amyloid Plaques
244 Citations (Scopus)

Fatal familial insomnia and familial Creutzfeldt-Jakob disease: Different prion proteins determined by a DNA polymorphism

Monari, L., Chen, S. G., Brown, P., Parchi, P., Petersen, R. B., Mikol, J., Gray, F., Cortelli, P., Montagna, P., Ghetti, B., Goldfarb, L. G., Gajdusek, D. C., Lugaresi, E., Gambetti, P. & Autilio-Gambetti, L., Mar 29 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 7, p. 2839-2842 4 p.

Research output: Contribution to journalArticle

Fatal Familial Insomnia
Creutzfeldt-Jakob Syndrome
Codon
DNA
Peptide Hydrolases
2 Citations (Scopus)

Molecular characterization of a novel cDNA from murine cerebellum, developmental expression, and distribution in brain

Kambouris, M., Sangameswaran, L., Triarhou, L. C., Kozak, C. A., Dlouhy, S., Ghetti, B. & Hodes, M. E., 1994, In : Molecular Brain Research. 25, 3-4, p. 192-199 8 p.

Research output: Contribution to journalArticle

Cerebellum
Complementary DNA
Immune Sera
Brain
Clone Cells
6 Citations (Scopus)

Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library

Kambouris, M., Triarhou, L. C., Dlouhy, S., Sangameswaran, L., Luo, F., Ghetti, B. & Hodes, M. E., 1994, In : Molecular Brain Research. 25, 3-4, p. 183-191 9 p.

Research output: Contribution to journalArticle

Gene Library
Complementary DNA
Clone Cells
Antibodies
Immune Sera
3 Citations (Scopus)

Studies on the striatal dopamine uptake system of weaver mutant mice and effects of ventral mesencephalic grafts

Triarhou, L. C., Stotz, E. H., Low, W. C., Norton, J., Ghetti, B., Landwehrmeyer, B., Palacios, J. M. & Simon, J. R., Nov 1994, In : Neurochemical Research. 19, 11, p. 1349-1358 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
Grafts
Dopamine
Mazindol
20 Citations (Scopus)

The weaver mutant mouse as a model of nigrostriatal dysfunction

Simon, J. R. & Ghetti, B., Aug 1994, In : Molecular Neurobiology. 9, 1-3, p. 183-189 7 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Corpus Striatum
Anatomic Models
Dopaminergic Neurons
1993
40 Citations (Scopus)

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Tagliavini, F., Giaccone, G., Prelli, F., Verga, L., Porro, M., Trojanowski, J. Q., Farlow, M., Frangione, B., Ghetti, B. & Bugiani, O., Jul 9 1993, In : Brain Research. 616, 1-2, p. 325-329 5 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Alzheimer Disease
Amyloid Plaques
Post Translational Protein Processing
Immunohistochemistry
4 Citations (Scopus)
Neurologic Mutant Mice
Purkinje Cells
In Situ Hybridization
RNA
Brain
11 Citations (Scopus)

Characterization of Amyloid Familial β-Peptide in Familial Alzheimer′s Disease with APP717 Mutations

Liepnieks, J. J., Ghetti, B., Farlow, M., Roses, A. D. & Benson, M., Dec 15 1993, In : Biochemical and Biophysical Research Communications. 197, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Peptides
Mutation
2 Citations (Scopus)

Dopamine-depleting effects of MPTP and reserpine in weaver mutant mice

Richter, J. A., Ghetti, B. & Simon, J. R., Dec 1993, In : Molecular and Chemical Neuropathology. 20, 3, p. 219-228 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopamine Agents
Dopaminergic Neurons
4 Citations (Scopus)

Embryonic cerebellar graft development during acute phase of gliosis in the cerebellum of pcd mutant mice.

Chang, A. C. & Ghetti, B., 1993, In : Chinese Journal of Physiology. 36, 3, p. 141-149 9 p.

Research output: Contribution to journalArticle

Gliosis
Purkinje Cells
Cerebellum
Transplants
Calcium-Binding Proteins
Gerstmann-Straussler-Scheinker Disease
Amyloid Plaques
Prion Proteins
22 Citations (Scopus)

Hypospermatogenesis is the cause of infertility in the Male weaver mutant mouse

Vogelweid, C. M., Verina, T., Norton, J., Harruff, R. & Ghetti, B., 1993, In : Journal of Neurogenetics. 9, 2, p. 89-104 16 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Oligospermia
Male Infertility
Seminiferous Tubules
Spermatids
10 Citations (Scopus)
Neurologic Mutant Mice
Substantia Nigra
Dopamine
Desipramine
Fluoxetine
7 Citations (Scopus)
Neurologic Mutant Mice
Microtubule-Associated Proteins
Amyloid beta-Protein Precursor
Dopaminergic Neurons
Phosphoproteins
8 Citations (Scopus)
Neurologic Mutant Mice
Amyloid beta-Protein Precursor
In Situ Hybridization
Protein Isoforms
RNA
7 Citations (Scopus)

RFLP analysis for APP 717 mutations associated with Alzheimer's disease

Zeldenrust, S. R., Murrell, J., Farlow, M., Ghetti, B., Roses, A. D. & Benson, M., 1993, In : Journal of Medical Genetics. 30, 6, p. 476-478 3 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Restriction Fragment Length Polymorphisms
Alzheimer Disease
Mutation
Codon
17 Citations (Scopus)

Serotonin content is elevated in the dopamine deficient striatum of the weaver mutant mouse

Stotz, E. H., Triarhou, L. C., Ghetti, B. & Simon, J. R., Mar 26 1993, In : Brain Research. 606, 2, p. 267-272 6 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Serotonin
Corpus Striatum
Immunohistochemistry
225 Citations (Scopus)

Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro

Tagliavini, F., Prelli, F., Verga, L., Giaccone, G., Sarma, R., Gorevic, P., Ghetti, B., Passerini, F., Ghibaudi, E., Forloni, G., Salmona, M., Bugiani, O. & Frangione, B., Oct 15 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9678-9682 5 p.

Research output: Contribution to journalArticle

Amyloid
Peptides
Brain Diseases
PrP 27-30 Protein
Staining and Labeling
52 Citations (Scopus)

βPP participates in PrP-amyloid plaques of gerstmann-sträussler-scheinker disease, Indiana kindred

Bugiani, O., Giaccone, G., Verga, L., Pollo, B., Frangione, B., Farlow, M., Tagliavini, F. & Ghetti, B., 1993, In : Journal of Neuropathology and Experimental Neurology. 52, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Neurites
Synaptophysin
Ubiquitin C
Neurofibrillary Tangles
1992
14 Citations (Scopus)

Abnormal eye movements in Gerstmann-Straussler-Scheinker disease

Yee, R. D., Farlow, M., Suzuki, D. A., Betelak, K. F. & Ghetti, B., 1992, In : Archives of Ophthalmology. 110, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Gerstmann-Straussler-Scheinker Disease
Dyskinesias
Eye Movements
Basal Ganglia Diseases
Cerebellar Diseases
26 Citations (Scopus)

Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouse

Richter, J. A., Stotz, E. H., Ghetti, B. & Simon, J. R., May 1992, In : Neurochemical Research. 17, 5, p. 437-441 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Tyrosine 3-Monooxygenase
Dopamine
Corpus Striatum
Kinetic parameters