Bernardino Ghetti

  • 30716 Citations
  • 85 h-Index
1967 …2021
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Publications 1967 2019

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Article
1994
8 Citations (Scopus)
Chromosomes, Human, Pair 16
Libraries
Clone Cells
Genes
Cricetinae
1 Citation (Scopus)

cDNA approaches to isolation of the mouse mutant weaver gene

Hodes, M. E., Dlouhy, S. R., Wei, J. J., Wang, Y., Sangameswaran, L., Lazar, V., Triarhou, L. C. & Ghetti, B., Nov 1 1994, In : Neurochemical Research. 19, 11, p. 1359-1362 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Gene Library
Complementary DNA
Genes
Recessive Genes
3 Citations (Scopus)

Cerebrospinal fluid levels of amyloid β-protein precursor are low in gerstmann-sträussler-scheinker disease, Indiana kindred

Farlow, M. R., Ghetti, B., Dlouhy, S., Giaccone, G., Bugiani, O., Tagliavini, F. & Wagner, S., Aug 1994, In : Neurology. 44, 8, p. 1508-1510 3 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Protein Precursors
Cerebrospinal Fluid
Asymptomatic Diseases
Amyloid Plaques
26 Citations (Scopus)
Amyloid beta-Protein Precursor
Alzheimer Disease
Genes
Lod Score
Neurofibrillary Tangles
18 Citations (Scopus)

Correlated quantitative studies of the neostriatum, nucleus accumbens, substantia nigra, and ventral tegmental area in normal and weaver mutant mice

Bayer, S. A., Triarhou, L. C., Thomas, J. D. & Ghetti, B., Nov 16 1994, In : Journal of Neuroscience. 14, 11 II, p. 6901-6910 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Neostriatum
Ventral Tegmental Area
Nucleus Accumbens
Substantia Nigra
63 Citations (Scopus)

Familial Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles

Ghetti, B., Tagliavini, F., Giaccone, G., Bugiani, O., Frangione, B., Farlow, M. R. & Dlouhy, S. R., Feb 1 1994, In : Molecular Neurobiology. 8, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Codon
Cerebellar Ataxia
Microtubule-Associated Proteins
Amyloid Plaques
249 Citations (Scopus)

Fatal familial insomnia and familial Creutzfeldt-Jakob disease: Different prion proteins determined by a DNA polymorphism

Monari, L., Chen, S. G., Brown, P., Parchi, P., Petersen, R. B., Mikol, J., Gray, F., Cortelli, P., Montagna, P., Ghetti, B., Goldfarb, L. G., Gajdusek, D. C., Lugaresi, E., Gambetti, P. & Autilio-Gambetti, L., Mar 29 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 7, p. 2839-2842 4 p.

Research output: Contribution to journalArticle

Open Access
Fatal Familial Insomnia
Creutzfeldt-Jakob Syndrome
Codon
DNA
Peptide Hydrolases
2 Citations (Scopus)

Molecular characterization of a novel cDNA from murine cerebellum, developmental expression, and distribution in brain

Kambouris, M., Sangameswaran, L., Triarhou, L. C., Kozak, C. A., Dlouhy, S. R., Ghetti, B. & Hodes, M. E., Sep 1994, In : Molecular Brain Research. 25, 3-4, p. 192-199 8 p.

Research output: Contribution to journalArticle

Cerebellum
Complementary DNA
Immune Sera
Brain
Clone Cells
6 Citations (Scopus)

Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library

Kambouris, M., Triarhou, L. C., Dlouhy, S. R., Sangameswaran, L., Luo, F., Ghetti, B. & Hodes, M. E., Sep 1994, In : Molecular Brain Research. 25, 3-4, p. 183-191 9 p.

Research output: Contribution to journalArticle

Gene Library
Complementary DNA
Clone Cells
Antibodies
Immune Sera
3 Citations (Scopus)

Studies on the striatal dopamine uptake system of weaver mutant mice and effects of ventral mesencephalic grafts

Triarhou, L. C., Stotz, E. H., Low, W. C., Norton, J., Ghetti, B., Landwehrmeyer, B., Palacios, J. M. & Simon, J. R., Nov 1 1994, In : Neurochemical Research. 19, 11, p. 1349-1358 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
Grafts
Dopamine
Mazindol
21 Citations (Scopus)

The weaver mutant mouse as a model of nigrostriatal dysfunction

Simon, J. R. & Ghetti, B., Aug 1 1994, In : Molecular Neurobiology. 9, 1-3, p. 183-189 7 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Corpus Striatum
Anatomic Models
Dopaminergic Neurons
1993
40 Citations (Scopus)

A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Tagliavini, F., Giaccone, G., Prelli, F., Verga, L., Porro, M., Trojanowski, J. Q., Farlow, M. R., Frangione, B., Ghetti, B. & Bugiani, O., Jul 9 1993, In : Brain research. 616, 1-2, p. 325-329 5 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Alzheimer Disease
Amyloid Plaques
Post Translational Protein Processing
Immunohistochemistry
4 Citations (Scopus)
Neurologic Mutant Mice
Purkinje Cells
In Situ Hybridization
RNA
Brain
11 Citations (Scopus)

Characterization of amyloid familial β-peptide in familial alzheimer′s disease with APP717 mutations

Liepnieks, J. J., Ghetti, B., Farlow, M., Roses, A. D. & Benson, M. D., Dec 15 1993, In : Biochemical and Biophysical Research Communications. 197, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Peptides
Mutation
2 Citations (Scopus)

Dopamine-depleting effects of MPTP and reserpine in weaver mutant mice

Richter, J. A., Ghetti, B. & Simon, J. R., Dec 1 1993, In : Molecular and Chemical Neuropathology. 20, 3, p. 219-228 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Dopamine Agents
Dopaminergic Neurons
4 Citations (Scopus)

Embryonic cerebellar graft development during acute phase of gliosis in the cerebellum of pcd mutant mice.

Chang, A. C. & Ghetti, B., 1993, In : The Chinese journal of physiology. 36, 3, p. 141-149 9 p.

Research output: Contribution to journalArticle

Gliosis
Purkinje Cells
Cerebellum
Transplants
Calcium-Binding Proteins
23 Citations (Scopus)

Hypospermatogenesis is the cause of infertility in the Male weaver mutant mouse

Vogelweid, C. M., Verina, T., Norton, J., Harruff, R. & Ghetti, B., Jan 1 1993, In : Journal of Neurogenetics. 9, 2, p. 89-104 16 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Oligospermia
Male Infertility
Seminiferous Tubules
Spermatids
10 Citations (Scopus)

Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse

Simon, J. R. & Ghetti, B., May 1993, In : Neurochemistry International. 22, 5, p. 471-477 7 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Substantia Nigra
Dopamine
Desipramine
Fluoxetine
7 Citations (Scopus)
Neurologic Mutant Mice
Microtubule-Associated Proteins
Amyloid beta-Protein Precursor
Dopaminergic Neurons
Phosphoproteins
8 Citations (Scopus)
Neurologic Mutant Mice
Amyloid beta-Protein Precursor
In Situ Hybridization
Protein Isoforms
RNA
7 Citations (Scopus)

RFLP analysis for APP 717 mutations associated with Alzheimer's disease

Zeldenrust, S. R., Murrell, J., Farlow, M., Ghetti, B., Roses, A. D. & Benson, M. D., Jan 1 1993, In : Journal of Medical Genetics. 30, 6, p. 476-478 3 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Restriction Fragment Length Polymorphisms
Alzheimer Disease
Mutation
Codon
17 Citations (Scopus)

Serotonin content is elevated in the dopamine deficient striatum of the weaver mutant mouse

Stotz, E. H., Triarhou, L. C., Ghetti, B. & Simon, J. R., Mar 26 1993, In : Brain research. 606, 2, p. 267-272 6 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Serotonin
Corpus Striatum
Immunohistochemistry
226 Citations (Scopus)

Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro

Tagliavini, F., Prelli, F., Verga, L., Giaccone, G., Sarma, R., Gorevic, P., Ghetti, B., Passerini, F., Ghibaudi, E., Forloni, G., Salmona, M., Bugiani, O. & Frangione, B., Oct 15 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9678-9682 5 p.

Research output: Contribution to journalArticle

Open Access
Amyloid
Peptides
Brain Diseases
PrP 27-30 Protein
Staining and Labeling
51 Citations (Scopus)

βPP participates in PrP-amyloid plaques of gerstmann-sträussler-scheinker disease, Indiana kindred

Bugiani, O., Giaccone, G., Verga, L., Pollo, B., Frangione, B., Farlow, M. R., Tagliavini, F. & Ghetti, B., Jan 1993, In : Journal of Neuropathology and Experimental Neurology. 52, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Neurites
Synaptophysin
Ubiquitin C
Neurofibrillary Tangles
1992
15 Citations (Scopus)

Abnormal Eye Movements in Gerstmann-Sträussler-Scheinker Disease

Yee, R. D., Farlow, M. R., Suzuki, D. A., Betelak, K. F. & Ghetti, B., Jan 1992, In : Archives of Ophthalmology. 110, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Dyskinesias
Eye Movements
Gerstmann-Straussler-Scheinker Disease
Basal Ganglia Diseases
Cerebellar Diseases
26 Citations (Scopus)

Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouse

Richter, J. A., Stotz, E. H., Ghetti, B. & Simon, J. R., May 1 1992, In : Neurochemical Research. 17, 5, p. 437-441 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Tyrosine 3-Monooxygenase
Dopamine
Corpus Striatum
Kinetic parameters
23 Citations (Scopus)

Degeneration of mesencephalic dopamine neurons in weaver mutant mice

Ghetti, B. & Triarhou, L. C., Mar 1992, In : Neurochemistry International. 20, SUPPL., p. 305-307 3 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Nerve Degeneration
Dopaminergic Neurons
Mesencephalon
Dopamine
1 Citation (Scopus)
Open Access
Neurologic Mutant Mice
Suspensions
Genetic Background
21 Citations (Scopus)
Cerebellar Nuclei
Purkinje Cells
Suspensions
Cerebellar Cortex
Transplants
176 Citations (Scopus)

Linkage of the Indiana kindred of gerstmann-sträussler-scheinker disease to the prion protein gene

Dlouhy, S. R., Hsiao, K., Farlow, M. R., Foroud, T., Conneally, P. M., Johnson, P., Prusiner, S. B., Hodes, M. E. & Ghetti, B., Apr 1992, In : Nature genetics. 1, 1, p. 64-67 4 p.

Research output: Contribution to journalArticle

Prion Diseases
Codon
Valine
Genes
Lod Score
53 Citations (Scopus)

Low cerebrospinal-fluid concentrations of soluble amyloid β-protein precursor in hereditary Alzheimer's disease

Farlow, M., Ghetti, B., Benson, M. D., van Nostrand, W. E., Farrow, J. S. & Wagner, S. L., Aug 22 1992, In : The Lancet. 340, 8817, p. 453-454 2 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Amyloid beta-Protein Precursor
Cerebrospinal Fluid
Alzheimer Disease
Genes
204 Citations (Scopus)

Mutant prion proteins in gerstmann-sträussler-scheinker disease with neurofibrillary tangles

Hsiao, K., Dlouhy, S. R., Farlow, M. R., Cass, C., Da Costa, M., Conneally, P. M., Hodes, M. E., Ghetti, B. & Prusiner, S. B., Apr 1992, In : Nature genetics. 1, 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Mutant Proteins
Codon
Amyloid Plaques
Glutamine
78 Citations (Scopus)

Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Giaccone, G., Verga, L., Bugiani, O., Frangione, B., Serban, D., Prusiner, S. B., Farlow, M. R., Ghetti, B. & Tagliavini, F., Oct 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 19, p. 9349-9353 5 p.

Research output: Contribution to journalArticle

Open Access
Amyloid Plaques
Amyloid
Immune Sera
Endopeptidase K
Protein Isoforms
9 Citations (Scopus)

Serotonin fiber innervation of cerebellar cell suspensions intraparenchymally grafted to the cerebellum of pcd mutant mice

Triarhou, L. C., Low, W. C. & Ghetti, B., May 1 1992, In : Neurochemical Research. 17, 5, p. 475-482 8 p.

Research output: Contribution to journalArticle

Purkinje Cells
Cerebellum
Serotonin
Suspensions
Fibers
23 Citations (Scopus)
Amyloidogenic Proteins
Inborn Genetic Diseases
Thymine
Guanine
Alzheimer Disease
13 Citations (Scopus)
Neurologic Mutant Mice
Choline O-Acetyltransferase
Choline
gamma-Aminobutyric Acid
Dopamine
1991
871 Citations (Scopus)

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

Murrell, J., Farlow, M., Ghetti, B. & Benson, M. D., Jan 1 1991, In : Science. 254, 5028, p. 97-99 3 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Amyloid beta-Protein Precursor
Alzheimer Disease
Mutation
Amyloid Plaques
164 Citations (Scopus)

Amyloid protein of Gerstmann-Straussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58

Tagliavini, F., Prelli, F., Ghiso, J., Bugiani, O., Serban, D., Prusiner, S. B., Farlow, M. R., Ghetti, B. & Frangione, B., Mar 18 1991, In : EMBO Journal. 10, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

Gerstmann-Straussler-Scheinker Disease
Amyloidogenic Proteins
Codon
Glycine
Amyloid
16 Citations (Scopus)

Asymmetrical cerebral atrophy in Alzheimer's disease

Bugiani, O., Constantinidis, J., Ghetti, B., Bouras, C. & Tagliavini, F., Jan 1 1991, In : Clinical Neuropathology. 10, 2, p. 55-60 6 p.

Research output: Contribution to journalArticle

Atrophy
Alzheimer Disease
Brain
12 Citations (Scopus)

In Vitro Release of Endogenous Dopamine from the Striatum of the Weaver Mutant Mouse

Simon, J. R., Yu, H., Richter, J. A., Vasko, M. R. & Ghetti, B., Nov 1991, In : Journal of Neurochemistry. 57, 5, p. 1478-1482 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Corpus Striatum
Amphetamine
Potassium
18 Citations (Scopus)

Serotonin-immunoreactivity in the cerebellum of two neurological mutant mice and the corresponding wild-type genetic stocks

Triarhou, L. C. & Ghetti, B., Jan 1 1991, In : Journal of chemical neuroanatomy. 4, 6, p. 421-428 8 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Cerebellum
Serotonin
Purkinje Cells
Cerebellar Cortex
26 Citations (Scopus)

Stabilisation of neurone number in the inferior olivary complex of aged 'Purkinje cell degeneration' mutant mice

Triarhou, L. C. & Ghetti, B., May 1 1991, In : Acta Neuropathologica. 81, 6, p. 597-602 6 p.

Research output: Contribution to journalArticle

Purkinje Cells
Neurons
Atrophy
Cerebellar Nuclei
Medulla Oblongata
6 Citations (Scopus)

Unique cerebellar phenotype combining granule and Purkinje cell loss: Morphological evidence for weaver*pcd double mutant mice

Ghetti, B., Triarhou, L. C., Alyea, C. J., Dlouhy, S. R. & Karn, R. C., Jan 1 1991, In : Journal of Neurocytology. 20, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

Purkinje Cells
Phenotype
Cerebellum
Breeding
Genotype
1990
17 Citations (Scopus)

Age-related changes in striatal dopamine D2 receptor binding in weaver mice and effects of ventral mesencephalic grafts

Kaseda, Y., Ghetti, B., Low, W. C., Norton, J., Brittain, H., Triarhou, L. C., Richter, J. A. & Simon, J. R., Dec 1 1990, In : Experimental Brain Research. 83, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
Dopamine D2 Receptors
Spiperone
Transplants
46 Citations (Scopus)

Alzheimer patients and Down patients: Abnormal presynaptic terminals are related to cerebral preamyloid deposits

Bugiani, O., Giaccone, G., Verga, L., Pollo, B., Ghetti, B., Frangione, B. & Tagliavini, F., Oct 30 1990, In : Neuroscience Letters. 119, 1, p. 56-59 4 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Amyloid
Neuropil
Neurites
Down Syndrome
5 Citations (Scopus)

Chapter 21 Dopamine neurone grafting to the weaver mouse neostriatum

Triarhou, L. C., Low, W. C. & Ghetti, B., Jan 1 1990, In : Progress in Brain Research. 82, C, p. 187-195 9 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Neostriatum
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
Transplantation
6 Citations (Scopus)

Chapter 22 Timing of neuronal replacement in cerebellar degenerative ataxia of Purkinje cell type

Ghetti, B., Triarhou, L. C., Alyea, C. J., Low, W. C. & Chang, A. C., Jan 1 1990, In : Progress in Brain Research. 82, C, p. 197-202 6 p.

Research output: Contribution to journalArticle

Cerebellar Ataxia
Purkinje Cells
Cell Transplantation
18 Citations (Scopus)

Intrastriatal implants of mesencephalic cell suspensions in weaver mutant mice: ultrastructural relationships of dopaminergic dendrites and axons issued from the graft

Triarhou, L. C., Brundin, P., Doucet, G., Norton, J., Björklund, A. & Ghetti, B., Jan 1 1990, In : Experimental Brain Research. 79, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dendrites
Axons
Suspensions
Transplants
51 Citations (Scopus)

Neurofibrillary tangles of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease share antigenic determinants with those of Alzheimer disease

Giaccone, G., Tagliavini, F., Verga, L., Frangione, B., Farlow, M. R., Bugiani, O. & Ghetti, B., Oct 22 1990, In : Brain research. 530, 2, p. 325-329 5 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Epitopes
Alzheimer Disease
Amyloidosis
Ubiquitin
1989
48 Citations (Scopus)

Alzheimer patients: preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system

Bugiani, O., Giaccone, G., Frangione, B., Ghetti, B. & Tagliavini, F., Sep 11 1989, In : Neuroscience Letters. 103, 3, p. 263-268 6 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Central Nervous System
Amyloid
Immune Sera
Alzheimer Disease