Bernardino Ghetti

  • 29265 Citations
  • 81 h-Index
1967 …2021
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Publications 1967 2019

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1992
22 Citations (Scopus)

Degeneration of mesencephalic dopamine neurons in weaver mutant mice

Ghetti, B. & Triarhou, L. C., 1992, In : Neurochemistry International. 20, SUPPL., p. 305-307 3 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Nerve Degeneration
Dopaminergic Neurons
Mesencephalon
Dopamine
1 Citation (Scopus)
Neurologic Mutant Mice
Suspensions
Genetic Background
21 Citations (Scopus)
Cerebellar Nuclei
Purkinje Cells
Suspensions
Cerebellar Cortex
Transplants
175 Citations (Scopus)

Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene

Dlouhy, S., Hsiao, K., Farlow, M., Foroud, T., Conneally, P. M., Johnson, P., Prusiner, S. B., Hodes, M. E. & Ghetti, B., Apr 1992, In : Nature Genetics. 1, 1, p. 64-67 4 p.

Research output: Contribution to journalArticle

Prion Diseases
Codon
Valine
Genes
Lod Score
53 Citations (Scopus)

Low cerebrospinal-fluid concentrations of soluble amyloid β-protein precursor in hereditary Alzheimer's disease

Farlow, M., Ghetti, B., Benson, M., van Nostrand, W. E., Farrow, J. S. & Wagner, S. L., Aug 22 1992, In : The Lancet. 340, 8817, p. 453-454 2 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Amyloid beta-Protein Precursor
Cerebrospinal Fluid
Alzheimer Disease
Genes
201 Citations (Scopus)

Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles

Hsiao, K., Dlouhy, S., Farlow, M., Cass, C., Da Costa, M., Conneally, P. M., Hodes, M. E., Ghetti, B. & Prusiner, S. B., Apr 1992, In : Nature Genetics. 1, 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Mutant Proteins
Codon
Amyloid Plaques
Glutamine
77 Citations (Scopus)

Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred

Giaccone, G., Verga, L., Bugiani, O., Frangione, B., Serban, D., Prusiner, S. B., Farlow, M., Ghetti, B. & Tagliavini, F., Oct 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 19, p. 9349-9353 5 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Immune Sera
Endopeptidase K
Protein Isoforms
9 Citations (Scopus)

Serotonin fiber innervation of cerebellar cell suspensions intraparenchymally grafted to the cerebellum of pcd mutant mice

Triarhou, L. C., Low, W. C. & Ghetti, B., May 1992, In : Neurochemical Research. 17, 5, p. 475-482 8 p.

Research output: Contribution to journalArticle

Purkinje Cells
Cerebellum
Serotonin
Suspensions
Fibers
22 Citations (Scopus)
Amyloidogenic Proteins
Inborn Genetic Diseases
Thymine
Guanine
Alzheimer Disease
13 Citations (Scopus)
Neurologic Mutant Mice
Choline O-Acetyltransferase
Choline
gamma-Aminobutyric Acid
Dopamine
1991
850 Citations (Scopus)

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

Murrell, J., Farlow, M., Ghetti, B. & Benson, M., Oct 4 1991, In : Science. 254, 5028, p. 97-99 3 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Amyloid beta-Protein Precursor
Alzheimer Disease
Mutation
Amyloid Plaques
161 Citations (Scopus)

Amyloid protein of Gerstmann - Sträussler - Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58

Tagliavini, F., Prelli, F., Ghiso, J., Bugiani, O., Serban, D., Prusiner, S. B., Farlow, M., Ghetti, B. & Frangione, B., 1991, In : EMBO Journal. 10, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Codon
Glycine
Amyloid
Endopeptidase K
16 Citations (Scopus)

Asymmetrical cerebral atrophy in Alzheimer's disease

Bugiani, O., Constantinidis, J., Ghetti, B., Bouras, C. & Tagliavini, F., 1991, In : Clinical Neuropathology. 10, 2, p. 55-60 6 p.

Research output: Contribution to journalArticle

Atrophy
Alzheimer Disease
Brain
11 Citations (Scopus)

In vitro release of endogenous dopamine from the striatum of the weaver mutant mouse

Simon, J. R., Yu, H., Richter, J. A., Vasko, M. & Ghetti, B., Nov 1991, In : Journal of Neurochemistry. 57, 5, p. 1478-1482 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Corpus Striatum
Amphetamine
Potassium
18 Citations (Scopus)
Neurologic Mutant Mice
Cerebellum
Serotonin
Purkinje Cells
Cerebellar Cortex
26 Citations (Scopus)

Stabilisation of neurone number in the inferior olivary complex of aged 'Purkinje cell degeneration' mutant mice

Triarhou, L. C. & Ghetti, B., May 1991, In : Acta Neuropathologica. 81, 6, p. 597-602 6 p.

Research output: Contribution to journalArticle

Purkinje Cells
Neurons
Atrophy
Cerebellar Nuclei
Medulla Oblongata
6 Citations (Scopus)

Unique cerebellar phenotype combining granule and Purkinje cell loss: Morphological evidence for weaver*pcd double mutant mice

Ghetti, B., Triarhou, L. C., Alyea, C. J., Dlouhy, S. & Karn, R. C., Jan 1991, In : Journal of Neurocytology. 20, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

Purkinje Cells
Phenotype
Cerebellum
Breeding
Genotype
1990
17 Citations (Scopus)

Age-related changes in striatal dopamine D2 receptor binding in weaver mice and effects of ventral mesencephalic grafts

Kaseda, Y., Ghetti, B., Low, W. C., Norton, J., Brittain, H., Triarhou, L. C., Richter, J. A. & Simon, J. R., Dec 1990, In : Experimental Brain Research. 83, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
Dopamine D2 Receptors
Spiperone
Transplants
46 Citations (Scopus)

Alzheimer patients and Down patients: Abnormal presynaptic terminals are related to cerebral preamyloid deposits

Bugiani, O., Giaccone, G., Verga, L., Pollo, B., Ghetti, B., Frangione, B. & Tagliavini, F., Oct 30 1990, In : Neuroscience Letters. 119, 1, p. 56-59 4 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Amyloid
Neuropil
Neurites
Down Syndrome
5 Citations (Scopus)

Dopamine neurone grafting to the weaver mouse neostriatum

Triarhou, L. C., Low, W. C. & Ghetti, B., 1990, In : Progress in Brain Research. 82, p. 187-195 9 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Neostriatum
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
Transplantation
18 Citations (Scopus)

Intrastriatal implants of mesencephalic cell suspensions in weaver mutant mice: ultrastructural relationships of dopaminergic dendrites and axons issued from the graft

Triarhou, L. C., Brundin, P., Doucet, G., Norton, J., Björklund, A. & Ghetti, B., Jan 1990, In : Experimental Brain Research. 79, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dendrites
Axons
Suspensions
Transplants
51 Citations (Scopus)

Neurofibrillary tangles of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease share antigenic determinants with those of Alzheimer disease

Giaccone, G., Tagliavini, F., Verga, L., Frangione, B., Farlow, M., Bugiani, O. & Ghetti, B., Oct 22 1990, In : Brain Research. 530, 2, p. 325-329 5 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Epitopes
Alzheimer Disease
Amyloidosis
Ubiquitin
6 Citations (Scopus)

Timing of neuronal replacement in cerebellar degenerative ataxia of Purkinje cell type

Ghetti, B., Triarhou, L. C., Alyea, C. J., Low, W. C. & Chang, A. C., 1990, In : Progress in Brain Research. 82, p. 197-202 6 p.

Research output: Contribution to journalArticle

Cerebellar Ataxia
Purkinje Cells
Cell Transplantation
1989
48 Citations (Scopus)

Alzheimer patients: preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system

Bugiani, O., Giaccone, G., Frangione, B., Ghetti, B. & Tagliavini, F., Sep 11 1989, In : Neuroscience Letters. 103, 3, p. 263-268 6 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Central Nervous System
Amyloid
Immune Sera
Alzheimer Disease
44 Citations (Scopus)

Degeneration and graft-induced restoration of dopamine innervation in the weaver mouse neostriatum: a quantitative radioautographic study of [3H]dopamine uptake

Doucet, G., Brundin, P., Seth, S., Murata, Y., Strecker, R. E., Triarhou, L. C., Ghetti, B. & Björklund, A., Oct 1989, In : Experimental Brain Research. 77, 3, p. 552-568 17 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Neostriatum
Dopamine
Transplants
Tyrosine 3-Monooxygenase
15 Citations (Scopus)

Developmental expression of polypeptide PEP-19 in cerebellar cell suspensions transplanted into the cerebellum of pcd mutant mice

Chang, A. C., Triarhou, L. C., Alyea, C. J., Low, W. C. & Ghetti, B., Aug 1989, In : Experimental Brain Research. 76, 3, p. 639-645 7 p.

Research output: Contribution to journalArticle

Purkinje Cells
Cerebellum
Suspensions
Peptides
Transplantation
79 Citations (Scopus)

Gerstmann-straussler-scheinker disease. I. extending the clinical spectrum

Farlow, M., Yee, R. D., Dlouhy, S., Conneally, P. M., Azzarelli, B. & Ghetti, B., 1989, In : Neurology. 39, 11, p. 1446-1452 7 p.

Research output: Contribution to journalArticle

Gerstmann-Straussler-Scheinker Disease
Eye Movements
Dementia
Gait Ataxia
Eye Abnormalities
154 Citations (Scopus)

Gerstmann-sträussler-scheinker disease. II. Neurofibrillary tangles and plaques with PrP-amyloid coexist in an affected family

Ghetti, B., Tagliavini, F., Masters, C. L., Beyreuther, K., Ciaccone, G., Verga, L., Farlow, M., Conneally, P. M., Dlouhy, S., Azzarelli, B. & Bugiani, O., 1989, In : Neurology. 39, 11, p. 1453-1461 9 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Amyloid
Amyloid Plaques
Antibodies
Amyloid beta-Peptides
33 Citations (Scopus)

The dendritic dopamine projection of the substantia nigra: phenotypic denominator of weaver gene action in hetero- and homozygosity

Triarhou, L. C. & Ghetti, B., Nov 6 1989, In : Brain Research. 501, 2, p. 373-381 9 p.

Research output: Contribution to journalArticle

Substantia Nigra
Dopamine
Genes
Mesencephalon
Heterozygote
1988
5 Citations (Scopus)

Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice

Mendelsohn, L. G., Smith, M. C., Lucaites, V. L., Kerchner, G. A. & Ghetti, B., Aug 23 1988, In : Brain Research. 458, 2, p. 361-366 6 p.

Research output: Contribution to journalArticle

IGF Type 2 Receptor
Cerebellar Cortex
Purkinje Cells
Cerebellum
Insulin-Like Growth Factor II
10 Citations (Scopus)
Purkinje Cells
gamma-Aminobutyric Acid
Glutamic Acid
Glycine
Age Groups
6 Citations (Scopus)

Layer-specific innervation of the dopamine-deficient frontal cortex in weaver mutant mice by grafted mesencephalic dopaminergic neurones

Triarhou, L. C., Low, W. C. & Ghetti, B., Oct 1988, In : Cell and Tissue Research. 254, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopaminergic Neurons
Frontal Lobe
Neurons
Dopamine
151 Citations (Scopus)

Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice

Triarhou, L. C., Norton, J. & Ghetti, B., Apr 1988, In : Experimental Brain Research. 70, 2, p. 256-265 10 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
antineoplaston A10
Homozygote
Dopamine
Cell Count
19 Citations (Scopus)

Progressive supranuclear palsy with hypertrophy of the olives - An immunocytochemical study of the cytoskeleton of argyrophilic neurons

Giaccone, G., Tagliavini, F., Street, J. S., Ghetti, B. & Bugiani, O., Jan 1988, In : Acta Neuropathologica. 77, 1, p. 14-20 7 p.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Olea
Cytoskeleton
Hypertrophy
Neurons
15 Citations (Scopus)

Reinstatement of synaptic connectivity in the striatum of weaver mutant mice following transplantation of ventral mesencephalic anlagen

Triarhou, L. C., Low, W. C., Norton, J. & Ghetti, B., Apr 1988, In : Journal of Neurocytology. 17, 2, p. 233-243 11 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine
Transplantation
Tyrosine 3-Monooxygenase
Transplants
15 Citations (Scopus)

Serotonin concentration and turnover in cerebelum and other brain regions of pcd mutant mice

Ghetti, B., Perry, K. W. & Fuller, R. W., Aug 23 1988, In : Brain Research. 458, 2, p. 367-371 5 p.

Research output: Contribution to journalArticle

Purkinje Cells
Serotonin
Cerebellum
Brain
Hydroxyindoleacetic Acid
25 Citations (Scopus)
Neurologic Mutant Mice
Tyrosine 3-Monooxygenase
Dopamine
Corpus Striatum
Presynaptic Terminals
1987
28 Citations (Scopus)

Aluminum-induced decreases in choline acetyltransferase, tyrosine hydroxylase, and glutamate decarboxylase in selected regions of rabbit brain

Hofstetter, J. R., Vincent, I., Bugiani, O., Ghetti, B. & Richter, J. A., Jun 1987, In : Neurochemical Pathology. 6, 3, p. 177-193 17 p.

Research output: Contribution to journalArticle

Tyrosine Decarboxylase
Glutamate Decarboxylase
Choline O-Acetyltransferase
Tyrosine 3-Monooxygenase
Aluminum
51 Citations (Scopus)

Anterograde transsynaptic degeneration in the deep cerebellar nuclei of Purkinje cell degeneration (pcd) mutant mice

Triarhou, L. C., Norton, J. & Ghetti, B., May 1 1987, In : Experimental Brain Research. 66, 3, p. 577-588 12 p.

Research output: Contribution to journalArticle

Cerebellar Nuclei
Purkinje Cells
Cerebellum
Atrophy
Neurons

Anterograde transsynaptic degeneration in the deep cerebellar nuclei of Purkinje cell degeneration (pcd) mutant mice

Triarhou, L. C., Norton, J. & Ghetti, B., May 1987, In : Experimental Brain Research. 66, 3, p. 577-588 12 p.

Research output: Contribution to journalArticle

Cerebellar Nuclei
Purkinje Cells
Cerebellum
Atrophy
Neurons
3 Citations (Scopus)

Cerebellar transplants into mutant mice with Purkinje and granule cell degeneration

Low, W. C., Triarhou, L. C. & Ghetti, B., 1987, In : Annals of the New York Academy of Sciences. 495, p. 740-744 5 p.

Research output: Contribution to journalArticle

Transplants
Purkinje Cells
Cells
Degeneration
Mouse
24 Citations (Scopus)

Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice

Kaseda, Y., Ghetti, B., Low, W. C., Richter, J. A. & Simon, J. R., Sep 29 1987, In : Brain Research. 422, 1, p. 178-181 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Dopamine D2 Receptors
Spiperone
Nucleus Accumbens
Genotype
22 Citations (Scopus)

Functional innervation of the striatum by ventral mesencephalic grafts in mice with inherited nigrostriatal dopamine deficiency

Low, W. C., Triarhou, L. C., Kaseda, Y., Norton, J. & Ghetti, B., Dec 1 1987, In : Brain Research. 435, 1-2, p. 315-321 7 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Dopamine
Transplants
Neurologic Mutant Mice
Corpus Striatum
64 Citations (Scopus)

Nerve cell atrophy and loss in the inferior olivary complex of 'Purkinje cell degeneration' mutant mice

Ghetti, B., Norton, J. & Triarhou, L. C., 1987, In : Journal of Comparative Neurology. 260, 3, p. 409-422 14 p.

Research output: Contribution to journalArticle

Purkinje Cells
Atrophy
Neurons
Olea
Microscopy
19 Citations (Scopus)

Neuroanatomical substrate of behavioural impairment in weaver mutant mice

Triarhou, L. C., Ghetti, B. & Lalonde, R., Oct 1987, In : Experimental Brain Research. 68, 2, p. 434-436 3 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Animal Behavior
Substantia Nigra
Motor Activity
11 Citations (Scopus)

Norepinephrine metabolism in the cerebellum of the purkinje cell degeneration (pcd) mutant mouse

Ghetti, B., Perry, K. W. & Fuller, R. W., 1987, In : Neurochemistry International. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Purkinje Cells
Cerebellum
Norepinephrine
Dihydroxyphenylalanine
Hypothalamus
62 Citations (Scopus)

Selective loss of monoaminergic neurons in weaver mutant mice- an immunocytochemical study

Gupta, M., Felten, D. L. & Ghetti, B., Feb 3 1987, In : Brain Research. 402, 2, p. 379-382 4 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Ventral Tegmental Area
Locus Coeruleus
Tyrosine 3-Monooxygenase
Neurons
10 Citations (Scopus)

Synaptic investment of striatal cellular domains by grafted dopamine neurons in weaver mutant mice

Triarhou, L. C., Low, W. C. & Ghetti, B., Dec 1987, In : Naturwissenschaften. 74, 12, p. 591-593 3 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Corpus Striatum
Caudate Nucleus
Dopaminergic Neurons
Putamen
17 Citations (Scopus)

Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy

Triarhou, L. C., Low, W. C. & Ghetti, B., Jun 1987, In : Anatomy and Embryology. 176, 2, p. 145-154 10 p.

Research output: Contribution to journalArticle

Atrophy
Transplantation
Transplants
Purkinje Cells
Cerebellar Cortex
1986

"Aluminum's disease" and Alzheimer's disease

Ghetti, B. & Bugiani, O., 1986, In : Neurobiology of Aging. 7, 6, p. 536-537 2 p.

Research output: Contribution to journalArticle

Aluminum
Alzheimer Disease