Beth Pflug

  • 1699 Citations
  • 24 h-Index
19912016
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Publications 1991 2016

  • 1699 Citations
  • 24 h-Index
  • 36 Article
  • 1 Conference contribution
2016
4 Citations (Scopus)

Metabolic and molecular regulation of dietary polyunsaturated fatty acids on prostate cancer

Zhao, H., Pflug, B., Lai, X. & Wang, M., Mar 1 2016, In : Proteomics - Clinical Applications. 10, 3, p. 267-279 13 p.

Research output: Contribution to journalArticle

Fish Oils
Unsaturated Fatty Acids
Prostatic Neoplasms
Fatty Acids
Oleic Acid
2 Citations (Scopus)

Pyruvate dehydrogenase alpha 1 as a target of omega-3 polyunsaturated fatty acids in human prostate cancer through a global phosphoproteomic analysis

Zhao, H., Pflug, B., Lai, X. & Wang, M., Sep 1 2016, In : Proteomics. 16, 17, p. 2419-2431 13 p.

Research output: Contribution to journalArticle

Fish Oils
Omega-3 Fatty Acids
Pyruvic Acid
Unsaturated Fatty Acids
Prostatic Neoplasms
2015
19 Citations (Scopus)

Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase

Fako, V. E., Wu, X., Pflug, B., Liu, J. Y. & Zhang, J-T., Jan 22 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 778-784 7 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Proton Pump Inhibitors
Drug Delivery Systems
Neoplasms
Pharmaceutical Databases
2011
82 Citations (Scopus)

Role of the endothelin axis and its antagonists in the treatment of cancer

Bagnato, A., Loizidou, M., Pflug, B., Curwen, J. & Growcott, J., May 2011, In : British Journal of Pharmacology. 163, 2, p. 220-233 14 p.

Research output: Contribution to journalArticle

Endothelins
Endothelin-1
Neoplasms
Therapeutics
Endothelin B Receptors
2010
30 Citations (Scopus)

Pregnane X receptor as a therapeutic target to inhibit androgen activity

Zhang, B., Cheng, Q., Ou, Z., Lee, J. H., Xu, M., Kochhar, U., Ren, S., Huang, M., Pflug, B. & Xie, W., Dec 2010, In : Endocrinology. 151, 12, p. 5721-5729 9 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Rifampin
Therapeutics
Small Interfering RNA
2009
30 Citations (Scopus)

Translocator protein blockade reduces prostate tumor growth

Fafalios, A., Akhavan, A., Parwani, A. V., Bies, R., McHugh, K. J. & Pflug, B., Oct 1 2009, In : Clinical Cancer Research. 15, 19, p. 6177-6184 8 p.

Research output: Contribution to journalArticle

Prostate
Prostatic Neoplasms
Growth
Lorazepam
Neoplasms
2008
1 Citation (Scopus)
Transgenic Mice
Prostate
Adenocarcinoma
Apoptosis
Growth
24 Citations (Scopus)

Longitudinal analysis of androgen deprivation of prostate cancer cells identifies pathways to androgen independence

D'Antonio, J. M., Ma, C., Monzon, F. A. & Pflug, B., May 15 2008, In : Prostate. 68, 7, p. 698-714 17 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Gene Expression
Disease Progression
Cell Survival
9 Citations (Scopus)

Therapeutic Effects of Endothelin-A Receptor Antagonist on Bladder Overactivity in Rats with Chronic Spinal Cord Injury

Ogawa, T., Sasatomi, K., Hiragata, S., Seki, S., Nishizawa, O., Chermansky, C. J., Pflug, B., Nelson, J. B., Chancellor, M. B. & Yoshimura, N., Feb 2008, In : Urology. 71, 2, p. 341-345 5 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Spinal Cord Injuries
Urinary Bladder
Endothelin A Receptors
Pressure
2007
18 Citations (Scopus)

Distinct Patterns of Endothelin Axis Expression in Primary Prostate Cancer

Godara, G., Pecher, S., Jukic, D. M., D'Antonio, J. M., Akhavan, A., Nelson, J. B. & Pflug, B., Jul 2007, In : Urology. 70, 1, p. 209-215 7 p.

Research output: Contribution to journalArticle

Endothelins
Neprilysin
Prostatic Neoplasms
Prostatic Intraepithelial Neoplasia
Adenocarcinoma
46 Citations (Scopus)

Endothelin-1 promotes cell survival in renal cell carcinoma through the ETA receptor

Pflug, B., Zheng, H., Udan, M. S., D'Antonio, J. M., Marshall, F. F., Brooks, J. D. & Nelson, J. B., Feb 8 2007, In : Cancer Letters. 246, 1-2, p. 139-148 10 p.

Research output: Contribution to journalArticle

Endothelin-1
Renal Cell Carcinoma
Cell Survival
Cell Line
Methylation
2006
43 Citations (Scopus)

Endothelin receptor A blockade enhances taxane effects in prostate cancer

Akhavan, A., McHugh, K. H., Guruli, G., Bies, R., Zamboni, W. C., Strychor, S., Nelson, J. B. & Pflug, B., 2006, In : Neoplasia. 8, 9, p. 725-732 8 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Prostatic Neoplasms
docetaxel
Heterografts
Endothelins
77 Citations (Scopus)

Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma

Shah, U. S., Dhir, R., Gollin, S. M., Chandran, U. R., Lewis, D., Acquafondata, M. & Pflug, B., Apr 2006, In : Human Pathology. 37, 4, p. 401-409 9 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Gene Dosage
Prostate
Adenocarcinoma
Prostatic Neoplasms
2005
71 Citations (Scopus)

Endothelin-1 inhibits apoptosis in prostate cancer

Nelson, J. B., Udan, M. S., Guruli, G. & Pflug, B., Jul 2005, In : Neoplasia. 7, 7, p. 631-637 7 p.

Research output: Contribution to journalArticle

Endothelin-1
Prostatic Neoplasms
Apoptosis
Endothelin A Receptors
Endothelin B Receptors
31 Citations (Scopus)

Role of endothelin axis in progression to aggressive phenotype of prostate adenocarcinoma

Godara, G., Cannon, G. W., Cannon, G. M., Bies, R., Nelson, J. B. & Pflug, B., Sep 15 2005, In : Prostate. 65, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Endothelins
Paclitaxel
Prostate
Adenocarcinoma
Phenotype
2004
19 Citations (Scopus)

Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats

Ogawa, T., Kamo, I., Pflug, B., Nelson, J. B., Seki, S., Igawa, Y., Nishizawa, O., De Groat, W. C., Chancellor, M. B. & Yoshimura, N., Oct 2004, In : Journal of Urology. 172, 4 I, p. 1533-1537 5 p.

Research output: Contribution to journalArticle

Endothelin Receptors
Urination
Endothelin-1
A 192621
Reflex
4 Citations (Scopus)

Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines

Pecher, S., Pflug, B., Brink, A. K. W. & Nelson, J. B., Aug 1 2004, In : Prostate. 60, 3, p. 175-177 3 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Prostatic Neoplasms
Cell Line
A 192621
Endothelins
43 Citations (Scopus)

Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops

Guruli, G., Pflug, B., Pecher, S., Makarenkova, V., Shurin, M. R. & Nelson, J. B., Oct 1 2004, In : Blood. 104, 7, p. 2107-2115 9 p.

Research output: Contribution to journalArticle

Endothelin A Receptors
Endothelin Receptors
Dendritic Cells
Endothelin-1
T-cells
2003
44 Citations (Scopus)

Increased Fatty Acid Synthase Expression and Activity During Progression of Prostate Cancer in the TRAMP Model

Pflug, B., Pecher, S. M., Brink, A. W., Nelson, J. B. & Foster, B. A., Nov 1 2003, In : Prostate. 57, 3, p. 245-254 10 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Transgenic Mice
Prostate
Prostatic Neoplasms
Adenocarcinoma
2002
38 Citations (Scopus)

Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice

DeMiguel, F., Lee, S. O., Lou, W., Xiao, X., Pflug, B., Nelson, J. B. & Gao, A. C., Jun 1 2002, In : Prostate. 52, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Nude Mice
Androgens
Prostatic Neoplasms
Growth
Prostate-Specific Antigen
2001
244 Citations (Scopus)

Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells

Ackerstaff, E., Pflug, B., Nelson, J. B. & Bhujwalla, Z. M., May 1 2001, In : Cancer Research. 61, 9, p. 3599-3603 5 p.

Research output: Contribution to journalArticle

Choline
Magnetic Resonance Spectroscopy
Epithelial Cells
Androgens
Prostate
25 Citations (Scopus)

Dexamethasone reduces the expression of p75 neurotrophin receptor and apoptosis in contused spinal cord

Brandoli, C., Shi, B., Pflug, B., Andrews, P., Wrathall, J. R. & Mocchetti, I., Feb 19 2001, In : Molecular Brain Research. 87, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Contusions
Spinal Cord Injuries
Dexamethasone
Spinal Cord
131 Citations (Scopus)

Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression

Pizer, E. S., Pflug, B., Steven Bova, G., Han, W. F., Udan, M. S. & Nelson, J. B., May 1 2001, In : Prostate. 47, 2, p. 102-110 9 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
Androgens
Prostatic Neoplasms
Therapeutics
Antimetabolites
10 Citations (Scopus)

TrkA induces differentiation but not apoptosis in C6-2B glioma cells

Pflug, B., Colangelo, A. M., Tornatore, C. & Mocchetti, I., Jun 15 2001, In : Journal of Neuroscience Research. 64, 6, p. 636-645 10 p.

Research output: Contribution to journalArticle

Glioma
Nerve Growth Factor
Apoptosis
Nerve Growth Factor Receptor
Oligodendroglia
1999
44 Citations (Scopus)

Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines

Pflug, B., Reiter, R. E. & Nelson, J. B., 1999, In : Prostate. 40, 4, p. 269-273 5 p.

Research output: Contribution to journalArticle

Caveolins
Androgens
Prostatic Neoplasms
Cell Line
Clone Cells
1998
51 Citations (Scopus)
Nerve Growth Factor Receptor
Nerve Growth Factor
Tumor Cell Line
Prostate
Cell Death
1997
45 Citations (Scopus)

Loss of low-affinity nerve growth factor receptor during malignant transformation of the human prostate

Perez, M., Regan, T., Pflug, B., Lynch, J. & Djakiew, D., Mar 1 1997, In : Prostate. 30, 4, p. 274-279 6 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Prostate
Adenocarcinoma
Epithelium
Prostate-Specific Antigen
27 Citations (Scopus)

Two peptides derived from the nerve growth factor precursor are biologically active

Dicou, E., Pflug, B., Magazin, M., Lehy, T., Djakiew, D., Ferrara, P., Nerrière, V. & Harvie, D., 1997, In : Journal of Cell Biology. 136, 2, p. 389-398 10 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Peptides
Protein Precursors
PC12 Cells
Adenocarcinoma
1996
11 Citations (Scopus)

Role of the low-affinity nerve growth factor receptor and the high-affinity Trk nerve growth factor receptor in human prostate carcinogenesis

Djakiew, D., Delsite, R., Dalal, R. & Pflug, B., 1996, In : Radiation Oncology Investigations. 3, 6, p. 333-339 7 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
nerves
affinity
Prostate
Carcinogenesis
1995
95 Citations (Scopus)

Expression of a Trk high affinity nerve growth factor receptor in the human prostate

Pflug, B., Dionne, C., Kaplan, D. R., Lynch, J. & Djakiew, D., 1995, In : Endocrinology. 136, 1, p. 262-268 7 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Nerve Growth Factor
Prostate
Epithelium
Proteins
1994
39 Citations (Scopus)

Postnatal expression of nerve growth factor receptors in the rat testis

Djakiew, D., Pflug, B., Dionne, C. & Onoda, M., 1994, In : Biology of Reproduction. 51, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptors
Nerve Growth Factor Receptor
Testis
Receptor Protein-Tyrosine Kinases
Nerve Growth Factor
1993
61 Citations (Scopus)

Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein

Djakiew, D., Pflug, B., Delsite, R., Onoda, M., Lynch, J. H., Arand, G. & Thompson, E. W., Mar 15 1993, In : Cancer Research. 53, 6, p. 1416-1420 5 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Chemotaxis
Stromal Cells
Tumor Cell Line
Prostate
20 Citations (Scopus)

Stromal-Epithelial paracrine interactions in the neoplastic rat and human prostate

Djakiew, D., Pflug, B. & Onoda, M., 1993, Advances in Experimental Medicine and Biology. Vol. 330. p. 185-202 18 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Neoplasm Proteins
Drug Dose Response Relationship
Growth Substances
Cultured Tumor Cells
Species Specificity
1992
6 Citations (Scopus)

Density dependent polarized secretion of a prostatic epithelial cell line

Djakiew, D., Pflug, B., Delsite, R., Lynch, J. H. & Onoda, M., 1992, In : Prostate. 20, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Epithelial Cells
Cell Line
Peptide Hydrolases
Cell Count
Serum-Free Culture Media
105 Citations (Scopus)
Nerve Growth Factor Receptor
Nerve Growth Factor
Tumor Cell Line
Prostate
Epithelial Cells
1991
27 Citations (Scopus)

Germ cell mitogenic activity is associated with nerve growth factor-Like protein(s)

Onoda, M., Pflug, B. & Djakiew, D., Dec 1991, In : Journal of Cellular Physiology. 149, 3, p. 536-543 8 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Germ Cells
Cells
Proteins
Fibroblasts
123 Citations (Scopus)

Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate

Djakiew, D., Delsite, R., Pflug, B., Wrathall, J., Lynch, J. H. & Onoda, M., Jun 15 1991, In : Cancer Research. 51, 12, p. 3304-3310 7 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Stromal Cells
Prostate
Epithelial Cells
Cell Line