Brittney-Shea Herbert

  • 3118 Citations
  • 27 h-Index
19992019
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Publications 1999 2019

  • 3118 Citations
  • 27 h-Index
  • 60 Article
2019
2 Citations (Scopus)

Global gene expression of histologically normal primary skin cells from BCNS subjects reveals "single-hit" effects that are influenced by rapamycin

Phatak, A., Athar, M., Crowell, J. A., Leffel, D., Herbert, B-S., Bale, A. E. & Kopelovich, L., Feb 1 2019, In : Oncotarget. 10, 14, p. 1360-1387 28 p.

Research output: Contribution to journalArticle

Sirolimus
Keratinocytes
Fibroblasts
Gene Expression
Skin
2018
1 Citation (Scopus)

Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers

Tanaka, H., Phipps, E. A., Wei, T., Wu, X., Goswami, C., Liu, Y., Sledge, G. W., Mina, L. & Herbert, B-S., Jan 1 2018, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

Telomere
Leukocytes
Genes
Haploinsufficiency
Telomere Shortening
1 Citation (Scopus)

Development of a New Monochrome Multiplex qPCR Method for Relative Telomere Length Measurement in Cancer

Dahlgren, P. N., Bishop, K., Dey, S., Herbert, B-S. & Tanaka, H., May 1 2018, In : Neoplasia (United States). 20, 5, p. 425-431 7 p.

Research output: Contribution to journalArticle

Multiplex Polymerase Chain Reaction
Telomere
Neoplasms
DNA
Polymerase Chain Reaction
2017
12 Citations (Scopus)

SOX17 Regulates Conversion of Human Fibroblasts into Endothelial Cells and Erythroblasts by Dedifferentiation into CD34+ Progenitor Cells

Zhang, L., Jambusaria, A., Hong, Z., Marsboom, G., Toth, P. T., Herbert, B-S., Malik, A. B. & Rehman, J., Jun 20 2017, In : Circulation. 135, 25, p. 2505-2523 19 p.

Research output: Contribution to journalArticle

Cell Dedifferentiation
Erythroblasts
Stem Cells
Endothelial Cells
Fibroblasts
2016
5 Citations (Scopus)

Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells

Subbaramaiah, K., Brown, K. A., Zahid, H., Balmus, G., Weiss, R. S., Herbert, B-S. & Dannenberg, A. J., Jul 29 2016, In : Journal of Biological Chemistry. 291, 31, p. 16011-16023 13 p.

Research output: Contribution to journalArticle

Li-Fraumeni Syndrome
Aromatase
Stromal Cells
Adenosine Triphosphatases
Breast

Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD

de Almeida, R. M. C., Clendenon, S. G., Richards, W. G., Boedigheimer, M., Damore, M., Rossetti, S., Harris, P. C., Herbert, B. S., Xu, W. M., Wandinger-Ness, A., Ward, H. H., Glazier, J. A. & Bacallao, R. L., Nov 21 2016, In : Human Genomics. 10, 1, 1 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Gene Expression Profiling
Cysts
Kidney
Disease Progression
6 Citations (Scopus)

Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD

De Almeida, R. M. C., Clendenon, S. G., Richards, W. G., Boedigheimer, M., Damore, M., Rossetti, S., Harris, P. C., Herbert, B-S., Xu, W. M., Wandinger-Ness, A., Ward, H. H., Glazier, J. A. & Bacallao, R., Nov 21 2016, In : Human Genomics. 10, 1, p. 1-24 24 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Gene Expression Profiling
Cysts
Kidney
Disease Progression
2015
12 Citations (Scopus)
Neoplastic Stem Cells
Telomerase
Breast Neoplasms
Population
Neoplasms
2014
13 Citations (Scopus)

p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling

Kochhar, A., Kopelovich, L., Sue, E., Guttenplan, J. B., Herbert, B-S., Dannenberg, A. J. & Subbaramaiah, K., 2014, In : Cancer Prevention Research. 7, 6, p. 596-606 11 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Adenosine Triphosphatases
Polycyclic Aromatic Hydrocarbons
24 Citations (Scopus)

P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Okayama, S., Kopelovich, L., Balmus, G., Weiss, R. S., Herbert, B-S., Dannenberg, A. J. & Subbaramaiah, K., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6513-6525 13 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Genes
Tumor Suppressor Genes
Proteins
Tumors
10 Citations (Scopus)

Phenotypic plasticity in normal breast derived epithelial cells

Sauder, C. A. M., Koziel, J. E., Choi, M., Fox, M. J., Grimes, B., Badve, S., Blosser, R. J., Radovich, M., Lam, C. C., Vaughan, M. B., Herbert, B-S. & Clare, S. E., Jun 10 2014, In : BMC cell biology [electronic resource]. 15, 1, 20.

Research output: Contribution to journalArticle

Breast
Epithelial Cells
Stromal Cells
Cell Culture Techniques
Tissue Banks
28 Citations (Scopus)

Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells

Sprouse, A. A. & Herbert, B-S., Oct 1 2014, In : Anticancer Research. 34, 10, p. 5363-5374 12 p.

Research output: Contribution to journalArticle

Paclitaxel
Breast Neoplasms
Triple Negative Breast Neoplasms
Cell Line
Apoptosis
28 Citations (Scopus)

Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic mps1 kinase inhibitor NMS-P715

Slee, R. B., Grimes, B., Bansal, R., Gore, J., Blackburn, C., Brown, L., Gasaway, R., Jeong, J., Victorino, J., March, K. L., Colombo, R., Herbert, B-S. & Korc, M., Feb 2014, In : Molecular Cancer Therapeutics. 13, 2, p. 307-315 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Phosphotransferases
Chromosomal Instability
Growth
M Phase Cell Cycle Checkpoints
23 Citations (Scopus)

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation

Abou Alaiwi, W. A., Muntean, B. S., Ratnam, S., Joe, B., Liu, L., Booth, R. L., Rodriguez, I., Herbert, B-S., Bacallao, R., Fruttiger, M., Mak, T. W., Zhou, J. & Nauli, S. M., Feb 11 2014, In : Circulation. 129, 6, p. 660-672 13 p.

Research output: Contribution to journalArticle

Cystic Kidney Diseases
Ploidies
Aneurysm
Cilia
Polycystic Kidney Diseases
2013
9 Citations (Scopus)

A Telomerase Immortalized Human Proximal Tubule Cell Line with a Truncation Mutation (Q4004X) in Polycystin-1

Herbert, B-S., Grimes, B., Xu, W. M., Werner, M., Ward, C., Rossetti, S., Harris, P., Bello-Reuss, E., Ward, H. H., Miller, C., Gattone, V. H., Phillips, C., Wandinger-Ness, A. & Bacallao, R., Jan 28 2013, In : PLoS One. 8, 1, e55191.

Research output: Contribution to journalArticle

telomerase
proximal tubules
Telomerase
Cells
cell lines
7 Citations (Scopus)

Heritable one-hit events defining cancer prevention?

Kopelovich, L. & Herbert, B-S., Aug 15 2013, In : Cell Cycle. 12, 16, p. 2553-2557 5 p.

Research output: Contribution to journalArticle

Neoplasms
Mutation
Inborn Genetic Diseases
Aneuploidy
Chromosome Aberrations
2012
59 Citations (Scopus)

Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability

Slee, R. B., Steiner, C. M., Herbert, B-S., Vance, G., Hickey, R. J., Schwarz, T., Christan, S., Radovich, M., Schneider, B., Schindelhauer, D. & Grimes, B., Jul 5 2012, In : Oncogene. 31, 27, p. 3244-3253 10 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Heterochromatin
Centromere
Chromatin
Neoplasms
9 Citations (Scopus)

Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT)

Alvarez, M. B., Childress, P., Philip, B. K., Gerard-O'Riley, R., Hanlon, M., Herbert, B-S., Robling, A., Pavalko, F. & Bidwell, J., May 2012, In : Journal of Cellular Physiology. 227, 5, p. 1873-1882 10 p.

Research output: Contribution to journalArticle

Telomerase
Osteoblasts
Parathyroid Hormone
Mesenchymal Stromal Cells
Bone
39 Citations (Scopus)

Pharmaceutical regulation of telomerase and its clinical potential

Sprouse, A. A., Steding, C. E. & Herbert, B-S., Jan 2012, In : Journal of Cellular and Molecular Medicine. 16, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Telomerase
Pharmaceutical Preparations
Telomere
Neoplasms
Chromosomal Instability
2011
17 Citations (Scopus)

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, X. N., Moe, S., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R., Herbert, B-S. & Gattone, V. H., Sep 2 2011, In : Kidney International. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
Cysts
Rodentia
Pathology
Kidney
85 Citations (Scopus)

Influence of nano-carrier architecture on in vitro siRNA delivery performance and in vivo biodistribution: Polyplexes vs micelleplexes

Gary, D. J., Lee, H., Sharma, R., Lee, J. S., Kim, Y., Cui, Z. Y., Jia, D., Bowman, V. D., Chipman, P. R., Wan, L., Zou, Y., Mao, G., Park, K., Herbert, B-S., Konieczny, S. F. & Won, Y. Y., May 24 2011, In : ACS Nano. 5, 5, p. 3493-3505 13 p.

Research output: Contribution to journalArticle

Small Interfering RNA
Polyethylene glycols
delivery
micelles
Micelles
19 Citations (Scopus)

Medical genetics and epigenetics of telomerase

Koziel, J. E., Fox, M. J., Steding, C. E., Sprouse, A. A. & Herbert, B-S., Mar 2011, In : Journal of Cellular and Molecular Medicine. 15, 3, p. 457-467 11 p.

Research output: Contribution to journalArticle

Telomerase
Medical Genetics
Epigenomics
Telomere
Untranslated RNA
29 Citations (Scopus)

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B-S., Chan, R. & Wells, C., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Extracellular Signal-Regulated MAP Kinases
Breast
Epithelial Cells
Telomerase
Telomere
Cell Biology
Medicine
2010
27 Citations (Scopus)

A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.

Herbert, B. S., Chanoux, R. A., Liu, Y., Baenziger, P. H., Goswami, C. P., McClintick, J., Edenberg, H. J., Pennington, R. E., Lipkin, S. M. & Kopelovich, L., Oct 2010, In : Oncotarget. 1, 6, p. 405-422 18 p.

Research output: Contribution to journalArticle

Li-Fraumeni Syndrome
Stromal Cells
Breast
Epithelial Cells
Mutation
23 Citations (Scopus)

Disabled-2 downregulation promotes epithelial-to-mesenchymal transition

Martin, J. C., Herbert, B-S. & Hocevar, B. A., Nov 23 2010, In : British Journal of Cancer. 103, 11, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Down-Regulation
Breast Neoplasms
Protein Isoforms
Breast
2009
2 Citations (Scopus)

Disruption of telomere homeostasis as a new cancer treatment strategy

Herbert, B-S., Mar 2009, In : Memo - Magazine of European Medical Oncology. 2, 1, p. 21-24 4 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Telomere
Telomerase
Neoplasms
Maintenance
31 Citations (Scopus)

Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab

Goldblatt, E. M., Erickson, P. A., Gentry, E. R., Gryaznov, S. M. & Herbert, B-S., Nov 2009, In : Breast Cancer Research and Treatment. 118, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

Telomerase
Breast Neoplasms
Lipids
Telomere Shortening
Therapeutics
9 Citations (Scopus)

Meeting report: Second international meeting on quadruplex DNA

Herbert, B-S., Huppert, J. L., Johnson, F. B., Lane, A. N. & Phan, A. T., Sep 2009, In : Biochimie. 91, 9, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

G-Quadruplexes
DNA
Biophysics
Posters
Nanotechnology
101 Citations (Scopus)
Endothelial cells
p38 Mitogen-Activated Protein Kinases
Tumor Necrosis Factor-alpha
Regeneration
Telomere
18 Citations (Scopus)

Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists

Dikmen, Z. G., Ozgurtas, T., Gryaznov, S. M. & Herbert, B-S., Apr 2009, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 4, p. 240-247 8 p.

Research output: Contribution to journalArticle

Telomerase
Neoplastic Stem Cells
Neoplasm Metastasis
Recurrence
Neoplasms
45 Citations (Scopus)

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

Goldblatt, E. M., Gentry, E. R., Fox, M. J., Gryaznov, S. M., Shen, C. & Herbert, B-S., Jul 1 2009, In : Molecular Cancer Therapeutics. 8, 7, p. 2027-2035 9 p.

Research output: Contribution to journalArticle

Telomerase
Paclitaxel
Breast Neoplasms
Growth
Telomere
2008
51 Citations (Scopus)

Factors impacting human telomere homeostasis and age-related disease

Gilley, D., Herbert, B-S., Huda, N., Tanaka, H. & Reed, T., Jan 2008, In : Mechanisms of Ageing and Development. 129, 1-2, p. 27-34 8 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Telomere
Human engineering
Aging of materials
Telomerase
2007
23 Citations (Scopus)

Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent

Gryaznov, S. M., Jackson, S., Dikmen, G., Harley, C., Herbert, B-S., Wright, W. E. & Shay, J. W., Oct 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, p. 1577-1579 3 p.

Research output: Contribution to journalArticle

Telomerase
Oligonucleotides
Antineoplastic Agents
Tumors
Cells
51 Citations (Scopus)

Shared environmental factors associated with telomere length maintenance in elderly male twins

Huda, N., Tanaka, H., Herbert, B-S., Reed, T. & Gilley, D., Oct 2007, In : Aging Cell. 6, 5, p. 709-713 5 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Telomere
Telomere Shortening
Korean War
Dizygotic Twins
52 Citations (Scopus)

Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

Gomez-Millan, J., Goldblatt, E. M., Gryaznov, S. M., Mendonca, M. & Herbert, B-S., Mar 1 2007, In : International Journal of Radiation Oncology Biology Physics. 67, 3, p. 897-905 9 p.

Research output: Contribution to journalArticle

telomeres
Telomerase
Radiation Tolerance
Telomere
multiple docking adapters
2006
77 Citations (Scopus)

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker

Malkas, L. H., Herbert, B-S., Abdel-Aziz, W., Dobrolecki, L. E., Liu, Y., Agarwal, B., Hoelz, D., Badve, S., Schnaper, L., Arnold, R. J., Mechref, Y., Novotny, M. V., Loehrer, P., Goulet, R. J. & Mickey, R. J., Dec 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19472-19477 6 p.

Research output: Contribution to journalArticle

Proliferating Cell Nuclear Antigen
Protein Isoforms
Biomarkers
Breast Neoplasms
Neoplasms
149 Citations (Scopus)

Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol

Herbert, B-S., Hochreiter, A. E., Wright, W. E. & Shay, J. W., Aug 2006, In : Nature Protocols. 1, 3, p. 1583-1590 8 p.

Research output: Contribution to journalArticle

Telomerase
Amplification
Assays
Real-Time Polymerase Chain Reaction
Tissue Extracts
13 Citations (Scopus)

Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model

Canales, B. K., Li, Y., Thompson, M. G., Gleason, J. M., Chen, Z., Malaeb, B., Corey, D. R., Herbert, B-S., Shay, J. W. & Koeneman, K. S., Mar 2006, In : Urologic Oncology: Seminars and Original Investigations. 24, 2 SPEC. ISS., p. 141-151 11 p.

Research output: Contribution to journalArticle

Telomerase
Oligonucleotides
Androgens
Prostatic Neoplasms
docetaxel
10 Citations (Scopus)

Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier

Lewis, C. M., Herbert, B-S., Bu, D., Halloway, S., Beck, A., Shadeo, A., Zhang, C., Ashfaq, R., Shay, J. W. & Euhus, D. M., Sep 2006, In : Breast Cancer Research and Treatment. 99, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

Telomerase
Breast
Epithelial Cells
Mutation
Glass
106 Citations (Scopus)

Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer

Hochreiter, A. E., Xiao, H., Goldblatt, E. M., Gryaznov, S. M., Miller, K., Badve, S., Sledge, G. W. & Herbert, B-S., May 15 2006, In : Clinical Cancer Research. 12, 10, p. 3184-3192 9 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Maintenance
Breast Neoplasms
Neoplasm Metastasis
2005
144 Citations (Scopus)

Lipid modification of GRN163, an N3′→P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

Herbert, B-S., Gellert, G. C., Hochreiter, A., Pongracz, K., Wright, W. E., Zielinska, D., Chin, A. C., Harley, C. B., Shay, J. W. & Gryaznov, S. M., Aug 4 2005, In : Oncogene. 24, 33, p. 5262-5268 7 p.

Research output: Contribution to journalArticle

Telomerase
Oligonucleotides
Lipids
Transfection
Neoplasms
67 Citations (Scopus)

Telomere dysfunction in aging and cancer

Gilley, D., Tanaka, H. & Herbert, B-S., May 2005, In : International Journal of Biochemistry and Cell Biology. 37, 5 SPEC. ISS., p. 1000-1013 14 p.

Research output: Contribution to journalArticle

Telomere
Aging of materials
Neoplasms
Telomerase
Cell death
2004
145 Citations (Scopus)

Cell-type-specific responses to chemotherapeutics in breast cancer

Troester, M. A., Hoadley, K. A., Sørlie, T., Herbert, B-S., Børresen-Dale, A. L., Lønning, P. E., Shay, J. W., Kaufmann, W. K. & Perou, C. M., Jun 15 2004, In : Cancer Research. 64, 12, p. 4218-4226 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Line
Fluorouracil
Doxorubicin
Genes
23 Citations (Scopus)

Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions

Zhang, H., Herbert, B-S., Pan, K. H., Shay, J. W. & Cohen, S. N., Aug 19 2004, In : Oncogene. 23, 37, p. 6193-6198 6 p.

Research output: Contribution to journalArticle

Cell Aging
Telomere
Breast
Epithelial Cells
Gene Expression
2003
4 Citations (Scopus)

Analysis of telomeres and telomerase.

Herbert, B-S., Shay, J. W. & Wright, W. E., Nov 2003, In : Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]. Chapter 18

Research output: Contribution to journalArticle

Telomerase
Telomere
Cell Aging
Southern Blotting
Human Activities
22 Citations (Scopus)

Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells

Velicescu, M., Yu, J., Herbert, B-S., Shay, J. W., Granada, E. & Dubeau, L., Sep 15 2003, In : Cancer Research. 63, 18, p. 5813-5820 8 p.

Research output: Contribution to journalArticle

Telomere
Aneuploidy
Ploidies
Telomerase
Epithelial Cells
15 Citations (Scopus)

A peroxisome proliferator-activated receptor-γ agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells

Herbert, B-S., Pearce, V. P., Hynan, L. S., LaRue, D. M., Wright, W. E., Kopelovich, L. & Shay, J. W., Apr 15 2003, In : Cancer Research. 63, 8, p. 1914-1919 6 p.

Research output: Contribution to journalArticle

Drug Repositioning
Peroxisome Proliferator-Activated Receptors
rosiglitazone
Li-Fraumeni Syndrome
Breast
64 Citations (Scopus)

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells

Ramirez, R. D., Herbert, B-S., Vaughan, M. B., Zou, Y., Gandia, K., Morales, C. P., Wright, W. E. & Shay, J. W., Jan 23 2003, In : Oncogene. 22, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 4
Cell Aging
Telomere
Epithelial Cells
Up-Regulation
7 Citations (Scopus)

Novel short oligonucleotide conjugates as inhibitors of human telomerase

Pongracz, K., Li, S., Herbert, B-S., Pruzan, R., Wunder, E., Chin, A., Piatyszek, M., Shay, J. & Gryaznov, S. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1627-1629 3 p.

Research output: Contribution to journalArticle

Telomerase
Oligonucleotides
Assays
RNA
Enzymes