Brittney-Shea Herbert

  • 3212 Citations
  • 27 h-Index
19992020

Research output per year

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Publications

  • 3212 Citations
  • 27 h-Index
  • 51 Article
  • 5 Review article
  • 4 Comment/debate
  • 1 Editorial
1999

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

Herbert, B. S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W. & Corey, D. R., Dec 7 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 25, p. 14276-14281 6 p.

Research output: Contribution to journalArticle

482 Scopus citations

N-(4-hydroxyphenyl)retinamide activation of transforming growth factor- β and induction of apoptosis in human breast cancer cells

Herbert, B. S., Sanders, B. G. & Kline, K., Jan 1 1999, In : Nutrition and Cancer. 34, 2, p. 121-132 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2000

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

Ouellette, M. M., Liao, M., Herbert, B. S., Johnson, M., Holt, S. E., Liss, H. S., Shay, J. W. & Wright, W. E., Apr 7 2000, In : Journal of Biological Chemistry. 275, 14, p. 10072-10076 5 p.

Research output: Contribution to journalArticle

202 Scopus citations
2001

Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells

Herbert, B. S., Wright, A. C., Passons, C. M., Wright, W. E., Ali, I. U., Kopelovich, L. & Shay, J. W., Jan 3 2001, In : Journal of the National Cancer Institute. 93, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Ramirez, R. D., Morales, C. P., Herbert, B. S., Rohde, J. M., Passons, C., Shay, J. W. & Wright, W. E., Mar 14 2001, In : Genes and Development. 15, 4, p. 398-403 6 p.

Research output: Contribution to journalArticle

381 Scopus citations

Telomerase and breast cancer

Herbert, B. S., Wright, W. E. & Shay, J. W., May 12 2001, In : Breast Cancer Research. 3, 3, p. 146-149 4 p.

Research output: Contribution to journalComment/debate

57 Scopus citations

Telomerase inhibitors - Oligonucleotide phosphoramidates as potential therapeutic agents

Gryaznov, S., Pongracz, K., Matray, T., Schultz, R., Pruzan, R., Aimi, J., Chin, A., Harley, C., Shea-Herbert, B., Shay, J., Oshima, Y., Asai, A. & Yamashita, Y., 2001, In : Nucleosides, Nucleotides and Nucleic Acids. 20, 4-7, p. 401-410 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
2002

Erratum: Oligonucleotide N3′ → P5′ phosphoramidates as efficient telomerase inhibitors (Oncogene (2002) 21 (638-642))

Herbert, B. S., Pongracz, K., Shay, J. W. & Gryaznov, S. M., Apr 18 2002, In : Oncogene. 21, 17, 1 p.

Research output: Contribution to journalComment/debate

Oligonucleotide N3′→P5′ phosphoramidates as efficient telomerase inhibitors

Shea-Herbert, B., Pongracz, K., Shay, J. W. & Gryaznov, S. M., Jan 21 2002, In : Oncogene. 21, 1, p. 638-642 5 p.

Research output: Contribution to journalReview article

107 Scopus citations

p16INK4a inactivation is not required to immortalize human mammary epithelial cells

Herbert, B. S., Wright, W. E. & Shay, J. W., Nov 7 2002, In : Oncogene. 21, 51, p. 7897-7900 4 p.

Research output: Contribution to journalArticle

69 Scopus citations
2003

Analysis of telomeres and telomerase.

Herbert, B. S., Shay, J. W. & Wright, W. E., Nov 2003, In : Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]. Chapter 18, p. Unit 18.6

Research output: Contribution to journalArticle

4 Scopus citations

Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells

Velicescu, M., Yu, J., Herbert, B. S., Shay, J. W., Granada, E. & Dubeau, L., Sep 15 2003, In : Cancer Research. 63, 18, p. 5813-5820 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

A peroxisome proliferator-activated receptor-γ agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells

Herbert, B. S., Pearce, V. P., Hynan, L. S., LaRue, D. M., Wright, W. E., Kopelovich, L. & Shay, J. W., Apr 15 2003, In : Cancer Research. 63, 8, p. 1914-1919 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells

Ramirez, R. D., Herbert, B. S., Vaughan, M. B., Zou, Y., Gandia, K., Morales, C. P., Wright, W. E. & Shay, J. W., Jan 23 2003, In : Oncogene. 22, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Novel short oligonucleotide conjugates as inhibitors of human telomerase

Pongracz, K., Li, S., Herbert, B. S., Pruzan, R., Wunder, E., Chin, A., Piatyszek, M., Shay, J. & Gryaznov, S. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1627-1629 3 p.

Research output: Contribution to journalArticle

7 Scopus citations
2004

Cell-type-specific responses to chemotherapeutics in breast cancer

Troester, M. A., Hoadley, K. A., Sørlie, T., Herbert, B. S., Børresen-Dale, A. L., Lønning, P. E., Shay, J. W., Kaufmann, W. K. & Perou, C. M., Jun 15 2004, In : Cancer Research. 64, 12, p. 4218-4226 9 p.

Research output: Contribution to journalArticle

146 Scopus citations

Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions

Zhang, H., Herbert, B. S., Pan, K. H., Shay, J. W. & Cohen, S. N., Aug 19 2004, In : Oncogene. 23, 37, p. 6193-6198 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2005

Lipid modification of GRN163, an N3′→P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

Herbert, B. S., Gellert, G. C., Hochreiter, A., Pongracz, K., Wright, W. E., Zielinska, D., Chin, A. C., Harley, C. B., Shay, J. W. & Gryaznov, S. M., Aug 4 2005, In : Oncogene. 24, 33, p. 5262-5268 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Telomere dysfunction in aging and cancer

Gilley, D., Tanaka, H. & Herbert, B. S., May 2005, In : International Journal of Biochemistry and Cell Biology. 37, 5 SPEC. ISS., p. 1000-1013 14 p.

Research output: Contribution to journalReview article

67 Scopus citations
2006

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker

Malkas, L. H., Herbert, B. S., Abdel-Aziz, W., Dobrolecki, L. E., Liu, Y., Agarwal, B., Hoelz, D., Badve, S., Schnaper, L., Arnold, R. J., Mechref, Y., Novotny, M. V., Loehrer, P., Goulet, R. J. & Mickey, R. J., Dec 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19472-19477 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol

Herbert, B. S., Hochreiter, A. E., Wright, W. E. & Shay, J. W., Aug 1 2006, In : Nature protocols. 1, 3, p. 1583-1590 8 p.

Research output: Contribution to journalArticle

152 Scopus citations

Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model

Canales, B. K., Li, Y., Thompson, M. G., Gleason, J. M., Chen, Z., Malaeb, B., Corey, D. R., Herbert, B. S., Shay, J. W. & Koeneman, K. S., Jan 1 2006, In : Urologic Oncology: Seminars and Original Investigations. 24, 2 SPEC. ISS., p. 141-151 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier

Lewis, C. M., Herbert, B. S., Bu, D., Halloway, S., Beck, A., Shadeo, A., Zhang, C., Ashfaq, R., Shay, J. W. & Euhus, D. M., Sep 1 2006, In : Breast Cancer Research and Treatment. 99, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer

Hochreiter, A. E., Xiao, H., Goldblatt, E. M., Gryaznov, S. M., Miller, K. D., Badve, S., Sledge, G. W. & Herbert, B. S., May 15 2006, In : Clinical Cancer Research. 12, 10, p. 3184-3192 9 p.

Research output: Contribution to journalArticle

107 Scopus citations
2007

Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent

Gryaznov, S. M., Jackson, S., Dikmen, G., Harley, C., Herbert, B. S., Wright, W. E. & Shay, J. W., Oct 1 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, p. 1577-1579 3 p.

Research output: Contribution to journalArticle

24 Scopus citations

Shared environmental factors associated with telomere length maintenance in elderly male twins

Huda, N., Tanaka, H., Herbert, B. S., Reed, T. & Gilley, D., Oct 1 2007, In : Aging Cell. 6, 5, p. 709-713 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

Gomez-Millan, J., Goldblatt, E. M., Gryaznov, S. M., Mendonca, M. S. & Herbert, B. S., Mar 1 2007, In : International Journal of Radiation Oncology Biology Physics. 67, 3, p. 897-905 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2008

Factors impacting human telomere homeostasis and age-related disease

Gilley, D., Herbert, B. S., Huda, N., Tanaka, H. & Reed, T., Jan 1 2008, In : Mechanisms of Ageing and Development. 129, 1-2, p. 27-34 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
2009

Disruption of telomere homeostasis as a new cancer treatment strategy

Herbert, B. S., Mar 1 2009, In : Memo - Magazine of European Medical Oncology. 2, 1, p. 21-24 4 p.

Research output: Contribution to journalReview article

2 Scopus citations

Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab

Goldblatt, E. M., Erickson, P. A., Gentry, E. R., Gryaznov, S. M. & Herbert, B. S., Nov 1 2009, In : Breast Cancer Research and Treatment. 118, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Meeting report: Second international meeting on quadruplex DNA

Herbert, B. S., Huppert, J. L., Johnson, F. B., Lane, A. N. & Phan, A. T., Sep 1 2009, In : Biochimie. 91, 9, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
101 Scopus citations

Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists

Dikmen, Z. G., Ozgurtas, T., Gryaznov, S. M. & Herbert, B. S., Apr 2009, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 4, p. 240-247 8 p.

Research output: Contribution to journalReview article

19 Scopus citations

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

Goldblatt, E. M., Gentry, E. R., Fox, M. J., Gryaznov, S. M., Shen, C. & Herbert, B. S., Jul 1 2009, In : Molecular cancer therapeutics. 8, 7, p. 2027-2035 9 p.

Research output: Contribution to journalArticle

46 Scopus citations
2010

A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.

Herbert, B. S., Chanoux, R. A., Liu, Y., Baenziger, P. H., Goswami, C. P., McClintick, J. N., Edenberg, H. J., Pennington, R. E., Lipkin, S. M. & Kopelovich, L., Oct 2010, In : Oncotarget. 1, 6, p. 405-422 18 p.

Research output: Contribution to journalArticle

27 Scopus citations

Disabled-2 downregulation promotes epithelial-to-mesenchymal transition

Martin, J. C., Herbert, B. S. & Hocevar, B. A., Nov 23 2010, In : British Journal of Cancer. 103, 11, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, N. X., Moe, S. M., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R. L., Herbert, B. S. & Gattone, V. H., Sep 2 2011, In : Kidney international. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Influence of nano-carrier architecture on in vitro siRNA delivery performance and in vivo biodistribution: Polyplexes vs micelleplexes

Gary, D. J., Lee, H., Sharma, R., Lee, J. S., Kim, Y., Cui, Z. Y., Jia, D., Bowman, V. D., Chipman, P. R., Wan, L., Zou, Y., Mao, G., Park, K., Herbert, B. S., Konieczny, S. F. & Won, Y. Y., May 24 2011, In : ACS Nano. 5, 5, p. 3493-3505 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Medical genetics and epigenetics of telomerase

Koziel, J. E., Fox, M. J., Steding, C. E., Sprouse, A. A. & Herbert, B. S., Mar 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 3, p. 457-467 11 p.

Research output: Contribution to journalReview article

20 Scopus citations

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B. S., Chan, R. & Wells, C. D., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability

Slee, R. B., Steiner, C. M., Herbert, B. S., Vance, G. H., Hickey, R. J., Schwarz, T., Christan, S., Radovich, M., Schneider, B. P., Schindelhauer, D. & Grimes, B. R., Jul 5 2012, In : Oncogene. 31, 27, p. 3244-3253 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
12 Scopus citations

Pharmaceutical regulation of telomerase and its clinical potential

Sprouse, A. A., Steding, C. E. & Herbert, B. S., Jan 1 2012, In : Journal of Cellular and Molecular Medicine. 16, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

43 Scopus citations
2013

A Telomerase Immortalized Human Proximal Tubule Cell Line with a Truncation Mutation (Q4004X) in Polycystin-1

Herbert, B. S., Grimes, B. R., Xu, W. M., Werner, M., Ward, C., Rossetti, S., Harris, P., Bello-Reuss, E., Ward, H. H., Miller, C., Gattone, V. H., Phillips, C. L., Wandinger-Ness, A. & Bacallao, R. L., Jan 28 2013, In : PloS one. 8, 1, e55191.

Research output: Contribution to journalArticle

9 Scopus citations

Heritable one-hit events defining cancer prevention?

Kopelovich, L. & Shea-Herbert, B., Aug 15 2013, In : Cell Cycle. 12, 16, p. 2553-2557 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling

Kochhar, A., Kopelovich, L., Sue, E., Guttenplan, J. B., Herbert, B. S., Dannenberg, A. J. & Subbaramaiah, K., Jun 2014, In : Cancer Prevention Research. 7, 6, p. 596-606 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Okayama, S., Kopelovich, L., Balmus, G., Weiss, R. S., Herbert, B. S., Dannenberg, A. J. & Subbaramaiah, K., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6513-6525 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Phenotypic plasticity in normal breast derived epithelial cells

Sauder, C. A. M., Koziel, J. E., Choi, M. R., Fox, M. J., Grimes, B. R., Badve, S., Blosser, R. J., Radovich, M., Lam, C. C., Vaughan, M. B., Herbert, B. S. & Clare, S. E., Jun 10 2014, In : BMC Cell Biology. 15, 1, 20.

Research output: Contribution to journalArticle

10 Scopus citations

Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells

Sprouse, A. A. & Herbert, B. S., Oct 1 2014, In : Anticancer Research. 34, 10, p. 5363-5374 12 p.

Research output: Contribution to journalArticle

31 Scopus citations