Brittney-Shea Herbert

  • 3212 Citations
  • 27 h-Index
19992020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

  • 3212 Citations
  • 27 h-Index
  • 51 Article
  • 5 Review article
  • 4 Comment/debate
  • 1 Editorial
Article

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker

Malkas, L. H., Herbert, B. S., Abdel-Aziz, W., Dobrolecki, L. E., Liu, Y., Agarwal, B., Hoelz, D., Badve, S., Schnaper, L., Arnold, R. J., Mechref, Y., Novotny, M. V., Loehrer, P., Goulet, R. J. & Mickey, R. J., Dec 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19472-19477 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers

Tanaka, H., Phipps, E. A., Wei, T., Wu, X., Goswami, C., Liu, Y., Sledge, G. W., Mina, L. & Herbert, B. S., Apr 2018, In : Molecular Carcinogenesis. 57, 4, p. 567-575 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.

Herbert, B. S., Chanoux, R. A., Liu, Y., Baenziger, P. H., Goswami, C. P., McClintick, J. N., Edenberg, H. J., Pennington, R. E., Lipkin, S. M. & Kopelovich, L., Oct 2010, In : Oncotarget. 1, 6, p. 405-422 18 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Analysis of telomeres and telomerase.

Herbert, B. S., Shay, J. W. & Wright, W. E., Nov 2003, In : Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]. Chapter 18, p. Unit 18.6

Research output: Contribution to journalArticle

4 Scopus citations

Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells

Velicescu, M., Yu, J., Herbert, B. S., Shay, J. W., Granada, E. & Dubeau, L., Sep 15 2003, In : Cancer Research. 63, 18, p. 5813-5820 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

A peroxisome proliferator-activated receptor-γ agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells

Herbert, B. S., Pearce, V. P., Hynan, L. S., LaRue, D. M., Wright, W. E., Kopelovich, L. & Shay, J. W., Apr 15 2003, In : Cancer Research. 63, 8, p. 1914-1919 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

A Telomerase Immortalized Human Proximal Tubule Cell Line with a Truncation Mutation (Q4004X) in Polycystin-1

Herbert, B. S., Grimes, B. R., Xu, W. M., Werner, M., Ward, C., Rossetti, S., Harris, P., Bello-Reuss, E., Ward, H. H., Miller, C., Gattone, V. H., Phillips, C. L., Wandinger-Ness, A. & Bacallao, R. L., Jan 28 2013, In : PloS one. 8, 1, e55191.

Research output: Contribution to journalArticle

9 Scopus citations

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells

Ramirez, R. D., Herbert, B. S., Vaughan, M. B., Zou, Y., Gandia, K., Morales, C. P., Wright, W. E. & Shay, J. W., Jan 23 2003, In : Oncogene. 22, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Calcimimetics inhibit renal pathology in rodent nephronophthisis

Chen, N. X., Moe, S. M., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R. L., Herbert, B. S. & Gattone, V. H., Sep 2 2011, In : Kidney international. 80, 6, p. 612-619 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability

Slee, R. B., Steiner, C. M., Herbert, B. S., Vance, G. H., Hickey, R. J., Schwarz, T., Christan, S., Radovich, M., Schneider, B. P., Schindelhauer, D. & Grimes, B. R., Jul 5 2012, In : Oncogene. 31, 27, p. 3244-3253 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Cell-type-specific responses to chemotherapeutics in breast cancer

Troester, M. A., Hoadley, K. A., Sørlie, T., Herbert, B. S., Børresen-Dale, A. L., Lønning, P. E., Shay, J. W., Kaufmann, W. K. & Perou, C. M., Jun 15 2004, In : Cancer Research. 64, 12, p. 4218-4226 9 p.

Research output: Contribution to journalArticle

146 Scopus citations

Development of a New Monochrome Multiplex qPCR Method for Relative Telomere Length Measurement in Cancer

Dahlgren, P. N., Bishop, K., Dey, S., Herbert, B-S. & Tanaka, H., May 1 2018, In : Neoplasia (United States). 20, 5, p. 425-431 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Disabled-2 downregulation promotes epithelial-to-mesenchymal transition

Martin, J. C., Herbert, B. S. & Hocevar, B. A., Nov 23 2010, In : British Journal of Cancer. 103, 11, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions

Zhang, H., Herbert, B. S., Pan, K. H., Shay, J. W. & Cohen, S. N., Aug 19 2004, In : Oncogene. 23, 37, p. 6193-6198 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells

Herbert, B. S., Wright, A. C., Passons, C. M., Wright, W. E., Ali, I. U., Kopelovich, L. & Shay, J. W., Jan 3 2001, In : Journal of the National Cancer Institute. 93, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Factors impacting human telomere homeostasis and age-related disease

Gilley, D., Herbert, B. S., Huda, N., Tanaka, H. & Reed, T., Jan 1 2008, In : Mechanisms of Ageing and Development. 129, 1-2, p. 27-34 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Global gene expression of histologically normal primary skin cells from BCNS subjects reveals "single-hit" effects that are influenced by rapamycin

Phatak, A., Athar, M., Crowell, J. A., Leffel, D., Herbert, B-S., Bale, A. E. & Kopelovich, L., Feb 1 2019, In : Oncotarget. 10, 14, p. 1360-1387 28 p.

Research output: Contribution to journalArticle

2 Scopus citations

Heritable one-hit events defining cancer prevention?

Kopelovich, L. & Shea-Herbert, B., Aug 15 2013, In : Cell Cycle. 12, 16, p. 2553-2557 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells

Subbaramaiah, K., Brown, K. A., Zahid, H., Balmus, G., Weiss, R. S., Herbert, B. S. & Dannenberg, A. J., Jul 29 2016, In : Journal of Biological Chemistry. 291, 31, p. 16011-16023 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
12 Scopus citations

Influence of nano-carrier architecture on in vitro siRNA delivery performance and in vivo biodistribution: Polyplexes vs micelleplexes

Gary, D. J., Lee, H., Sharma, R., Lee, J. S., Kim, Y., Cui, Z. Y., Jia, D., Bowman, V. D., Chipman, P. R., Wan, L., Zou, Y., Mao, G., Park, K., Herbert, B. S., Konieczny, S. F. & Won, Y. Y., May 24 2011, In : ACS Nano. 5, 5, p. 3493-3505 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

Herbert, B. S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W. & Corey, D. R., Dec 7 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 25, p. 14276-14281 6 p.

Research output: Contribution to journalArticle

482 Scopus citations

Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab

Goldblatt, E. M., Erickson, P. A., Gentry, E. R., Gryaznov, S. M. & Herbert, B. S., Nov 1 2009, In : Breast Cancer Research and Treatment. 118, 1, p. 21-32 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Lipid modification of GRN163, an N3′→P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

Herbert, B. S., Gellert, G. C., Hochreiter, A., Pongracz, K., Wright, W. E., Zielinska, D., Chin, A. C., Harley, C. B., Shay, J. W. & Gryaznov, S. M., Aug 4 2005, In : Oncogene. 24, 33, p. 5262-5268 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Meeting report: Second international meeting on quadruplex DNA

Herbert, B. S., Huppert, J. L., Johnson, F. B., Lane, A. N. & Phan, A. T., Sep 1 2009, In : Biochimie. 91, 9, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

N-(4-hydroxyphenyl)retinamide activation of transforming growth factor- β and induction of apoptosis in human breast cancer cells

Herbert, B. S., Sanders, B. G. & Kline, K., Jan 1 1999, In : Nutrition and Cancer. 34, 2, p. 121-132 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol

Herbert, B. S., Hochreiter, A. E., Wright, W. E. & Shay, J. W., Aug 1 2006, In : Nature protocols. 1, 3, p. 1583-1590 8 p.

Research output: Contribution to journalArticle

152 Scopus citations

Novel short oligonucleotide conjugates as inhibitors of human telomerase

Pongracz, K., Li, S., Herbert, B. S., Pruzan, R., Wunder, E., Chin, A., Piatyszek, M., Shay, J. & Gryaznov, S. M., 2003, In : Nucleosides, Nucleotides and Nucleic Acids. 22, 5-8, p. 1627-1629 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent

Gryaznov, S. M., Jackson, S., Dikmen, G., Harley, C., Herbert, B. S., Wright, W. E. & Shay, J. W., Oct 1 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, p. 1577-1579 3 p.

Research output: Contribution to journalArticle

24 Scopus citations

p16INK4a inactivation is not required to immortalize human mammary epithelial cells

Herbert, B. S., Wright, W. E. & Shay, J. W., Nov 7 2002, In : Oncogene. 21, 51, p. 7897-7900 4 p.

Research output: Contribution to journalArticle

69 Scopus citations

p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling

Kochhar, A., Kopelovich, L., Sue, E., Guttenplan, J. B., Herbert, B. S., Dannenberg, A. J. & Subbaramaiah, K., Jun 2014, In : Cancer Prevention Research. 7, 6, p. 596-606 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Okayama, S., Kopelovich, L., Balmus, G., Weiss, R. S., Herbert, B. S., Dannenberg, A. J. & Subbaramaiah, K., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6513-6525 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pharmaceutical regulation of telomerase and its clinical potential

Sprouse, A. A., Steding, C. E. & Herbert, B. S., Jan 2012, In : Journal of Cellular and Molecular Medicine. 16, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Phenotypic plasticity in normal breast derived epithelial cells

Sauder, C. A. M., Koziel, J. E., Choi, M. R., Fox, M. J., Grimes, B. R., Badve, S., Blosser, R. J., Radovich, M., Lam, C. C., Vaughan, M. B., Herbert, B. S. & Clare, S. E., Jun 10 2014, In : BMC Cell Biology. 15, 1, 20.

Research output: Contribution to journalArticle

10 Scopus citations
101 Scopus citations

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Ramirez, R. D., Morales, C. P., Herbert, B. S., Rohde, J. M., Passons, C., Shay, J. W. & Wright, W. E., 2001, In : Genes and Development. 15, 4, p. 398-403 6 p.

Research output: Contribution to journalArticle

381 Scopus citations

Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells

Sprouse, A. A. & Herbert, B. S., Oct 1 2014, In : Anticancer Research. 34, 10, p. 5363-5374 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic mps1 kinase inhibitor NMS-P715

Slee, R. B., Grimes, B. R., Bansal, R., Gore, J., Blackburn, C., Brown, L., Gasaway, R., Jeong, J., Victorino, J., March, K. L., Colombo, R., Herbert, B. S. & Korc, M., Feb 2014, In : Molecular cancer therapeutics. 13, 2, p. 307-315 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Shared environmental factors associated with telomere length maintenance in elderly male twins

Huda, N., Tanaka, H., Herbert, B. S., Reed, T. & Gilley, D., Oct 1 2007, In : Aging Cell. 6, 5, p. 709-713 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model

Canales, B. K., Li, Y., Thompson, M. G., Gleason, J. M., Chen, Z., Malaeb, B., Corey, D. R., Herbert, B. S., Shay, J. W. & Koeneman, K. S., Jan 1 2006, In : Urologic Oncology: Seminars and Original Investigations. 24, 2 SPEC. ISS., p. 141-151 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

SOX17 Regulates Conversion of Human Fibroblasts into Endothelial Cells and Erythroblasts by Dedifferentiation into CD34+ Progenitor Cells

Zhang, L., Jambusaria, A., Hong, Z., Marsboom, G., Toth, P. T., Herbert, B. S., Malik, A. B. & Rehman, J., Jun 20 2017, In : Circulation. 135, 25, p. 2505-2523 19 p.

Research output: Contribution to journalArticle

13 Scopus citations

Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

Gomez-Millan, J., Goldblatt, E. M., Gryaznov, S. M., Mendonca, M. S. & Herbert, B. S., Mar 1 2007, In : International Journal of Radiation Oncology Biology Physics. 67, 3, p. 897-905 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

Ouellette, M. M., Liao, M., Herbert, B. S., Johnson, M., Holt, S. E., Liss, H. S., Shay, J. W. & Wright, W. E., Apr 7 2000, In : Journal of Biological Chemistry. 275, 14, p. 10072-10076 5 p.

Research output: Contribution to journalArticle

202 Scopus citations

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation

Abou Alaiwi, W. A., Muntean, B. S., Ratnam, S., Joe, B., Liu, L., Booth, R. L., Rodriguez, I., Herbert, B. S., Bacallao, R. L., Fruttiger, M., Mak, T. W., Zhou, J. & Nauli, S. M., Feb 11 2014, In : Circulation. 129, 6, p. 660-672 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier

Lewis, C. M., Herbert, B. S., Bu, D., Halloway, S., Beck, A., Shadeo, A., Zhang, C., Ashfaq, R., Shay, J. W. & Euhus, D. M., Sep 1 2006, In : Breast Cancer Research and Treatment. 99, 1, p. 103-115 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Telomerase inhibitors - Oligonucleotide phosphoramidates as potential therapeutic agents

Gryaznov, S., Pongracz, K., Matray, T., Schultz, R., Pruzan, R., Aimi, J., Chin, A., Harley, C., Shea-Herbert, B., Shay, J., Oshima, Y., Asai, A. & Yamashita, Y., 2001, In : Nucleosides, Nucleotides and Nucleic Acids. 20, 4-7, p. 401-410 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer

Hochreiter, A. E., Xiao, H., Goldblatt, E. M., Gryaznov, S. M., Miller, K. D., Badve, S., Sledge, G. W. & Herbert, B. S., May 15 2006, In : Clinical Cancer Research. 12, 10, p. 3184-3192 9 p.

Research output: Contribution to journalArticle

107 Scopus citations

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B. S., Chan, R. & Wells, C. D., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
15 Scopus citations

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

Goldblatt, E. M., Gentry, E. R., Fox, M. J., Gryaznov, S. M., Shen, C. & Herbert, B. S., Jul 1 2009, In : Molecular cancer therapeutics. 8, 7, p. 2027-2035 9 p.

Research output: Contribution to journalArticle

46 Scopus citations