Bruce Molitoris

  • 15399 Citations
  • 61 h-Index
1974 …2019
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Publications 1974 2019

  • 15399 Citations
  • 61 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
1993
39 Citations (Scopus)
Cell Polarity
Pathologic Processes
Actin Cytoskeleton
Cell Biology
Epithelium
32 Citations (Scopus)

Mechanism of ischemia-enhanced aminoglycoside binding and uptake by proximal tubule cells

Molitoris, B., Meyer, C., Dahl, R. & Geerdes, A., May 1993, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 264, 5 33-5

Research output: Contribution to journalArticle

Aminoglycosides
Gentamicins
Ischemia
Membranes
Phosphatidylinositols
51 Citations (Scopus)
Adenosine Triphosphatases
Adenosine Triphosphate
Ouabain
Membranes
LLC-PK1 Cells
1994
179 Citations (Scopus)

Alterations in epithelial polarity and the pathogenesis of disease states

Fish, E. M. & Molitoris, B., 1994, In : New England Journal of Medicine. 330, 22, p. 1580-1588 9 p.

Research output: Contribution to journalArticle

Cell Polarity
Epithelial Cells
Disease Progression
Maintenance
3 Citations (Scopus)

Apically and basolaterally internalized aminoglycosides colocalize in LLC- PK1 lysosomes and alter cell function

Ford, D. M., Dahl, R. H., Lamp, C. A. & Molitoris, B., 1994, In : American Journal of Physiology - Cell Physiology. 266, 1 35-1

Research output: Contribution to journalArticle

Aminoglycosides
Lysosomes
Gentamicins
Membranes
LLC-PK1 Cells

Characterization of the beta2-microglobulin endocytic pathway in rat proximal tubule cells

Sundin, D. P., Cohen, M., Dahl, R., Falk, S. & Molitoris, B., 1994, In : The American journal of physiology. 267, 3 part 2

Research output: Contribution to journalArticle

proximal tubules
rats
cells
22 Citations (Scopus)

Characterization of the β2-microglobulin endocytic pathway in rat proximal tubule cells

Sundin, D. P., Cohen, M., Dahl, R., Falk, S. & Molitoris, B., Sep 1994, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 267, 3 36-3

Research output: Contribution to journalArticle

Microvilli
Gold
Membranes
Coated Vesicles
Proteins
30 Citations (Scopus)
Acidosis
Actin Cytoskeleton
Actins
Adenosine Triphosphate
Ischemia
20 Citations (Scopus)

Inherited diseases of the glomerular basement membrane

Bodziak, K. A., Hammond, W. S. & Molitoris, B., 1994, In : American Journal of Kidney Diseases. 23, 4, p. 605-618 14 p.

Research output: Contribution to journalArticle

Hereditary Nephritis
Glomerular Basement Membrane
Nail-Patella Syndrome
Hematuria
Kidney Transplantation
54 Citations (Scopus)

Membrane adsorption of β2-microglobulin: Equilibrium and kinetic characterization

Clark, W. R., Macias, W. L., Molitoris, B. & Wang, N. H. L., Oct 1994, In : Kidney International. 46, 4, p. 1140-1146 7 p.

Research output: Contribution to journalArticle

Adsorption
Membranes
Amyloidosis
Dialysis
Buffers
1995
10 Citations (Scopus)
LLC-PK1 Cells
Gold
gold
proximal tubules
Molecular Weight
3 Citations (Scopus)

HWA-448 reduces gentamicin toxicity in LLC-PK1 cells

Ford, D. M., Thieme, R. E., Lamp, C. A., Covington, S. J. & Molitoris, B., 1995, In : Journal of Pharmacology and Experimental Therapeutics. 274, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Gentamicins
Phospholipids
Cell Membrane
Enzymes
64 Citations (Scopus)

Plasma protein adsorption to highly permeable hemodialysis membranes

Clark, W. R., Macias, W. L., Molitoris, B. & Wang, N. H. L., 1995, In : Kidney International. 48, 2, p. 481-488 8 p.

Research output: Contribution to journalArticle

Adsorption
Renal Dialysis
Blood Proteins
Membranes
Bovine Serum Albumin
1996
54 Citations (Scopus)
Spectrin
Ankyrins
Adenosine Triphosphate
Octoxynol
LLC-PK1 Cells

Recovery of the actin cytoskeleton during cellular repair is independent of protein synthesis

Hosford, M., Sandoval, R. & Molitoris, B., 1996, In : Journal of Investigative Medicine. 44, 1

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Repair
Recovery
Proteins
31 Citations (Scopus)

Surface membrane polarity of proximal tubular cells: Alterations as a basis for malfunction

Molitoris, B. & Wagner, M., 1996, In : Kidney International. 49, 6, p. 1592-1597 6 p.

Research output: Contribution to journalArticle

Membranes
Actin Cytoskeleton
Membrane Proteins
Cell-Matrix Junctions
Membrane Lipids
Myosin Type I
Proximal Kidney Tubule
Myosins
Actins
Adenosine Triphosphate
1997
87 Citations (Scopus)

Acute renal failure in the 21st century: Recommendations for management and outcomes assessment

DuBose, T. D., Warnock, D. G., Mehta, R. L., Bonventre, J. V., Hammerman, M. R., Molitoris, B., Paller, M. S., Siegel, N. J., Scherbenske, J. & Striker, G. E., May 1997, In : American Journal of Kidney Diseases. 29, 5, p. 793-799 7 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Outcome Assessment (Health Care)
Renal Replacement Therapy
Mortality
National Institutes of Health (U.S.)
29 Citations (Scopus)
Myosin Type I
LLC-PK1 Cells
Adenosine Triphosphate
Actins
Microvilli
24 Citations (Scopus)

Cell biology of aminoglycoside nephrotoxicity: Newer aspects

Molitoris, B., 1997, In : Current Opinion in Nephrology and Hypertension. 6, 4, p. 384-388 5 p.

Research output: Contribution to journalArticle

Aminoglycosides
Endocytosis
Cell Biology
Low Density Lipoprotein Receptor-Related Protein-2
Golgi Apparatus
21 Citations (Scopus)

Cellular mechanism of aminoglycoside tolerance in long-term gentamicin treatment

Sundin, D. P., Meyer, C., Dahl, R., Geerdes, A., Sandoval, R. & Molitoris, B., 1997, In : American Journal of Physiology - Cell Physiology. 272, 4 41-4

Research output: Contribution to journalArticle

Aminoglycosides
Gentamicins
Membranes
Low Density Lipoprotein Receptor-Related Protein-2
Rats
Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
14 Citations (Scopus)
Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
74 Citations (Scopus)
Actin Cytoskeleton
Actins
Microfilament Proteins
Cell Polarity
Proteins
47 Citations (Scopus)

Role of the actin cytoskeleton in ischemia-induced cell injury and repair

Molitoris, B., Leiser, J. & Wagner, M., Dec 1997, In : Pediatric Nephrology. 11, 6, p. 761-767 7 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Ischemia
Wounds and Injuries
Membranes
Adenosine Triphosphate
1998
68 Citations (Scopus)

Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells

Sandoval, R., Leiser, J. & Molitoris, B., Feb 1998, In : Journal of the American Society of Nephrology. 9, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Aminoglycosides
Gentamicins
Anti-Bacterial Agents
18 Citations (Scopus)

Ischemic acute renal failure: Exciting times at our fingertips

Molitoris, B., 1998, In : Current Opinion in Nephrology and Hypertension. 7, 4, p. 405-406 2 p.

Research output: Contribution to journalArticle

Growth Substances
alpha-MSH
Calcium-Calmodulin-Dependent Protein Kinases
Heat-Shock Proteins
Acute Kidney Injury
137 Citations (Scopus)

Mechanisms of cellular injury in ischemic acute renal failure

Sutton, T. & Molitoris, B., 1998, In : Seminars in Nephrology. 18, 5, p. 490-497 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Actin Cytoskeleton
Cell Communication
Wounds and Injuries
Cell Polarity
1999
10 Citations (Scopus)

Acute renal failure

Molitoris, B., Sep 1999, In : Drugs of Today. 35, 9, p. 659-666 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Azotemia
Urine
Therapeutics
79 Citations (Scopus)

Ischemia activates actin depolymerizing factor: Role in proximal tubule microvillar actin alterations

Schwartz, N., Hosford, M., Sandoval, R. M., Wagner, M., Atkinson, S. J., Bamburg, J. & Molitoris, B., Apr 1999, In : American Journal of Physiology - Renal Physiology. 276, 4 45-4

Research output: Contribution to journalArticle

Destrin
Actins
Ischemia
Microvilli
Actin Cytoskeleton
30 Citations (Scopus)

Pathophysiology and functional significance of apical membrane disruption during ischemia

Ashworth, S. L. & Molitoris, B., 1999, In : Current Opinion in Nephrology and Hypertension. 8, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Ischemia
Actins
Membranes
30 Citations (Scopus)

Renal epithelial polarity in health and disease

Wagner, M. & Molitoris, B., Feb 1999, In : Pediatric Nephrology. 13, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Kidney
Health
Epithelial Cells
Polycystic Kidney Diseases
Membranes
109 Citations (Scopus)

The role of cell adhesion molecules in ischemic acute renal failure

Molitoris, B. & Marrs, J., May 1999, In : The American Journal of Medicine. 106, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Reperfusion Injury
Acute Kidney Injury
Integrins
Neutrophils
2000
150 Citations (Scopus)

Acute renal failure in the new millennium: Time to consider combination therapy

Kelly, K. & Molitoris, B., 2000, In : Seminars in Nephrology. 20, 1, p. 4-19 16 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Therapeutics
Renal Replacement Therapy
Theoretical Models
Morbidity

Dialytic care of patients with acute renal failure

Yaqub, M. & Molitoris, B., Jan 2000, In : Drugs of Today. 36, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Replacement Therapy
Patient Care
Dialysis
Membranes
30 Citations (Scopus)
LLC-PK1 Cells
Golgi Apparatus
Gentamicins
Fluorescence
Aminoglycosides
2001
19 Citations (Scopus)

Characteristics of EYFP-actin and visualization of actin dynamics during ATP depletion and repletion

Herget-Rosenthal, S., Hosford, M., Kribben, A., Atkinson, S. J., Sandoval, R. M. & Molitoris, B., 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Actins
Visualization
Adenosine Triphosphate
Fluorescence
Proteins
26 Citations (Scopus)

Erythropoietin requirements increase following hospitalization in end-stage renal disease patients

Yaqub, M., Leiser, J. & Molitoris, B., 2001, In : American Journal of Nephrology. 21, 5, p. 390-396 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Chronic Kidney Failure
Hemoglobins
Hospitalization
Renal Dialysis
65 Citations (Scopus)

Gentamicin inhibits renal protein and phospholipid metabolism in rats: Implications involving intracellular trafficking

Sundin, D. P., Sandoval, R. & Molitoris, B., 2001, In : Journal of the American Society of Nephrology. 12, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

Gentamicins
Phospholipids
Kidney
Microvilli
Proteins
1 Citation (Scopus)

Ischemia-induced tight junction dysfunction in the kidney

Marrs, J. A. & Molitoris, B., Jan 1 2001, Tight Junctions. CRC Press, p. 533-552 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tight Junctions
Ischemia
Epithelial Cells
Waste Products
Kidney
49 Citations (Scopus)

Ischemic injury induces ADF relocalization to the apical domain of rat proximal tubule cells

Ashworth, S. L., Sandoval, R. M., Hosford, M., Hamburg, J. R. & Molitoris, B., May 2001, In : American Journal of Physiology - Renal Physiology. 280, 5 49-5

Research output: Contribution to journalArticle

Destrin
Ischemia
Wounds and Injuries
Actins
Microvilli
2002
24 Citations (Scopus)

Cardiovascular disease in patients with chronic kidney disease

Jaradat, M. I. & Molitoris, B., Nov 2002, In : Seminars in Nephrology. 22, 6, p. 459-473 15 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Cardiovascular Diseases
Anemia
Renal Replacement Therapy
Left Ventricular Hypertrophy
92 Citations (Scopus)

Endothelial injury and dysfunction in ischemic acute renal failure

Molitoris, B., Sandoval, R. & Sutton, T., 2002, In : Critical Care Medicine. 30, 5 SUPPL.

Research output: Contribution to journalArticle

Acute Kidney Injury
Endothelial Cells
Wounds and Injuries
Actins
P-Selectin
235 Citations (Scopus)

Functional studies of the kidney of living animals using multicolor two-photon microscopy

Dunn, K., Sandoval, R. M., Kelly, K., Dagher, P., Tanner, G. A., Atkinson, S. J., Bacallao, R. & Molitoris, B., Sep 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3

Research output: Contribution to journalArticle

Photons
Microscopy
Microscopic examination
Animals
Kidney
57 Citations (Scopus)
Actin Cytoskeleton
Vascular Smooth Muscle
Smooth Muscle Myocytes
Ischemia
Actins
387 Citations (Scopus)

Microvascular endothelial injury and dysfunction during ischemic acute renal failure

Sutton, T., Fisher, C. J. & Molitoris, B., 2002, In : Kidney International. 62, 5, p. 1539-1549 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
7 Citations (Scopus)

Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells

Sandoval, R. M., Bacallao, R., Dunn, K., Leiser, J. D. & Molitoris, B., Dec 1 2002, In : American Journal of Physiology - Renal Physiology. 283, 6 52-6

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Gentamicins
Nucleotides
trans-Golgi Network
2003
44 Citations (Scopus)

ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion

Ashworth, S. L., Southgate, E. L., Sandoval, R. M., Meberg, P. J., Bamburg, J. R. & Molitoris, B., Apr 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Actins
Adenosine Triphosphate
Three-Dimensional Imaging
150 Citations (Scopus)
Transferases
Labeling
Apoptosis
Sensitivity and Specificity
Propidium
1 Citation (Scopus)

Establishment of Polarity in Epithelial Cells of the Developing Nephron

Karp, S. & Molitoris, B., Mar 15 2003, The Kidney: From Normal Development to Congenital Disease. Elsevier Inc., p. 211-220 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nephrons
Epithelial Cells
Membranes
Scaffolds
Actins