Bruce Molitoris

  • 15399 Citations
  • 61 h-Index
1974 …2019
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Publications 1974 2019

  • 15399 Citations
  • 61 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
2003
232 Citations (Scopus)
Endothelium
Ischemia
Kidney
Wounds and Injuries
Acute Kidney Injury
37 Citations (Scopus)

Intravital imaging of the kidney using multiparameter multiphoton microscopy.

Dunn, K., Sandoval, R. M. & Molitoris, B., 2003, In : Nephron - Experimental Nephrology. 94, 1

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Animal Structures
Endocytosis
57 Citations (Scopus)

Newly developed techniques to study and diagnose acute renal failure

Dagher, P., Herget-Rosenthal, S., Ruehm, S. G., Jo, S. K., Star, R. A., Agarwal, R. & Molitoris, B., Aug 1 2003, In : Journal of the American Society of Nephrology. 14, 8, p. 2188-2198 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Animal Models
Magnetic Resonance Imaging
Renal Circulation
Regional Blood Flow
90 Citations (Scopus)

Transitioning to therapy in ischemic acute renal failure

Molitoris, B., Jan 1 2003, In : Journal of the American Society of Nephrology. 14, 1, p. 265-267 3 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Ischemia
Therapeutics
89 Citations (Scopus)

Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts

Kwon, O., Molitoris, B., Pescovitz, M. & Kelly, K., May 1 2003, In : American Journal of Kidney Diseases. 41, 5, p. 1074-1087 14 p.

Research output: Contribution to journalArticle

Interleukin-8
Acute Kidney Injury
Allografts
Actins
Interleukin-6
2004
53 Citations (Scopus)

Actin cytoskeleton in ischemic acute renal failure

Molitoris, B., Harrington, J. T., Perrone, R., Jaber, B., Herman, I. M., Balakrishnan, V. S., Pahari, D. K. & Levey, A. S., Aug 2004, In : Kidney International. 66, 2, p. 871-883 13 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Tropomyosin
Endocytosis
Actin Cytoskeleton
Acute Kidney Injury
244 Citations (Scopus)

Endothelial injury and dysfunction: Role in the extension phase of acute renal failure

Molitoris, B. & Sutton, T., Aug 2004, In : Kidney International. 66, 2, p. 496-499 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
6 Citations (Scopus)

Evolving basic concepts in ischemic injury

De Broe, M. E., Bonventre, J. V., Molitoris, B. & Haller, H., Aug 2004, In : Kidney International. 66, 2, p. 479 1 p.

Research output: Contribution to journalArticle

Wounds and Injuries
72 Citations (Scopus)
Secretory Pathway
Aminoglycosides
Gentamicins
Endoplasmic Reticulum
Cytosol

High pressure freezing and freeze substitution: Advances in renal research

Pennington, J. G., Miller, C. A., Sandoval, R., Gattone, V. H., Molitoris, B. & Bacallao, R., 2004, In : Microscopy and Microanalysis. 10, SUPPL. 2, p. 1226-1227 2 p.

Research output: Contribution to journalArticle

Freezing
freezing
Substitution reactions
substitutes
84 Citations (Scopus)

Mechanism of Actin Polymerization in Cellular ATP Depletion

Atkinson, S. J., Hosford, M. A. & Molitoris, B., Feb 13 2004, In : Journal of Biological Chemistry. 279, 7, p. 5194-5199 6 p.

Research output: Contribution to journalArticle

Polymerization
Actins
Adenosine Triphosphate
Thymosin
Profilins
18 Citations (Scopus)

Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments

Ashworth, S. L., Wean, S. E., Campos-Bilderback, S., Temm-Grove, C. J., Southgate, E. L., Vrhovski, B., Gunning, P., Weinberger, R. P. & Molitoris, B., May 2004, In : American Journal of Physiology - Renal Physiology. 286, 5 55-5

Research output: Contribution to journalArticle

Tropomyosin
Microvilli
Actin Cytoskeleton
Ischemia
Kidney
104 Citations (Scopus)
Photons
Folic Acid
Microscopy
Microscopic examination
Kidney
2005
30 Citations (Scopus)

Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: Enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model

Raikwar, S. P., Temm, C. J., Raikwar, N. S., Kao, C., Molitoris, B. & Gardner, T., Dec 2005, In : Molecular Therapy. 12, 6, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

Angiostatins
Endostatins
Prostate
Growth
Prostatic Neoplasms
134 Citations (Scopus)

Intravital multiphoton microscopy of dynamic renal processes

Molitoris, B. & Sandoval, R. M., Jun 2005, In : American Journal of Physiology - Renal Physiology. 288, 6 57-6

Research output: Contribution to journalArticle

Microscopy
Research Personnel
Kidney
Physiologic Monitoring
Endocytosis
36 Citations (Scopus)

Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney

Tanner, G. A., Sandoval, R. M., Molitoris, B., Bamburg, J. R. & Ashworth, S. L., Sep 2005, In : American Journal of Physiology - Renal Physiology. 289, 3 58-3

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Photons
Punctures
Kidney
Genes

Microscopy as a quantitative science

Molitoris, B., Jul 2005, In : International Journal of Artificial Organs. 28, 7, p. 663-665 3 p.

Research output: Contribution to journalArticle

Microscopic examination
42 Citations (Scopus)

Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies

Yu, W., Sandoval, R. M. & Molitoris, B., Nov 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5

Research output: Contribution to journalArticle

Dextrans
Kidney
Bowman Capsule
Rats
Capsules
20 Citations (Scopus)

Renal blood flow in sepsis: A complex issue

Molitoris, B., Aug 2005, In : Critical Care. 9, 4, p. 327-328 2 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Sepsis
Microvessels
Endothelium
2006
1 Citation (Scopus)

Advances in imaging the kidney and cellular processes

Herget-Rosenthal, S. & Molitoris, B., Mar 2006, In : Nephron - Experimental Nephrology. 103, 2

Research output: Contribution to journalArticle

Nephrology
Diagnostic Imaging
Kidney
28 Citations (Scopus)

A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy

Sandoval, R. M., Reilly, J. P., Running, W., Campos-Bilderback, S., Santos, J. R., Phillips, C. & Molitoris, B., Oct 2006, In : Journal of the American Society of Nephrology. 17, 10, p. 2697-2705 9 p.

Research output: Contribution to journalArticle

Gentamicins
Aminoglycosides
Klebsiella pneumoniae
Bacillus subtilis
Acute Kidney Injury
24 Citations (Scopus)

Cofilin mediates ATP depletion-induced endothelial cell actin alterations

Suurna, M. V., Ashworth, S. L., Hosford, M., Sandoval, R. M., Wean, S. E., Shah, B. M., Bamburg, J. R. & Molitoris, B., Jun 2006, In : American Journal of Physiology - Renal Physiology. 290, 6

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Actins
Endothelial Cells
Adenosine Triphosphate
Destrin
533 Citations (Scopus)

Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001

Xue, J. L., Daniels, F., Star, R. A., Kimmel, P. L., Eggers, P. W., Molitoris, B., Himmelfarb, J. & Collins, A. J., Apr 2006, In : Journal of the American Society of Nephrology. 17, 4, p. 1135-1142 8 p.

Research output: Contribution to journalArticle

Medicare
Acute Kidney Injury
Mortality
Incidence
Critical Care
11 Citations (Scopus)
Protein Transport
Vacuoles
Gentamicins
Saccharomyces cerevisiae
Yeasts
23 Citations (Scopus)

Pharmacophotonics: Utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney

Molitoris, B. & Sandoval, R. M., Oct 31 2006, In : Advanced Drug Delivery Reviews. 58, 7, p. 809-823 15 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Drug Trafficking
Research Personnel
1 Citation (Scopus)

The role of statin therapy in patients with chronic kidney disease

Decker, B. & Molitoris, B., Jun 2006, In : Clinical Geriatrics. 14, 6, p. 29-34 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chronic Renal Insufficiency
Therapeutics
2007
104 Citations (Scopus)

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Gupta, A., Rhodes, G. J., Berg, D. T., Gerlitz, B., Molitoris, B. & Grinnell, B. W., Jul 2007, In : American Journal of Physiology - Renal Physiology. 293, 1

Research output: Contribution to journalArticle

Angiotensins
Protein C
Acute Kidney Injury
Lipopolysaccharides
Down-Regulation
4018 Citations (Scopus)

Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A., Bagga, A., Bakkaloglu, A., Bonventre, J. V., Burdmann, E. A., Chen, Y., Devarajan, P., D'Intini, V., Dobb, G., Durbin, C. G., Eckardt, K. U., Guerin, C., Herget-Rosenthal, S., Hoste, E. & 19 others, Joannidis, M., Kellum, J. A., Kirpalani, A., Lassnigg, A., Le Gall, J. R., Levin, A., Lombardi, R., Macias, W., Manthous, C., Mehta, R. L., Molitoris, B. A., Ronco, C., Schetz, M., Schortgen, F., Shah, S. V., Tan, P. S. K., Wang, H., Warnock, D. G. & Webb, S., Mar 1 2007, In : Critical Care. 11, R31.

Research output: Contribution to journalArticle

Acute Kidney Injury
Translational Medical Research
Creatinine
Urine
Nephrology
26 Citations (Scopus)

Controversies in nephrology: Response to 'renal albumin handling, facts, and artifacts'

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Nov 2007, In : Kidney International. 72, 10, p. 1195-1197 3 p.

Research output: Contribution to journalArticle

Nephrology
Artifacts
Albumins
Kidney
Albuminuria
61 Citations (Scopus)

Improving outcomes from acute kidney injury

Molitoris, B., Levin, A., Warnock, D. G., Joannidis, M., Mehta, R. L., Kellum, J. A., Ronco, C. & Shah, S., Jul 2007, In : Journal of the American Society of Nephrology. 18, 7, p. 1992-1994 3 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
41 Citations (Scopus)

Improving outcomes from acute kidney injury: Report of an initiative

Bagga, A., Bakkaloglu, A., Devarajan, P., Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Joannidis, M. & Levin, A., Oct 2007, In : Pediatric Nephrology. 22, 10, p. 1655-1658 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Creatinine
Nephrology
Critical Care
84 Citations (Scopus)

Improving Outcomes From Acute Kidney Injury: Report of an Initiative

Levin, A., Warnock, D. G., Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B. & Ronco, C., Jul 2007, In : American Journal of Kidney Diseases. 50, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

International Cooperation
Acute Kidney Injury
Creatinine
41 Citations (Scopus)

Improving outcomes from acute kidney injury (AKI): Report on an initiative

Ronco, C., Levin, A., Warnock, D. G., Metha, R. L., Kellum, J. A., Shah, S. & Molitoris, B., May 2007, In : International Journal of Artificial Organs. 30, 5, p. 373-376 4 p.

Research output: Contribution to journalArticle

Pediatrics
Acute Kidney Injury
Nephrology
Critical Care
Patient Care
102 Citations (Scopus)

Improving outcomes of acute kidney injury: Report of an initiative

Molitoris, B., Levin, A., Warnock, D. G., Joannidis, M., Mehta, R. L., Kellum, J. A., Ronco, C. & Shah, S. V., Aug 2007, In : Nature Clinical Practice Nephrology. 3, 8, p. 439-442 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Insufficiency
Creatinine
Serum
1 Citation (Scopus)

Multi-photon microscopy: Linking drug mechanism to disease physiology

Grinnell, B. W., Gupta, A., Sandoval, R. M. & Molitoris, B., Nov 2007, In : American Pharmaceutical Review. 10, 6

Research output: Contribution to journalArticle

Photons
Microscopy
Pharmaceutical Preparations
Physiological Phenomena
Preclinical Drug Evaluations
13 Citations (Scopus)

Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy

Hörbelt, M., Wotzlaw, C., Sutton, T., Molitoris, B., Philipp, T., Kribben, A., Fandrey, J. & Pietruck, F., Aug 2007, In : Kidney International. 72, 4, p. 422-429 8 p.

Research output: Contribution to journalArticle

Photons
Cations
Microscopy
Fluorescence
Kidney
25 Citations (Scopus)

Progression of bacterial infections studied in real time -novel perspectives provided by multiphoton microscopy

Månsson, L. E., Melican, K., Molitoris, B. & Richter-Dahlfors, A., Oct 2007, In : Cellular Microbiology. 9, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

Bacterial Infections
Microscopy
Microscopic examination
Imaging techniques
Pathogens
4 Citations (Scopus)

Quantifying dynamic kidney processes utilizing multi-photon microscopy

Molitoris, B. & Sandoval, R. M., 2007, Contributions to Nephrology. Vol. 156. p. 227-235 9 p. (Contributions to Nephrology; vol. 156).

Research output: Chapter in Book/Report/Conference proceedingChapter

Photons
Microscopy
Research Personnel
Kidney
Technology
72 Citations (Scopus)
Optical Imaging
Kidney
Glomerular Filtration Rate
Fluorescent Dyes
Animal Models
65 Citations (Scopus)

Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals

Månsson, L. E., Melican, K., Boekel, J., Sandoval, R. M., Hautefort, I., Tanner, G. A., Molitoris, B. & Richter-dahlfors, A., Feb 2007, In : Cellular Microbiology. 9, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

Time and motion study
Time and Motion Studies
Bacterial Infections
Animals
Microdissection
2 Citations (Scopus)

Renal endothelium

Molitoris, B., Jan 1 2007, Endothelial Biomedicine. Cambridge University Press, p. 1271-1277 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endothelial cells
Endothelium
Kidney
Endothelial Cells
Color films
1 Citation (Scopus)

Response to 'Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique' [4]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1411 1 p.

Research output: Contribution to journalArticle

Bowman Capsule
Punctures
Microscopy
Albumins
1 Citation (Scopus)

Response to 'On the origin of albuminuria' [2]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1409-1410 2 p.

Research output: Contribution to journalArticle

Albuminuria
281 Citations (Scopus)

The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states

Russo, L. M., Sandoval, R. M., McKee, M., Osicka, T. M., Collins, A. B., Brown, D., Molitoris, B. & Comper, W. D., Mar 13 2007, In : Kidney International. 71, 6, p. 504-513 10 p.

Research output: Contribution to journalArticle

Albumins
Kidney
Albuminuria
Endocytosis
Low Density Lipoprotein Receptor-Related Protein-2
46 Citations (Scopus)

Two-photon microscopy: Visualization of kidney dynamics

Ashworth, S. L., Sandoval, R. M., Tanner, G. A. & Molitoris, B., Aug 2007, In : Kidney International. 72, 4, p. 416-421 6 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Proteins
Software
2008

Authors' response

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A. & Joannidis, M., Jul 25 2008, In : Critical Care. 12, 4, 423.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis

Melican, K., Boekel, J., Månsson, L. E., Sandoval, R. M., Tanner, G. A., Källskog, Ö., Palm, F., Molitoris, B. & Richter-Dahlfors, A., 2008, In : Cellular Microbiology. 10, 10, p. 1987-1998 12 p.

Research output: Contribution to journalArticle

Pathogens
Bacterial Infections
Anticoagulants
Escherichia coli
Heparin
9 Citations (Scopus)
Chronic Renal Insufficiency
Outcome Assessment (Health Care)
Kidney
Acute Kidney Injury
Chronic Kidney Failure
58 Citations (Scopus)

Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified delphi process

Kellum, J. A., Mehta, R. L., Levin, A., Molitoris, B., Warnock, D. G., Shah, S. V., Joannidis, M. & Ronco, C., May 2008, In : Clinical Journal of the American Society of Nephrology. 3, 3, p. 887-894 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Research
Developed Countries
Translational Medical Research
Developing Countries
88 Citations (Scopus)

Evaluation and initial management of acute kidney injury

Himmelfarb, J., Joannidis, M., Molitoris, B., Schietz, M., Okusa, M. D., Warnock, D., Laghi, F., Goldstein, S. L., Prielipp, R., Parikh, C. R., Pannu, N., Lobo, S. M., Shah, S., D'Intini, V. & Kellum, J. A., Jul 2008, In : Clinical Journal of the American Society of Nephrology. 3, 4, p. 962-967 6 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Biomarkers
Comorbidity
Mortality