Bruce Molitoris

  • 15399 Citations
  • 61 h-Index
1974 …2019
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Publications 1974 2019

  • 15399 Citations
  • 61 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
2013
19 Citations (Scopus)

Measuring glomerular filtration rate in the intensive care unit: No substitutes please

Molitoris, B., Sep 4 2013, In : Critical Care. 17, 5, 181.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Intensive Care Units
Chronic Renal Insufficiency
Creatinine
1 Citation (Scopus)

Pathophysiology of Acute Kidney Injury

Molitoris, B. & Sharfuddin, A., 2013, Seldin and Geibisch's The Kidney. Elsevier Inc., Vol. 2. p. 2527-2575 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Acute Kidney Injury
15 Citations (Scopus)
Macromolecules
Photons
Wistar Rats
Rats
Microscopy
23 Citations (Scopus)

Recruiting the Next Generation of Nephrologists

Parker, M. G., Pivert, K. A., Ibrahim, T. & Molitoris, B., Jul 2013, In : Advances in Chronic Kidney Disease. 20, 4, p. 326-335 10 p.

Research output: Contribution to journalArticle

Nephrology
Kidney Diseases
Physicians
Research
Quality of Life
2014
3 Citations (Scopus)
Organizational Innovation
Precision Medicine
Nephrology
Kidney Diseases
18 Citations (Scopus)

Dynamic multiphoton microscopy: Focusing light on acute kidney injury

Hall, A. M. & Molitoris, B., Sep 1 2014, In : Physiology. 29, 5, p. 334-342 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Microscopy
Light
Rodentia
Kidney
17 Citations (Scopus)

Effects of biomechanical forces on signaling in the cortical collecting duct (CCD)

Carrisoza-Gaytan, R., Liu, Y., Flores, D., Else, C., Lee, H. G., Rhodes, G., Sandoval, R. M., Kleyman, T. R., Lee, F. Y. I., Molitoris, B., Satlin, L. M. & Rohatgi, R., Jul 15 2014, In : American Journal of Physiology - Renal Physiology. 307, 2

Research output: Contribution to journalArticle

Dinoprostone
Cations
Paracrine Communication
Collagen Type IV
Furosemide

Fluorescent dextrans in intravital multi- photon microscopy

Sandoval, R. M. & Molitoris, B., Jan 1 2014, Advances in Intravital Microscopy: From Basic to Clinical Research. Springer Netherlands, p. 205-219 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dextrans
Photons
Microscopy
Kidney
Polymers
5 Citations (Scopus)
Microscopy
Albumins
Permeability
3 Citations (Scopus)

Screening: Screening for kidney disease- A lost opportunity

Molitoris, B., Jan 2014, In : Nature Reviews Nephrology. 10, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

Mass Screening
Kidney Diseases
Chronic Renal Insufficiency
122 Citations (Scopus)

The proximal tubule and albuminuria: Really!

Dickson, L. E., Wagner, M., Sandoval, R. M. & Molitoris, B., Mar 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

Albuminuria
Albumins
Transcytosis
Albumin Receptors
Low Density Lipoprotein Receptor-Related Protein-2
94 Citations (Scopus)

Therapeutic translation in acute kidney injury: The epithelial/endothelial axis

Molitoris, B., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2355-2363 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Chronic Renal Insufficiency
Cell Communication
Chronic Kidney Failure
Endothelial Cells
2 Citations (Scopus)
Albuminuria
Photons
Microscopy
Aptitude
Fluorescent Dyes
2015
3 Citations (Scopus)

Contrast material-induced nephropathy: Causation quandaries

Mitchell, A., Molitoris, B. & Teague, S. D., Jun 1 2015, In : Radiology. 275, 3, p. 928-929 2 p.

Research output: Contribution to journalArticle

X Ray Computed Tomography
Acute Kidney Injury
Causality
Contrast Media
Gentamicins
16 Citations (Scopus)

Cross-disciplinary biomarkers research: Lessons learned by the CKD biomarkers consortium

CKD Biomarkers Consortium, Jan 1 2015, In : Clinical Journal of the American Society of Nephrology. 10, 5, p. 894-902 9 p.

Research output: Contribution to journalArticle

Biomarkers
Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Feasibility Studies
Quality Control
10 Citations (Scopus)

Nephrology research - The past, present and future

Floege, J., Mak, R. H., Molitoris, B., Remuzzi, G. & Ronco, P., Nov 1 2015, In : Nature Reviews Nephrology. 11, 11, p. 677-687 11 p.

Research output: Contribution to journalArticle

Nephrology
Research
Atypical Hemolytic Uremic Syndrome
65 Citations (Scopus)

Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): A randomised clinical trial

de Zeeuw, D., Anzalone, D. A., Cain, V. A., Cressman, M. D., Heerspink, H. J. L., Molitoris, B., Monyak, J. T., Parving, H. H., Remuzzi, G., Sowers, J. R. & Vidt, D. G., Mar 1 2015, In : The Lancet Diabetes and Endocrinology. 3, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Kidney
Creatinine
Proteinuria
Urine
49 Citations (Scopus)

Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury

Verma, S. K. & Molitoris, B., Jan 1 2015, In : Seminars in Nephrology. 35, 1, p. 96-107 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Endothelium
Ischemia
11 Citations (Scopus)

Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy

Ferrell, N., Sandoval, R. M., Bian, A., Campos-Bilderback, S., Molitoris, B. & Fissell, W. H., Mar 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 6, p. F588-F593

Research output: Contribution to journalArticle

Nephrectomy
Rheology
Hemodynamics
Theoretical Models
Blood Flow Velocity
10 Citations (Scopus)

Urinary biomarkers: Alone are they enough?

Molitoris, B., Jul 1 2015, In : Journal of the American Society of Nephrology. 26, 7, p. 1485-1488 4 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Insulin-Like Growth Factor Binding Proteins
Acute Kidney Injury
Renal Dialysis
Biomarkers
2016
13 Citations (Scopus)

ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial

McCullough, P. A., Bennett-Guerrero, E., Chawla, L. S., Beaver, T., Mehta, R. L., Molitoris, B., Eldred, A., Ball, G., Lee, H. J., Houser, M. T. & Khan, S., Aug 20 2016, In : Journal of the American Heart Association. 5, 8

Research output: Contribution to journalArticle

Acute Kidney Injury
Thoracic Surgery
Clinical Trials
Placebos
Biomarkers
9 Citations (Scopus)

Mechanism of increased clearance of glycated albumin by proximal tubule cells

Wagner, M., Myslinski, J., Pratap, S., Flores, B., Rhodes, G., Campos-Bilderback, S., Sandoval, R. M., Kumar, S., Patel, M., Ashish & Molitoris, B., May 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 10, p. F1089-F1102

Research output: Contribution to journalArticle

Albumins
Transcytosis
glycosylated serum albumin
Proximal Kidney Tubule
Serum Albumin
35 Citations (Scopus)

Proximal tubules have the capacity to regulate uptake of albumin

Wagner, M., Campos-Bilderback, S., Chowdhury, M., Flores, B., Lai, X., Myslinski, J., Pandit, S., Sandoval, R. M., Wean, S. E., Wei, Y., Satlin, L. M., Wiggins, R. C., Witzmann, F. & Molitoris, B., Feb 1 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 482-494 13 p.

Research output: Contribution to journalArticle

Albumins
Serum Albumin
Albumin Receptors
Proteins
Angiopoietin-2
20 Citations (Scopus)

Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success

Molitoris, B. & Reilly, E. S., 2016, (Accepted/In press) In : Seminars in Nephrology.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Kidney
Nephrology
Wounds and Injuries
41 Citations (Scopus)

Renal Hemodynamics in AKI: In Search of New Treatment Targets

The ADQI XIII Work Group, Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Hemodynamics
Kidney
Nephrons
Microvessels
Renal Insufficiency
7 Citations (Scopus)
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney
Technology
Disease Progression

Tubular mechanisms in proteinuria

Verma, S. K. & Molitoris, B., Jan 1 2016, Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer International Publishing, p. 23-40 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Low Density Lipoprotein Receptor-Related Protein-2
Factor IX
Proteinuria
Electron microscopy
affinity
2017
1 Citation (Scopus)

Aminoglycoside-Induced Nephrotoxicity

Decker, B. & Molitoris, B., Dec 15 2017, Renal Toxicology. Elsevier Inc., Vol. 14-15. p. 256-273 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aminoglycosides
Endocytosis
Kidney
Incidence
Low Density Lipoprotein Receptor-Related Protein-2
6 Citations (Scopus)

Hydrodynamic isotonic fluid delivery ameliorates moderate-to-severe ischemia-reperfusion injury in rat kidneys

Collett, J. A., Corridon, P. R., Mehrotra, P., Kolb, A. L., Rhodes, G. J., Miller, C. A., Molitoris, B., Pennington, J. G., Sandoval, R. M., Atkinson, S. J., Campos-Bilderback, S., Basile, D. & Bacallao, R., Jul 1 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2081-2092 12 p.

Research output: Contribution to journalArticle

Hydrodynamics
Reperfusion Injury
Kidney
Renal Veins
Wounds and Injuries
6 Citations (Scopus)

Inhibition of avb5 integrin attenuates vascular permeability and protects against renal ischemia-reperfusion injury

McCurley, A., Alimperti, S., Campos-Bilderback, S., Sandoval, R. M., Calvino, J. E., Reynolds, T. L., Quigley, C., Mugford, J. W., Polacheck, W. J., Gomez, I. G., Dovey, J., Marsh, G., Huang, A., Qian, F., Weinreb, P. H., Dolinski, B. M., Moore, S., Duffield, J. S., Chen, C. S., Molitoris, B. & 2 others, Violette, S. M. & Crackower, M. A., Jun 1 2017, In : Journal of the American Society of Nephrology. 28, 6, p. 1741-1752 12 p.

Research output: Contribution to journalArticle

Capillary Permeability
Reperfusion Injury
Integrins
Kidney
Pericytes
5 Citations (Scopus)

Intravital imaging of the kidney in a rat model of salt-sensitive hypertension

Endres, B. T., Sandoval, R. M., Rhodes, G. J., Campos-Bilderback, S., Kamocka, M., McDermott-Roe, C., Staruschenko, A., Molitoris, B., Geurts, A. M. & Palygin, O., Aug 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 2, p. F163-F173

Research output: Contribution to journalArticle

Albuminuria
Salts
Albumins
Hypertension
Kidney
3 Citations (Scopus)

Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology

Sandoval, R. M. & Molitoris, B., 2017, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Physiology
Photons
Microscopy
Microscopic examination
Kidney

Practical Considerations of Renal Biopsies in Critical Care Patients

Modi, J. R., Liapis, H., Molitoris, B. & Eadon, M., Dec 6 2017, Critical Care Nephrology: Third Edition. Elsevier Inc., p. 167-173.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Critical Care
Kidney
Biopsy
Disease Management
Acute Kidney Injury

The Physiology of the Glomerulus

Dean, D. F. & Molitoris, B., Dec 6 2017, Critical Care Nephrology: Third Edition. Elsevier Inc., p. 35-42.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Arterioles
Glomerular Filtration Barrier
Low Density Lipoprotein Receptor-Related Protein-2
Epithelial Cells
Sodium Potassium Chloride Symporter Inhibitors
22 Citations (Scopus)

Two-photon intravital fluorescence lifetime imaging of the kidney reveals cell-type specific metabolic signatures

Hato, T., Winfree, S., Day, R., Sandoval, R. M., Molitoris, B., Yoder, M., Wiggins, R. C., Zheng, Y., Dunn, K. & Dagher, P., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2420-2430 11 p.

Research output: Contribution to journalArticle

Optical Imaging
Photons
Microscopy
Kidney
Metabolome
2018
6 Citations (Scopus)

A novel method for rapid bedside measurement of GFR

Rizk, D. V., Meier, D., Sandoval, R. M., Chacana, T., Reilly, E. S., Seegmiller, J. C., DeNoia, E., Strickland, J. S., Muldoon, J. & Molitoris, B., Jun 1 2018, In : Journal of the American Society of Nephrology. 29, 6, p. 1609-1613 5 p.

Research output: Contribution to journalArticle

Iohexol
Rhodamines
Plasma Volume
Biomarkers
Cystatin C
15 Citations (Scopus)

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients with Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial

Pickkers, P., Mehta, R. L., Murray, P. T., Joannidis, M., Molitoris, B., Kellum, J. A., Bachler, M., Hoste, E. A. J., Hoiting, O., Krell, K., Ostermann, M., Rozendaal, W., Valkonen, M., Brealey, D., Beishuizen, A., Meziani, F., Murugan, R., De Geus, H., Payen, D., Van Den Berg, E. & 1 others, Arend, J., Jan 1 2018, (Accepted/In press) In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalArticle

Acute Kidney Injury
Alkaline Phosphatase
Creatinine
Sepsis
Randomized Controlled Trials
1 Citation (Scopus)

Exogenous gene transmission of isocitrate dehydrogenase 2 mimics ischemic preconditioning protection

Kolb, A. L., Corridon, P. R., Zhang, S., Xu, W., Witzmann, F., Collett, J. A., Rhodes, G. J., Winfree, S., Bready, D., Pfeffenberger, Z. J., Pomerantz, J. M., Hato, T., Nagami, G. T., Molitoris, B., Basile, D., Atkinson, S. J. & Bacallao, R., Apr 1 2018, In : Journal of the American Society of Nephrology. 29, 4, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Ischemic Preconditioning
Mitochondria
Cytoprotection
Wounds and Injuries
1 Citation (Scopus)

Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147

Schulz, A., Chuquimia, O. D., Antypas, H., Steiner, S. E., Sandoval, R. M., Tanner, G. A., Molitoris, B., Richter-Dahlfors, A. & Melican, K., Nov 1 2018, In : Pathogens and Disease. 76, 8, fty087.

Research output: Contribution to journalArticle

Lipid A
Bacterial Infections
Blood Vessels
Uropathogenic Escherichia coli
Kidney
2019

A novel fluorescent clinical method to rapidly quantify plasma volume

Molitoris, B., George, A. G., Murray, P. T., Meier, D., Reilly, E. S., Barreto, E., Sandoval, R. M., Rizk, D. V., Shaw, A. D. & Peacock, W. F., Mar 1 2019, In : CardioRenal Medicine. 9, 3, p. 168-179 12 p.

Research output: Contribution to journalArticle

Open Access
Plasma Volume
Healthy Volunteers
Blood Volume
Dextrans
Fluorescent Dyes

Application of physiological shear stress to renal tubular epithelial cells

Ferrell, N., Sandoval, R. M., Molitoris, B., Brakeman, P., Roy, S. & Fissell, W. H., Jan 1 2019, Methods in Cell Biology. Academic Press Inc., (Methods in Cell Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Epithelial Cells
Kidney
Lab-On-A-Chip Devices
Kidney Tubules
Nephrons

Beyond Biomarkers: Machine Learning in Diagnosing Acute Kidney Injury

Molitoris, B., May 1 2019, In : Mayo Clinic Proceedings. 94, 5, p. 748-750 3 p.

Research output: Contribution to journalEditorial

Acute Kidney Injury
Biomarkers
Machine Learning

DNA damage response protects against progressive kidney disease

Molitoris, B. A., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4574-4575 2 p.

Research output: Contribution to journalReview article

Kidney Diseases
DNA Damage
Wounds and Injuries
G2 Phase Cell Cycle Checkpoints
Acute Kidney Injury

Fluorescent Imaging and Microscopy for Dynamic Processes in Rats

Sandoval, R. M., Molitoris, B. & Palygin, O., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 151-175 25 p. (Methods in Molecular Biology; vol. 2018).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microscopy
Photons
Kidney
Genetically Modified Animals
Translational Medical Research

The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration

Uchida, M., Maier, B., Waghwani, H. K., Selivanovitch, E., Louise Pay, S., Avera, J., Jun Yun, E., Sandoval, R. M., Molitoris, B., Zollman, A., Douglas, T. & Hato, T., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

Open Access
Proximal Kidney Tubule
Glomerular Filtration Barrier
Endocytosis
Proteins
Antioxidants