Bruce Molitoris

  • 15549 Citations
  • 62 h-Index
1974 …2019
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Publications 1974 2019

  • 15549 Citations
  • 62 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
41 Citations (Scopus)

Renal Hemodynamics in AKI: In Search of New Treatment Targets

The ADQI XIII Work Group, Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Hemodynamics
Kidney
Nephrons
Microvessels
Renal Insufficiency
18 Citations (Scopus)

Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments

Ashworth, S. L., Wean, S. E., Campos-Bilderback, S., Temm-Grove, C. J., Southgate, E. L., Vrhovski, B., Gunning, P., Weinberger, R. P. & Molitoris, B., May 2004, In : American Journal of Physiology - Renal Physiology. 286, 5 55-5

Research output: Contribution to journalArticle

Tropomyosin
Microvilli
Actin Cytoskeleton
Ischemia
Kidney
1 Citation (Scopus)

Response to 'Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique' [4]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1411 1 p.

Research output: Contribution to journalArticle

Bowman Capsule
Punctures
Microscopy
Albumins
1 Citation (Scopus)

Response to 'On the origin of albuminuria' [2]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1409-1410 2 p.

Research output: Contribution to journalArticle

Albuminuria
7 Citations (Scopus)
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney
Technology
Disease Progression
88 Citations (Scopus)

Role of microfilaments in maintenance of proximal tubule structural and functional integrity

Kellerman, P. S., Clark, R. A. F., Hoilien, C. A., Linas, S. L. & Molitoris, B., 1990, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259, 2 28-2

Research output: Contribution to journalArticle

Actin Cytoskeleton
Maintenance
Cytochalasin D
Perfusion
Sodium
47 Citations (Scopus)

Role of the actin cytoskeleton in ischemia-induced cell injury and repair

Molitoris, B., Leiser, J. & Wagner, M., Dec 1997, In : Pediatric Nephrology. 11, 6, p. 761-767 7 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Ischemia
Wounds and Injuries
Membranes
Adenosine Triphosphate
5 Citations (Scopus)

Role of the actin cytoskeleton in ischemic injury

Molitoris, B., Dahl, R. & Geerdes, A., 1992, In : Chest. 101, 3 SUPPL.

Research output: Contribution to journalArticle

Cell Polarity
Intercellular Junctions
Actin Cytoskeleton
Actins
Ischemia
3 Citations (Scopus)

Screening: Screening for kidney disease- A lost opportunity

Molitoris, B., Jan 2014, In : Nature Reviews Nephrology. 10, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

Mass Screening
Kidney Diseases
Chronic Renal Insufficiency
4 Citations (Scopus)

Sequence of protein feeding and value of alfalfa meal and fish meal for pregnant gilts and sows.

Baker, D. H., Molitoris, B., Jensen, A. H. & Harmon, B. G., Feb 1974, In : Journal of Animal Science. 38, 2, p. 325-329 5 p.

Research output: Contribution to journalArticle

obstetric labor
Obstetric Labor
Animal Pregnancy
Fish Products
alfalfa meal
12 Citations (Scopus)

Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy

Ferrell, N., Sandoval, R. M., Bian, A., Campos-Bilderback, S., Molitoris, B. & Fissell, W. H., Mar 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 6, p. F588-F593

Research output: Contribution to journalArticle

Nephrectomy
Rheology
Hemodynamics
Theoretical Models
Blood Flow Velocity
194 Citations (Scopus)

siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury

Molitoris, B., Dagher, P., Sandoval, R. M., Campos-Bilderback, S., Ashush, H., Fridman, E., Brafman, A., Faerman, A., Atkinson, S. J., Thompson, J. D., Kalinski, H., Skaliter, R., Erlich, S. & Feinstein, E., Aug 2009, In : Journal of the American Society of Nephrology. 20, 8, p. 1754-1764 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Small Interfering RNA
Cisplatin
Kidney
Wounds and Injuries
117 Citations (Scopus)

Site and mechanism of enhanced gastrointestinal absorption of aluminum by citrate

Froment Ph., D., Molitoris, B., Buddington, B., Miller, N. & Alfrey, A. C., 1989, In : Kidney International. 36, 6, p. 978-984 7 p.

Research output: Contribution to journalArticle

Aluminum
Tight Junctions
Ruthenium Red
aluminum citrate
Gastrointestinal Absorption
85 Citations (Scopus)

Soluble thrombomodulin protects ischemic kidneys

Sharfuddin, A., Sandoval, R. M., Berg, D. T., McDougal, G. E., Campos-Bilderback, S., Phillips, C., Jones, B. E., Gupta, A., Grinnell, B. W. & Molitoris, B., Mar 2009, In : Journal of the American Society of Nephrology. 20, 3, p. 524-534 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Kidney
Protein C
Acute Kidney Injury
Microscopy
34 Citations (Scopus)

Static and dynamic components of renal cortical brush border and basolateral membrane fluidity: Role of cholesterol

Molitoris, B. & Hoilien, C., Nov 1987, In : Journal of Membrane Biology. 99, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

Membrane Fluidity
Microvilli
Cholesterol
Kidney
Membranes
31 Citations (Scopus)

Surface membrane polarity of proximal tubular cells: Alterations as a basis for malfunction

Molitoris, B. & Wagner, M., 1996, In : Kidney International. 49, 6, p. 1592-1597 6 p.

Research output: Contribution to journalArticle

Membranes
Actin Cytoskeleton
Membrane Proteins
Cell-Matrix Junctions
Membrane Lipids
11 Citations (Scopus)

Techniques to study nephron function: Microscopy and imaging

Molitoris, B. & Sandoval, R. M., May 2009, In : Pflugers Archiv European Journal of Physiology. 458, 1, p. 203-209 7 p.

Research output: Contribution to journalArticle

Fluorophores
Nephrons
Microscopy
Microscopic examination
Animals
56 Citations (Scopus)

Technology Insight: Biomarker development in acute kidney injury - What can we anticipate?

Molitoris, B., Melnikov, V. Y., Okusa, M. D. & Himmelfarb, J., Mar 2008, In : Nature Clinical Practice Nephrology. 4, 3, p. 154-165 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Biomarkers
Technology
Early Diagnosis
Blood Urea Nitrogen
4 Citations (Scopus)

The antibiotic gentamicin inhibits specific protein trafficking functions of the arf1/2 family of GTPases

Lin, L., Wagner, M., Cocklin, R., Kuzma, A., Harrington, M., Molitoris, B. & Goebl, M., Jan 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 246-254 9 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Protein Transport
Gentamicins
Anti-Bacterial Agents
Translational Peptide Chain Termination
1 Citation (Scopus)

The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration

Uchida, M., Maier, B., Waghwani, H. K., Selivanovitch, E., Louise Pay, S., Avera, J., Jun Yun, E., Sandoval, R. M., Molitoris, B., Zollman, A., Douglas, T. & Hato, T., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

Open Access
Proximal Kidney Tubule
Glomerular Filtration Barrier
Endocytosis
Proteins
Antioxidants
16 Citations (Scopus)

The choline requirement of broiler chicks during the seventh week of life.

Molitoris, B. & Baker, D. H., Jan 1976, In : Poultry Science. 55, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

choline
broiler chickens
sulfur amino acids
methionine
amino acid requirements

The distribution and disappearance of (23H) and (U14C) myoinositol in normal and diabetic dogs

Daughaday, W. H., Molitoris, B., Bier, D. M. & Yang, S., 1977, In : Diabetes. 26, sup.1

Research output: Contribution to journalArticle

Inositol
Dogs
Myosin Type I
Proximal Kidney Tubule
Myosins
Actins
Adenosine Triphosphate
73 Citations (Scopus)

The future nephrology workforce: Will there be one?

Parker, M. G., Ibrahim, T., Shaffer, R., Rosner, M. H. & Molitoris, B., Jun 1 2011, In : Clinical Journal of the American Society of Nephrology. 6, 6, p. 1501-1506 6 p.

Research output: Contribution to journalArticle

Nephrology
Mentors
Geriatrics
Medicine
Policy Making
282 Citations (Scopus)

The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states

Russo, L. M., Sandoval, R. M., McKee, M., Osicka, T. M., Collins, A. B., Brown, D., Molitoris, B. & Comper, W. D., Mar 13 2007, In : Kidney International. 71, 6, p. 504-513 10 p.

Research output: Contribution to journalArticle

Albumins
Kidney
Albuminuria
Endocytosis
Low Density Lipoprotein Receptor-Related Protein-2

The Physiology of the Glomerulus

Dean, D. F. & Molitoris, B., Dec 6 2017, Critical Care Nephrology: Third Edition. Elsevier Inc., p. 35-42.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Arterioles
Glomerular Filtration Barrier
Low Density Lipoprotein Receptor-Related Protein-2
Epithelial Cells
Sodium Potassium Chloride Symporter Inhibitors
22 Citations (Scopus)

The potential role of ischemia in renal disease progression.

Molitoris, B., May 1992, In : Kidney international. Supplement. 36

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Membrane Lipids
Chronic Kidney Failure
Disease Progression
Membrane Proteins
124 Citations (Scopus)

The proximal tubule and albuminuria: Really!

Dickson, L. E., Wagner, M., Sandoval, R. M. & Molitoris, B., Mar 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

Albuminuria
Albumins
Transcytosis
Albumin Receptors
Low Density Lipoprotein Receptor-Related Protein-2
11 Citations (Scopus)

Therapeutic drug monitoring in patients with chronic renal failure: Evaluation of the abbott TDxTM drug assay system

Sedman, A. J., Molitoris, B., Nakata, L. M. & Gal, J., 1986, In : American Journal of Nephrology. 6, 2, p. 132-134 3 p.

Research output: Contribution to journalArticle

Drug Monitoring
Chronic Kidney Failure
Digoxin
Pharmaceutical Preparations
Immunoassay
94 Citations (Scopus)

Therapeutic translation in acute kidney injury: The epithelial/endothelial axis

Molitoris, B., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2355-2363 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Chronic Renal Insufficiency
Cell Communication
Chronic Kidney Failure
Endothelial Cells
6 Citations (Scopus)

The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population

Yuan, B., Klein, M. H., Contiguglia, R. S., Mishell, J. L., Seligman, P. A., Miller, N. L., Molitoris, B., Alfrey, A. C. & Shapiro, J. I., 1989, In : Renal Failure. 11, 2-3, p. 91-96 6 p.

Research output: Contribution to journalArticle

Aluminum
Renal Dialysis
Anemia
Outpatients
Population
109 Citations (Scopus)

The role of cell adhesion molecules in ischemic acute renal failure

Molitoris, B. & Marrs, J., May 1999, In : The American Journal of Medicine. 106, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Reperfusion Injury
Acute Kidney Injury
Integrins
Neutrophils
1 Citation (Scopus)

The role of statin therapy in patients with chronic kidney disease

Decker, B. & Molitoris, B., Jun 2006, In : Clinical Geriatrics. 14, 6, p. 29-34 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chronic Renal Insufficiency
Therapeutics
43 Citations (Scopus)

Toxicological and pharmacokinetic properties of chemically modified siRNAs targeting p53 RNA following intravenous administration

Thompson, J. D., Kornbrust, D. J., Foy, J. W. D., Solano, E. C. R., Schneider, D. J., Feinstein, E., Molitoris, B. & Erlich, S., Aug 1 2012, In : Nucleic Acid Therapeutics. 22, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Intravenous Administration
Toxicology
RNA
Reperfusion Injury
90 Citations (Scopus)

Transitioning to therapy in ischemic acute renal failure

Molitoris, B., Jan 1 2003, In : Journal of the American Society of Nephrology. 14, 1, p. 265-267 3 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Ischemia
Therapeutics

Tubular mechanisms in proteinuria

Verma, S. K. & Molitoris, B., Jan 1 2016, Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer International Publishing, p. 23-40 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Low Density Lipoprotein Receptor-Related Protein-2
Factor IX
Proteinuria
Electron microscopy
affinity
36 Citations (Scopus)

Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact

Presson, R., Brown, M. B., Fisher, A. J., Sandoval, R. M., Dunn, K., Lorenz, K. S., Delp, E. J., Salama, P., Molitoris, B. & Petrache, I., Jul 2011, In : American Journal of Pathology. 179, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Photons
Artifacts
Thorax
Microscopy
Leukocytes
24 Citations (Scopus)

Two-photon intravital fluorescence lifetime imaging of the kidney reveals cell-type specific metabolic signatures

Hato, T., Winfree, S., Day, R., Sandoval, R. M., Molitoris, B., Yoder, M., Wiggins, R. C., Zheng, Y., Dunn, K. & Dagher, P., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2420-2430 11 p.

Research output: Contribution to journalArticle

Optical Imaging
Photons
Microscopy
Kidney
Metabolome
48 Citations (Scopus)

Two-photon microscopy: Visualization of kidney dynamics

Ashworth, S. L., Sandoval, R. M., Tanner, G. A. & Molitoris, B., Aug 2007, In : Kidney International. 72, 4, p. 416-421 6 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Proteins
Software
104 Citations (Scopus)
Photons
Folic Acid
Microscopy
Microscopic examination
Kidney
89 Citations (Scopus)

Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts

Kwon, O., Molitoris, B., Pescovitz, M. & Kelly, K., May 1 2003, In : American Journal of Kidney Diseases. 41, 5, p. 1074-1087 14 p.

Research output: Contribution to journalArticle

Interleukin-8
Acute Kidney Injury
Allografts
Actins
Interleukin-6
10 Citations (Scopus)

Urinary biomarkers: Alone are they enough?

Molitoris, B., Jul 1 2015, In : Journal of the American Society of Nephrology. 26, 7, p. 1485-1488 4 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Insulin-Like Growth Factor Binding Proteins
Acute Kidney Injury
Renal Dialysis
Biomarkers
82 Citations (Scopus)

Uropathogenic escherichia coli P and type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction

Melican, K., Sandoval, R. M., Kader, A., Josefsson, L., Tanner, G. A., Molitoris, B. & Richter-Dahlfors, A., Feb 2011, In : PLoS Pathogens. 7, 2, e1001298.

Research output: Contribution to journalArticle

Uropathogenic Escherichia coli
Nephrons
Bacterial Infections
Epithelium
Bowman Capsule
2 Citations (Scopus)
Albuminuria
Photons
Microscopy
Aptitude
Fluorescent Dyes
27 Citations (Scopus)

Utilization of nitrogen from selected purines and pyrimidines and from urea by the young chick

Baker, D. H. & Molitoris, B., 1974, In : Journal of Nutrition. 104, 5, p. 553-557 5 p.

Research output: Contribution to journalArticle

Pyrimidines
Purines
pyrimidines
purines
Urea
6 Citations (Scopus)

Yet another advance in understanding albuminuria?

Molitoris, B., Dec 2010, In : Journal of the American Society of Nephrology. 21, 12, p. 2013-2015 3 p.

Research output: Contribution to journalArticle

Animal Disease Models
Podocytes
Albuminuria
Kidney Diseases
Glomerular Filtration Rate