Bruce Molitoris

  • 15617 Citations
  • 62 h-Index
1974 …2019
If you made any changes in Pure, your changes will be visible here soon.

Publications 1974 2019

  • 15617 Citations
  • 62 h-Index
  • 224 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
62 Citations (Scopus)

Characterization of ischemia-induced loss of epithelial polarity

Molitoris, B., Hoilien, C. A., Dahl, R., Ahnen, D. J., Wilson, P. D. & Kim, J., Dec 1988, In : Journal of Membrane Biology. 106, 3, p. 233-242 10 p.

Research output: Contribution to journalArticle

Ischemia
Proximal Kidney Tubule
Membranes
Membrane Lipids
Adenosine Triphosphatases
19 Citations (Scopus)

Characteristics of EYFP-actin and visualization of actin dynamics during ATP depletion and repletion

Herget-Rosenthal, S., Hosford, M., Kribben, A., Atkinson, S. J., Sandoval, R. M. & Molitoris, B., 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Actins
Visualization
Adenosine Triphosphate
Fluorescence
Proteins
21 Citations (Scopus)

Cellular mechanism of aminoglycoside tolerance in long-term gentamicin treatment

Sundin, D. P., Meyer, C., Dahl, R., Geerdes, A., Sandoval, R. & Molitoris, B., 1997, In : American Journal of Physiology - Cell Physiology. 272, 4 41-4

Research output: Contribution to journalArticle

Aminoglycosides
Gentamicins
Membranes
Low Density Lipoprotein Receptor-Related Protein-2
Rats
55 Citations (Scopus)
Spectrin
Ankyrins
Adenosine Triphosphate
Octoxynol
LLC-PK1 Cells
24 Citations (Scopus)

Cell biology of aminoglycoside nephrotoxicity: Newer aspects

Molitoris, B., 1997, In : Current Opinion in Nephrology and Hypertension. 6, 4, p. 384-388 5 p.

Research output: Contribution to journalArticle

Aminoglycosides
Endocytosis
Cell Biology
Low Density Lipoprotein Receptor-Related Protein-2
Golgi Apparatus
24 Citations (Scopus)

Cardiovascular disease in patients with chronic kidney disease

Jaradat, M. I. & Molitoris, B., Nov 2002, In : Seminars in Nephrology. 22, 6, p. 459-473 15 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Cardiovascular Diseases
Anemia
Renal Replacement Therapy
Left Ventricular Hypertrophy
15 Citations (Scopus)

Bilateral congenital renal arteriovenous fistulas

Ullian, M. E. & Molitoris, B., 1987, In : Clinical Nephrology. 27, 6, p. 293-297 5 p.

Research output: Contribution to journalArticle

Arteriovenous Fistula
Fistula
Kidney
Hypertension
Renin

Beyond Biomarkers: Machine Learning in Diagnosing Acute Kidney Injury

Molitoris, B., May 1 2019, In : Mayo Clinic Proceedings. 94, 5, p. 748-750 3 p.

Research output: Contribution to journalEditorial

Acute Kidney Injury
Biomarkers
Machine Learning
41 Citations (Scopus)

Beta-2-Microglobulin-Associated amyloidosis in chronic hemodialysis patients with carpal tunnel syndrome

Ullian, M. E., Hammond, W. S., Alfrey, A. C., Schultz, A. & Molitoris, B., 1989, In : Medicine (United States). 68, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Carpal Tunnel Syndrome
Synovial Membrane
Bone Diseases
Muscular Diseases
71 Citations (Scopus)

Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis

Melican, K., Boekel, J., Månsson, L. E., Sandoval, R. M., Tanner, G. A., Källskog, Ö., Palm, F., Molitoris, B. & Richter-Dahlfors, A., 2008, In : Cellular Microbiology. 10, 10, p. 1987-1998 12 p.

Research output: Contribution to journalArticle

Pathogens
Bacterial Infections
Anticoagulants
Escherichia coli
Heparin

Authors' response

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A. & Joannidis, M., Jul 25 2008, In : Critical Care. 12, 4, 423.

Research output: Contribution to journalArticle

29 Citations (Scopus)
Myosin Type I
LLC-PK1 Cells
Adenosine Triphosphate
Actins
Microvilli
149 Citations (Scopus)

A statistical method for determining the breakpoint of two lines

Jones, R. H. & Molitoris, B., Aug 15 1984, In : Analytical Biochemistry. 141, 1, p. 287-290 4 p.

Research output: Contribution to journalArticle

Statistical tests
Statistical methods
Confidence Intervals
Testing
15 Citations (Scopus)

Assessment of the quantity of biologically available choline in soybean meal.

Molitoris, B. & Baker, D. H., Feb 1976, In : Journal of Animal Science. 42, 2, p. 481-489 9 p.

Research output: Contribution to journalArticle

choline
Choline
Soybeans
Biological Assay
Biological Availability
3 Citations (Scopus)
Organizational Innovation
Precision Medicine
Nephrology
Kidney Diseases
1 Citation (Scopus)

ASN policy on managing conflicts of interest

Stokes, J. B., Haupt, A., Molitoris, B., Kokemueller, P. & Ibrahim, T., Sep 2009, In : Journal of the American Society of Nephrology. 20, 9, p. 1853-1859 7 p.

Research output: Contribution to journalArticle

Organizational Policy
Conflict of Interest
Nephrology
Medical Societies

Application of physiological shear stress to renal tubular epithelial cells

Ferrell, N., Sandoval, R. M., Molitoris, B., Brakeman, P., Roy, S. & Fissell, W. H., Jan 1 2019, Methods in Cell Biology. Academic Press Inc., (Methods in Cell Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Epithelial Cells
Kidney
Lab-On-A-Chip Devices
Kidney Tubules
Nephrons
50 Citations (Scopus)

A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals

Wang, E., Meier, D. J., Sandoval, R. M., Von Hendy-Willson, V. E., Pressler, B. M., Bunch, R. M., Alloosh, M., Sturek, M., Schwartz, G. J. & Molitoris, B., Jan 1 2012, In : Kidney International. 81, 1, p. 112-117 6 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Glomerular Filtration Rate
Fluorescence
Plasma Volume
Blood Vessels
23 Citations (Scopus)

Apically and basolaterally internalized aminoglycosides colocalize in LLC- PK1 lysosomes and alter cell function

Ford, D. M., Dahl, R. H., Lamp, C. A. & Molitoris, B., 1994, In : American Journal of Physiology - Cell Physiology. 266, 1 35-1

Research output: Contribution to journalArticle

Aminoglycosides
Lysosomes
Gentamicins
Membranes
LLC-PK1 Cells
152 Citations (Scopus)
Transferases
Labeling
Apoptosis
Sensitivity and Specificity
Propidium
7 Citations (Scopus)

A novel method for rapid bedside measurement of GFR

Rizk, D. V., Meier, D., Sandoval, R. M., Chacana, T., Reilly, E. S., Seegmiller, J. C., DeNoia, E., Strickland, J. S., Muldoon, J. & Molitoris, B., Jun 1 2018, In : Journal of the American Society of Nephrology. 29, 6, p. 1609-1613 5 p.

Research output: Contribution to journalArticle

Iohexol
Rhodamines
Plasma Volume
Biomarkers
Cystatin C

A novel fluorescent clinical method to rapidly quantify plasma volume

Molitoris, B. A., George, A. G., Murray, P. T., Meier, D., Reilly, E. S., Barreto, E., Sandoval, R. M., Rizk, D. V., Shaw, A. D. & Peacock, W. F., Mar 1 2019, In : CardioRenal Medicine. 9, 3, p. 168-179 12 p.

Research output: Contribution to journalArticle

Open Access
Plasma Volume
Healthy Volunteers
Blood Volume
Dextrans
Fluorescent Dyes
28 Citations (Scopus)

A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy

Sandoval, R. M., Reilly, J. P., Running, W., Campos-Bilderback, S., Santos, J. R., Phillips, C. & Molitoris, B., Oct 2006, In : Journal of the American Society of Nephrology. 17, 10, p. 2697-2705 9 p.

Research output: Contribution to journalArticle

Gentamicins
Aminoglycosides
Klebsiella pneumoniae
Bacillus subtilis
Acute Kidney Injury
13 Citations (Scopus)

A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney

Imamura, R., Isaka, Y., Sandoval, R. M., Ichimaru, N., Abe, T., Okumi, M., Yazawa, K., Kitamura, H., Kaimori, J., Nonomura, N., Rakugi, H., Molitoris, B. & Takahara, S., Dec 2012, In : Clinical and Experimental Nephrology. 16, 6, p. 852-862 11 p.

Research output: Contribution to journalArticle

Erythropoietin
Fibrosis
Kidney
Hemoglobins
carbamylated erythropoietin
1 Citation (Scopus)

Aminoglycoside-Induced Nephrotoxicity

Decker, B. & Molitoris, B., Dec 15 2017, Renal Toxicology. Elsevier Inc., Vol. 14-15. p. 256-273 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aminoglycosides
Endocytosis
Kidney
Incidence
Low Density Lipoprotein Receptor-Related Protein-2

Aminoglycoside-Induced Nephrotoxicity

Decker, B. & Molitoris, B., Aug 12 2010, Renal Toxicology. Elsevier Inc., Vol. 7. p. 329-346 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aminoglycosides
Endocytosis
Kidney
Incidence
Low Density Lipoprotein Receptor-Related Protein-2
68 Citations (Scopus)

Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells

Sandoval, R., Leiser, J. & Molitoris, B., Feb 1998, In : Journal of the American Society of Nephrology. 9, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Aminoglycosides
Gentamicins
Anti-Bacterial Agents
93 Citations (Scopus)

Alterations in the establishment and maintenance of epithelial cell polarity as a basis for disease processes

Molitoris, B. & Nelson, W. J., Jan 1990, In : Journal of Clinical Investigation. 85, 1, p. 3-9 7 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Alterations in epithelial polarity and the pathogenesis of disease states

Fish, E. M. & Molitoris, B., 1994, In : New England Journal of Medicine. 330, 22, p. 1580-1588 9 p.

Research output: Contribution to journalArticle

Cell Polarity
Epithelial Cells
Disease Progression
Maintenance
1 Citation (Scopus)

AKI is around the world but public recognition is lacking

Molitoris, B., 2013, In : Clinical Journal of the American Society of Nephrology. 8, 9, p. 1467-1468 2 p.

Research output: Contribution to journalArticle

Health Knowledge, Attitudes, Practice
Health Policy
Acute Kidney Injury
Biomedical Research
31 Citations (Scopus)

AKI: A path forward

Bonventre, J. V., Basile, D., Liu, K. D., McKay, D., Molitoris, B., Nath, K. A., Nickolas, T. L., Okusa, M. D., Palevsky, P. M., Schnellmann, R., Rys-Sikora, K., Kimmel, P. L. & Star, R. A., 2013, In : Clinical Journal of the American Society of Nephrology. 8, 9, p. 1606-1608 3 p.

Research output: Contribution to journalArticle

Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Kidney
Kidney Diseases
Animal Models
1 Citation (Scopus)

Advances in imaging the kidney and cellular processes

Herget-Rosenthal, S. & Molitoris, B., Mar 2006, In : Nephron - Experimental Nephrology. 103, 2

Research output: Contribution to journalArticle

Nephrology
Diagnostic Imaging
Kidney
44 Citations (Scopus)

ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion

Ashworth, S. L., Southgate, E. L., Sandoval, R. M., Meberg, P. J., Bamburg, J. R. & Molitoris, B., Apr 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Actins
Adenosine Triphosphate
Three-Dimensional Imaging
30 Citations (Scopus)

Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: Enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model

Raikwar, S. P., Temm, C. J., Raikwar, N. S., Kao, C., Molitoris, B. & Gardner, T., Dec 2005, In : Molecular Therapy. 12, 6, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

Angiostatins
Endostatins
Prostate
Growth
Prostatic Neoplasms
150 Citations (Scopus)

Acute renal failure in the new millennium: Time to consider combination therapy

Kelly, K. J. & Molitoris, B. A., 2000, In : Seminars in Nephrology. 20, 1, p. 4-19 16 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Therapeutics
Renal Replacement Therapy
Theoretical Models
Morbidity
88 Citations (Scopus)

Acute renal failure in the 21st century: Recommendations for management and outcomes assessment

DuBose, T. D., Warnock, D. G., Mehta, R. L., Bonventre, J. V., Hammerman, M. R., Molitoris, B., Paller, M. S., Siegel, N. J., Scherbenske, J. & Striker, G. E., May 1997, In : American Journal of Kidney Diseases. 29, 5, p. 793-799 7 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Outcome Assessment (Health Care)
Renal Replacement Therapy
Mortality
National Institutes of Health (U.S.)
10 Citations (Scopus)

Acute renal failure

Molitoris, B., Sep 1999, In : Drugs of Today. 35, 9, p. 659-666 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Azotemia
Urine
Therapeutics

Acute parathyroid hormone stimulation of myo inositol release by isolated perfused dog kidneys

Molitoris, B., Hruska, K. & Daughaday, W. H., 1976, In : Clinical Research. 24, 4

Research output: Contribution to journalArticle

Inositol
Parathyroid Hormone
Dogs
Kidney
4079 Citations (Scopus)

Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A., Bagga, A., Bakkaloglu, A., Bonventre, J. V., Burdmann, E. A., Chen, Y., Devarajan, P., D'Intini, V., Dobb, G., Durbin, C. G., Eckardt, K. U., Guerin, C., Herget-Rosenthal, S., Hoste, E. & 19 others, Joannidis, M., Kellum, J. A., Kirpalani, A., Lassnigg, A., Le Gall, J. R., Levin, A., Lombardi, R., Macias, W., Manthous, C., Mehta, R. L., Molitoris, B. A., Ronco, C., Schetz, M., Schortgen, F., Shah, S. V., Tan, P. S. K., Wang, H., Warnock, D. G. & Webb, S., Mar 1 2007, In : Critical Care. 11, R31.

Research output: Contribution to journalArticle

Acute Kidney Injury
Translational Medical Research
Creatinine
Urine
Nephrology
99 Citations (Scopus)

Acute kidney injury in older adults

Anderson, S., Eldadah, B., Halter, J. B., Hazzard, W. R., Himmelfarb, J., Horne, F. M., Kimmel, P. L., Molitoris, B., Murthy, M., O'Hare, A. M., Schmader, K. E. & High, K. P., Jan 2011, In : Journal of the American Society of Nephrology. 22, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Geriatrics
Patient Preference
Chronic Renal Insufficiency
Creatinine
691 Citations (Scopus)

Acute kidney injury increases risk of ESRD among elderly

Ishani, A., Xue, J. L., Himmelfarb, J., Eggers, P. W., Kimmel, P. L., Molitoris, B. & Collins, A. J., Jan 2009, In : Journal of the American Society of Nephrology. 20, 1, p. 223-228 6 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Chronic Kidney Failure
Chronic Renal Insufficiency
Medicare
Confidence Intervals
2 Citations (Scopus)

Acute Kidney Injury

Molitoris, B., Jul 2011, Goldman's Cecil Medicine: Twenty Fourth Edition. Elsevier Inc., Vol. 1. p. 756-761 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)

Activated protein C and acute kidney injury: Selective targeting of PAR-1

Gupta, A., Williams, M. D., Macias, W. L., Molitoris, B. & Grinnell, B. W., 2009, In : Current Drug Targets. 10, 12, p. 1212-1226 15 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Protein C
Acute Kidney Injury
Protein C Deficiency
Tissue Survival
106 Citations (Scopus)

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Gupta, A., Rhodes, G. J., Berg, D. T., Gerlitz, B., Molitoris, B. & Grinnell, B. W., Jul 2007, In : American Journal of Physiology - Renal Physiology. 293, 1

Research output: Contribution to journalArticle

Angiotensins
Protein C
Acute Kidney Injury
Lipopolysaccharides
Down-Regulation
53 Citations (Scopus)

Actin cytoskeleton in ischemic acute renal failure

Molitoris, B., Harrington, J. T., Perrone, R., Jaber, B., Herman, I. M., Balakrishnan, V. S., Pahari, D. K. & Levey, A. S., Aug 2004, In : Kidney International. 66, 2, p. 871-883 13 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Tropomyosin
Endocytosis
Actin Cytoskeleton
Acute Kidney Injury
13 Citations (Scopus)

ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial

McCullough, P. A., Bennett-Guerrero, E., Chawla, L. S., Beaver, T., Mehta, R. L., Molitoris, B. A., Eldred, A., Ball, G., Lee, H. J., Houser, M. T. & Khan, S., Aug 20 2016, In : Journal of the American Heart Association. 5, 8

Research output: Contribution to journalArticle

Acute Kidney Injury
Thoracic Surgery
Clinical Trials
Placebos
Biomarkers
9 Citations (Scopus)
Microvilli
Membrane Proteins
Phospholipids
Membrane Fluidity
Gels