Bruce Molitoris

  • 15029 Citations
  • 60 h-Index
1974 …2019
If you made any changes in Pure, your changes will be visible here soon.

Publications 1974 2019

  • 15029 Citations
  • 60 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
Article
9 Citations (Scopus)
Microvilli
Membrane Proteins
Phospholipids
Membrane Fluidity
Gels
12 Citations (Scopus)

ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial

McCullough, P. A., Bennett-Guerrero, E., Chawla, L. S., Beaver, T., Mehta, R. L., Molitoris, B., Eldred, A., Ball, G., Lee, H. J., Houser, M. T. & Khan, S., Aug 20 2016, In : Journal of the American Heart Association. 5, 8

Research output: Contribution to journalArticle

Acute Kidney Injury
Thoracic Surgery
Clinical Trials
Placebos
Biomarkers
53 Citations (Scopus)

Actin cytoskeleton in ischemic acute renal failure

Molitoris, B., Harrington, J. T., Perrone, R., Jaber, B., Herman, I. M., Balakrishnan, V. S., Pahari, D. K. & Levey, A. S., Aug 2004, In : Kidney International. 66, 2, p. 871-883 13 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Tropomyosin
Endocytosis
Actin Cytoskeleton
Acute Kidney Injury
104 Citations (Scopus)

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Gupta, A., Rhodes, G. J., Berg, D. T., Gerlitz, B., Molitoris, B. & Grinnell, B. W., Jul 2007, In : American Journal of Physiology - Renal Physiology. 293, 1

Research output: Contribution to journalArticle

Angiotensins
Protein C
Acute Kidney Injury
Lipopolysaccharides
Down-Regulation
26 Citations (Scopus)

Activated protein C and acute kidney injury: Selective targeting of PAR-1

Gupta, A., Williams, M. D., Macias, W. L., Molitoris, B. & Grinnell, B. W., 2009, In : Current Drug Targets. 10, 12, p. 1212-1226 15 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Protein C
Acute Kidney Injury
Protein C Deficiency
Tissue Survival
655 Citations (Scopus)

Acute kidney injury increases risk of ESRD among elderly

Ishani, A., Xue, J. L., Himmelfarb, J., Eggers, P. W., Kimmel, P. L., Molitoris, B. & Collins, A. J., Jan 2009, In : Journal of the American Society of Nephrology. 20, 1, p. 223-228 6 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Chronic Kidney Failure
Chronic Renal Insufficiency
Medicare
Confidence Intervals
91 Citations (Scopus)

Acute kidney injury in older adults

Anderson, S., Eldadah, B., Halter, J. B., Hazzard, W. R., Himmelfarb, J., Horne, F. M., Kimmel, P. L., Molitoris, B., Murthy, M., O'Hare, A. M., Schmader, K. E. & High, K. P., Jan 2011, In : Journal of the American Society of Nephrology. 22, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Geriatrics
Patient Preference
Chronic Renal Insufficiency
Creatinine
3854 Citations (Scopus)

Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A., Bagga, A., Bakkaloglu, A., Bonventre, J. V., Burdmann, E. A., Chen, Y., Devarajan, P., D'Intini, V., Dobb, G., Durbin, C. G., Eckardt, K. U., Guerin, C., Herget-Rosenthal, S., Hoste, E. & 19 others, Joannidis, M., Kellum, J. A., Kirpalani, A., Lassnigg, A., Le Gall, J. R., Levin, A., Lombardi, R., Macias, W., Manthous, C., Mehta, R. L., Molitoris, B. A., Ronco, C., Schetz, M., Schortgen, F., Shah, S. V., Tan, P. S. K., Wang, H., Warnock, D. G. & Webb, S., Mar 1 2007, In : Critical Care. 11, R31.

Research output: Contribution to journalArticle

Acute Kidney Injury
Translational Medical Research
Creatinine
Urine
Nephrology

Acute parathyroid hormone stimulation of myo inositol release by isolated perfused dog kidneys

Molitoris, B., Hruska, K. & Daughaday, W. H., 1976, In : Clinical Research. 24, 4

Research output: Contribution to journalArticle

Inositol
Parathyroid Hormone
Dogs
Kidney
9 Citations (Scopus)

Acute renal failure

Molitoris, B., Sep 1999, In : Drugs of Today. 35, 9, p. 659-666 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Azotemia
Urine
Therapeutics
87 Citations (Scopus)

Acute renal failure in the 21st century: Recommendations for management and outcomes assessment

DuBose, T. D., Warnock, D. G., Mehta, R. L., Bonventre, J. V., Hammerman, M. R., Molitoris, B., Paller, M. S., Siegel, N. J., Scherbenske, J. & Striker, G. E., May 1997, In : American Journal of Kidney Diseases. 29, 5, p. 793-799 7 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Outcome Assessment (Health Care)
Renal Replacement Therapy
Mortality
National Institutes of Health (U.S.)
149 Citations (Scopus)

Acute renal failure in the new millennium: Time to consider combination therapy

Kelly, K. & Molitoris, B., 2000, In : Seminars in Nephrology. 20, 1, p. 4-19 16 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Therapeutics
Renal Replacement Therapy
Theoretical Models
Morbidity
30 Citations (Scopus)

Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: Enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model

Raikwar, S. P., Temm, C. J., Raikwar, N. S., Kao, C., Molitoris, B. & Gardner, T., Dec 2005, In : Molecular Therapy. 12, 6, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

Angiostatins
Endostatins
Prostate
Growth
Prostatic Neoplasms
44 Citations (Scopus)

ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion

Ashworth, S. L., Southgate, E. L., Sandoval, R. M., Meberg, P. J., Bamburg, J. R. & Molitoris, B., Apr 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Actins
Adenosine Triphosphate
Three-Dimensional Imaging
1 Citation (Scopus)

Advances in imaging the kidney and cellular processes

Herget-Rosenthal, S. & Molitoris, B., Mar 2006, In : Nephron - Experimental Nephrology. 103, 2

Research output: Contribution to journalArticle

Nephrology
Diagnostic Imaging
Kidney
31 Citations (Scopus)

AKI: A path forward

Bonventre, J. V., Basile, D., Liu, K. D., McKay, D., Molitoris, B., Nath, K. A., Nickolas, T. L., Okusa, M. D., Palevsky, P. M., Schnellmann, R., Rys-Sikora, K., Kimmel, P. L. & Star, R. A., 2013, In : Clinical Journal of the American Society of Nephrology. 8, 9, p. 1606-1608 3 p.

Research output: Contribution to journalArticle

Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Kidney
Kidney Diseases
Animal Models
1 Citation (Scopus)

AKI is around the world but public recognition is lacking

Molitoris, B., 2013, In : Clinical Journal of the American Society of Nephrology. 8, 9, p. 1467-1468 2 p.

Research output: Contribution to journalArticle

Health Knowledge, Attitudes, Practice
Health Policy
Acute Kidney Injury
Biomedical Research
179 Citations (Scopus)

Alterations in epithelial polarity and the pathogenesis of disease states

Fish, E. M. & Molitoris, B., 1994, In : New England Journal of Medicine. 330, 22, p. 1580-1588 9 p.

Research output: Contribution to journalArticle

Cell Polarity
Epithelial Cells
Disease Progression
Maintenance
93 Citations (Scopus)

Alterations in the establishment and maintenance of epithelial cell polarity as a basis for disease processes

Molitoris, B. & Nelson, W. J., Jan 1990, In : Journal of Clinical Investigation. 85, 1, p. 3-9 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells

Sandoval, R., Leiser, J. & Molitoris, B., Feb 1998, In : Journal of the American Society of Nephrology. 9, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Aminoglycosides
Gentamicins
Anti-Bacterial Agents
10 Citations (Scopus)

A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney

Imamura, R., Isaka, Y., Sandoval, R. M., Ichimaru, N., Abe, T., Okumi, M., Yazawa, K., Kitamura, H., Kaimori, J., Nonomura, N., Rakugi, H., Molitoris, B. & Takahara, S., Dec 2012, In : Clinical and Experimental Nephrology. 16, 6, p. 852-862 11 p.

Research output: Contribution to journalArticle

Erythropoietin
Fibrosis
Kidney
Hemoglobins
carbamylated erythropoietin
28 Citations (Scopus)

A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy

Sandoval, R. M., Reilly, J. P., Running, W., Campos-Bilderback, S., Santos, J. R., Phillips, C. & Molitoris, B., Oct 2006, In : Journal of the American Society of Nephrology. 17, 10, p. 2697-2705 9 p.

Research output: Contribution to journalArticle

Gentamicins
Aminoglycosides
Klebsiella pneumoniae
Bacillus subtilis
Acute Kidney Injury

A novel fluorescent clinical method to rapidly quantify plasma volume

Molitoris, B., George, A. G., Murray, P. T., Meier, D., Reilly, E. S., Barreto, E., Sandoval, R. M., Rizk, D. V., Shaw, A. D. & Peacock, W. F., Mar 1 2019, In : CardioRenal Medicine. 9, 3, p. 168-179 12 p.

Research output: Contribution to journalArticle

Open Access
Plasma Volume
Healthy Volunteers
Blood Volume
Dextrans
Fluorescent Dyes
4 Citations (Scopus)

A novel method for rapid bedside measurement of GFR

Rizk, D. V., Meier, D., Sandoval, R. M., Chacana, T., Reilly, E. S., Seegmiller, J. C., DeNoia, E., Strickland, J. S., Muldoon, J. & Molitoris, B., Jun 1 2018, In : Journal of the American Society of Nephrology. 29, 6, p. 1609-1613 5 p.

Research output: Contribution to journalArticle

Iohexol
Rhodamines
Plasma Volume
Biomarkers
Cystatin C
150 Citations (Scopus)
Transferases
Labeling
Apoptosis
Sensitivity and Specificity
Propidium
3 Citations (Scopus)

Apically and basolaterally internalized aminoglycosides colocalize in LLC- PK1 lysosomes and alter cell function

Ford, D. M., Dahl, R. H., Lamp, C. A. & Molitoris, B., 1994, In : American Journal of Physiology - Cell Physiology. 266, 1 35-1

Research output: Contribution to journalArticle

Aminoglycosides
Lysosomes
Gentamicins
Membranes
LLC-PK1 Cells
50 Citations (Scopus)

A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals

Wang, E., Meier, D. J., Sandoval, R. M., Von Hendy-Willson, V. E., Pressler, B. M., Bunch, R. M., Alloosh, M., Sturek, M., Schwartz, G. J. & Molitoris, B., Jan 1 2012, In : Kidney International. 81, 1, p. 112-117 6 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Glomerular Filtration Rate
Fluorescence
Plasma Volume
Blood Vessels
1 Citation (Scopus)

ASN policy on managing conflicts of interest

Stokes, J. B., Haupt, A., Molitoris, B., Kokemueller, P. & Ibrahim, T., Sep 2009, In : Journal of the American Society of Nephrology. 20, 9, p. 1853-1859 7 p.

Research output: Contribution to journalArticle

Organizational Policy
Conflict of Interest
Nephrology
Medical Societies
2 Citations (Scopus)
Organizational Innovation
Precision Medicine
Nephrology
Kidney Diseases
14 Citations (Scopus)

Assessment of the quantity of biologically available choline in soybean meal.

Molitoris, B. & Baker, D. H., Feb 1976, In : Journal of Animal Science. 42, 2, p. 481-489 9 p.

Research output: Contribution to journalArticle

choline
Choline
Soybeans
Biological Assay
Biological Availability
148 Citations (Scopus)

A statistical method for determining the breakpoint of two lines

Jones, R. H. & Molitoris, B., Aug 15 1984, In : Analytical Biochemistry. 141, 1, p. 287-290 4 p.

Research output: Contribution to journalArticle

Statistical tests
Statistical methods
Confidence Intervals
Testing
29 Citations (Scopus)
Myosin Type I
LLC-PK1 Cells
Adenosine Triphosphate
Actins
Microvilli

Authors' response

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A. & Joannidis, M., Jul 25 2008, In : Critical Care. 12, 4, 423.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis

Melican, K., Boekel, J., Månsson, L. E., Sandoval, R. M., Tanner, G. A., Källskog, Ö., Palm, F., Molitoris, B. & Richter-Dahlfors, A., 2008, In : Cellular Microbiology. 10, 10, p. 1987-1998 12 p.

Research output: Contribution to journalArticle

Pathogens
Bacterial Infections
Anticoagulants
Escherichia coli
Heparin
40 Citations (Scopus)

Beta-2-Microglobulin-Associated amyloidosis in chronic hemodialysis patients with carpal tunnel syndrome

Ullian, M. E., Hammond, W. S., Alfrey, A. C., Schultz, A. & Molitoris, B., 1989, In : Medicine (United States). 68, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

beta 2-Microglobulin
Carpal Tunnel Syndrome
Synovial Membrane
Bone Diseases
Muscular Diseases
15 Citations (Scopus)

Bilateral congenital renal arteriovenous fistulas

Ullian, M. E. & Molitoris, B., 1987, In : Clinical Nephrology. 27, 6, p. 293-297 5 p.

Research output: Contribution to journalArticle

Arteriovenous Fistula
Fistula
Kidney
Hypertension
Renin
24 Citations (Scopus)

Cardiovascular disease in patients with chronic kidney disease

Jaradat, M. I. & Molitoris, B., Nov 2002, In : Seminars in Nephrology. 22, 6, p. 459-473 15 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Cardiovascular Diseases
Anemia
Renal Replacement Therapy
Left Ventricular Hypertrophy
24 Citations (Scopus)

Cell biology of aminoglycoside nephrotoxicity: Newer aspects

Molitoris, B., 1997, In : Current Opinion in Nephrology and Hypertension. 6, 4, p. 384-388 5 p.

Research output: Contribution to journalArticle

Aminoglycosides
Endocytosis
Cell Biology
Low Density Lipoprotein Receptor-Related Protein-2
Golgi Apparatus
54 Citations (Scopus)
Spectrin
Ankyrins
Adenosine Triphosphate
Octoxynol
LLC-PK1 Cells
21 Citations (Scopus)

Cellular mechanism of aminoglycoside tolerance in long-term gentamicin treatment

Sundin, D. P., Meyer, C., Dahl, R., Geerdes, A., Sandoval, R. & Molitoris, B., 1997, In : American Journal of Physiology - Cell Physiology. 272, 4 41-4

Research output: Contribution to journalArticle

Aminoglycosides
Gentamicins
Membranes
Low Density Lipoprotein Receptor-Related Protein-2
Rats
19 Citations (Scopus)

Characteristics of EYFP-actin and visualization of actin dynamics during ATP depletion and repletion

Herget-Rosenthal, S., Hosford, M., Kribben, A., Atkinson, S. J., Sandoval, R. M. & Molitoris, B., 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Actins
Visualization
Adenosine Triphosphate
Fluorescence
Proteins
62 Citations (Scopus)

Characterization of ischemia-induced loss of epithelial polarity

Molitoris, B., Hoilien, C. A., Dahl, R., Ahnen, D. J., Wilson, P. D. & Kim, J., Dec 1988, In : Journal of Membrane Biology. 106, 3, p. 233-242 10 p.

Research output: Contribution to journalArticle

Ischemia
Proximal Kidney Tubule
Membranes
Membrane Lipids
Adenosine Triphosphatases

Characterization of the beta2-microglobulin endocytic pathway in rat proximal tubule cells

Sundin, D. P., Cohen, M., Dahl, R., Falk, S. & Molitoris, B., 1994, In : The American journal of physiology. 267, 3 part 2

Research output: Contribution to journalArticle

proximal tubules
rats
cells
22 Citations (Scopus)

Characterization of the β2-microglobulin endocytic pathway in rat proximal tubule cells

Sundin, D. P., Cohen, M., Dahl, R., Falk, S. & Molitoris, B., Sep 1994, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 267, 3 36-3

Research output: Contribution to journalArticle

Microvilli
Gold
Membranes
Coated Vesicles
Proteins
19 Citations (Scopus)

Choline utilization in the chick as influenced by levels of dietary protein and methionine

Molitoris, B. & Baker, D. H., 1976, In : Journal of Nutrition. 106, 3, p. 412-418 7 p.

Research output: Contribution to journalArticle

Dietary Proteins
choline
Choline
Methionine
dietary protein
12 Citations (Scopus)

Chronic endothelin-1 infusion elevates glomerular sieving coefficient and proximal tubular albumin reuptake in the rat

Saleh, M. A., Sandoval, R. M., Rhodes, G. J., Campos-Bilderback, S., Molitoris, B. & Pollock, D. M., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 634-637 4 p.

Research output: Contribution to journalArticle

Endothelin-1
Rats
Albumins
Albuminuria
Permeability
5 Citations (Scopus)

Circulating Micro-RNAs in Acute Kidney injury: Early observations

Molitoris, J. K. & Molitoris, B., Jul 1 2011, In : Clinical Journal of the American Society of Nephrology. 6, 7, p. 1517-1519 3 p.

Research output: Contribution to journalArticle

MicroRNAs
Acute Kidney Injury
87 Citations (Scopus)

Citrate: A major factor in the toxicity of orally administered aluminum compounds

Molitoris, B., Froment, D. H., Mackenzie, T. A., Huffer, W. H. & Alfrey, A. C., 1989, In : Kidney International. 36, 6, p. 949-953 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Cofilin mediates ATP depletion-induced endothelial cell actin alterations

Suurna, M. V., Ashworth, S. L., Hosford, M., Sandoval, R. M., Wean, S. E., Shah, B. M., Bamburg, J. R. & Molitoris, B., Jun 2006, In : American Journal of Physiology - Renal Physiology. 290, 6

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Actins
Endothelial Cells
Adenosine Triphosphate
Destrin
21 Citations (Scopus)

Concentration of Myo-inositol in skeletal muscle of the rat occurs without active transport

Molitoris, B., Karl, I. E. & Daughaday, W. H., 1980, In : Journal of Clinical Investigation. 65, 4, p. 783-788 6 p.

Research output: Contribution to journalArticle

Active Biological Transport
Inositol
Skeletal Muscle
Phosphatidylinositols
Muscles