Bruce Molitoris

  • 15557 Citations
  • 62 h-Index
1974 …2019
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Publications 1974 2019

Article
388 Citations (Scopus)

Microvascular endothelial injury and dysfunction during ischemic acute renal failure

Sutton, T. A., Fisher, C. J. & Molitoris, B. A., Nov 2002, In : Kidney international. 62, 5, p. 1539-1549 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
19 Citations (Scopus)

Mild ischemia predisposes the S3 segment to gentamicin toxicity

Spiegel, D. M., Shanley, P. F. & Molitoris, B. A., Sep 1990, In : Kidney international. 38, 3, p. 459-464 6 p.

Research output: Contribution to journalArticle

Open Access
Gentamicins
Ischemia
Kidney
Creatinine
Inulin
12 Citations (Scopus)

Multiphoton microscopy applied for real-time intravital imaging of bacterial infections in vivo

Choong, F. X., Sandoval, R. M., Molitoris, B. & Richter-Dahlfors, A., 2012, In : Methods in Enzymology. 506, p. 35-61 27 p.

Research output: Contribution to journalArticle

Bacterial Infections
Microscopy
Microscopic examination
Imaging techniques
Infection
62 Citations (Scopus)

Multiple factors influence glomerular albumin permeability in rats

Sandoval, R. M., Wagner, M. C., Patel, M., Campos-Bilderback, S. B., Rhodes, G. J., Wang, E., Wean, S. E., Clendenon, S. S. & Molitoris, B. A., Mar 1 2012, In : Journal of the American Society of Nephrology. 23, 3, p. 447-457 11 p.

Research output: Contribution to journalArticle

Albumins
Permeability
Wistar Rats
Microscopy
Transcytosis
23 Citations (Scopus)

Myo-inositol uptake by rat cultured inner medullary collecting tubule cells: Effect of osmolality

Veis, J. H., Molitoris, B. A., Teitelbaum, I., Mansour, J. A. & Berl, T., Jan 1 1991, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 260, 5 29-5, p. F619-F625

Research output: Contribution to journalArticle

Inositol
Osmolar Concentration
Cycloheximide
Nocodazole
Osmoregulation
61 Citations (Scopus)
Adenosine Triphosphatases
Adenosine Triphosphate
Ouabain
Membranes
LLC-PK1 Cells
11 Citations (Scopus)

Nephrology research - The past, present and future

Floege, J., Mak, R. H., Molitoris, B., Remuzzi, G. & Ronco, P., Nov 1 2015, In : Nature Reviews Nephrology. 11, 11, p. 677-687 11 p.

Research output: Contribution to journalArticle

Nephrology
Research
Atypical Hemolytic Uremic Syndrome
7 Citations (Scopus)

Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells

Sandoval, R. M., Bacallao, R. L., Dunn, K. W., Leiser, J. D. & Molitoris, B. A., Dec 1 2002, In : American Journal of Physiology - Renal Physiology. 283, 6 52-6, p. F1422-F1429

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Gentamicins
Nucleotides
trans-Golgi Network
14 Citations (Scopus)

Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy

Hörbelt, M., Wotzlaw, C., Sutton, T. A., Molitoris, B. A., Philipp, T., Kribben, A., Fandrey, J. & Pietruck, F., Aug 1 2007, In : Kidney international. 72, 4, p. 422-429 8 p.

Research output: Contribution to journalArticle

Photons
Cations
Microscopy
Fluorescence
Kidney

Parathyroid hormone (PTH) induced turnover of myoinositol in isolated perfused dog kidneys

Hruska, K. A., Molitoris, B. A. & Daughaday, W. H., Jan 1 1976, In : Kidney international. 10, 6, 1 p.

Research output: Contribution to journalArticle

Inositol
Parathyroid Hormone
Dogs
Kidney
65 Citations (Scopus)

Plasma protein adsorption to highly permeable hemodialysis membranes

Clark, W. R., Macias, W. L., Molitoris, B. A. & Wang, N. H. L., Aug 1995, In : Kidney international. 48, 2, p. 481-488 8 p.

Research output: Contribution to journalArticle

Open Access
Adsorption
Renal Dialysis
Blood Proteins
Membranes
Bovine Serum Albumin
2 Citations (Scopus)

Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147

Schulz, A., Chuquimia, O. D., Antypas, H., Steiner, S. E., Sandoval, R. M., Tanner, G. A., Molitoris, B., Richter-Dahlfors, A. & Melican, K., Nov 1 2018, In : Pathogens and Disease. 76, 8, fty087.

Research output: Contribution to journalArticle

Lipid A
Bacterial Infections
Blood Vessels
Uropathogenic Escherichia coli
Kidney
37 Citations (Scopus)

Proximal tubules have the capacity to regulate uptake of albumin

Wagner, M., Campos-Bilderback, S., Chowdhury, M., Flores, B., Lai, X., Myslinski, J., Pandit, S., Sandoval, R. M., Wean, S. E., Wei, Y., Satlin, L. M., Wiggins, R. C., Witzmann, F. & Molitoris, B., Feb 1 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 482-494 13 p.

Research output: Contribution to journalArticle

Albumins
Serum Albumin
Albumin Receptors
Proteins
Angiopoietin-2
14 Citations (Scopus)

Putting the actin cytoskeleton into perspective: Pathophysiology of ischemie alterations

Molitoris, B. A., Dec 1 1997, In : American Journal of Physiology. 272, 4 PART 2, p. F434-F442

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
21 Citations (Scopus)

Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success

Molitoris, B. & Reilly, E. S., 2016, (Accepted/In press) In : Seminars in Nephrology.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Kidney
Nephrology
Wounds and Injuries
16 Citations (Scopus)
Macromolecules
Photons
Wistar Rats
Rats
Microscopy
44 Citations (Scopus)

Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies

Yu, W., Sandoval, R. M. & Molitoris, B. A., Nov 1 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5, p. C1197-C1208

Research output: Contribution to journalArticle

Dextrans
Kidney
Bowman Capsule
Rats
Capsules
74 Citations (Scopus)

Rapid determination of renal filtration function using an optical ratiometric imaging approach

Yu, W., Sandoval, R. M. & Molitoris, B. A., Jun 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 6, p. F1873-F1880

Research output: Contribution to journalArticle

Optical Imaging
Kidney
Glomerular Filtration Rate
Fluorescent Dyes
Animal Models
31 Citations (Scopus)
Glomerular Filtration Rate
Acute Kidney Injury
Dextrans
Photons
Kidney
23 Citations (Scopus)

Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers

Molitoris, B. A., Alfrey, A. C., Alfrey, P. S. & Miller, N. L., Jan 1 1988, In : Kidney international. 34, 1, p. 98-101 4 p.

Research output: Contribution to journalArticle

Open Access
Deferoxamine
Aluminum
Renal Dialysis
polysulfone P 1700
Dialysis
67 Citations (Scopus)

Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals

Månsson, L. E., Melican, K., Boekel, J., Sandoval, R. M., Hautefort, I., Tanner, G. A., Molitoris, B. A. & Richter-dahlfors, A., Feb 1 2007, In : Cellular Microbiology. 9, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

Time and motion study
Time and Motion Studies
Bacterial Infections
Animals
Microdissection

Recovery of the actin cytoskeleton during cellular repair is independent of protein synthesis

Hosford, M., Sandoval, R. & Molitoris, B. A., Jan 1 1996, In : Journal of Investigative Medicine. 44, 1, p. 169A

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Repair
Recovery
Proteins

Renal apical membrane cholesterol and fluidity in regulation of phosphate transport

Molitoris, B. A., Alfrey, A. C., Harris, R. A. & Simon, F. R., Dec 1 1985, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 18, 1, p. F12-F19

Research output: Contribution to journalArticle

Membrane Fluidity
Phosphates
Cholesterol
Kidney
Membranes
20 Citations (Scopus)

Renal blood flow in sepsis: A complex issue

Molitoris, B. A., Aug 1 2005, In : Critical Care. 9, 4, p. 327-328 2 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Sepsis
Microvessels
Endothelium
101 Citations (Scopus)

Renal cortical brush-border and basolateral membranes: Cholesterol and phospholipid Composition and relative turnover

Molitoris, B. & Simon, F. R., Oct 1985, In : Journal of Membrane Biology. 83, 3, p. 207-215 9 p.

Research output: Contribution to journalArticle

Microvilli
Phospholipids
Cholesterol
Kidney
Membranes
67 Citations (Scopus)

Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): A randomised clinical trial

de Zeeuw, D., Anzalone, D. A., Cain, V. A., Cressman, M. D., Heerspink, H. J. L., Molitoris, B. A., Monyak, J. T., Parving, H. H., Remuzzi, G., Sowers, J. R. & Vidt, D. G., Mar 1 2015, In : The Lancet Diabetes and Endocrinology. 3, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Kidney
Creatinine
Proteinuria
Urine
42 Citations (Scopus)

Renal Hemodynamics in AKI: In Search of New Treatment Targets

The ADQI XIII Work Group, Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Hemodynamics
Kidney
Nephrons
Microvessels
Renal Insufficiency
18 Citations (Scopus)

Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments

Ashworth, S. L., Wean, S. E., Campos, S. B., Temm-Grove, C. J., Southgate, E. L., Vrhovski, B., Gunning, P., Weinberger, R. P. & Molitoris, B. A., May 1 2004, In : American Journal of Physiology - Renal Physiology. 286, 5 55-5, p. F988-F996

Research output: Contribution to journalArticle

Tropomyosin
Microvilli
Actin Cytoskeleton
Ischemia
Kidney
7 Citations (Scopus)
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney
Technology
Disease Progression
88 Citations (Scopus)

Role of microfilaments in maintenance of proximal tubule structural and functional integrity

Kellerman, P. S., Clark, R. A. F., Hoilien, C. A., Linas, S. L. & Molitoris, B. A., Jan 1 1990, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259, 2 28-2, p. F279-F285

Research output: Contribution to journalArticle

Actin Cytoskeleton
Maintenance
Cytochalasin D
Actins
Perfusion
47 Citations (Scopus)

Role of the actin cytoskeleton in ischemia-induced cell injury and repair

Molitoris, B. A., Leiser, J. & Wagner, M. C., Dec 1 1997, In : Pediatric Nephrology. 11, 6, p. 761-767 7 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Ischemia
Wounds and Injuries
Membranes
Adenosine Triphosphate
5 Citations (Scopus)

Role of the actin cytoskeleton in ischemic injury

Molitoris, B. A., Dahl, R. & Geerdes, A., Jan 1 1992, In : Chest. 101, 3 SUPPL., p. 52S-53S

Research output: Contribution to journalArticle

Cell Polarity
Intercellular Junctions
Actin Cytoskeleton
Actins
Ischemia
3 Citations (Scopus)

Screening: Screening for kidney disease- A lost opportunity

Molitoris, B. A., Jan 1 2014, In : Nature Reviews Nephrology. 10, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

Mass Screening
Kidney Diseases
Chronic Renal Insufficiency
4 Citations (Scopus)

Sequence of protein feeding and value of alfalfa meal and fish meal for pregnant gilts and sows.

Baker, D. H., Molitoris, B. A., Jensen, A. H. & Harmon, B. G., Feb 1974, In : Journal of animal science. 38, 2, p. 325-329 5 p.

Research output: Contribution to journalArticle

obstetric labor
Obstetric Labor
Animal Pregnancy
Fish Products
alfalfa meal
12 Citations (Scopus)

Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy

Ferrell, N., Sandoval, R. M., Bian, A., Campos-Bilderback, S. B., Molitoris, B. A. & Fissell, W. H., Mar 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 6, p. F588-F593

Research output: Contribution to journalArticle

Nephrectomy
Rheology
Hemodynamics
Theoretical Models
Blood Flow Velocity
194 Citations (Scopus)

siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury

Molitoris, B. A., Dagher, P. C., Sandoval, R. M., Campos, S. B., Ashush, H., Fridman, E., Brafman, A., Faerman, A., Atkinson, S. J., Thompson, J. D., Kalinski, H., Skaliter, R., Erlich, S. & Feinstein, E., Aug 1 2009, In : Journal of the American Society of Nephrology. 20, 8, p. 1754-1764 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Small Interfering RNA
Cisplatin
Kidney
Wounds and Injuries
117 Citations (Scopus)

Site and mechanism of enhanced gastrointestinal absorption of aluminum by citrate

Froment Ph., D., Molitoris, B. A., Buddington, B., Miller, N. & Alfrey, A. C., Jan 1 1989, In : Kidney international. 36, 6, p. 978-984 7 p.

Research output: Contribution to journalArticle

Aluminum
Tight Junctions
Ruthenium Red
aluminum citrate
Gastrointestinal Absorption
85 Citations (Scopus)

Soluble thrombomodulin protects ischemic kidneys

Sharfuddin, A. A., Sandoval, R. M., Berg, D. T., McDougal, G. E., Campos, S. B., Phillips, C. L., Jones, B. E., Gupta, A., Grinnell, B. W. & Molitoris, B. A., Mar 1 2009, In : Journal of the American Society of Nephrology. 20, 3, p. 524-534 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Kidney
Protein C
Acute Kidney Injury
Microscopy
34 Citations (Scopus)
Membrane Fluidity
Microvilli
Cholesterol
Kidney
Membranes
31 Citations (Scopus)

Surface membrane polarity of proximal tubular cells: Alterations as a basis for malfunction

Molitoris, B. A. & Wagner, M. C., Jan 1 1996, In : Kidney international. 49, 6, p. 1592-1597 6 p.

Research output: Contribution to journalArticle

Open Access
Membranes
Actin Cytoskeleton
Membrane Proteins
Cell-Matrix Junctions
Membrane Lipids
11 Citations (Scopus)

Techniques to study nephron function: Microscopy and imaging

Molitoris, B. A. & Sandoval, R. M., May 1 2009, In : Pflugers Archiv European Journal of Physiology. 458, 1, p. 203-209 7 p.

Research output: Contribution to journalArticle

Fluorophores
Nephrons
Microscopy
Microscopic examination
Animals
4 Citations (Scopus)

The antibiotic gentamicin inhibits specific protein trafficking functions of the arf1/2 family of GTPases

Lin, L., Wagner, M. C., Cocklin, R., Kuzma, A., Harrington, M., Molitoris, B. A. & Goebl, M. G., Jan 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 246-254 9 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Protein Transport
Gentamicins
Anti-Bacterial Agents
Translational Peptide Chain Termination
1 Citation (Scopus)

The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration

Uchida, M., Maier, B., Waghwani, H. K., Selivanovitch, E., Louise Pay, S., Avera, J., Jun Yun, E., Sandoval, R. M., Molitoris, B., Zollman, A., Douglas, T. & Hato, T., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

Open Access
Proximal Kidney Tubule
Glomerular Filtration Barrier
Endocytosis
Proteins
Antioxidants
16 Citations (Scopus)

The choline requirement of broiler chicks during the seventh week of life.

Molitoris, B. A. & Baker, D. H., Jan 1976, In : Poultry science. 55, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Open Access
choline
broiler chickens
sulfur amino acids
methionine
amino acid requirements

The distribution and disappearance of (23H) and (U14C) myoinositol in normal and diabetic dogs

Daughaday, W. H., Molitoris, B., Bier, D. M. & Yang, S., Jan 1 1977, In : Diabetes. 26, sup.1, p. no. 97

Research output: Contribution to journalArticle

Inositol
Dogs
Myosin Type I
Proximal Kidney Tubule
Myosins
Actins
Adenosine Triphosphate
74 Citations (Scopus)

The future nephrology workforce: Will there be one?

Parker, M. G., Ibrahim, T., Shaffer, R., Rosner, M. H. & Molitoris, B. A., Jun 1 2011, In : Clinical Journal of the American Society of Nephrology. 6, 6, p. 1501-1506 6 p.

Research output: Contribution to journalArticle

Nephrology
Mentors
Geriatrics
Medicine
Policy Making
282 Citations (Scopus)

The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states

Russo, L. M., Sandoval, R. M., McKee, M., Osicka, T. M., Collins, A. B., Brown, D., Molitoris, B. A. & Comper, W. D., Mar 13 2007, In : Kidney international. 71, 6, p. 504-513 10 p.

Research output: Contribution to journalArticle

Albumins
Kidney
Albuminuria
Endocytosis
Low Density Lipoprotein Receptor-Related Protein-2
22 Citations (Scopus)

The potential role of ischemia in renal disease progression

Molitoris, B. A., Jan 1 1992, In : Kidney International, Supplement. 36, p. S-21-S-25

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Membrane Lipids
Chronic Kidney Failure
Disease Progression
Membrane Proteins