Bruce Molitoris

  • 15549 Citations
  • 62 h-Index
1974 …2019
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Publications 1974 2019

  • 15549 Citations
  • 62 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
Article
58 Citations (Scopus)

New insights into the cell biology of ischemic acute renal failure

Molitoris, B., 1991, In : Journal of the American Society of Nephrology. 1, 12, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cell Biology
Membranes
Membrane Proteins
Membrane Lipids
58 Citations (Scopus)

Newly developed techniques to study and diagnose acute renal failure

Dagher, P., Herget-Rosenthal, S., Ruehm, S. G., Jo, S. K., Star, R. A., Agarwal, R. & Molitoris, B., Aug 1 2003, In : Journal of the American Society of Nephrology. 14, 8, p. 2188-2198 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Animal Models
Magnetic Resonance Imaging
Renal Circulation
Regional Blood Flow
7 Citations (Scopus)

Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells

Sandoval, R. M., Bacallao, R., Dunn, K., Leiser, J. D. & Molitoris, B., Dec 1 2002, In : American Journal of Physiology - Renal Physiology. 283, 6 52-6

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Gentamicins
Nucleotides
trans-Golgi Network
14 Citations (Scopus)

Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy

Hörbelt, M., Wotzlaw, C., Sutton, T., Molitoris, B., Philipp, T., Kribben, A., Fandrey, J. & Pietruck, F., Aug 2007, In : Kidney International. 72, 4, p. 422-429 8 p.

Research output: Contribution to journalArticle

Photons
Cations
Microscopy
Fluorescence
Kidney

Parathyroid hormone (PTH) induced turnover of myoinositol in isolated perfused dog kidneys

Hruska, K. A., Molitoris, B. & Daughaday, W. H., 1976, In : Kidney International. 10, 6, p. 490 1 p.

Research output: Contribution to journalArticle

Inositol
Parathyroid Hormone
Dogs
Kidney
30 Citations (Scopus)

Pathophysiology and functional significance of apical membrane disruption during ischemia

Ashworth, S. L. & Molitoris, B., 1999, In : Current Opinion in Nephrology and Hypertension. 8, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Ischemia
Actins
Membranes
323 Citations (Scopus)

Pathophysiology of ischemic acute kidney injury

Sharfuddin, A. & Molitoris, B., Apr 2011, In : Nature Reviews Nephrology. 7, 4, p. 189-200 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Ischemia
Chronic Renal Insufficiency
Wounds and Injuries
Cell Communication
24 Citations (Scopus)

Pharmacophotonics: Utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney

Molitoris, B. & Sandoval, R. M., Oct 31 2006, In : Advanced Drug Delivery Reviews. 58, 7, p. 809-823 15 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Drug Trafficking
Research Personnel
65 Citations (Scopus)

Plasma protein adsorption to highly permeable hemodialysis membranes

Clark, W. R., Macias, W. L., Molitoris, B. & Wang, N. H. L., 1995, In : Kidney International. 48, 2, p. 481-488 8 p.

Research output: Contribution to journalArticle

Adsorption
Renal Dialysis
Blood Proteins
Membranes
Bovine Serum Albumin
25 Citations (Scopus)

Progression of bacterial infections studied in real time -novel perspectives provided by multiphoton microscopy

Månsson, L. E., Melican, K., Molitoris, B. & Richter-Dahlfors, A., Oct 2007, In : Cellular Microbiology. 9, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

Bacterial Infections
Microscopy
Microscopic examination
Imaging techniques
Pathogens
1 Citation (Scopus)

Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147

Schulz, A., Chuquimia, O. D., Antypas, H., Steiner, S. E., Sandoval, R. M., Tanner, G. A., Molitoris, B., Richter-Dahlfors, A. & Melican, K., Nov 1 2018, In : Pathogens and Disease. 76, 8, fty087.

Research output: Contribution to journalArticle

Lipid A
Bacterial Infections
Blood Vessels
Uropathogenic Escherichia coli
Kidney
37 Citations (Scopus)

Proximal tubules have the capacity to regulate uptake of albumin

Wagner, M., Campos-Bilderback, S., Chowdhury, M., Flores, B., Lai, X., Myslinski, J., Pandit, S., Sandoval, R. M., Wean, S. E., Wei, Y., Satlin, L. M., Wiggins, R. C., Witzmann, F. & Molitoris, B., Feb 1 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 482-494 13 p.

Research output: Contribution to journalArticle

Albumins
Serum Albumin
Albumin Receptors
Proteins
Angiopoietin-2
74 Citations (Scopus)
Actin Cytoskeleton
Actins
Microfilament Proteins
Cell Polarity
Proteins
14 Citations (Scopus)
Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
Actin Cytoskeleton
Actins
Cell Polarity
Proteins
Exocytosis
20 Citations (Scopus)

Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success

Molitoris, B. & Reilly, E. S., 2016, (Accepted/In press) In : Seminars in Nephrology.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Kidney
Nephrology
Wounds and Injuries
16 Citations (Scopus)
Macromolecules
Photons
Wistar Rats
Rats
Microscopy
44 Citations (Scopus)

Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies

Yu, W., Sandoval, R. M. & Molitoris, B., Nov 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5

Research output: Contribution to journalArticle

Dextrans
Kidney
Bowman Capsule
Rats
Capsules
74 Citations (Scopus)
Optical Imaging
Kidney
Glomerular Filtration Rate
Fluorescent Dyes
Animal Models
31 Citations (Scopus)
Glomerular Filtration Rate
Acute Kidney Injury
Dextrans
Photons
Kidney
23 Citations (Scopus)

Rapid removal of DFO-chelated aluminum during hemodialysis using polysulfone dialyzers

Molitoris, B., Alfrey, A. C., Alfrey, P. S. & Miller, N. L., 1988, In : Kidney International. 34, 1, p. 98-101 4 p.

Research output: Contribution to journalArticle

Deferoxamine
Aluminum
Renal Dialysis
polysulfone P 1700
Dialysis
66 Citations (Scopus)

Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals

Månsson, L. E., Melican, K., Boekel, J., Sandoval, R. M., Hautefort, I., Tanner, G. A., Molitoris, B. & Richter-dahlfors, A., Feb 2007, In : Cellular Microbiology. 9, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

Time and motion study
Time and Motion Studies
Bacterial Infections
Animals
Microdissection

Recovery of the actin cytoskeleton during cellular repair is independent of protein synthesis

Hosford, M., Sandoval, R. & Molitoris, B., 1996, In : Journal of Investigative Medicine. 44, 1

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actins
Repair
Recovery
Proteins
23 Citations (Scopus)

Recruiting the Next Generation of Nephrologists

Parker, M. G., Pivert, K. A., Ibrahim, T. & Molitoris, B., Jul 2013, In : Advances in Chronic Kidney Disease. 20, 4, p. 326-335 10 p.

Research output: Contribution to journalArticle

Nephrology
Kidney Diseases
Physicians
Research
Quality of Life
20 Citations (Scopus)

Renal blood flow in sepsis: A complex issue

Molitoris, B., Aug 2005, In : Critical Care. 9, 4, p. 327-328 2 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Sepsis
Microvessels
Endothelium
101 Citations (Scopus)

Renal cortical brush-border and basolateral membranes: Cholesterol and phospholipid Composition and relative turnover

Molitoris, B. & Simon, F. R., Oct 1985, In : Journal of Membrane Biology. 83, 3, p. 207-215 9 p.

Research output: Contribution to journalArticle

Microvilli
Phospholipids
Cholesterol
Kidney
Membranes
66 Citations (Scopus)

Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): A randomised clinical trial

de Zeeuw, D., Anzalone, D. A., Cain, V. A., Cressman, M. D., Heerspink, H. J. L., Molitoris, B., Monyak, J. T., Parving, H. H., Remuzzi, G., Sowers, J. R. & Vidt, D. G., Mar 1 2015, In : The Lancet Diabetes and Endocrinology. 3, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Kidney
Creatinine
Proteinuria
Urine
50 Citations (Scopus)

Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury

Verma, S. K. & Molitoris, B., Jan 1 2015, In : Seminars in Nephrology. 35, 1, p. 96-107 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Endothelium
Ischemia
30 Citations (Scopus)

Renal epithelial polarity in health and disease

Wagner, M. & Molitoris, B., Feb 1999, In : Pediatric Nephrology. 13, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Kidney
Health
Epithelial Cells
Polycystic Kidney Diseases
Membranes
41 Citations (Scopus)

Renal Hemodynamics in AKI: In Search of New Treatment Targets

The ADQI XIII Work Group, Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Hemodynamics
Kidney
Nephrons
Microvessels
Renal Insufficiency
18 Citations (Scopus)

Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments

Ashworth, S. L., Wean, S. E., Campos-Bilderback, S., Temm-Grove, C. J., Southgate, E. L., Vrhovski, B., Gunning, P., Weinberger, R. P. & Molitoris, B., May 2004, In : American Journal of Physiology - Renal Physiology. 286, 5 55-5

Research output: Contribution to journalArticle

Tropomyosin
Microvilli
Actin Cytoskeleton
Ischemia
Kidney
1 Citation (Scopus)

Response to 'Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique' [4]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1411 1 p.

Research output: Contribution to journalArticle

Bowman Capsule
Punctures
Microscopy
Albumins
1 Citation (Scopus)

Response to 'On the origin of albuminuria' [2]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1409-1410 2 p.

Research output: Contribution to journalArticle

Albuminuria
7 Citations (Scopus)
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney
Technology
Disease Progression
88 Citations (Scopus)

Role of microfilaments in maintenance of proximal tubule structural and functional integrity

Kellerman, P. S., Clark, R. A. F., Hoilien, C. A., Linas, S. L. & Molitoris, B., 1990, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259, 2 28-2

Research output: Contribution to journalArticle

Actin Cytoskeleton
Maintenance
Cytochalasin D
Perfusion
Sodium
47 Citations (Scopus)

Role of the actin cytoskeleton in ischemia-induced cell injury and repair

Molitoris, B., Leiser, J. & Wagner, M., Dec 1997, In : Pediatric Nephrology. 11, 6, p. 761-767 7 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Ischemia
Wounds and Injuries
Membranes
Adenosine Triphosphate
5 Citations (Scopus)

Role of the actin cytoskeleton in ischemic injury

Molitoris, B., Dahl, R. & Geerdes, A., 1992, In : Chest. 101, 3 SUPPL.

Research output: Contribution to journalArticle

Cell Polarity
Intercellular Junctions
Actin Cytoskeleton
Actins
Ischemia
3 Citations (Scopus)

Screening: Screening for kidney disease- A lost opportunity

Molitoris, B., Jan 2014, In : Nature Reviews Nephrology. 10, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

Mass Screening
Kidney Diseases
Chronic Renal Insufficiency
4 Citations (Scopus)

Sequence of protein feeding and value of alfalfa meal and fish meal for pregnant gilts and sows.

Baker, D. H., Molitoris, B., Jensen, A. H. & Harmon, B. G., Feb 1974, In : Journal of Animal Science. 38, 2, p. 325-329 5 p.

Research output: Contribution to journalArticle

obstetric labor
Obstetric Labor
Animal Pregnancy
Fish Products
alfalfa meal
12 Citations (Scopus)

Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy

Ferrell, N., Sandoval, R. M., Bian, A., Campos-Bilderback, S., Molitoris, B. & Fissell, W. H., Mar 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 6, p. F588-F593

Research output: Contribution to journalArticle

Nephrectomy
Rheology
Hemodynamics
Theoretical Models
Blood Flow Velocity
194 Citations (Scopus)

siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury

Molitoris, B., Dagher, P., Sandoval, R. M., Campos-Bilderback, S., Ashush, H., Fridman, E., Brafman, A., Faerman, A., Atkinson, S. J., Thompson, J. D., Kalinski, H., Skaliter, R., Erlich, S. & Feinstein, E., Aug 2009, In : Journal of the American Society of Nephrology. 20, 8, p. 1754-1764 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Small Interfering RNA
Cisplatin
Kidney
Wounds and Injuries
117 Citations (Scopus)

Site and mechanism of enhanced gastrointestinal absorption of aluminum by citrate

Froment Ph., D., Molitoris, B., Buddington, B., Miller, N. & Alfrey, A. C., 1989, In : Kidney International. 36, 6, p. 978-984 7 p.

Research output: Contribution to journalArticle

Aluminum
Tight Junctions
Ruthenium Red
aluminum citrate
Gastrointestinal Absorption
85 Citations (Scopus)

Soluble thrombomodulin protects ischemic kidneys

Sharfuddin, A., Sandoval, R. M., Berg, D. T., McDougal, G. E., Campos-Bilderback, S., Phillips, C., Jones, B. E., Gupta, A., Grinnell, B. W. & Molitoris, B., Mar 2009, In : Journal of the American Society of Nephrology. 20, 3, p. 524-534 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Kidney
Protein C
Acute Kidney Injury
Microscopy
34 Citations (Scopus)

Static and dynamic components of renal cortical brush border and basolateral membrane fluidity: Role of cholesterol

Molitoris, B. & Hoilien, C., Nov 1987, In : Journal of Membrane Biology. 99, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

Membrane Fluidity
Microvilli
Cholesterol
Kidney
Membranes
31 Citations (Scopus)

Surface membrane polarity of proximal tubular cells: Alterations as a basis for malfunction

Molitoris, B. & Wagner, M., 1996, In : Kidney International. 49, 6, p. 1592-1597 6 p.

Research output: Contribution to journalArticle

Membranes
Actin Cytoskeleton
Membrane Proteins
Cell-Matrix Junctions
Membrane Lipids
11 Citations (Scopus)

Techniques to study nephron function: Microscopy and imaging

Molitoris, B. & Sandoval, R. M., May 2009, In : Pflugers Archiv European Journal of Physiology. 458, 1, p. 203-209 7 p.

Research output: Contribution to journalArticle

Fluorophores
Nephrons
Microscopy
Microscopic examination
Animals
56 Citations (Scopus)

Technology Insight: Biomarker development in acute kidney injury - What can we anticipate?

Molitoris, B., Melnikov, V. Y., Okusa, M. D. & Himmelfarb, J., Mar 2008, In : Nature Clinical Practice Nephrology. 4, 3, p. 154-165 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Biomarkers
Technology
Early Diagnosis
Blood Urea Nitrogen
4 Citations (Scopus)

The antibiotic gentamicin inhibits specific protein trafficking functions of the arf1/2 family of GTPases

Lin, L., Wagner, M., Cocklin, R., Kuzma, A., Harrington, M., Molitoris, B. & Goebl, M., Jan 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 246-254 9 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Protein Transport
Gentamicins
Anti-Bacterial Agents
Translational Peptide Chain Termination
1 Citation (Scopus)

The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration

Uchida, M., Maier, B., Waghwani, H. K., Selivanovitch, E., Louise Pay, S., Avera, J., Jun Yun, E., Sandoval, R. M., Molitoris, B., Zollman, A., Douglas, T. & Hato, T., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

Open Access
Proximal Kidney Tubule
Glomerular Filtration Barrier
Endocytosis
Proteins
Antioxidants
16 Citations (Scopus)

The choline requirement of broiler chicks during the seventh week of life.

Molitoris, B. & Baker, D. H., Jan 1976, In : Poultry Science. 55, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

choline
broiler chickens
sulfur amino acids
methionine
amino acid requirements