Bruce Molitoris

  • 15399 Citations
  • 61 h-Index
1974 …2019
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Publications 1974 2019

  • 15399 Citations
  • 61 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
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Article
2019

A novel fluorescent clinical method to rapidly quantify plasma volume

Molitoris, B., George, A. G., Murray, P. T., Meier, D., Reilly, E. S., Barreto, E., Sandoval, R. M., Rizk, D. V., Shaw, A. D. & Peacock, W. F., Mar 1 2019, In : CardioRenal Medicine. 9, 3, p. 168-179 12 p.

Research output: Contribution to journalArticle

Open Access
Plasma Volume
Healthy Volunteers
Blood Volume
Dextrans
Fluorescent Dyes

The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration

Uchida, M., Maier, B., Waghwani, H. K., Selivanovitch, E., Louise Pay, S., Avera, J., Jun Yun, E., Sandoval, R. M., Molitoris, B., Zollman, A., Douglas, T. & Hato, T., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

Open Access
Proximal Kidney Tubule
Glomerular Filtration Barrier
Endocytosis
Proteins
Antioxidants
2018
6 Citations (Scopus)

A novel method for rapid bedside measurement of GFR

Rizk, D. V., Meier, D., Sandoval, R. M., Chacana, T., Reilly, E. S., Seegmiller, J. C., DeNoia, E., Strickland, J. S., Muldoon, J. & Molitoris, B., Jun 1 2018, In : Journal of the American Society of Nephrology. 29, 6, p. 1609-1613 5 p.

Research output: Contribution to journalArticle

Iohexol
Rhodamines
Plasma Volume
Biomarkers
Cystatin C
15 Citations (Scopus)

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients with Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial

Pickkers, P., Mehta, R. L., Murray, P. T., Joannidis, M., Molitoris, B., Kellum, J. A., Bachler, M., Hoste, E. A. J., Hoiting, O., Krell, K., Ostermann, M., Rozendaal, W., Valkonen, M., Brealey, D., Beishuizen, A., Meziani, F., Murugan, R., De Geus, H., Payen, D., Van Den Berg, E. & 1 others, Arend, J., Jan 1 2018, (Accepted/In press) In : JAMA - Journal of the American Medical Association.

Research output: Contribution to journalArticle

Acute Kidney Injury
Alkaline Phosphatase
Creatinine
Sepsis
Randomized Controlled Trials
1 Citation (Scopus)

Exogenous gene transmission of isocitrate dehydrogenase 2 mimics ischemic preconditioning protection

Kolb, A. L., Corridon, P. R., Zhang, S., Xu, W., Witzmann, F., Collett, J. A., Rhodes, G. J., Winfree, S., Bready, D., Pfeffenberger, Z. J., Pomerantz, J. M., Hato, T., Nagami, G. T., Molitoris, B., Basile, D., Atkinson, S. J. & Bacallao, R., Apr 1 2018, In : Journal of the American Society of Nephrology. 29, 4, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Ischemic Preconditioning
Mitochondria
Cytoprotection
Wounds and Injuries
1 Citation (Scopus)

Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147

Schulz, A., Chuquimia, O. D., Antypas, H., Steiner, S. E., Sandoval, R. M., Tanner, G. A., Molitoris, B., Richter-Dahlfors, A. & Melican, K., Nov 1 2018, In : Pathogens and Disease. 76, 8, fty087.

Research output: Contribution to journalArticle

Lipid A
Bacterial Infections
Blood Vessels
Uropathogenic Escherichia coli
Kidney
2017
6 Citations (Scopus)

Hydrodynamic isotonic fluid delivery ameliorates moderate-to-severe ischemia-reperfusion injury in rat kidneys

Collett, J. A., Corridon, P. R., Mehrotra, P., Kolb, A. L., Rhodes, G. J., Miller, C. A., Molitoris, B., Pennington, J. G., Sandoval, R. M., Atkinson, S. J., Campos-Bilderback, S., Basile, D. & Bacallao, R., Jul 1 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2081-2092 12 p.

Research output: Contribution to journalArticle

Hydrodynamics
Reperfusion Injury
Kidney
Renal Veins
Wounds and Injuries
6 Citations (Scopus)

Inhibition of avb5 integrin attenuates vascular permeability and protects against renal ischemia-reperfusion injury

McCurley, A., Alimperti, S., Campos-Bilderback, S., Sandoval, R. M., Calvino, J. E., Reynolds, T. L., Quigley, C., Mugford, J. W., Polacheck, W. J., Gomez, I. G., Dovey, J., Marsh, G., Huang, A., Qian, F., Weinreb, P. H., Dolinski, B. M., Moore, S., Duffield, J. S., Chen, C. S., Molitoris, B. & 2 others, Violette, S. M. & Crackower, M. A., Jun 1 2017, In : Journal of the American Society of Nephrology. 28, 6, p. 1741-1752 12 p.

Research output: Contribution to journalArticle

Capillary Permeability
Reperfusion Injury
Integrins
Kidney
Pericytes
5 Citations (Scopus)

Intravital imaging of the kidney in a rat model of salt-sensitive hypertension

Endres, B. T., Sandoval, R. M., Rhodes, G. J., Campos-Bilderback, S., Kamocka, M., McDermott-Roe, C., Staruschenko, A., Molitoris, B., Geurts, A. M. & Palygin, O., Aug 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 2, p. F163-F173

Research output: Contribution to journalArticle

Albuminuria
Salts
Albumins
Hypertension
Kidney
3 Citations (Scopus)

Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology

Sandoval, R. M. & Molitoris, B., 2017, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Physiology
Photons
Microscopy
Microscopic examination
Kidney
22 Citations (Scopus)

Two-photon intravital fluorescence lifetime imaging of the kidney reveals cell-type specific metabolic signatures

Hato, T., Winfree, S., Day, R., Sandoval, R. M., Molitoris, B., Yoder, M., Wiggins, R. C., Zheng, Y., Dunn, K. & Dagher, P., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2420-2430 11 p.

Research output: Contribution to journalArticle

Optical Imaging
Photons
Microscopy
Kidney
Metabolome
2016
13 Citations (Scopus)

ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial

McCullough, P. A., Bennett-Guerrero, E., Chawla, L. S., Beaver, T., Mehta, R. L., Molitoris, B., Eldred, A., Ball, G., Lee, H. J., Houser, M. T. & Khan, S., Aug 20 2016, In : Journal of the American Heart Association. 5, 8

Research output: Contribution to journalArticle

Acute Kidney Injury
Thoracic Surgery
Clinical Trials
Placebos
Biomarkers
9 Citations (Scopus)

Mechanism of increased clearance of glycated albumin by proximal tubule cells

Wagner, M., Myslinski, J., Pratap, S., Flores, B., Rhodes, G., Campos-Bilderback, S., Sandoval, R. M., Kumar, S., Patel, M., Ashish & Molitoris, B., May 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 10, p. F1089-F1102

Research output: Contribution to journalArticle

Albumins
Transcytosis
glycosylated serum albumin
Proximal Kidney Tubule
Serum Albumin
35 Citations (Scopus)

Proximal tubules have the capacity to regulate uptake of albumin

Wagner, M., Campos-Bilderback, S., Chowdhury, M., Flores, B., Lai, X., Myslinski, J., Pandit, S., Sandoval, R. M., Wean, S. E., Wei, Y., Satlin, L. M., Wiggins, R. C., Witzmann, F. & Molitoris, B., Feb 1 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 482-494 13 p.

Research output: Contribution to journalArticle

Albumins
Serum Albumin
Albumin Receptors
Proteins
Angiopoietin-2
20 Citations (Scopus)

Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success

Molitoris, B. & Reilly, E. S., 2016, (Accepted/In press) In : Seminars in Nephrology.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Kidney
Nephrology
Wounds and Injuries
41 Citations (Scopus)

Renal Hemodynamics in AKI: In Search of New Treatment Targets

The ADQI XIII Work Group, Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Hemodynamics
Kidney
Nephrons
Microvessels
Renal Insufficiency
7 Citations (Scopus)
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney
Technology
Disease Progression
2015
3 Citations (Scopus)

Contrast material-induced nephropathy: Causation quandaries

Mitchell, A., Molitoris, B. & Teague, S. D., Jun 1 2015, In : Radiology. 275, 3, p. 928-929 2 p.

Research output: Contribution to journalArticle

X Ray Computed Tomography
Acute Kidney Injury
Causality
Contrast Media
Gentamicins
16 Citations (Scopus)

Cross-disciplinary biomarkers research: Lessons learned by the CKD biomarkers consortium

CKD Biomarkers Consortium, Jan 1 2015, In : Clinical Journal of the American Society of Nephrology. 10, 5, p. 894-902 9 p.

Research output: Contribution to journalArticle

Biomarkers
Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Feasibility Studies
Quality Control
10 Citations (Scopus)

Nephrology research - The past, present and future

Floege, J., Mak, R. H., Molitoris, B., Remuzzi, G. & Ronco, P., Nov 1 2015, In : Nature Reviews Nephrology. 11, 11, p. 677-687 11 p.

Research output: Contribution to journalArticle

Nephrology
Research
Atypical Hemolytic Uremic Syndrome
65 Citations (Scopus)

Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): A randomised clinical trial

de Zeeuw, D., Anzalone, D. A., Cain, V. A., Cressman, M. D., Heerspink, H. J. L., Molitoris, B., Monyak, J. T., Parving, H. H., Remuzzi, G., Sowers, J. R. & Vidt, D. G., Mar 1 2015, In : The Lancet Diabetes and Endocrinology. 3, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Kidney
Creatinine
Proteinuria
Urine
49 Citations (Scopus)

Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury

Verma, S. K. & Molitoris, B., Jan 1 2015, In : Seminars in Nephrology. 35, 1, p. 96-107 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Endothelium
Ischemia
11 Citations (Scopus)

Shear stress is normalized in glomerular capillaries following 5⁄6 nephrectomy

Ferrell, N., Sandoval, R. M., Bian, A., Campos-Bilderback, S., Molitoris, B. & Fissell, W. H., Mar 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 6, p. F588-F593

Research output: Contribution to journalArticle

Nephrectomy
Rheology
Hemodynamics
Theoretical Models
Blood Flow Velocity
10 Citations (Scopus)

Urinary biomarkers: Alone are they enough?

Molitoris, B., Jul 1 2015, In : Journal of the American Society of Nephrology. 26, 7, p. 1485-1488 4 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Insulin-Like Growth Factor Binding Proteins
Acute Kidney Injury
Renal Dialysis
Biomarkers
2014
3 Citations (Scopus)
Organizational Innovation
Precision Medicine
Nephrology
Kidney Diseases
18 Citations (Scopus)

Dynamic multiphoton microscopy: Focusing light on acute kidney injury

Hall, A. M. & Molitoris, B., Sep 1 2014, In : Physiology. 29, 5, p. 334-342 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Microscopy
Light
Rodentia
Kidney
17 Citations (Scopus)

Effects of biomechanical forces on signaling in the cortical collecting duct (CCD)

Carrisoza-Gaytan, R., Liu, Y., Flores, D., Else, C., Lee, H. G., Rhodes, G., Sandoval, R. M., Kleyman, T. R., Lee, F. Y. I., Molitoris, B., Satlin, L. M. & Rohatgi, R., Jul 15 2014, In : American Journal of Physiology - Renal Physiology. 307, 2

Research output: Contribution to journalArticle

Dinoprostone
Cations
Paracrine Communication
Collagen Type IV
Furosemide
5 Citations (Scopus)
Microscopy
Albumins
Permeability
3 Citations (Scopus)

Screening: Screening for kidney disease- A lost opportunity

Molitoris, B., Jan 2014, In : Nature Reviews Nephrology. 10, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

Mass Screening
Kidney Diseases
Chronic Renal Insufficiency
122 Citations (Scopus)

The proximal tubule and albuminuria: Really!

Dickson, L. E., Wagner, M., Sandoval, R. M. & Molitoris, B., Mar 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

Albuminuria
Albumins
Transcytosis
Albumin Receptors
Low Density Lipoprotein Receptor-Related Protein-2
94 Citations (Scopus)

Therapeutic translation in acute kidney injury: The epithelial/endothelial axis

Molitoris, B., Jun 2 2014, In : Journal of Clinical Investigation. 124, 6, p. 2355-2363 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Chronic Renal Insufficiency
Cell Communication
Chronic Kidney Failure
Endothelial Cells
2 Citations (Scopus)
Albuminuria
Photons
Microscopy
Aptitude
Fluorescent Dyes
2013
31 Citations (Scopus)

AKI: A path forward

Bonventre, J. V., Basile, D., Liu, K. D., McKay, D., Molitoris, B., Nath, K. A., Nickolas, T. L., Okusa, M. D., Palevsky, P. M., Schnellmann, R., Rys-Sikora, K., Kimmel, P. L. & Star, R. A., 2013, In : Clinical Journal of the American Society of Nephrology. 8, 9, p. 1606-1608 3 p.

Research output: Contribution to journalArticle

Research
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Kidney
Kidney Diseases
Animal Models
1 Citation (Scopus)

AKI is around the world but public recognition is lacking

Molitoris, B., 2013, In : Clinical Journal of the American Society of Nephrology. 8, 9, p. 1467-1468 2 p.

Research output: Contribution to journalArticle

Health Knowledge, Attitudes, Practice
Health Policy
Acute Kidney Injury
Biomedical Research
82 Citations (Scopus)

In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury

Hall, A. M., Rhodes, G. J., Sandoval, R. M., Corridon, P. R. & Molitoris, B., Jan 2013, In : Kidney International. 83, 1, p. 72-83 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Ischemia
Mitochondrial Membrane Potential
NAD
19 Citations (Scopus)

Measuring glomerular filtration rate in the intensive care unit: No substitutes please

Molitoris, B., Sep 4 2013, In : Critical Care. 17, 5, 181.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Intensive Care Units
Chronic Renal Insufficiency
Creatinine
15 Citations (Scopus)
Macromolecules
Photons
Wistar Rats
Rats
Microscopy
23 Citations (Scopus)

Recruiting the Next Generation of Nephrologists

Parker, M. G., Pivert, K. A., Ibrahim, T. & Molitoris, B., Jul 2013, In : Advances in Chronic Kidney Disease. 20, 4, p. 326-335 10 p.

Research output: Contribution to journalArticle

Nephrology
Kidney Diseases
Physicians
Research
Quality of Life
2012
12 Citations (Scopus)

A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney

Imamura, R., Isaka, Y., Sandoval, R. M., Ichimaru, N., Abe, T., Okumi, M., Yazawa, K., Kitamura, H., Kaimori, J., Nonomura, N., Rakugi, H., Molitoris, B. & Takahara, S., Dec 2012, In : Clinical and Experimental Nephrology. 16, 6, p. 852-862 11 p.

Research output: Contribution to journalArticle

Erythropoietin
Fibrosis
Kidney
Hemoglobins
carbamylated erythropoietin
50 Citations (Scopus)

A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals

Wang, E., Meier, D. J., Sandoval, R. M., Von Hendy-Willson, V. E., Pressler, B. M., Bunch, R. M., Alloosh, M., Sturek, M., Schwartz, G. J. & Molitoris, B., Jan 1 2012, In : Kidney International. 81, 1, p. 112-117 6 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Glomerular Filtration Rate
Fluorescence
Plasma Volume
Blood Vessels
13 Citations (Scopus)

Chronic endothelin-1 infusion elevates glomerular sieving coefficient and proximal tubular albumin reuptake in the rat

Saleh, M. A., Sandoval, R. M., Rhodes, G. J., Campos-Bilderback, S., Molitoris, B. & Pollock, D. M., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 634-637 4 p.

Research output: Contribution to journalArticle

Endothelin-1
Rats
Albumins
Albuminuria
Permeability
9 Citations (Scopus)

Designing clinical trials in acute kidney injury

Molitoris, B., Okusa, M. D., Palevsky, P. M., Kimmel, P. L. & Star, R. A., May 1 2012, In : Clinical Journal of the American Society of Nephrology. 7, 5, p. 842-843 2 p.

Research output: Contribution to journalArticle

Translational Medical Research
Acute Kidney Injury
Clinical Trials
65 Citations (Scopus)

Design of clinical trials in acute kidney injury: Report from an NIDDK workshop on trial methodology

Palevsky, P. M., Molitoris, B., Okusa, M. D., Levin, A., Waikar, S. S., Wald, R., Chertow, G. M., Murray, P. T., Parikh, C. R., Shaw, A. D., Go, A. S., Faubel, S. G., Kellum, J. A., Chinchilli, V. M., Liu, K. D., Cheung, A. K., Weisbord, S. D., Chawla, L. S., Kaufman, J. S., Devarajan, P. & 15 others, Toto, R. M., Hsu, C. Y., Greene, T., Mehta, R. L., Stokes, J. B., Thompson, A. M., Taylor Thompson, B., Westenfelder, C. S., Tumlin, J. A., Warnock, D. G., Shah, S. V., Xie, Y., Duggan, E. G., Kimmel, P. L. & Star, R. A., May 1 2012, In : Clinical Journal of the American Society of Nephrology. 7, 5, p. 844-850 7 p.

Research output: Contribution to journalArticle

National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Acute Kidney Injury
Clinical Trials
Education
Sample Size
31 Citations (Scopus)

Design of clinical trials in acute kidney injury: A report from an NIDDK workshop-prevention trials

Okusa, M. D., Molitoris, B., Palevsky, P. M., Chinchilli, V. M., Liu, K. D., Cheung, A. K., Weisbord, S. D., Faubel, S., Kellum, J. A., Wald, R., Chertow, G. M., Levin, A., Waikar, S. S., Murray, P. T., Parikh, C. R., Shaw, A. D., Go, A. S., Chawla, L. S., Kaufman, J. S., Devarajan, P. & 15 others, Toto, R. M., Hsu, C. Y., Greene, T. H., Mehta, R. L., Stokes, J. B., Thompson, A. M., Taylor Thompson, B., Westenfelder, C. S., Tumlin, J. A., Warnock, D. G., Shah, S. V., Xie, Y., Duggan, E. G., Kimmel, P. L. & Star, R. A., May 1 2012, In : Clinical Journal of the American Society of Nephrology. 7, 5, p. 851-855 5 p.

Research output: Contribution to journalArticle

National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Acute Kidney Injury
Clinical Trials
Education
Mortality
26 Citations (Scopus)

Design of clinical trials in AKI: A report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings

Molitoris, B., Okusa, M. D., Palevsky, P. M., Chawla, L. S., Kaufman, J. S., Devarajan, P., Toto, R. M., Hsu, C. Y., Greene, T. H., Faubel, S. G., Kellum, J. A., Wald, R., Chertow, G. M., Levin, A., Waikar, S. S., Murray, P. T., Parikh, C. R., Shaw, A. D., Go, A. S., Chinchilli, V. M. & 15 others, Liu, K. D., Cheung, A. K., Weisbord, S. D., Mehta, R. L., Stokes, J. B., Thompson, A. M., Taylor Thompson, B., Westenfelder, C. S., Tumlin, J. A., Warnock, D. G., Shah, S. V., Xie, Y., Duggan, E. G., Kimmel, P. L. & Star, R. A., May 1 2012, In : Clinical Journal of the American Society of Nephrology. 7, 5, p. 856-860 5 p.

Research output: Contribution to journalArticle

National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Sepsis
Clinical Trials
Education
Wounds and Injuries
6 Citations (Scopus)

Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet

Molitoris, B., Sep 24 2012, In : Critical Care. 16, 5, 158.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Acute Kidney Injury
Biomarkers
Critical Care
Creatinine
11 Citations (Scopus)

Multiphoton microscopy applied for real-time intravital imaging of bacterial infections in vivo

Choong, F. X., Sandoval, R. M., Molitoris, B. & Richter-Dahlfors, A., 2012, In : Methods in Enzymology. 506, p. 35-61 27 p.

Research output: Contribution to journalArticle

Bacterial Infections
Microscopy
Microscopic examination
Imaging techniques
Infection
61 Citations (Scopus)

Multiple factors influence glomerular albumin permeability in rats

Sandoval, R. M., Wagner, M., Patel, M., Campos-Bilderback, S., Rhodes, G. J., Wang, E., Wean, S. E., Clendenon, S. S. & Molitoris, B., Mar 2012, In : Journal of the American Society of Nephrology. 23, 3, p. 447-457 11 p.

Research output: Contribution to journalArticle

Albumins
Permeability
Wistar Rats
Microscopy
Transcytosis
42 Citations (Scopus)

Toxicological and pharmacokinetic properties of chemically modified siRNAs targeting p53 RNA following intravenous administration

Thompson, J. D., Kornbrust, D. J., Foy, J. W. D., Solano, E. C. R., Schneider, D. J., Feinstein, E., Molitoris, B. & Erlich, S., Aug 1 2012, In : Nucleic Acid Therapeutics. 22, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Intravenous Administration
Toxicology
RNA
Reperfusion Injury