Bruce Molitoris

  • 15549 Citations
  • 62 h-Index
1974 …2019
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Publications 1974 2019

  • 15549 Citations
  • 62 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
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Article
2011
98 Citations (Scopus)

Acute kidney injury in older adults

Anderson, S., Eldadah, B., Halter, J. B., Hazzard, W. R., Himmelfarb, J., Horne, F. M., Kimmel, P. L., Molitoris, B., Murthy, M., O'Hare, A. M., Schmader, K. E. & High, K. P., Jan 2011, In : Journal of the American Society of Nephrology. 22, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Geriatrics
Patient Preference
Chronic Renal Insufficiency
Creatinine
5 Citations (Scopus)

Circulating Micro-RNAs in Acute Kidney injury: Early observations

Molitoris, J. K. & Molitoris, B., Jul 1 2011, In : Clinical Journal of the American Society of Nephrology. 6, 7, p. 1517-1519 3 p.

Research output: Contribution to journalArticle

MicroRNAs
Acute Kidney Injury

Disease-specific kidney imaging: Introduction

Molitoris, B., May 2011, In : Seminars in Nephrology. 31, 3, p. 235-236 2 p.

Research output: Contribution to journalArticle

Kidney Diseases
Diagnostic Imaging
176 Citations (Scopus)

Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury

Basile, D., Friedrich, J. L., Spahic, J., Knipe, N., Mang, H., Leonard, E. C., Changizi-Ashtiyani, S., Bacallao, R., Molitoris, B. & Sutton, T., Mar 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 3

Research output: Contribution to journalArticle

Acute Kidney Injury
Blood Vessels
Endothelial Cells
Vascular Endothelial Growth Factor A
Bromodeoxyuridine
13 Citations (Scopus)

Implications of a Nephrology Workforce Shortage for Dialysis Patient Care

Mehrotra, R., Shaffer, R. N. & Molitoris, B., May 2011, In : Seminars in Dialysis. 24, 3, p. 275-277 3 p.

Research output: Contribution to journalArticle

Nephrology
Dialysis
Patient Care
Vulnerable Populations
Health Policy
323 Citations (Scopus)

Pathophysiology of ischemic acute kidney injury

Sharfuddin, A. & Molitoris, B., Apr 2011, In : Nature Reviews Nephrology. 7, 4, p. 189-200 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Ischemia
Chronic Renal Insufficiency
Wounds and Injuries
Cell Communication
4 Citations (Scopus)

The antibiotic gentamicin inhibits specific protein trafficking functions of the arf1/2 family of GTPases

Lin, L., Wagner, M., Cocklin, R., Kuzma, A., Harrington, M., Molitoris, B. & Goebl, M., Jan 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 246-254 9 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Protein Transport
Gentamicins
Anti-Bacterial Agents
Translational Peptide Chain Termination
73 Citations (Scopus)

The future nephrology workforce: Will there be one?

Parker, M. G., Ibrahim, T., Shaffer, R., Rosner, M. H. & Molitoris, B., Jun 1 2011, In : Clinical Journal of the American Society of Nephrology. 6, 6, p. 1501-1506 6 p.

Research output: Contribution to journalArticle

Nephrology
Mentors
Geriatrics
Medicine
Policy Making
36 Citations (Scopus)

Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact

Presson, R., Brown, M. B., Fisher, A. J., Sandoval, R. M., Dunn, K., Lorenz, K. S., Delp, E. J., Salama, P., Molitoris, B. & Petrache, I., Jul 2011, In : American Journal of Pathology. 179, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Photons
Artifacts
Thorax
Microscopy
Leukocytes
82 Citations (Scopus)

Uropathogenic escherichia coli P and type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction

Melican, K., Sandoval, R. M., Kader, A., Josefsson, L., Tanner, G. A., Molitoris, B. & Richter-Dahlfors, A., Feb 2011, In : PLoS Pathogens. 7, 2, e1001298.

Research output: Contribution to journalArticle

Uropathogenic Escherichia coli
Nephrons
Bacterial Infections
Epithelium
Bowman Capsule
2010
30 Citations (Scopus)

Intravital two-photon microscopy assessment of renal protection efficacy of siRNA for p53 in experimental rat kidney transplantation models

Imamura, R., Isaka, Y., Sandoval, R. M., Ori, A., Adamsky, S., Feinstein, E., Molitoris, B. & Takahara, S., 2010, In : Cell Transplantation. 19, 12, p. 1659-1670 12 p.

Research output: Contribution to journalArticle

Photons
Kidney Transplantation
Small Interfering RNA
Rats
Microscopy
12 Citations (Scopus)

Lessons from Haiti on disaster relief

Portilla, D., Shaffer, R. N., Okusa, M. D., Mehrotra, R., Molitoris, B., Bunchman, T. E. & Ibrahim, T., Nov 1 2010, In : Clinical Journal of the American Society of Nephrology. 5, 11, p. 2122-2129 8 p.

Research output: Contribution to journalArticle

Organizational Objectives
Disaster Medicine
Disaster Planning
Haiti
International Cooperation
31 Citations (Scopus)
Glomerular Filtration Rate
Acute Kidney Injury
Dextrans
Photons
Kidney
6 Citations (Scopus)

Yet another advance in understanding albuminuria?

Molitoris, B., Dec 2010, In : Journal of the American Society of Nephrology. 21, 12, p. 2013-2015 3 p.

Research output: Contribution to journalArticle

Animal Disease Models
Podocytes
Albuminuria
Kidney Diseases
Glomerular Filtration Rate
2009
25 Citations (Scopus)

Activated protein C and acute kidney injury: Selective targeting of PAR-1

Gupta, A., Williams, M. D., Macias, W. L., Molitoris, B. & Grinnell, B. W., 2009, In : Current Drug Targets. 10, 12, p. 1212-1226 15 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Protein C
Acute Kidney Injury
Protein C Deficiency
Tissue Survival
689 Citations (Scopus)

Acute kidney injury increases risk of ESRD among elderly

Ishani, A., Xue, J. L., Himmelfarb, J., Eggers, P. W., Kimmel, P. L., Molitoris, B. & Collins, A. J., Jan 2009, In : Journal of the American Society of Nephrology. 20, 1, p. 223-228 6 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Chronic Kidney Failure
Chronic Renal Insufficiency
Medicare
Confidence Intervals
1 Citation (Scopus)

ASN policy on managing conflicts of interest

Stokes, J. B., Haupt, A., Molitoris, B., Kokemueller, P. & Ibrahim, T., Sep 2009, In : Journal of the American Society of Nephrology. 20, 9, p. 1853-1859 7 p.

Research output: Contribution to journalArticle

Organizational Policy
Conflict of Interest
Nephrology
Medical Societies
36 Citations (Scopus)

Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation

Campos-Bilderback, S., Ashworth, S. L., Wean, S., Hosford, M., Sandoval, R. M., Hallett, M. A., Atkinson, S. J. & Molitoris, B., Mar 2009, In : American Journal of Physiology - Renal Physiology. 296, 3

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Actins
Stress Fibers
Endothelial Cells
Cytokines
21 Citations (Scopus)

Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI

Atthe, B. K., Babsky, A. M., Hopewell, P. N., Phillips, C., Molitoris, B. & Bansal, N., Nov 2009, In : American Journal of Physiology - Renal Physiology. 297, 5

Research output: Contribution to journalArticle

Necrosis
Sodium
Magnetic Resonance Imaging
Ischemia
Kidney
10 Citations (Scopus)

Illuminating mitochondrial function and dysfunction using multiphoton technology

Weinberg, J. M. & Molitoris, B., Jun 2009, In : Journal of the American Society of Nephrology. 20, 6, p. 1164-1166 3 p.

Research output: Contribution to journalArticle

Multiphoton Fluorescence Microscopy
Distal Kidney Tubule
Proximal Kidney Tubule
Mitochondria
Technology
161 Citations (Scopus)

Impaired tubular uptake explains albuminuria in early diabetic nephropathy

Russo, L. M., Sandoval, R. M., Campos-Bilderback, S., Molitoris, B., Comper, W. D. & Brown, D., Mar 2009, In : Journal of the American Society of Nephrology. 20, 3, p. 489-494 6 p.

Research output: Contribution to journalArticle

Albuminuria
Diabetic Nephropathies
Albumins
Proximal Kidney Tubule
Photons
13 Citations (Scopus)

Ironing Out the Pathogenesis of Acute Kidney Injury

Hingorani, S., Molitoris, B. & Himmelfarb, J., Apr 2009, In : American Journal of Kidney Diseases. 53, 4, p. 569-571 3 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins
Antimicrobial Cationic Peptides
Alpha-Globulins
Lipocalins
beta 2-Microglobulin
1 Citation (Scopus)

Managing conflicts of interest: The road ahead

Stokes, J. B., Berns, A. S., Henrich, W. L., McKinney, T. D., Molitoris, B. & Palmer, B. F., Sep 2009, In : Journal of the American Society of Nephrology. 20, 9, p. 1860-1862 3 p.

Research output: Contribution to journalArticle

Organizational Policy
Conflict of Interest
Nephrology
Medical Societies
194 Citations (Scopus)

siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury

Molitoris, B., Dagher, P., Sandoval, R. M., Campos-Bilderback, S., Ashush, H., Fridman, E., Brafman, A., Faerman, A., Atkinson, S. J., Thompson, J. D., Kalinski, H., Skaliter, R., Erlich, S. & Feinstein, E., Aug 2009, In : Journal of the American Society of Nephrology. 20, 8, p. 1754-1764 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Small Interfering RNA
Cisplatin
Kidney
Wounds and Injuries
85 Citations (Scopus)

Soluble thrombomodulin protects ischemic kidneys

Sharfuddin, A., Sandoval, R. M., Berg, D. T., McDougal, G. E., Campos-Bilderback, S., Phillips, C., Jones, B. E., Gupta, A., Grinnell, B. W. & Molitoris, B., Mar 2009, In : Journal of the American Society of Nephrology. 20, 3, p. 524-534 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Kidney
Protein C
Acute Kidney Injury
Microscopy
11 Citations (Scopus)

Techniques to study nephron function: Microscopy and imaging

Molitoris, B. & Sandoval, R. M., May 2009, In : Pflugers Archiv European Journal of Physiology. 458, 1, p. 203-209 7 p.

Research output: Contribution to journalArticle

Fluorophores
Nephrons
Microscopy
Microscopic examination
Animals
2008

Authors' response

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A. & Joannidis, M., Jul 25 2008, In : Critical Care. 12, 4, 423.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis

Melican, K., Boekel, J., Månsson, L. E., Sandoval, R. M., Tanner, G. A., Källskog, Ö., Palm, F., Molitoris, B. & Richter-Dahlfors, A., 2008, In : Cellular Microbiology. 10, 10, p. 1987-1998 12 p.

Research output: Contribution to journalArticle

Pathogens
Bacterial Infections
Anticoagulants
Escherichia coli
Heparin
9 Citations (Scopus)
Chronic Renal Insufficiency
Outcome Assessment (Health Care)
Kidney
Acute Kidney Injury
Chronic Kidney Failure
58 Citations (Scopus)

Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified delphi process

Kellum, J. A., Mehta, R. L., Levin, A., Molitoris, B., Warnock, D. G., Shah, S. V., Joannidis, M. & Ronco, C., May 2008, In : Clinical Journal of the American Society of Nephrology. 3, 3, p. 887-894 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Research
Developed Countries
Translational Medical Research
Developing Countries
88 Citations (Scopus)

Evaluation and initial management of acute kidney injury

Himmelfarb, J., Joannidis, M., Molitoris, B., Schietz, M., Okusa, M. D., Warnock, D., Laghi, F., Goldstein, S. L., Prielipp, R., Parikh, C. R., Pannu, N., Lobo, S. M., Shah, S., D'Intini, V. & Kellum, J. A., Jul 2008, In : Clinical Journal of the American Society of Nephrology. 3, 4, p. 962-967 6 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Biomarkers
Comorbidity
Mortality
15 Citations (Scopus)

Imaging techniques in acute kidney injury

Sharfuddin, A., Sandoval, R. M. & Molitoris, B., Sep 2008, In : Nephron - Clinical Practice. 109, 4

Research output: Contribution to journalArticle

Photons
Acute Kidney Injury
Microscopy
Research Personnel
Kidney
1 Citation (Scopus)
Acute Kidney Injury
Creatinine
Serum
Mortality
Urine
50 Citations (Scopus)

Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1

Wagner, M., Rhodes, G., Wang, E., Pruthi, V., Arif, E., Saleem, M. A., Wean, S. E., Garg, P., Verma, R., Holzman, L. B., Gattone, V., Molitoris, B. & Nihalani, D., Dec 19 2008, In : Journal of Biological Chemistry. 283, 51, p. 35579-35589 11 p.

Research output: Contribution to journalArticle

Podocytes
Diaphragms
Diaphragm
Kidney
Ischemia
56 Citations (Scopus)

Technology Insight: Biomarker development in acute kidney injury - What can we anticipate?

Molitoris, B., Melnikov, V. Y., Okusa, M. D. & Himmelfarb, J., Mar 2008, In : Nature Clinical Practice Nephrology. 4, 3, p. 154-165 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Biomarkers
Technology
Early Diagnosis
Blood Urea Nitrogen
2007
106 Citations (Scopus)

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Gupta, A., Rhodes, G. J., Berg, D. T., Gerlitz, B., Molitoris, B. & Grinnell, B. W., Jul 2007, In : American Journal of Physiology - Renal Physiology. 293, 1

Research output: Contribution to journalArticle

Angiotensins
Protein C
Acute Kidney Injury
Lipopolysaccharides
Down-Regulation
4051 Citations (Scopus)

Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury

Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Levin, A., Bagga, A., Bakkaloglu, A., Bonventre, J. V., Burdmann, E. A., Chen, Y., Devarajan, P., D'Intini, V., Dobb, G., Durbin, C. G., Eckardt, K. U., Guerin, C., Herget-Rosenthal, S., Hoste, E. & 19 others, Joannidis, M., Kellum, J. A., Kirpalani, A., Lassnigg, A., Le Gall, J. R., Levin, A., Lombardi, R., Macias, W., Manthous, C., Mehta, R. L., Molitoris, B. A., Ronco, C., Schetz, M., Schortgen, F., Shah, S. V., Tan, P. S. K., Wang, H., Warnock, D. G. & Webb, S., Mar 1 2007, In : Critical Care. 11, R31.

Research output: Contribution to journalArticle

Acute Kidney Injury
Translational Medical Research
Creatinine
Urine
Nephrology
26 Citations (Scopus)

Controversies in nephrology: Response to 'renal albumin handling, facts, and artifacts'

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Nov 2007, In : Kidney International. 72, 10, p. 1195-1197 3 p.

Research output: Contribution to journalArticle

Nephrology
Artifacts
Albumins
Kidney
Albuminuria
62 Citations (Scopus)

Improving outcomes from acute kidney injury

Molitoris, B., Levin, A., Warnock, D. G., Joannidis, M., Mehta, R. L., Kellum, J. A., Ronco, C. & Shah, S., Jul 2007, In : Journal of the American Society of Nephrology. 18, 7, p. 1992-1994 3 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
41 Citations (Scopus)

Improving outcomes from acute kidney injury: Report of an initiative

Bagga, A., Bakkaloglu, A., Devarajan, P., Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B., Ronco, C., Warnock, D. G., Joannidis, M. & Levin, A., Oct 2007, In : Pediatric Nephrology. 22, 10, p. 1655-1658 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Creatinine
Nephrology
Critical Care
85 Citations (Scopus)

Improving Outcomes From Acute Kidney Injury: Report of an Initiative

Levin, A., Warnock, D. G., Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B. & Ronco, C., Jul 2007, In : American Journal of Kidney Diseases. 50, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

International Cooperation
Acute Kidney Injury
Creatinine
41 Citations (Scopus)

Improving outcomes from acute kidney injury (AKI): Report on an initiative

Ronco, C., Levin, A., Warnock, D. G., Metha, R. L., Kellum, J. A., Shah, S. & Molitoris, B., May 2007, In : International Journal of Artificial Organs. 30, 5, p. 373-376 4 p.

Research output: Contribution to journalArticle

Pediatrics
Acute Kidney Injury
Nephrology
Critical Care
Patient Care
103 Citations (Scopus)

Improving outcomes of acute kidney injury: Report of an initiative

Molitoris, B., Levin, A., Warnock, D. G., Joannidis, M., Mehta, R. L., Kellum, J. A., Ronco, C. & Shah, S. V., Aug 2007, In : Nature Clinical Practice Nephrology. 3, 8, p. 439-442 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Insufficiency
Creatinine
Serum
1 Citation (Scopus)

Multi-photon microscopy: Linking drug mechanism to disease physiology

Grinnell, B. W., Gupta, A., Sandoval, R. M. & Molitoris, B., Nov 2007, In : American Pharmaceutical Review. 10, 6

Research output: Contribution to journalArticle

Photons
Microscopy
Pharmaceutical Preparations
Physiological Phenomena
Preclinical Drug Evaluations
14 Citations (Scopus)

Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy

Hörbelt, M., Wotzlaw, C., Sutton, T., Molitoris, B., Philipp, T., Kribben, A., Fandrey, J. & Pietruck, F., Aug 2007, In : Kidney International. 72, 4, p. 422-429 8 p.

Research output: Contribution to journalArticle

Photons
Cations
Microscopy
Fluorescence
Kidney
25 Citations (Scopus)

Progression of bacterial infections studied in real time -novel perspectives provided by multiphoton microscopy

Månsson, L. E., Melican, K., Molitoris, B. & Richter-Dahlfors, A., Oct 2007, In : Cellular Microbiology. 9, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

Bacterial Infections
Microscopy
Microscopic examination
Imaging techniques
Pathogens
74 Citations (Scopus)
Optical Imaging
Kidney
Glomerular Filtration Rate
Fluorescent Dyes
Animal Models
66 Citations (Scopus)

Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals

Månsson, L. E., Melican, K., Boekel, J., Sandoval, R. M., Hautefort, I., Tanner, G. A., Molitoris, B. & Richter-dahlfors, A., Feb 2007, In : Cellular Microbiology. 9, 2, p. 413-424 12 p.

Research output: Contribution to journalArticle

Time and motion study
Time and Motion Studies
Bacterial Infections
Animals
Microdissection
1 Citation (Scopus)

Response to 'Albumin concentration in the Bowman's capsule: Multiphoton microscopy vs micropuncture technique' [4]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1411 1 p.

Research output: Contribution to journalArticle

Bowman Capsule
Punctures
Microscopy
Albumins
1 Citation (Scopus)

Response to 'On the origin of albuminuria' [2]

Russo, L. M., Sandoval, R. M., Brown, D., Molitoris, B. & Comper, W. D., Dec 2007, In : Kidney International. 72, 11, p. 1409-1410 2 p.

Research output: Contribution to journalArticle

Albuminuria