Bruce Molitoris

  • 15549 Citations
  • 62 h-Index
1974 …2019
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Publications 1974 2019

  • 15549 Citations
  • 62 h-Index
  • 223 Article
  • 20 Chapter
  • 2 Editorial
  • 1 Review article
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Article
2007
282 Citations (Scopus)

The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states

Russo, L. M., Sandoval, R. M., McKee, M., Osicka, T. M., Collins, A. B., Brown, D., Molitoris, B. & Comper, W. D., Mar 13 2007, In : Kidney International. 71, 6, p. 504-513 10 p.

Research output: Contribution to journalArticle

Albumins
Kidney
Albuminuria
Endocytosis
Low Density Lipoprotein Receptor-Related Protein-2
48 Citations (Scopus)

Two-photon microscopy: Visualization of kidney dynamics

Ashworth, S. L., Sandoval, R. M., Tanner, G. A. & Molitoris, B., Aug 2007, In : Kidney International. 72, 4, p. 416-421 6 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Proteins
Software
2006
1 Citation (Scopus)

Advances in imaging the kidney and cellular processes

Herget-Rosenthal, S. & Molitoris, B., Mar 2006, In : Nephron - Experimental Nephrology. 103, 2

Research output: Contribution to journalArticle

Nephrology
Diagnostic Imaging
Kidney
28 Citations (Scopus)

A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy

Sandoval, R. M., Reilly, J. P., Running, W., Campos-Bilderback, S., Santos, J. R., Phillips, C. & Molitoris, B., Oct 2006, In : Journal of the American Society of Nephrology. 17, 10, p. 2697-2705 9 p.

Research output: Contribution to journalArticle

Gentamicins
Aminoglycosides
Klebsiella pneumoniae
Bacillus subtilis
Acute Kidney Injury
24 Citations (Scopus)

Cofilin mediates ATP depletion-induced endothelial cell actin alterations

Suurna, M. V., Ashworth, S. L., Hosford, M., Sandoval, R. M., Wean, S. E., Shah, B. M., Bamburg, J. R. & Molitoris, B., Jun 2006, In : American Journal of Physiology - Renal Physiology. 290, 6

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Actins
Endothelial Cells
Adenosine Triphosphate
Destrin
535 Citations (Scopus)

Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001

Xue, J. L., Daniels, F., Star, R. A., Kimmel, P. L., Eggers, P. W., Molitoris, B., Himmelfarb, J. & Collins, A. J., Apr 2006, In : Journal of the American Society of Nephrology. 17, 4, p. 1135-1142 8 p.

Research output: Contribution to journalArticle

Medicare
Acute Kidney Injury
Mortality
Incidence
Critical Care
11 Citations (Scopus)
Protein Transport
Vacuoles
Gentamicins
Saccharomyces cerevisiae
Yeasts
24 Citations (Scopus)

Pharmacophotonics: Utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney

Molitoris, B. & Sandoval, R. M., Oct 31 2006, In : Advanced Drug Delivery Reviews. 58, 7, p. 809-823 15 p.

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Drug Trafficking
Research Personnel
1 Citation (Scopus)

The role of statin therapy in patients with chronic kidney disease

Decker, B. & Molitoris, B., Jun 2006, In : Clinical Geriatrics. 14, 6, p. 29-34 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chronic Renal Insufficiency
Therapeutics
2005
30 Citations (Scopus)

Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: Enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model

Raikwar, S. P., Temm, C. J., Raikwar, N. S., Kao, C., Molitoris, B. & Gardner, T., Dec 2005, In : Molecular Therapy. 12, 6, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

Angiostatins
Endostatins
Prostate
Growth
Prostatic Neoplasms
135 Citations (Scopus)

Intravital multiphoton microscopy of dynamic renal processes

Molitoris, B. & Sandoval, R. M., Jun 2005, In : American Journal of Physiology - Renal Physiology. 288, 6 57-6

Research output: Contribution to journalArticle

Microscopy
Research Personnel
Kidney
Physiologic Monitoring
Endocytosis
36 Citations (Scopus)

Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney

Tanner, G. A., Sandoval, R. M., Molitoris, B., Bamburg, J. R. & Ashworth, S. L., Sep 2005, In : American Journal of Physiology - Renal Physiology. 289, 3 58-3

Research output: Contribution to journalArticle

Green Fluorescent Proteins
Photons
Punctures
Kidney
Genes

Microscopy as a quantitative science

Molitoris, B., Jul 2005, In : International Journal of Artificial Organs. 28, 7, p. 663-665 3 p.

Research output: Contribution to journalArticle

Microscopic examination
44 Citations (Scopus)

Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies

Yu, W., Sandoval, R. M. & Molitoris, B., Nov 2005, In : American Journal of Physiology - Cell Physiology. 289, 5 58-5

Research output: Contribution to journalArticle

Dextrans
Kidney
Bowman Capsule
Rats
Capsules
20 Citations (Scopus)

Renal blood flow in sepsis: A complex issue

Molitoris, B., Aug 2005, In : Critical Care. 9, 4, p. 327-328 2 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Sepsis
Microvessels
Endothelium
2004
53 Citations (Scopus)

Actin cytoskeleton in ischemic acute renal failure

Molitoris, B., Harrington, J. T., Perrone, R., Jaber, B., Herman, I. M., Balakrishnan, V. S., Pahari, D. K. & Levey, A. S., Aug 2004, In : Kidney International. 66, 2, p. 871-883 13 p.

Research output: Contribution to journalArticle

Actin Depolymerizing Factors
Tropomyosin
Endocytosis
Actin Cytoskeleton
Acute Kidney Injury
245 Citations (Scopus)

Endothelial injury and dysfunction: Role in the extension phase of acute renal failure

Molitoris, B. A. & Sutton, T. A., Aug 2004, In : Kidney International. 66, 2, p. 496-499 4 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
6 Citations (Scopus)

Evolving basic concepts in ischemic injury

De Broe, M. E., Bonventre, J. V., Molitoris, B. & Haller, H., Aug 2004, In : Kidney International. 66, 2, p. 479 1 p.

Research output: Contribution to journalArticle

Wounds and Injuries
72 Citations (Scopus)
Secretory Pathway
Aminoglycosides
Gentamicins
Endoplasmic Reticulum
Cytosol

High pressure freezing and freeze substitution: Advances in renal research

Pennington, J. G., Miller, C. A., Sandoval, R., Gattone, V. H., Molitoris, B. & Bacallao, R., 2004, In : Microscopy and Microanalysis. 10, SUPPL. 2, p. 1226-1227 2 p.

Research output: Contribution to journalArticle

Freezing
freezing
Substitution reactions
substitutes
84 Citations (Scopus)

Mechanism of Actin Polymerization in Cellular ATP Depletion

Atkinson, S. J., Hosford, M. A. & Molitoris, B., Feb 13 2004, In : Journal of Biological Chemistry. 279, 7, p. 5194-5199 6 p.

Research output: Contribution to journalArticle

Polymerization
Actins
Adenosine Triphosphate
Thymosin
Profilins
18 Citations (Scopus)

Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments

Ashworth, S. L., Wean, S. E., Campos-Bilderback, S., Temm-Grove, C. J., Southgate, E. L., Vrhovski, B., Gunning, P., Weinberger, R. P. & Molitoris, B., May 2004, In : American Journal of Physiology - Renal Physiology. 286, 5 55-5

Research output: Contribution to journalArticle

Tropomyosin
Microvilli
Actin Cytoskeleton
Ischemia
Kidney
104 Citations (Scopus)
Photons
Folic Acid
Microscopy
Microscopic examination
Kidney
2003
44 Citations (Scopus)

ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion

Ashworth, S. L., Southgate, E. L., Sandoval, R. M., Meberg, P. J., Bamburg, J. R. & Molitoris, B., Apr 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Actins
Adenosine Triphosphate
Three-Dimensional Imaging
151 Citations (Scopus)
Transferases
Labeling
Apoptosis
Sensitivity and Specificity
Propidium
234 Citations (Scopus)
Endothelium
Ischemia
Kidney
Wounds and Injuries
Acute Kidney Injury
37 Citations (Scopus)

Intravital imaging of the kidney using multiparameter multiphoton microscopy.

Dunn, K., Sandoval, R. M. & Molitoris, B., 2003, In : Nephron - Experimental Nephrology. 94, 1

Research output: Contribution to journalArticle

Photons
Microscopy
Kidney
Animal Structures
Endocytosis
58 Citations (Scopus)

Newly developed techniques to study and diagnose acute renal failure

Dagher, P., Herget-Rosenthal, S., Ruehm, S. G., Jo, S. K., Star, R. A., Agarwal, R. & Molitoris, B., Aug 1 2003, In : Journal of the American Society of Nephrology. 14, 8, p. 2188-2198 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Animal Models
Magnetic Resonance Imaging
Renal Circulation
Regional Blood Flow
90 Citations (Scopus)

Transitioning to therapy in ischemic acute renal failure

Molitoris, B., Jan 1 2003, In : Journal of the American Society of Nephrology. 14, 1, p. 265-267 3 p.

Research output: Contribution to journalArticle

Renal Circulation
Acute Kidney Injury
Ischemia
Therapeutics
89 Citations (Scopus)

Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts

Kwon, O., Molitoris, B., Pescovitz, M. & Kelly, K., May 1 2003, In : American Journal of Kidney Diseases. 41, 5, p. 1074-1087 14 p.

Research output: Contribution to journalArticle

Interleukin-8
Acute Kidney Injury
Allografts
Actins
Interleukin-6
2002
24 Citations (Scopus)

Cardiovascular disease in patients with chronic kidney disease

Jaradat, M. I. & Molitoris, B., Nov 2002, In : Seminars in Nephrology. 22, 6, p. 459-473 15 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Cardiovascular Diseases
Anemia
Renal Replacement Therapy
Left Ventricular Hypertrophy
92 Citations (Scopus)

Endothelial injury and dysfunction in ischemic acute renal failure

Molitoris, B., Sandoval, R. & Sutton, T., 2002, In : Critical Care Medicine. 30, 5 SUPPL.

Research output: Contribution to journalArticle

Acute Kidney Injury
Endothelial Cells
Wounds and Injuries
Actins
P-Selectin
237 Citations (Scopus)

Functional studies of the kidney of living animals using multicolor two-photon microscopy

Dunn, K., Sandoval, R. M., Kelly, K., Dagher, P., Tanner, G. A., Atkinson, S. J., Bacallao, R. & Molitoris, B., Sep 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3

Research output: Contribution to journalArticle

Photons
Microscopy
Microscopic examination
Animals
Kidney
57 Citations (Scopus)
Actin Cytoskeleton
Vascular Smooth Muscle
Smooth Muscle Myocytes
Ischemia
Actins
387 Citations (Scopus)

Microvascular endothelial injury and dysfunction during ischemic acute renal failure

Sutton, T., Fisher, C. J. & Molitoris, B., 2002, In : Kidney International. 62, 5, p. 1539-1549 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Kidney
Wounds and Injuries
Blood Vessels
Endothelial Cells
7 Citations (Scopus)

Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells

Sandoval, R. M., Bacallao, R., Dunn, K., Leiser, J. D. & Molitoris, B., Dec 1 2002, In : American Journal of Physiology - Renal Physiology. 283, 6 52-6

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Gentamicins
Nucleotides
trans-Golgi Network
2001
19 Citations (Scopus)

Characteristics of EYFP-actin and visualization of actin dynamics during ATP depletion and repletion

Herget-Rosenthal, S., Hosford, M., Kribben, A., Atkinson, S. J., Sandoval, R. M. & Molitoris, B., 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Actins
Visualization
Adenosine Triphosphate
Fluorescence
Proteins
26 Citations (Scopus)

Erythropoietin requirements increase following hospitalization in end-stage renal disease patients

Yaqub, M., Leiser, J. & Molitoris, B., 2001, In : American Journal of Nephrology. 21, 5, p. 390-396 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Chronic Kidney Failure
Hemoglobins
Hospitalization
Renal Dialysis
65 Citations (Scopus)

Gentamicin inhibits renal protein and phospholipid metabolism in rats: Implications involving intracellular trafficking

Sundin, D. P., Sandoval, R. & Molitoris, B., 2001, In : Journal of the American Society of Nephrology. 12, 1, p. 114-123 10 p.

Research output: Contribution to journalArticle

Gentamicins
Phospholipids
Kidney
Microvilli
Proteins
49 Citations (Scopus)

Ischemic injury induces ADF relocalization to the apical domain of rat proximal tubule cells

Ashworth, S. L., Sandoval, R. M., Hosford, M., Hamburg, J. R. & Molitoris, B., May 2001, In : American Journal of Physiology - Renal Physiology. 280, 5 49-5

Research output: Contribution to journalArticle

Destrin
Ischemia
Wounds and Injuries
Actins
Microvilli
2000
150 Citations (Scopus)

Acute renal failure in the new millennium: Time to consider combination therapy

Kelly, K. J. & Molitoris, B. A., 2000, In : Seminars in Nephrology. 20, 1, p. 4-19 16 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Therapeutics
Renal Replacement Therapy
Theoretical Models
Morbidity

Dialytic care of patients with acute renal failure

Yaqub, M. & Molitoris, B., Jan 2000, In : Drugs of Today. 36, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Replacement Therapy
Patient Care
Dialysis
Membranes
30 Citations (Scopus)
LLC-PK1 Cells
Golgi Apparatus
Gentamicins
Fluorescence
Aminoglycosides
1999
10 Citations (Scopus)

Acute renal failure

Molitoris, B., Sep 1999, In : Drugs of Today. 35, 9, p. 659-666 8 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Azotemia
Urine
Therapeutics
79 Citations (Scopus)

Ischemia activates actin depolymerizing factor: Role in proximal tubule microvillar actin alterations

Schwartz, N., Hosford, M., Sandoval, R. M., Wagner, M., Atkinson, S. J., Bamburg, J. & Molitoris, B., Apr 1999, In : American Journal of Physiology - Renal Physiology. 276, 4 45-4

Research output: Contribution to journalArticle

Destrin
Actins
Ischemia
Microvilli
Actin Cytoskeleton
30 Citations (Scopus)

Pathophysiology and functional significance of apical membrane disruption during ischemia

Ashworth, S. L. & Molitoris, B., 1999, In : Current Opinion in Nephrology and Hypertension. 8, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

Destrin
Actin Depolymerizing Factors
Ischemia
Actins
Membranes
30 Citations (Scopus)

Renal epithelial polarity in health and disease

Wagner, M. & Molitoris, B., Feb 1999, In : Pediatric Nephrology. 13, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Kidney
Health
Epithelial Cells
Polycystic Kidney Diseases
Membranes
109 Citations (Scopus)

The role of cell adhesion molecules in ischemic acute renal failure

Molitoris, B. & Marrs, J., May 1999, In : The American Journal of Medicine. 106, 5, p. 583-592 10 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Reperfusion Injury
Acute Kidney Injury
Integrins
Neutrophils
1998
68 Citations (Scopus)

Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells

Sandoval, R., Leiser, J. & Molitoris, B., Feb 1998, In : Journal of the American Society of Nephrology. 9, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

LLC-PK1 Cells
Golgi Apparatus
Aminoglycosides
Gentamicins
Anti-Bacterial Agents
18 Citations (Scopus)

Ischemic acute renal failure: Exciting times at our fingertips

Molitoris, B., 1998, In : Current Opinion in Nephrology and Hypertension. 7, 4, p. 405-406 2 p.

Research output: Contribution to journalArticle

Growth Substances
alpha-MSH
Calcium-Calmodulin-Dependent Protein Kinases
Heat-Shock Proteins
Acute Kidney Injury