Carmella Evans-Molina

  • 2734 Citations
  • 26 h-Index
20062020

Research output per year

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Publications

  • 2734 Citations
  • 26 h-Index
  • 62 Article
  • 17 Review article
  • 16 Comment/debate
  • 5 Letter
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Article
2020

Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation

Tong, X., Chaudhry, Z., Lee, C. C., Bone, R. N., Kanojia, S., Maddatu, J., Sohn, P., Weaver, S. A., Robertson, M. A., Petrache, I., Evans-Molina, C. & Kono, T., Jul 2020, In : Molecular Metabolism. 37, 100975.

Research output: Contribution to journalArticle

Open Access

Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison

Speake, C., Ylescupidez, A., Neiman, D., Shemer, R., Glaser, B., Tersey, S. A., Usmani-Brown, S., Clark, P., Wilhelm, J. J., Bellin, M. D., Herold, K. C., Mirmira, R. G., Dor, Y. & Evans-Molina, C., Jan 8 2020, In : Journal of Clinical Endocrinology and Metabolism. 105, 3, dgaa008.

Research output: Contribution to journalArticle

Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention

Nakayasu, E. S., Syed, F., Tersey, S. A., Gritsenko, M. A., Mitchell, H. D., Chan, C. Y., Dirice, E., Turatsinze, J. V., Cui, Y., Kulkarni, R. N., Eizirik, D. L., Qian, W. J., Webb-Robertson, B. J. M., Evans-Molina, C., Mirmira., R. G. & Metz, T. O., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 363-374.e6

Research output: Contribution to journalArticle

5 Scopus citations

Excess BMI accelerates islet autoimmunity in older children and adolescents

Type 1 Diabetes TrialNet Study Group, Mar 1 2020, In : Diabetes care. 43, 3, p. 580-587 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

High residual C-peptide likely contributes to glycemic control in type 1 diabetes

T1D Exchange β-Cell Function Study Group, Apr 1 2020, In : Journal of Clinical Investigation. 130, 4, p. 1850-1862 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening

Jacobsen, L. M., Bocchino, L., Evans-Molina, C., DiMeglio, L., Goland, R., Wilson, D. M., Atkinson, M. A., Aye, T., Russell, W. E., Wentworth, J. M., Boulware, D., Geyer, S. & Sosenko, J. M., Mar 1 2020, In : Diabetologia. 63, 3, p. 588-596 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

Sims, E. K., Syed, F., Nyalwidhe, J., Bahnson, H. T., Haataja, L., Speake, C., Morris, M. A., Balamurugan, A. N., Mirmira, R. G., Nadler, J., Mastracci, T. L., Arvan, P., Greenbaum, C. J. & Evans-Molina, C., Nov 2019, In : Translational Research. 213, p. 90-99 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes

Ocaña, G. J., Sims, E. K., Watkins, R. A., Ragg, S., Mather, K. J., Oram, R. A., Mirmira, R. G., DiMeglio, L. A., Blum, J. S. & Evans-Molina, C., Jan 2019, In : PloS one. 14, 1, e0208456.

Research output: Contribution to journalArticle

2 Scopus citations

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes

Type 1 Diabetes Trial Net and Diabetes Prevention Trial-Type-1 (DPT-1) Study Groups, Jun 2019, In : Pediatric Diabetes. 20, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

the Type 1 Diabetes TrialNet Study Group & the Immune Tolerance Network Study Group, Jan 1 2019, In : Diabetologia. 62, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic cell

Yamamoto, W. R., Bone, R. N., Sohn, P., Syed, F., Reissaus, C. A., Mosley, A. L., Wijeratne, A. B., True, J. D., Tong, X., Kono, T. & Evans-Molina, C., Jan 4 2019, In : Journal of Biological Chemistry. 294, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Loss of diurnal oscillatory rhythms in gut microbiota correlates with changes in circulating metabolites in type 2 diabetic db/db mice

Beli, E., Prabakaran, S., Krishnan, P., Evans-Molina, C. & Grant, M. B., Oct 2019, In : Nutrients. 11, 10, 2310.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes

Neyman, A., Nelson, J., Tersey, S. A., Mirmira, R. G., Evans-Molina, C. & Sims, E. K., Jan 2019, In : Diabetes, Obesity and Metabolism. 21, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Profiling of RNAs from human islet-derived exosomes in a model of type 1 diabetes

Krishnan, P., Syed, F., Kang, N. J., Mirmira, R. G. & Evans-Molina, C., Dec 1 2019, In : International journal of molecular sciences. 20, 23, 5903.

Research output: Contribution to journalArticle

Open Access

Proinsulin secretion is a persistent feature of type 1 diabetes

Sims, E. K., Bahnson, H. T., Nyalwidhe, J., Haataja, L., Davis, A. K., Speake, C., DiMeglio, L. A., Blum, J., Morris, M. A., Mirmira, R. G., Nadler, J., Mastracci, T. L., Marcovina, S., Qian, W. J., Yi, L., Swensen, A. C., Yip-Schneider, M., Schmidt, C. M., Considine, R. V., Arvan, P. & 2 others, Greenbaum, C. J. & Evans-Molina, C., Feb 1 2019, In : Diabetes care. 42, 2, p. 258-264 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss

Xu, G., Thielen, L. A., Chen, J., Grayson, T. B., Grimes, T., Bridges, S. L., Tse, H. M., Smith, B., Patel, R., Li, P., Evans-Molina, C., Ovalle, F. & Shalev, A., Oct 1 2019, In : American journal of physiology. Endocrinology and metabolism. 317, 4, p. E723-E730

Research output: Contribution to journalArticle

1 Scopus citations

The influence of type 2 diabetes-associated factors on type 1 diabetes

Redondo, M. J., Evans-Molina, C., Steck, A. K., Atkinson, M. A. & Sosenko, J., Aug 1 2019, In : Diabetes care. 42, 8, p. 1357-1364 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Impaired store-operated calcium entry and STIM1 loss lead to reduced insulin secretion and increased endoplasmic reticulum stress in the diabetic B-cell

Gilon, P., Roe, M. W., Evans-Molina, C., Kono, T., Tong, X., Taleb, S., Bone, R. N., Iida, H., Lee, C. C. & Sohn, P., Nov 1 2018, In : Diabetes. 67, 11, p. 2293-2304 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice

Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y., Prasad, R., Bhatwadekar, A., White, F. A., Townsend, S. D., Chan, L., Ryan, C. N., Morton, D., Moldovan, E. G., Chu, F. I., Oudit, G. Y., Derendorf, H., Adorini, L., Wang, X. X., Evans-Molina, C. & 7 others, Mirmira, R. G., Boulton, M. E., Yoder, M. C., Li, Q., Levi, M., Busik, J. V. & Grant, M. B., Sep 1 2018, In : Diabetes. 67, 9, p. 1867-1879 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

Sosenko, J. M., Geyer, S., Skyler, J. S., Rafkin, L. E., Ismail, H. M., Libman, I. M., Liu, Y. F., DiMeglio, L. A., Evans-Molina, C. & Palmer, J. P., May 2018, In : Pediatric Diabetes. 19, 3, p. 403-409 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis

Type 1 Diabetes TrialNet Study Group, Aug 9 2018, In : JCI Insight. 3, 15

Research output: Contribution to journalArticle

8 Scopus citations
2017

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Hatanaka, M., Anderson-Baucum, E., Lakhter, A., Kono, T., Maier, B., Tersey, S. A., Tanizawa, Y., Evans-Molina, C., Mirmira, R. G. & Sims, E. K., Dec 1 2017, In : Scientific reports. 7, 1, 3758.

Research output: Contribution to journalArticle

5 Scopus citations

Dysglycemia and Index60 as prediagnostic end points for type 1 diabetes prevention trials

Nathan, B. M., Boulware, D., Geyer, S., Atkinson, M. A., Colman, P., Goland, R., Russell, W., Wentworth, J. M., Wilson, D. M., Evans-Molina, C., Wherrett, D., Skyler, J. S., Moran, A. & Sosenko, J. M., Nov 1 2017, In : Diabetes care. 40, 11, p. 1494-1499 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of oral insulin on prevention of diabetes in relatives of patients with type 1 diabetes: A randomized clinical trial

Writing Committee for the Type 1 Diabetes TrialNet Oral Insulin Study Group, Nov 21 2017, In : JAMA - Journal of the American Medical Association. 318, 19, p. 1891-1902 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Ferrara, C. T., Geyer, S. M., Liu, Y. F., Evans-Molina, C., Libman, I. M., Besser, R., Becker, D. J., Rodriguez, H., Moran, A., Gitelman, S. E. & Redondo, M. J., May 1 2017, In : Diabetes care. 40, 5, p. 698-701 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α

Ocaña, G. J., Pérez, L., Guindon, L., Deffit, S. N., Evans-Molina, C., Thurmond, D. C. & Blum, J. S., Jun 2017, In : Immunology. 151, 2, p. 198-210 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells

Sims, E. K., Lakhter, A. J., Anderson-Baucum, E., Kono, T., Tong, X. & Evans-Molina, C., Jun 1 2017, In : Diabetologia. 60, 6, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation

Gordon, H. M., Majithia, N., MacDonald, P. E., Fox, J. E. M., Sharma, P. R., Byrne, F. L., Hoehn, K. L., Evans-Molina, C., Langman, L., Brayman, K. L. & Nunemaker, C. S., Jun 1 2017, In : Endocrine. 56, 3, p. 528-537 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Role of Age and Excess Body Mass Index in Progression to Type 1 Diabetes in At-Risk Adults

Type 1 Diabetes TrialNet Study Group, Dec 1 2017, In : The Journal of clinical endocrinology and metabolism. 102, 12, p. 4596-4603 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

A case of extragastrointestinal stromal tumor complicated by severe hypoglycemia: A unique presentation of a rare tumor

Saeed, Z., Taleb, S. & Evans-Molina, C., Dec 1 2016, In : BMC Cancer. 16, 1, 930.

Research output: Contribution to journalArticle

3 Scopus citations

CD40 promotes mhc class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity

Morris, D. L., Oatmen, K. E., Mergian, T. A., Cho, K. W., Delproposto, J. L., Singer, K., Evans-Molina, C., O’Rourke, R. W. & Lumeng, C. N., Jun 2016, In : Journal of Leukocyte Biology. 99, 6, p. 1107-1119 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Elevations in the fasting serum Proinsulin-to-C-peptide ratio precede the onset of type 1 diabetes

Sims, E. K., Chaudhry, Z., Watkins, R., Syed, F., Blum, J., Ouyang, F., Perkins, S. M., Mirmira, R. G., Sosenko, J., DiMeglio, L. A. & Evans-Molina, C., Sep 1 2016, In : Diabetes care. 39, 9, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

HLA-DRB115:01-DQA101:02-DQB106:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression

Pugliese, A., Boulware, D., Yu, L., Babu, S., Steck, A. K., Becker, D., Rodriguez, H., Di Meglio, L., Evans-Molina, C., Harrison, L. C., Schatz, D., Palmer, J. P., Greenbaum, C., Eisenbarth, G. S. & Sosenko, J. M., Apr 2016, In : Diabetes. 65, 4, p. 1109-1119 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

Watkins, R. A., Evans-Molina, C., Terrell, J. K., Day, K. H., Guindon, L., Restrepo, I. A., Mirmira, R., Blum, J. & DiMeglio, L., Feb 1 2016, In : Translational Research. 168, p. 96-106.e1

Research output: Contribution to journalArticle

28 Scopus citations

SERCA2 deficiency impairs pancreatic β-cell function in response to diet-induced obesity

Tong, X., Kono, T., Anderson-Baucum, E. K., Yamamoto, W., Gilon, P., Lebeche, D., Day, R. N., Shull, G. E. & Evans-Molina, C., Oct 1 2016, In : Diabetes. 65, 10, p. 3039-3052 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiong, X., Wang, G., Tao, R., Wu, P., Kono, T., Li, K., Ding, W. X., Tong, X., Tersey, S. A., Harris, R. A., Mirmira, R. G., Evans-Molina, C. & Dong, X. C., Jan 1 2016, In : Diabetologia. 59, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants

Meah, F. A., DiMeglio, L. A., Greenbaum, C. J., Blum, J. S., Sosenko, J. M., Pugliese, A., Geyer, S., Xu, P. & Evans-Molina, C., Jun 1 2016, In : Diabetologia. 59, 6, p. 1186-1195 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Elevations in circulating methylated and unmethylated preproinsulin DNA in new-onset type 1 diabetes

Fisher, M. M., Watkins, R. A., Blum, J., Evans-Molina, C., Chalasani, N., Dimeglio, L. A., Mather, K. J., Tersey, S. A. & Mirmira, R. G., Nov 2015, In : Diabetes. 64, 11, p. 3867-3872 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats

Blue, E. K., Ballman, K., Boyle, F., Oh, E., Kono, T., Quinney, S. K., Thurmond, D. C., Evans-Molina, C. & Haneline, L. S., Feb 11 2015, In : Pediatric Research. 77, 2, p. 316-325 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of Type 1 diabetes

Filgueiras, L. R., Brandt, S. L., Wang, S., Wang, Z., Morris, D. L., Evans-Molina, C., Mirmira, R. G., Jancar, S. & Serezani, C. H., Jan 27 2015, In : Science Signaling. 8, 361

Research output: Contribution to journalArticle

31 Scopus citations
13 Scopus citations

SET7/9 enzyme regulates cytokine-induced expression of inducible nitric-oxide synthase through methylation of Lysine 4 at histone 3 in the islet β cell

Fujimaki, K., Ogihara, T., Morris, D. L., Oda, H., Iida, H., Fujitani, Y., Mirmira, R. G., Evans-Molina, C. & Watada, H., Jul 3 2015, In : Journal of Biological Chemistry. 290, 27, p. 16607-16618 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

A case of calciphylaxis in a patient with hypoparathyroidism and normal renal function

Erdel, B. L., Juneja, R. & Evans-Molina, C., Jun 1 2014, In : Endocrine Practice. 20, 6, p. e102-e105

Research output: Contribution to journalArticle

7 Scopus citations

From immunobiology to β-cell biology: The changing perspective on type 1 diabetes

Maganti, A., Evans-Molina, C. & Mirmira, R. G., Jan 1 2014, In : Islets. 6, 2, p. e28778-1-e28778-5 e28778.

Research output: Contribution to journalArticle

20 Scopus citations

Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: Analysis of hASC-derived paracrine effectors

Kono, T. M., Sims, E. K., Moss, D. R., Yamamoto, W., Ahn, G., Diamond, J., Tong, X., Day, K. H., Territo, P. R., Hanenberg, H., Traktuev, D. O., March, K. L. & Evans-Molina, C., Jul 2014, In : STEM CELLS. 32, 7, p. 1831-1842 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway

Hatanaka, M., Maier, B., Sims, E. K., Templin, A. T., Kulkarni, R. N., Evans-Molina, C. & Mirmira, R. G., Oct 1 2014, In : Diabetes. 63, 10, p. 3404-3415 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell

Johnson, J. S., Kono, T., Tong, X., Yamamoto, W. R., Zarain-Herzberg, A., Merrins, M. J., Satin, L. S., Gilon, P. & Evans-Molina, C., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32798-32810 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy

Rajashekhar, G., Ramadan, A., Abburi, C., Callaghan, B., Traktuev, D. O., Evans-Molina, C., Maturi, R., Harris, A., Kern, T. S. & March, K. L., Jan 9 2014, In : PLoS ONE. 9, 1, e84671.

Research output: Contribution to journalArticle

48 Scopus citations

Shock wave lithotripsy targeting of the kidney and pancreas does not increase the severity of metabolic syndrome in a porcine model

Handa, R. K., Evan, A. P., Connors, B. A., Johnson, C. D., Liu, Z., Alloosh, M., Sturek, M., Evans-Molina, C., Mandeville, J. A., Gnessin, E. & Lingeman, J. E., Oct 1 2014, In : Journal of Urology. 192, 4, p. 1257-1265 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Divergent compensatory responses to high-fat diet between C57Bl6/J and c57BlKS/J inbred mouse strains

Sims, E. K., Hatanaka, M., Morris, D. L., Tersey, S. A., Kono, T., Chaudry, Z. Z., Day, K. H., Moss, D. R., Stull, N. D., Mirmira, R. G. & Evans-Molina, C., Dec 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 12, p. E1495-E1511

Research output: Contribution to journalArticle

21 Scopus citations