Carmella Evans-Molina

  • 2433 Citations
  • 23 h-Index
20062019
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Publications 2006 2019

  • 2433 Citations
  • 23 h-Index
  • 81 Article
  • 7 Review article
  • 3 Letter
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Article

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

Sims, E. K., Syed, F., Nyalwidhe, J., Bahnson, H. T., Haataja, L., Speake, C., Morris, M. A., Balamurugan, A. N., Mirmira, R., Nadler, J., Mastracci, T. L., Arvan, P., Greenbaum, C. J. & Evans-Molina, C., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Proinsulin
Medical problems
Type 1 Diabetes Mellitus
Proprotein Convertase 1
Processing
6 Citations (Scopus)

A case of calciphylaxis in a patient with hypoparathyroidism and normal renal function

Erdel, B. L., Juneja, R. & Evans-Molina, C., Jun 1 2014, In : Endocrine Practice. 20, 6

Research output: Contribution to journalArticle

Calciphylaxis
Hypoparathyroidism
Calcitriol
Kidney
Calcium
2 Citations (Scopus)

A case of extragastrointestinal stromal tumor complicated by severe hypoglycemia: A unique presentation of a rare tumor

Saeed, Z., Taleb, S. & Evans-Molina, C., Dec 1 2016, In : BMC Cancer. 16, 1, 930.

Research output: Contribution to journalArticle

Hypoglycemia
Insulin-Like Growth Factor II
Neoplasms
Insulin-Like Growth Factor I
Insulin

Achieving "PeaK-A" insulin secretion

Evans-Molina, C. & Mirmira, R., May 2013, In : Diabetes. 62, 5, p. 1389-1390 2 p.

Research output: Contribution to journalArticle

Insulin-Secreting Cells
Second Messenger Systems
Cyclic AMP-Dependent Protein Kinases
Hyperglycemia
Cyclic AMP
1 Citation (Scopus)

Adenosine and seizures - What's the big fat deal?

Evans-Molina, C., Jul 20 2011, In : Science Translational Medicine. 3, 92, 92ec113.

Research output: Contribution to journalArticle

Adenosine
Seizures
Fats

A hepatitis C mouse model that isn't chopped liver

Evans-Molina, C., Jun 22 2011, In : Science Translational Medicine. 3, 88, 88ec94.

Research output: Contribution to journalArticle

Hepatitis C
Liver
1 Citation (Scopus)

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes

Ocaña, G. J., Sims, E. K., Watkins, R. A., Ragg, S., Mather, K., Oram, R. A., Mirmira, R., DiMeglio, L., Blum, J. & Evans-Molina, C., Jan 1 2019, In : PLoS One. 14, 1, e0208456.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
autoimmunity
insulin-dependent diabetes mellitus
Biomarkers
Medical problems

A new FIX for hemophilia B

Evans-Molina, C., Jan 11 2012, In : Science Translational Medicine. 4, 116, 116ec5.

Research output: Contribution to journalArticle

Hemophilia B
86 Citations (Scopus)

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

Sturek, J. M., Castle, J. D., Trace, A. P., Page, L. C., Castle, A. M., Evans-Molina, C., Parks, J. S., Mirmira, R. & Hedrick, C. C., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2575-2589 15 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Secretory Pathway
Cholesterol
Thiazolidinediones
Insulin

A snooze button for the biological clock

Evans-Molina, C., Aug 17 2011, In : Science Translational Medicine. 3, 96, 96ec131.

Research output: Contribution to journalArticle

Biological Clocks

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes

Type 1 Diabetes Trial Net and Diabetes Prevention Trial-Type-1 (DPT-1) Study Groups, Jan 1 2019, In : Pediatric Diabetes.

Research output: Contribution to journalArticle

C-Peptide
Glucose Tolerance Test
Type 1 Diabetes Mellitus
Hemoglobins
Area Under Curve

A sweet spot for kallikrein in intracerebral hemorrhage

Evans-Molina, C., Mar 2 2011, In : Science Translational Medicine. 3, 72, 72ec27.

Research output: Contribution to journalArticle

Kallikreins
Cerebral Hemorrhage

A sweet success for diabetes research

Evans-Molina, C., Sep 21 2011, In : Science Translational Medicine. 3, 101, 101ec153.

Research output: Contribution to journalArticle

Research
3 Citations (Scopus)

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

the Type 1 Diabetes TrialNet Study Group & the Immune Tolerance Network Study Group, Jan 1 2018, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Fasting
C-Peptide
ROC Curve
Insulin
6 Citations (Scopus)

Biomarkers of islet beta cell stress and death in type 1 diabetes

Sims, E. K., Evans-Molina, C., Tersey, S. A., Eizirik, D. L. & Mirmira, R., Jan 1 2018, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Islets of Langerhans
Cell Death
Biomarkers
Therapeutics
31 Citations (Scopus)

Bisphenol A, obesity, and type 2 diabetes mellitus: Genuine concern or unnecessary preoccupation?

Mirmira, P. & Evans-Molina, C., 2014, In : Translational Research. 164, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Medical problems
Type 2 Diabetes Mellitus
Obesity
Food storage
Food Storage
14 Citations (Scopus)

CD40 promotes mhc class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity

Morris, D. L., Oatmen, K. E., Mergian, T. A., Cho, K. W., Delproposto, J. L., Singer, K., Evans-Molina, C., O’Rourke, R. W. & Lumeng, C. N., Jun 1 2016, In : Journal of Leukocyte Biology. 99, 6, p. 1107-1119 13 p.

Research output: Contribution to journalArticle

Adipose Tissue
Obesity
Macrophages
T-Lymphocytes
CD40 Ligand
3 Citations (Scopus)

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Hatanaka, M., Anderson-Baucum, E., Lakhter, A., Kono, T., Maier, B., Tersey, S. A., Tanizawa, Y., Evans-Molina, C., Mirmira, R. & Sims, E. K., Dec 1 2017, In : Scientific Reports. 7, 1, 3758.

Research output: Contribution to journalArticle

Protein Biosynthesis
High Fat Diet
DNA Damage
Fats
Polyribosomes

Chronic pain. Epigenetic modulation of CNS pathways: What a pain!

Evans-Molina, C., Dec 7 2011, In : Science Translational Medicine. 3, 112, 112ec198.

Research output: Contribution to journalArticle

Epigenomics
Chronic Pain
Pain
12 Citations (Scopus)

Development of insulin-producing cells from primitive biologic precursors

Evans-Molina, C., Vestermark, G. L. & Mirmira, R., Feb 2009, In : Current Opinion in Organ Transplantation. 14, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

Insulin
Stem Cells
Multipotent Stem Cells
Pluripotent Stem Cells
Hormones
19 Citations (Scopus)

Divergent compensatory responses to high-fat diet between C57Bl6/J and c57BlKS/J inbred mouse strains

Sims, E. K., Hatanaka, M., Morris, D. L., Tersey, S. A., Kono, T., Chaudry, Z. Z., Day, K. H., Moss, D. R., Stull, N. D., Mirmira, R. & Evans-Molina, C., Dec 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 12

Research output: Contribution to journalArticle

Inbred Strains Mice
High Fat Diet
Glucose Intolerance
Intra-Abdominal Fat
pioglitazone
5 Citations (Scopus)

Dysglycemia and Index60 as prediagnostic end points for type 1 diabetes prevention trials

Nathan, B. M., Boulware, D., Geyer, S., Atkinson, M. A., Colman, P., Goland, R., Russell, W., Wentworth, J. M., Wilson, D. M., Evans-Molina, C., Wherrett, D., Skyler, J. S., Moran, A. & Sosenko, J. M., Nov 1 2017, In : Diabetes Care. 40, 11, p. 1494-1499 6 p.

Research output: Contribution to journalArticle

Glucose Tolerance Test
Type 1 Diabetes Mellitus
C-Peptide
Incidence
Glucose
24 Citations (Scopus)

Effect of oral insulin on prevention of diabetes in relatives of patients with type 1 diabetes: A randomized clinical trial

Writing Committee for the Type 1 Diabetes TrialNet Oral Insulin Study Group, Nov 21 2017, In : JAMA - Journal of the American Medical Association. 318, 19, p. 1891-1902 12 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Randomized Controlled Trials
Insulin
Autoantibodies
Placebos
45 Citations (Scopus)

Elevations in circulating methylated and unmethylated preproinsulin DNA in new-onset type 1 diabetes

Fisher, M. M., Watkins, R. A., Blum, J., Evans-Molina, C., Chalasani, N., DiMeglio, L., Mather, K., Tersey, S. A. & Mirmira, R., Nov 1 2015, In : Diabetes. 64, 11, p. 3867-3872 6 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
DNA
preproinsulin
Autoimmune Hepatitis
Type 2 Diabetes Mellitus
31 Citations (Scopus)

Elevations in the fasting serum Proinsulin-to-C-peptide ratio precede the onset of type 1 diabetes

Sims, E. K., Chaudhry, Z., Watkins, R., Syed, F., Blum, J., Ouyang, F., Perkins, S., Mirmira, R., Sosenko, J., DiMeglio, L. & Evans-Molina, C., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

C-Peptide
Type 1 Diabetes Mellitus
Fasting
Serum
Endoplasmic Reticulum
2 Citations (Scopus)

Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic cell

Yamamoto, W. R., Bone, R. N., Sohn, P., Syed, F., Reissaus, C. A., Mosley, A., Wijeratne, A. B., True, J. D., Tong, X., Kono, T. & Evans-Molina, C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Medical problems
Unfolded Protein Response
35 Citations (Scopus)

Established and emerging biomarkers for the prediction of type 1 diabetes: A systematic review

Watkins, R. A., Evans-Molina, C., Blum, J. & DiMeglio, L., 2014, In : Translational Research. 164, 2, p. 110-121 12 p.

Research output: Contribution to journalArticle

Biomarkers
Medical problems
Type 1 Diabetes Mellitus
Autoantibodies
Autoimmune Diseases
19 Citations (Scopus)

Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Ferrara, C. T., Geyer, S. M., Liu, Y. F., Evans-Molina, C., Libman, I. M., Besser, R., Becker, D. J., Rodriguez, H., Moran, A., Gitelman, S. E. & Redondo, M. J., May 1 2017, In : Diabetes Care. 40, 5, p. 698-701 4 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Autoantibodies
Research Design
Multivariate Analysis
Pediatrics

Fetal DNA: A needle in the haystack

Evans-Molina, C., Mar 30 2011, In : Science Translational Medicine. 3, 76, 76ec43.

Research output: Contribution to journalArticle

Needles
DNA
3 Citations (Scopus)

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats

Blue, E. K., Ballman, K., Boyle, F., Oh, E., Kono, T., Quinney, S., Thurmond, D. C., Evans-Molina, C. & Haneline, L., Feb 11 2015, In : Pediatric Research. 77, 2, p. 316-325 10 p.

Research output: Contribution to journalArticle

Hematopoiesis
High Fat Diet
Hyperglycemia
Mothers
Glucose
18 Citations (Scopus)

From immunobiology to β-cell biology: The changing perspective on type 1 diabetes

Maganti, A., Evans-Molina, C. & Mirmira, R., 2014, In : Islets. 6, 2, p. e28778-1-e28778-5 e28778.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Cell Biology
Autoimmunity
Inbred NOD Mouse
Protein Folding
48 Citations (Scopus)

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets

Evans-Molina, C., Garmey, J. C., Ketchum, R., Brayman, K. L., Deng, S. & Mirmira, R., Mar 2007, In : Diabetes. 56, 3, p. 827-835 9 p.

Research output: Contribution to journalArticle

RNA Precursors
Insulin
Glucose
Genes
Messenger RNA
58 Citations (Scopus)

High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: Involvement of peroxisome proliferator-activated receptor γ signaling

So, W. Y., Cheng, Q., Chen, L., Evans-Molina, C., Xu, A., Lam, K. S. L. & Leung, P. S., Nov 2013, In : Diabetes. 62, 11, p. 3751-3759 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Islets of Langerhans
Glucose
rosiglitazone
Hyperglycemia
17 Citations (Scopus)

HLA-DRB115: 01-DQA101:02-DQB106:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression

Pugliese, A., Boulware, D., Yu, L., Babu, S., Steck, A. K., Becker, D., Rodriguez, H., DiMeglio, L., Evans-Molina, C., Harrison, L. C., Schatz, D., Palmer, J. P., Greenbaum, C., Eisenbarth, G. S. & Sosenko, J. M., Apr 1 2016, In : Diabetes. 65, 4, p. 1109-1119 11 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Autoantibodies
Haplotypes
Disease Progression
Histocompatibility Testing
34 Citations (Scopus)

Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: Analysis of hASC-derived paracrine effectors

Kono, T., Sims, E. K., Moss, D. R., Yamamoto, W., Ahn, G., Diamond, J., Tong, X., Day, K. H., Territo, P., Hanenberg, H., Traktuev, D., March, K. L. & Evans-Molina, C., 2014, In : Stem Cells. 32, 7, p. 1831-1842 12 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
Stromal Cells
Hyperglycemia
Stem Cells
Type 1 Diabetes Mellitus
4 Citations (Scopus)

Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell

Kono, T., Tong, X., Evans-Molina, C., Kono, T., Iida, H., Lee, C. C., Sohn, P., Gilon, P., Roe, M. W. & Evans-Molina, C., Nov 1 2018, In : Diabetes. 67, 11, p. 2293-2304 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Insulin
Calcium
Type 2 Diabetes Mellitus
5 Citations (Scopus)

Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α

Ocaña, G. J., Pérez, L., Guindon, L., Deffit, S. N., Evans-Molina, C., Thurmond, D. C. & Blum, J., 2017, (Accepted/In press) In : Immunology.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Insulin-Secreting Cells
Type 1 Diabetes Mellitus
Cytokines
Endoplasmic Reticulum Stress
167 Citations (Scopus)

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

Tersey, S. A., Nishiki, Y., Templin, A. T., Cabrera, S. M., Stull, N. D., Colvin, S. C., Evans-Molina, C., Rickus, J. L., Maier, B. & Mirmira, R., Apr 2012, In : Diabetes. 61, 4, p. 818-827 10 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Endoplasmic Reticulum Stress
Type 1 Diabetes Mellitus
Islets of Langerhans
Insulin
29 Citations (Scopus)

Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

Filgueiras, L. R., Brandt, S. L., Wang, S., Wang, Z., Morris, D. L., Evans-Molina, C., Mirmira, R., Jancar, S. & Serezani, C. H., Jan 27 2015, In : Science Signaling. 8, 361, p. ra10

Research output: Contribution to journalArticle

Leukotriene B4
Medical problems
Type 1 Diabetes Mellitus
Sepsis
Inflammation
32 Citations (Scopus)

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

Ogihara, T., Chuang, J. C., Vestermark, G. L., Garmey, J. C., Ketchum, R. J., Huang, X., Brayman, K. L., Thorner, M. O., Repa, J. J., Mirmira, R. & Evans-Molina, C., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5392-5404 13 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Liver
Chemical activation
Insulin
Gene Expression

Loss of diurnal oscillatory rhythms in gut microbiota correlates with changes in circulating metabolites in type 2 diabetic db/db mice

Beli, E., Prabakaran, S., Krishnan, P., Evans-Molina, C. & Grant, M. B., Oct 2019, In : Nutrients. 11, 10, 2310.

Research output: Contribution to journalArticle

Open Access
Circadian Rhythm
intestinal microorganisms
circadian rhythm
metabolites
mice
24 Citations (Scopus)

Lost in translation: Endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus

Evans-Molina, C., Hatanaka, M. & Mirmira, R., Sep 2013, In : Diabetes, Obesity and Metabolism. 15, S3, p. 159-169 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Diabetes Mellitus
Health
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
803 Citations (Scopus)

Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation

Hylek, E. M., Evans-Molina, C., Shea, C., Henault, L. E. & Regan, S., May 2007, In : Circulation. 115, 21, p. 2689-2696 8 p.

Research output: Contribution to journalArticle

Warfarin
Atrial Fibrillation
Hemorrhage
Therapeutics
Stroke
22 Citations (Scopus)

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells

Sims, E. K., Lakhter, A. J., Anderson-Baucum, E., Kono, T., Tong, X. & Evans-Molina, C., Mar 9 2017, (Accepted/In press) In : Diabetologia. p. 1-9 9 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
MicroRNAs
Apoptosis
Messenger RNA
Type 1 Diabetes Mellitus
13 Citations (Scopus)
Reticulum
AMP-Activated Protein Kinases
Calcium-Transporting ATPases
Protein Stability
Nitric Oxide

Obesity. Yo-yo dieting: Biology or behavior?

Evans-Molina, C., Nov 9 2011, In : Science Translational Medicine. 3, 108, 108ec180.

Research output: Contribution to journalArticle

Obesity
25 Citations (Scopus)

Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway

Hatanaka, M., Maier, B., Sims, E. K., Templin, A. T., Kulkarni, R. N., Evans-Molina, C. & Mirmira, R., Oct 1 2014, In : Diabetes. 63, 10, p. 3404-3415 12 p.

Research output: Contribution to journalArticle

Palmitates
Protein Biosynthesis
Sirolimus
Islets of Langerhans
Unfolded Protein Response
20 Citations (Scopus)

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell

Johnson, J. S., Kono, T., Tong, X., Yamamoto, W. R., Zarain-Herzberg, A., Merrins, M. J., Satin, L. S., Gilon, P. & Evans-Molina, C., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32798-32810 13 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Homeobox Genes
Islets of Langerhans
Endoplasmic Reticulum
Calcium