Carmella Evans-Molina

  • 2585 Citations
  • 24 h-Index
20062020

Research output per year

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Publications

  • 2585 Citations
  • 24 h-Index
  • 57 Article
  • 16 Comment/debate
  • 16 Review article
  • 4 Letter
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Article

Abnormalities in proinsulin processing in islets from individuals with longstanding T1D

Sims, E. K., Syed, F., Nyalwidhe, J., Bahnson, H. T., Haataja, L., Speake, C., Morris, M. A., Balamurugan, A. N., Mirmira, R. G., Nadler, J., Mastracci, T. L., Arvan, P., Greenbaum, C. J. & Evans-Molina, C., Nov 2019, In : Translational Research. 213, p. 90-99 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

A case of calciphylaxis in a patient with hypoparathyroidism and normal renal function

Erdel, B. L., Juneja, R. & Evans-Molina, C., Jun 1 2014, In : Endocrine Practice. 20, 6, p. e102-e105

Research output: Contribution to journalArticle

6 Scopus citations

A case of extragastrointestinal stromal tumor complicated by severe hypoglycemia: A unique presentation of a rare tumor

Saeed, Z., Taleb, S. & Evans-Molina, C., Dec 1 2016, In : BMC Cancer. 16, 1, 930.

Research output: Contribution to journalArticle

2 Scopus citations

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes

Ocaña, G. J., Sims, E. K., Watkins, R. A., Ragg, S., Mather, K. J., Oram, R. A., Mirmira, R. G., DiMeglio, L. A., Blum, J. S. & Evans-Molina, C., Jan 2019, In : PloS one. 14, 1, e0208456.

Research output: Contribution to journalArticle

1 Scopus citations

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

Sturek, J. M., Castle, J. D., Trace, A. P., Page, L. C., Castle, A. M., Evans-Molina, C., Parks, J. S., Mirmira, R. G. & Hedrick, C. C., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2575-2589 15 p.

Research output: Contribution to journalArticle

90 Scopus citations

Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes

Type 1 Diabetes Trial Net and Diabetes Prevention Trial-Type-1 (DPT-1) Study Groups, Jun 2019, In : Pediatric Diabetes. 20, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

the Type 1 Diabetes TrialNet Study Group & the Immune Tolerance Network Study Group, Jan 1 2019, In : Diabetologia. 62, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

CD40 promotes mhc class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity

Morris, D. L., Oatmen, K. E., Mergian, T. A., Cho, K. W., Delproposto, J. L., Singer, K., Evans-Molina, C., O’Rourke, R. W. & Lumeng, C. N., Jun 2016, In : Journal of Leukocyte Biology. 99, 6, p. 1107-1119 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Hatanaka, M., Anderson-Baucum, E., Lakhter, A., Kono, T., Maier, B., Tersey, S. A., Tanizawa, Y., Evans-Molina, C., Mirmira, R. G. & Sims, E. K., Dec 1 2017, In : Scientific reports. 7, 1, 3758.

Research output: Contribution to journalArticle

4 Scopus citations

Divergent compensatory responses to high-fat diet between C57Bl6/J and c57BlKS/J inbred mouse strains

Sims, E. K., Hatanaka, M., Morris, D. L., Tersey, S. A., Kono, T., Chaudry, Z. Z., Day, K. H., Moss, D. R., Stull, N. D., Mirmira, R. G. & Evans-Molina, C., Dec 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 12, p. E1495-E1511

Research output: Contribution to journalArticle

20 Scopus citations

Dysglycemia and Index60 as prediagnostic end points for type 1 diabetes prevention trials

Nathan, B. M., Boulware, D., Geyer, S., Atkinson, M. A., Colman, P., Goland, R., Russell, W., Wentworth, J. M., Wilson, D. M., Evans-Molina, C., Wherrett, D., Skyler, J. S., Moran, A. & Sosenko, J. M., Nov 1 2017, In : Diabetes care. 40, 11, p. 1494-1499 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effect of oral insulin on prevention of diabetes in relatives of patients with type 1 diabetes: A randomized clinical trial

Writing Committee for the Type 1 Diabetes TrialNet Oral Insulin Study Group, Nov 21 2017, In : JAMA - Journal of the American Medical Association. 318, 19, p. 1891-1902 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Elevations in circulating methylated and unmethylated preproinsulin DNA in new-onset type 1 diabetes

Fisher, M. M., Watkins, R. A., Blum, J., Evans-Molina, C., Chalasani, N., Dimeglio, L. A., Mather, K. J., Tersey, S. A. & Mirmira, R. G., Nov 2015, In : Diabetes. 64, 11, p. 3867-3872 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Elevations in the fasting serum Proinsulin-to-C-peptide ratio precede the onset of type 1 diabetes

Sims, E. K., Chaudhry, Z., Watkins, R., Syed, F., Blum, J., Ouyang, F., Perkins, S., Mirmira, R., Sosenko, J., DiMeglio, L. & Evans-Molina, C., Sep 1 2016, In : Diabetes Care. 39, 9, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic cell

Yamamoto, W. R., Bone, R. N., Sohn, P., Syed, F., Reissaus, C. A., Mosley, A. L., Wijeratne, A. B., True, J. D., Tong, X., Kono, T. & Evans-Molina, C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 1, p. 168-181 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Ferrara, C. T., Geyer, S. M., Liu, Y. F., Evans-Molina, C., Libman, I. M., Besser, R., Becker, D. J., Rodriguez, H., Moran, A., Gitelman, S. E. & Redondo, M. J., May 1 2017, In : Diabetes care. 40, 5, p. 698-701 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats

Blue, E. K., Ballman, K., Boyle, F., Oh, E., Kono, T., Quinney, S. K., Thurmond, D. C., Evans-Molina, C. & Haneline, L. S., Feb 11 2015, In : Pediatric Research. 77, 2, p. 316-325 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

From immunobiology to β-cell biology: The changing perspective on type 1 diabetes

Maganti, A., Evans-Molina, C. & Mirmira, R. G., Jan 1 2014, In : Islets. 6, 2, p. e28778-1-e28778-5 e28778.

Research output: Contribution to journalArticle

19 Scopus citations

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets

Evans-Molina, C., Garmey, J. C., Ketchum, R., Brayman, K. L., Deng, S. & Mirmira, R. G., Mar 1 2007, In : Diabetes. 56, 3, p. 827-835 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: Involvement of peroxisome proliferator-activated receptor γ signaling

So, W. Y., Cheng, Q., Chen, L., Evans-Molina, C., Xu, A., Lam, K. S. L. & Leung, P. S., Nov 1 2013, In : Diabetes. 62, 11, p. 3751-3759 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

HLA-DRB115:01-DQA101:02-DQB106:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression

Pugliese, A., Boulware, D., Yu, L., Babu, S., Steck, A. K., Becker, D., Rodriguez, H., Di Meglio, L., Evans-Molina, C., Harrison, L. C., Schatz, D., Palmer, J. P., Greenbaum, C., Eisenbarth, G. S. & Sosenko, J. M., Apr 2016, In : Diabetes. 65, 4, p. 1109-1119 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: Analysis of hASC-derived paracrine effectors

Kono, T. M., Sims, E. K., Moss, D. R., Yamamoto, W., Ahn, G., Diamond, J., Tong, X., Day, K. H., Territo, P. R., Hanenberg, H., Traktuev, D. O., March, K. L. & Evans-Molina, C., Jul 2014, In : STEM CELLS. 32, 7, p. 1831-1842 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell

Kono, T., Tong, X., Evans-Molina, C., Kono, T., Iida, H., Lee, C. C., Sohn, P., Gilon, P., Roe, M. W. & Evans-Molina, C., Nov 1 2018, In : Diabetes. 67, 11, p. 2293-2304 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α

Ocaña, G. J., Pérez, L., Guindon, L., Deffit, S. N., Evans-Molina, C., Thurmond, D. C. & Blum, J., 2017, (Accepted/In press) In : Immunology.

Research output: Contribution to journalArticle

5 Scopus citations

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

Tersey, S. A., Nishiki, Y., Templin, A. T., Cabrera, S. M., Stull, N. D., Colvin, S. C., Evans-Molina, C., Rickus, J. L., Maier, B. & Mirmira, R. G., Apr 1 2012, In : Diabetes. 61, 4, p. 818-827 10 p.

Research output: Contribution to journalArticle

173 Scopus citations

Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of Type 1 diabetes

Filgueiras, L. R., Brandt, S. L., Wang, S., Wang, Z., Morris, D. L., Evans-Molina, C., Mirmira, R. G., Jancar, S. & Serezani, C. H., Jan 27 2015, In : Science Signaling. 8, 361

Research output: Contribution to journalArticle

30 Scopus citations

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

Ogihara, T., Chuang, J. C., Vestermark, G. L., Garmey, J. C., Ketchum, R. J., Huang, X., Brayman, K. L., Thorner, M. O., Repa, J. J., Mirmira, R. G. & Evans-Molina, C., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5392-5404 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Loss of diurnal oscillatory rhythms in gut microbiota correlates with changes in circulating metabolites in type 2 diabetic db/db mice

Beli, E., Prabakaran, S., Krishnan, P., Evans-Molina, C. & Grant, M. B., Oct 2019, In : Nutrients. 11, 10, 2310.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation

Hylek, E. M., Evans-Molina, C., Shea, C., Henault, L. E. & Regan, S., May 1 2007, In : Circulation. 115, 21, p. 2689-2696 8 p.

Research output: Contribution to journalArticle

809 Scopus citations

MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells

Sims, E. K., Lakhter, A. J., Anderson-Baucum, E., Kono, T., Tong, X. & Evans-Molina, C., Jun 1 2017, In : Diabetologia. 60, 6, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
13 Scopus citations

Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway

Hatanaka, M., Maier, B., Sims, E. K., Templin, A. T., Kulkarni, R. N., Evans-Molina, C. & Mirmira, R. G., Oct 1 2014, In : Diabetes. 63, 10, p. 3404-3415 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell

Johnson, J. S., Kono, T., Tong, X., Yamamoto, W. R., Zarain-Herzberg, A., Merrins, M. J., Satin, L. S., Gilon, P. & Evans-Molina, C., Nov 21 2014, In : Journal of Biological Chemistry. 289, 47, p. 32798-32810 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Peroxisome proliferator-activated receptor γ activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure

Evans-Molina, C., Robbins, R. D., Kono, T., Tersey, S. A., Vestermark, G. L., Nunemaker, C. S., Garmey, J. C., Deering, T. G., Keller, S. R., Maier, B. & Mirmira, R. G., Apr 1 2009, In : Molecular and cellular biology. 29, 8, p. 2053-2067 15 p.

Research output: Contribution to journalArticle

94 Scopus citations

Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes

Neyman, A., Nelson, J., Tersey, S. A., Mirmira, R. G., Evans-Molina, C. & Sims, E. K., Jan 2019, In : Diabetes, Obesity and Metabolism. 21, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress

Kono, T., Ahn, G., Moss, D. R., Gann, L., Zarain-Herzberg, A., Nishiki, Y., Fueger, P. T., Ogihara, T. & Evans-Molina, C., Jan 1 2012, In : Molecular Endocrinology. 26, 2, p. 257-271 15 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations

Profiling of RNAs from human islet-derived exosomes in a model of type 1 diabetes

Krishnan, P., Syed, F., Kang, N. J., Mirmira, R. G. & Evans-Molina, C., Dec 1 2019, In : International journal of molecular sciences. 20, 23, 5903.

Research output: Contribution to journalArticle

Open Access

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

Watkins, R. A., Evans-Molina, C., Terrell, J. K., Day, K. H., Guindon, L., Restrepo, I. A., Mirmira, R., Blum, J. & DiMeglio, L., Feb 1 2016, In : Translational Research. 168, p. 96-106.e1

Research output: Contribution to journalArticle

26 Scopus citations

Proinsulin secretion is a persistent feature of type 1 diabetes

Sims, E. K., Bahnson, H. T., Nyalwidhe, J., Haataja, L., Davis, A. K., Speake, C., DiMeglio, L. A., Blum, J., Morris, M. A., Mirmira, R. G., Nadler, J., Mastracci, T. L., Marcovina, S., Qian, W. J., Yi, L., Swensen, A. C., Yip-Schneider, M., Schmidt, C. M., Considine, R. V., Arvan, P. & 2 others, Greenbaum, C. J. & Evans-Molina, C., Feb 1 2019, In : Diabetes care. 42, 2, p. 258-264 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy

Rajashekhar, G., Ramadan, A., Abburi, C., Callaghan, B., Traktuev, D. O., Evans-Molina, C., Maturi, R., Harris, A., Kern, T. S. & March, K. L., Jan 9 2014, In : PLoS ONE. 9, 1, e84671.

Research output: Contribution to journalArticle

44 Scopus citations

Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice

Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y., Prasad, R., Bhatwadekar, A., White, F. A., Townsend, S. D., Chan, L., Ryan, C. N., Morton, D., Moldovan, E. G., Chu, F. I., Oudit, G. Y., Derendorf, H., Adorini, L., Wang, X. X., Evans-Molina, C. & 7 others, Mirmira, R. G., Boulton, M. E., Yoder, M. C., Li, Q., Levi, M., Busik, J. V. & Grant, M. B., Sep 1 2018, In : Diabetes. 67, 9, p. 1867-1879 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1

Francis, J., Babu, D. A., Deering, T. G., Chakrabarti, S. K., Garmey, J. C., Evans-Molina, C., Taylor, D. G. & Mirmira, R. G., Dec 1 2006, In : Molecular Endocrinology. 20, 12, p. 3133-3145 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

SERCA2 deficiency impairs pancreatic β-cell function in response to diet-induced obesity

Tong, X., Kono, T., Anderson-Baucum, E. K., Yamamoto, W., Gilon, P., Lebeche, D., Day, R. N., Shull, G. E. & Evans-Molina, C., Oct 1 2016, In : Diabetes. 65, 10, p. 3039-3052 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss

Xu, G., Thielen, L. A., Chen, J., Grayson, T. B., Grimes, T., Bridges, S. L., Tse, H. M., Smith, B., Patel, R., Li, P., Evans-Molina, C., Ovalle, F. & Shalev, A., Oct 1 2019, In : American journal of physiology. Endocrinology and metabolism. 317, 4, p. E723-E730

Research output: Contribution to journalArticle

1 Scopus citations

SET7/9 enzyme regulates cytokine-induced expression of inducible nitric-oxide synthase through methylation of Lysine 4 at histone 3 in the islet β cell

Fujimaki, K., Ogihara, T., Morris, D. L., Oda, H., Iida, H., Fujitani, Y., Mirmira, R. G., Evans-Molina, C. & Watada, H., Jul 3 2015, In : Journal of Biological Chemistry. 290, 27, p. 16607-16618 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Shock wave lithotripsy targeting of the kidney and pancreas does not increase the severity of metabolic syndrome in a porcine model

Handa, R. K., Evan, A. P., Connors, B. A., Johnson, C. D., Liu, Z., Alloosh, M., Sturek, M., Evans-Molina, C., Mandeville, J. A., Gnessin, E. & Lingeman, J. E., Oct 1 2014, In : Journal of Urology. 192, 4, p. 1257-1265 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells

Xiong, X., Wang, G., Tao, R., Wu, P., Kono, T., Li, K., Ding, W. X., Tong, X., Tersey, S. A., Harris, R. A., Mirmira, R. G., Evans-Molina, C. & Dong, X. C., Jan 1 2016, In : Diabetologia. 59, 1, p. 151-160 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation

Gordon, H. M., Majithia, N., MacDonald, P. E., Fox, J. E. M., Sharma, P. R., Byrne, F. L., Hoehn, K. L., Evans-Molina, C., Langman, L., Brayman, K. L. & Nunemaker, C. S., Jun 1 2017, In : Endocrine. 56, 3, p. 528-537 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Streptozotocin is equally diabetogenic whether administered to fed or fasted mice

Chaudhry, Z. Z., Morris, D. L., Moss, D. R., Sims, E. K., Chiong, Y., Kono, T. & Evans-Molina, C., Dec 17 2013, In : Laboratory Animals. 47, 4, p. 257-265 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

Sosenko, J. M., Geyer, S., Skyler, J. S., Rafkin, L. E., Ismail, H. M., Libman, I. M., Liu, Y. F., DiMeglio, L. A., Evans-Molina, C. & Palmer, J. P., May 2018, In : Pediatric Diabetes. 19, 3, p. 403-409 7 p.

Research output: Contribution to journalArticle

7 Scopus citations