Chao-Hung Lee

  • 3564 Citations
  • 32 h-Index
1975 …2018
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Publications 1975 2017

  • 3564 Citations
  • 32 h-Index
  • 142 Article
  • 2 Chapter
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Article
2017
11 Citations (Scopus)

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells

Wang, L., Zhou, J., Yan, S., Lei, G., Lee, C-H. & Yin, X-M., Dec 1 2017, In : Scientific Reports. 7, 1, 12307.

Research output: Contribution to journalArticle

Hepatocytes
Ethanol
Ubiquitinated Proteins
Lipids
Liver
1 Citation (Scopus)

Mechanisms of action of vitamin D as supplemental therapy for Pneumocystis pneumonia

Lei, G. S., Zhang, C., Cheng, B. H. & Lee, C-H., Oct 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 10, e01226.

Research output: Contribution to journalArticle

Primaquine
Pneumocystis Pneumonia
Vitamin D
Sulfamethoxazole Drug Combination Trimethoprim
Cholecalciferol
2016
12 Citations (Scopus)

Regulation of Collagen V Expression and Epithelial-Mesenchymal Transition by miR-185 and miR-186 during Idiopathic Pulmonary Fibrosis

Lei, G. S., Kline, H. L., Lee, C. H., Wilkes, D. S. & Zhang, C., Sep 1 2016, In : American Journal of Pathology. 186, 9, p. 2310-2316 7 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Epithelial-Mesenchymal Transition
Collagen
Transforming Growth Factors
MicroRNAs
4 Citations (Scopus)

Vitamin D as supplemental therapy for Pneumocystis pneumonia

Lei, G. S., Zhang, C., Zimmerman, M. & Lee, C-H., Mar 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 3, p. 1289-1297 9 p.

Research output: Contribution to journalArticle

Primaquine
Pneumocystis Pneumonia
Cholecalciferol
Vitamin D
Sulfamethoxazole Drug Combination Trimethoprim
2015
6 Citations (Scopus)

Evaluation of two new enzyme immunoassay reagents for diagnosis of histoplasmosis in a cohort of clinically characterized patients

Zhang, C., Lei, G. S., Lee, C-H. & Hage, C., Jul 13 2015, In : Medical Mycology. 53, 8, p. 868-873 6 p.

Research output: Contribution to journalArticle

histoplasmosis
Histoplasmosis
analytical kits
enzyme immunoassays
Immunoenzyme Techniques
21 Citations (Scopus)

Myeloid-derived suppressor cells impair alveolar macrophages through PD-1 receptor ligation during Pneumocystis pneumonia

Lei, G. S., Zhang, C. & Lee, C-H., 2015, In : Infection and Immunity. 83, 2, p. 572-582 11 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Pneumocystis Pneumonia
Alveolar Macrophages
Ligation
Bone Marrow Cells
2014
24 Citations (Scopus)

(1-3)-Beta-D-glucan in association with lactate dehydrogenase as biomarkers of Pneumocystis pneumonia (PcP) in HIV-infected patients

Esteves, F., Lee, C-H., De Sousa, B., Badura, R., Seringa, M., Fernandes, C., Gaspar, J. F., Antunes, F. & Matos, O., 2014, In : European Journal of Clinical Microbiology and Infectious Diseases. 33, 7, p. 1173-1180 8 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
L-Lactate Dehydrogenase
beta-Glucans
Biomarkers
HIV
2013
13 Citations (Scopus)

All-Trans Retinoic Acid in Combination with Primaquine Clears Pneumocystis Infection

Lei, G. S., Zhang, C., Shao, S., Jung, H. W., Durant, P. J. & Lee, C-H., Jan 4 2013, In : PLoS One. 8, 1, e53479.

Research output: Contribution to journalArticle

Pneumocystis Infections
Primaquine
Pneumocystis
Pneumocystis Pneumonia
retinoic acid
2012
28 Citations (Scopus)

Accumulation of myeloid-derived suppressor cells in the lungs during Pneumocystis pneumonia

Zhang, C., Lei, G. S., Shao, S., Jung, H. W., Durant, P. J. & Lee, C-H., Oct 2012, In : Infection and Immunity. 80, 10, p. 3634-3641 8 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Bronchoalveolar Lavage Fluid
Lung
Pneumocystis
Arginase
2011
4 Citations (Scopus)

Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Liao, C. P., Hage, C., Durant, P. J., Tschang, D., Wang, S. H., Zhang, C. & Lee, C-H., Apr 1 2011, In : American Journal of Respiratory Cell and Molecular Biology. 44, 4, p. 540-547 8 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Nitric Oxide
Nitric Oxide Synthase Type II
Pneumocystis
2010
5 Citations (Scopus)

Airborne spread of Pneumocystis jirovecii

Bartlett, M. S. & Lee, C-H., Aug 1 2010, In : Clinical Infectious Diseases. 51, 3, p. 266 1 p.

Research output: Contribution to journalArticle

Air Microbiology
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
Preschool Children
16 Citations (Scopus)

Downregulation of PU.1 leads to decreased expression of dectin-1 in alveolar macrophages during Pneumocystis pneumonia

Zhang, C., Wang, S. H., Liao, C. P., Shao, S., Lasbury, M. E., Durant, P. J. & Lee, C-H., Mar 2010, In : Infection and Immunity. 78, 3, p. 1058-1065 8 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Down-Regulation
Pneumocystis
Luciferases
9 Citations (Scopus)

Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages

Cheng, B. H., Liu, Y., Xuei, X., Liao, C. P., Lu, D., Lasbury, M. E., Durant, P. J. & Lee, C-H., 2010, In : BMC Microbiology. 10, 103.

Research output: Contribution to journalArticle

Pneumocystis Infections
Alveolar Macrophages
Pneumocystis
Gene Expression
Pneumocystis Pneumonia
46 Citations (Scopus)

Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages

Petrusca, D., Gu, Y., Adamowicz, J. J., Rush, N. I., Hubbard, W. C., Smith, P. A., Berdyshev, E. V., Birukov, K. G., Lee, C-H., Tuder, R. M., Twigg, H., Vandivier, R. W. & Petrache, I., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 40322-40332 11 p.

Research output: Contribution to journalArticle

Sphingolipids
Ceramides
Alveolar Macrophages
Cells
Sphingosine
2009
6 Citations (Scopus)

Effects of decreased calmodulin protein on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Liao, C. P. & Lee, C-H., Aug 2009, In : Infection and Immunity. 77, 8, p. 3344-3354 11 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Calmodulin
1-Phosphatidylinositol 4-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
19 Citations (Scopus)

Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages

Liao, C. P., Lasbury, M. E., Wang, S. H., Zhang, C., Durant, P. J., Murakami, Y., Matsufuji, S. & Lee, C-H., Mar 20 2009, In : Journal of Biological Chemistry. 284, 12, p. 8174-8184 11 p.

Research output: Contribution to journalArticle

Pneumocystis
Alveolar Macrophages
Polyamines
Pneumocystis Pneumonia
Apoptosis
6 Citations (Scopus)

Polyamine transport as a target for treatment of Pneumocystis pneumonia

Liao, C. P., Phanstiel IV, O., Lasbury, M. E., Zhang, C., Shao, S., Durant, P. J., Cheng, B. H. & Lee, C-H., Dec 2009, In : Antimicrobial Agents and Chemotherapy. 53, 12, p. 5259-5264 6 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Polyamines
Ants
Alveolar Macrophages
Diamines
2008
17 Citations (Scopus)

Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia

Wang, S. H., Zhang, C., Lasbury, M. E., Liao, C. P., Durant, P. J., Tschang, D. & Lee, C-H., Apr 2008, In : Microbes and Infection. 10, 4, p. 334-341 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Pneumocystis Pneumonia
Knockout Mice
Pneumocystis
Lung
21 Citations (Scopus)

Pneumocystis pneumonia

Lu, J. J. & Lee, C-H., Nov 2008, In : Journal of the Formosan Medical Association. 107, 11, p. 830-842 13 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Pneumocystis carinii
Alveolar Macrophages
rRNA Genes
Polymerase Chain Reaction
2007
31 Citations (Scopus)

Polyamine-mediated apoptosis of alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Merali, S., Durant, P. J., Tschang, D., Ray, C. A. & Lee, C-H., Apr 13 2007, In : Journal of Biological Chemistry. 282, 15, p. 11009-11020 12 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Polyamines
Bronchoalveolar Lavage Fluid
Apoptosis
2006
1 Citation (Scopus)

Alterations in surfactant protein A form and clearance during Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Animal Disease Models
Pneumocystis Pneumonia
pneumonia
respiratory disease
1 Citation (Scopus)

Caspase-9 as a target for Pneumocystis pneumonia therapy

Lasbury, M. E., Wang, S. H., Zhang, C., Liao, C. P., Durant, P. J., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Caspase 10
Pneumocystis
Pneumocystis Pneumonia
pneumonia
respiratory disease
1 Citation (Scopus)

Expression and activation of complement protein and alveolar damage during pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Tschang, D., Wang, S. H., Zhang, C., Liao, C. P. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pulmonary Alveoli
Complement C5a
Pneumocystis
Animal Disease Models
Complement C3
2 Citations (Scopus)

GM-CSF expression in the lung during Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Animal Disease Models
Pneumocystis Pneumonia
pneumonia
respiratory disease
Bronchoalveolar Lavage Fluid
2 Citations (Scopus)

Inflammatory cells are sources of polyamines that induce alveolar macrophage to undergo apoptosis during Pneumocystis pneumonia

Liao, C. P., Lasbury, M. E., Wang, S. H., Zhang, C., Durant, P. J., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Pneumocystis Pneumonia
Ornithine Decarboxylase
pneumonia
36 Citations (Scopus)

Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Ray, C. A., Tschang, D., Schwendener, R. & Lee, C-H., Jun 1 2006, In : Journal of Immunology. 176, 11, p. 6443-6453 11 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Caspase Inhibitors
Caspase 9
Apoptosis
1 Citation (Scopus)

Survival pathway signal transduction is reduced in alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Ray, C. A., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Animal Disease Models
Proto-Oncogene Proteins c-akt
Pneumocystis Pneumonia
pneumonia
2 Citations (Scopus)

Syndecan-1 expression in the lung during Pneumocystis infection

Wang, S. H., Zhang, C., Liao, C. P., Lasbury, M. E., Durant, P. J., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Matrix Metalloproteinase 12
Syndecan-1
Pneumocystis Infections
Matrix Metalloproteinase 14
Animal Disease Models
5 Citations (Scopus)

Toll-like receptor 2 knockout reduces lung inflammation during Pneumocystis pneumonia but has no effect on phagocytosis of Pneumocystis organisms by alveolar macrophages

Zhang, C., Wang, S. H., Liao, C. P., Lasbury, M. E., Durant, P. J., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Toll-Like Receptor 2
Histocytochemistry
Pneumocystis Pneumonia
51 Citations (Scopus)

Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina

Zhang, C., Wang, S. H., Lasbury, M. E., Tschang, D., Liao, C. P., Durant, P. J. & Lee, C-H., Mar 2006, In : Infection and Immunity. 74, 3, p. 1857-1864 8 p.

Research output: Contribution to journalArticle

Pneumocystis
Murinae
Toll-Like Receptor 2
Alveolar Macrophages
Chemokine CXCL2
3 Citations (Scopus)

Transforming growth factor-β activation and signaling in the alveolar environment during Pneumocystis pneumonia

Ray, C. A., Lasbury, M. E., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C-H., Nov 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Smad Proteins
Animal Disease Models
Pneumocystis Pneumonia
pneumonia
respiratory disease
2005
49 Citations (Scopus)

Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells

Lee, J. C., Lee, C-H., Su, C. L., Huang, C. W., Lin, C. N. & Won, S. J., Oct 2005, In : Carcinogenesis. 26, 10, p. 1716-1730 15 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Apoptosis
Mitochondria
HT29 Cells
Justicia
2004
21 Citations (Scopus)

Effect of Bronchoalveolar Lavage Fluid from Pneumocystis carinii-Infected Hosts on Phagocytic Activity of Alveolar Macrophages

Lasbury, M. E., Lin, P., Tschang, D., Durant, P. J. & Lee, C-H., Apr 2004, In : Infection and Immunity. 72, 4, p. 2140-2147 8 p.

Research output: Contribution to journalArticle

Pneumocystis carinii
Bronchoalveolar Lavage Fluid
Alveolar Macrophages
Phagocytosis
Concanavalin A
2003
42 Citations (Scopus)

Correlation of organism burden and alveolar macrophage counts during infection with Pneumocystis carinii and recovery

Lasbury, M. E., Durant, P. J., Bartlett, M. S., Smith, J. W. & Lee, C-H., Mar 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 2, p. 293-302 10 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Alveolar Macrophages
Pneumocystis carinii
Recovery
Rats
4 Citations (Scopus)

Decrease in Alveolar Macrophage Number during Pneumocystis carinii Infection

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 630-631 2 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Animal Disease Models
Pneumocystis Pneumonia
Macrophage Activation
apoptosis
42 Citations (Scopus)

Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts

Lasbury, M. E., Tang, X., Durant, P. J. & Lee, C-H., Sep 1 2003, In : Infection and Immunity. 71, 9, p. 4943-4952 10 p.

Research output: Contribution to journalArticle

GATA2 Transcription Factor
Pneumocystis carinii
Alveolar Macrophages
Phagocytosis
Fluorescein

Environmental Stress and Encystment of Pneumocystis carinii

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 632-633 2 p.

Research output: Contribution to journalArticle

encystment
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
environmental stress
1 Citation (Scopus)

Inducible Nitric Oxide Synthase Expression in Pneumocystis carinii Pneumonia

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 634-635 2 p.

Research output: Contribution to journalArticle

Genetic Transcription
Animal Disease Models
Pneumocystis Pneumonia
pneumonia
Bronchoalveolar Lavage Fluid

Life Cycle Stage-Specific and Encystment Protein Profiles in Pneumocystis carinii

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 636 1 p.

Research output: Contribution to journalArticle

encystment
Pneumocystis carinii
Pneumocystis Pneumonia
Fungal Proteins
Life Cycle Stages
5 Citations (Scopus)

Numbers of Alveolar Macrophages are Increased during Pneumocystis Pneumonia in Mice

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 637-638 2 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
pneumonia
1 Citation (Scopus)

Pneumocystis carinii Cyst is Associated with Inflammation in the Host

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 639-640 2 p.

Research output: Contribution to journalArticle

Bronchogenic Cyst
Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
Immunosuppressive Agents

Pneumocystis carinii Factor Responsible for Reduced Phagocytic Activity in Alveolar Macrophages

Lasbury, M. E., Lin, P. M., Tschang, D., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 641-642 2 p.

Research output: Contribution to journalArticle

Animal Disease Models
Pneumocystis carinii
Pneumocystis Pneumonia
Bronchoalveolar Lavage Fluid
Alveolar Macrophages
21 Citations (Scopus)

Pneumocystis jiroveci in Portuguese immunocompromised patients: Association of specific ITS genotypes with treatment failure, bad clinical outcome and childhood

Matos, O., Lee, C-H., Jin, S., Li, B., Costa, M. C., Gonçalves, L. & Antunes, F., Nov 2003, In : Infection, Genetics and Evolution. 3, 4, p. 281-285 5 p.

Research output: Contribution to journalArticle

Dihydropteroate Synthase
Pneumocystis carinii
PCP
Immunocompromised Host
Treatment Failure

Transcriptional Changes in Alveolar Macrophages during Pneumocystis Pneumonia

Lee, C-H., Lasbury, M. E., Xuei, X., Jerome, R. E., Edenberg, H., Lu, D., Durant, P. J. & Tschang, D., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 645 1 p.

Research output: Contribution to journalArticle

Genetic Transcription
Nucleic Acid Hybridization
Animal Disease Models
Pneumocystis Pneumonia
pneumonia
1 Citation (Scopus)

Transtracheal Inoculation of Pneumocystis carinii in Immunocompetent Animals

Lasbury, M. E., Durant, P. J. & Lee, C-H., Nov 2003, In : Journal of Eukaryotic Microbiology. 50, SUPPL., p. 643-644 2 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Pneumocystis Infections
Histamine H1 Antagonists
immunocompetence
Immunocompetence
2002

Cleavase fragment length polymorphism analysis for genotyping and mutation detection.

Heisler, L. & Lee, C-H., 2002, In : Methods in molecular biology (Clifton, N.J.). 187, p. 165-178 14 p.

Research output: Contribution to journalArticle

Endodeoxyribonucleases
Fungal DNA
Pneumocystis
Nucleic Acid Conformation
Fluorescence Spectrometry
9 Citations (Scopus)

Evidence for the requirement of T cell costimulation in the pathogenesis of natural Pneumocystis carinii pulmonary infection

Baumgartner, R. E., Durant, P. J., Van Gessel, Y., Chattopadhyay, S., Beswick, R. L., Tadaki, D. K., Lasbury, M. E., Lee, C-H., Perrin, P. J. & Lee, K. P., 2002, In : Microbial Pathogenesis. 33, 5, p. 193-201 9 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Pneumocystis Pneumonia
T-Lymphocytes
Lung
Knockout Mice
2001
1 Citation (Scopus)

Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.

Asnicar, M. A., Henegariu, O., Shaw, M. M., Goheen, M. P., Bartlett, M. S., Smith, J. W. & Lee, C-H., 2001, In : BMC Microbiology. 1, 1, p. 8 1 p.

Research output: Contribution to journalArticle

Pneumocystis Infections
Adenosine Triphosphatases
Genes
Alveolar Epithelial Cells
Lung
3 Citations (Scopus)
Pneumocystis
Pneumocystis carinii
Pneumocystis Pneumonia
Bronchoalveolar Lavage Fluid
Alveolar Macrophages

Changes in alveolar macrophage number are early events in Pneumocystis carinii infection

Lasbury, M. E., Durant, P. J. & Lee, C-H., 2001, In : Journal of Eukaryotic Microbiology. 48, SUPPL.

Research output: Contribution to journalArticle

Severity of Illness Index
Pneumocystis
Pneumocystis Infections
immunocompetence
Immunocompetence