Chunhai Hao

  • 5265 Citations
  • 40 h-Index
19902014

Research output per year

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Publications

2014

Immunohistochemical demonstration of isocitrate dehydrogenase 1 (IDH1) mutation in a small subset of prostatic carcinomas

Mauzo, S. H., Lee, M., Petros, J., Hunter, S., Chang, C. M., Shu, H. K., Bellail, A. C., Hao, C. & Cohen, C., Apr 2014, In : Applied Immunohistochemistry and Molecular Morphology. 22, 4, p. 284-287 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
Open Access
20 Scopus citations

Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy

Willie, J. T., Laxpati, N. G., Drane, D. L., Gowda, A., Appin, C., Hao, C., Brat, D. J., Helmers, S. L., Saindane, A., Nour, S. G. & Gross, R. E., Jun 2014, In : Neurosurgery. 74, 6, p. 569-584 16 p.

Research output: Contribution to journalArticle

Open Access
178 Scopus citations

SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression

Bellail, A. C., Olson, J. J. & Hao, C., Jun 23 2014, In : Nature communications. 5, 4234.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
2013

Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma

Wang, Q., Wei, F., Li, C., Lv, G., Wang, G., Liu, T., Bellail, A. C. & Hao, C., Aug 22 2013, In : PLoS ONE. 8, 8, e73175.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Glioblastoma with oligodendroglioma component (GBM-O): Molecular genetic and clinical characteristics

Appin, C. L., Gao, J., Chisolm, C., Torian, M., Alexis, D., Vincentelli, C., Schniederjan, M. J., Hadjipanayis, C., Olson, J. J., Hunter, S., Hao, C. & Brat, D. J., Jul 1 2013, In : Brain Pathology. 23, 4, p. 454-461 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis

Shu, H. K. G., Yoon, Y., Hong, S., Xu, K., Gao, H., Hao, C., Torres-Gonzalez, E., Nayra, C., Rojas, M. & Shim, H., Nov 7 2013, In : PloS one. 8, 11, e79768.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin

Wang, Q., Wei, F., Lv, G., Li, C., Liu, T., Hadjipanayis, C. G., Zhang, G., Hao, C. & Bellail, A. C., Nov 4 2013, In : BMC Cancer. 13, 521.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2012

A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma

Bellail, A. C., Olson, J. J., Yang, X., Chen, Z. J. & Hao, C., Feb 2012, In : Cancer Discovery. 2, 2, p. 140-155 16 p.

Research output: Contribution to journalArticle

Open Access
77 Scopus citations

K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas

Wei, F., Liu, Y., Bellail, A. C., Olson, J. J., Sun, S. Y., Lu, G., Ding, L., Yuan, C., Wang, G. & Hao, C., Sep 1 2012, In : Cancer Letters. 322, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

RNAi-mediated targeting of noncoding and coding sequences in DNA repair gene messages efficiently radiosensitizes human tumor cells

Zheng, Z., Ng, W. L., Zhang, X., Olson, J. J., Hao, C., Curran, W. J. & Wang, Y., Mar 1 2012, In : Cancer Research. 72, 5, p. 1221-1228 8 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells

Li, B., Gao, S., Wei, F., Bellail, A. C., Hao, C. & Liu, T., Jul 1 2012, In : Oncology reports. 28, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

The roadmap of TRAIL apoptotic pathway-targeted cancer therapies: What is next?

Bellail, A. C. & Hao, C., May 1 2012, In : Expert Review of Anticancer Therapy. 12, 5, p. 547-549 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

TRAIL apoptotic pathway-targeted therapies for NSCLC

Bellail, A. & Hao, C., Jan 1 2012, In : Translational Lung Cancer Research. 1, 2, p. 155-157 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2011

Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3

Chen, S., Cao, W., Yue, P., Hao, C., Khuri, F. R. & Sun, S. Y., Oct 1 2011, In : Cancer Research. 71, 19, p. 6270-6281 12 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-flip

Ding, L., Yuan, C., Wei, F., Wang, G., Zhang, J., Bellail, A. C., Zhang, Z., Olson, J. J. & Hao, C., Oct 1 2011, In : Cancer Investigation. 29, 8, p. 511-520 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis

Qi, L., Bellail, A. C., Rossi, M. R., Zhang, Z., Pang, H., Hunter, S., Cohen, C., Moreno, C. S., Olson, J. J., Li, S. & Hao, C., Nov 1 2011, In : Apoptosis. 16, 11, p. 1150-1164 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex

Chan, C. B., Liu, X., Pradoldej, S., Hao, C., An, J., Yepes, M., Luo, H. R. & Ye, K., Jun 1 2011, In : Journal of Neuroscience. 31, 22, p. 8083-8092 10 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment

Lu, J., McEachern, D., Sun, H., Bai, L., Peng, Y., Qiu, S., Miller, R., Liao, J., Yi, H., Liu, M., Bellail, A., Hao, C., Sun, S. Y., Ting, A. T. & Wang, S., May 2011, In : Molecular cancer therapeutics. 10, 5, p. 902-914 13 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations
2010

DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas

Bellail, A. C., Tse, M. C. L., Song, J. H., Phuphanich, S., Olson, J. J., Sun, S. Y. & Hao, C., Jun 2010, In : Journal of Cellular and Molecular Medicine. 14, 6 A, p. 1303-1317 15 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations

Full scope of options

Hadjipanayis, C. G., Schuette, A. J., Boulis, N., Hao, C., Barrow, D. L. & Teo, C., Jul 2010, In : Neurosurgery. 67, 1, p. 197-203 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synergistic effect of celecoxib on TRAIL-induced apoptosis in hepatocellular carcinoma cells

Lu, G., Liu, Y., Ji, B., Wei, F., Hao, C. & Wang, G., Jun 2010, In : Cancer Investigation. 28, 6, p. 629-634 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation

Yan, D., Ng, W. L., Zhang, X., Wang, P., Zhang, Z., Mo, Y. Y., Mao, H., Hao, C., Olson, J. J., Curran, W. J. & Wang, Y., 2010, In : PloS one. 5, 7, e11397.

Research output: Contribution to journalArticle

Open Access
157 Scopus citations

Th1 and Th2 immune response in chronic hepatitis B patients during a long-term treatment with adefovir dipivoxil

Jiang, Y., Ma, Z., Xin, G., Yan, H., Li, W., Xu, H., Hao, C., Niu, J. & Zhao, P., Dec 1 2010, In : Mediators of Inflammation. 2010, 143026.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations
2009

Erratum: Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome (Proceedings of the National Academy of Sciences of the United States of America (2009) 13:2 (468-473))

Chan, C. B., Abe, M., Hashimoto, N., Hao, C., Williams, I. R., Liu, X., Nakao, S., Yamamoto, A., Zheng, C., Henter, J. I., Meeths, M., Nordenskjold, M., Li, S. Y., Hara-Nishimura, I., Asano, M. & Ye, K., Apr 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 14, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

Chan, C. B., Abe, M., Hashimoto, N., Hao, C., Williams, I. R., Liu, X., Nakao, S., Yamamoto, A., Li, S. Y., Hara-Nishimura, I., Asano, M. & Ye, K., Jan 13 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 2, p. 468-473 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Targeted quantitative mass spectrometric identification of differentially expressed proteins between bax-expressing and deficient colorectal carcinoma cells

Wang, P., Lo, A., Young, J. B., Song, J. H., Lai, R., Kneteman, N. M., Hao, C. & Li, A., Jul 6 2009, In : Journal of Proteome Research. 8, 7, p. 3403-3414 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

TRAIL agonists on clinical trials for cancer therapy: The promises and the challenges

Bellail, A. C., Qi, L., Mulligan, P., Chhabra, V. & Hao, C., May 11 2009, In : Reviews on Recent Clinical Trials. 4, 1, p. 34-41 8 p.

Research output: Contribution to journalReview article

139 Scopus citations
2008

Corrigendum to "Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells" [Cell Sig. 19 (11) (2007) 2237] (DOI:10.1016/j.cellsig.2007.06.001)

Wang, P., Zhang, J., Bellail, A., Jiang, W., Hugh, J., Kneteman, N. M. & Hao, C., Jan 1 2008, In : Cellular Signalling. 20, 1, 1 p.

Research output: Contribution to journalComment/debate

Electrosonic ejector microarray for drug and gene delivery

Zarnitsyn, V. G., Meacham, J. M., Varady, M. J., Hao, C., Degertekin, F. L. & Fedorov, A. G., Apr 1 2008, In : Biomedical Microdevices. 10, 2, p. 299-308 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2007

Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells

Wang, P., Zhang, J., Bellail, A., Jiang, W., Hugh, J., Kneteman, N. M. & Hao, C., Nov 2007, In : Cellular Signalling. 19, 11, p. 2237-2246 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Lipid rafts and nonrafts mediate tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic and nonapoptotic signals in non-small cell lung carcinoma cells

Song, J. H., Tse, M. C. L., Bellail, A., Phuphanich, S., Khuri, F., Kneteman, N. M. & Hao, C., Jul 15 2007, In : Cancer Research. 67, 14, p. 6946-6955 10 p.

Research output: Contribution to journalArticle

Open Access
110 Scopus citations

PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion

Liu, X., Hu, Y., Hao, C., Rempel, S. A. & Ye, K., Jul 26 2007, In : Oncogene. 26, 34, p. 4918-4927 10 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
2006

Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2

Wang, C. X., Song, J. H., Song, D. K., Yong, V. W., Shuaib, A. & Hao, C., Jul 1 2006, In : Cell Death and Differentiation. 13, 7, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy

Li, Y. C., Tzeng, C. C., Song, J. H., Tsia, F. J., Hsieh, L. J., Liao, S. J., Tsai, C. H., Van Meir, E. G., Hao, C. & Lin, C. C., May 1 2006, In : Clinical Cancer Research. 12, 9, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Human astrocytes are resistant to fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis

Song, J. H., Bellail, A., Tse, M. C. L., Yong, V. W. & Hao, C., Mar 22 2006, In : Journal of Neuroscience. 26, 12, p. 3299-3308 10 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis

Wang, P., Song, J. H., Song, D. K., Zhang, J. & Hao, C., Sep 1 2006, In : Cellular Signalling. 18, 9, p. 1528-1535 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Technical hurdles in a pilot clinical trial of combined B7-2 and GM-CSF immunogene therapy for glioblastomas and melanomas

Parney, I. F., Chang, L. J., Farr-Jones, M. A., Hao, C., Smylie, M. & Petruk, K. C., May 1 2006, In : Journal of Neuro-Oncology. 78, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2005

Apolipoprotein E ε4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: Relationship to dementia and hallucinations

Camicioli, R., Rajput, A., Rajput, M., Reece, C., Payami, H., Hao, C. & Rajput, A., Aug 1 2005, In : Movement Disorders. 20, 8, p. 989-994 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis

Xiao, C., Yang, B. F., Song, J. H., Schulman, H., Li, L. & Hao, C., Mar 10 2005, In : Experimental Cell Research. 304, 1, p. 244-255 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Interferon γ induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway

Song, J. H., Chen, X. W., Song, D. K., Wang, P., Shuaib, A. & Hao, C., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 12896-12901 6 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations

Saphenous vein harvest with SaphLITE system versus conventional technique: A prospective, randomized study

Wang, S., Tang, H., Wilkinson, V., Lukat, T., Gelfand, E. T., Koshal, A., Modry, D. L., Mullen, J. C., Hao, C. & Finegan, B. A., Jun 1 2005, In : Annals of Thoracic Surgery. 79, 6, p. 2018-2023 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2

Alladina, S. J., Song, J. H., Davidge, S. T., Hao, C. & Easton, A. S., Jul 1 2005, In : Journal of Vascular Research. 42, 4, p. 337-347 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2004

Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: A prospective randomized clinical trial

Roa, W., Brasher, P. M. A., Bauman, G., Anthes, M., Bruera, E., Chan, A., Fisher, B., Fulton, D., Gulavita, S., Hao, C., Husain, S., Murtha, A., Petruk, K., Stewart, D., Tai, P., Urtasun, R., Cairncross, J. G. & Forsyth, P., 2004, In : Journal of Clinical Oncology. 22, 9, p. 1583-1588 6 p.

Research output: Contribution to journalArticle

525 Scopus citations

Extratemporal resection for childhood epilepsy

Sinclair, D. B., Aronyk, K., Snyder, T., McKean, J. D. S., Wheatley, M., Gross, D., Bastos, A., Ahmed, S. N., Hao, C. & Colmers, W., Mar 2004, In : Pediatric Neurology. 30, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Modulation of TRAIL Signaling Complex

Hao, C., Song, J. H., Vilimanovich, U. & Kneteman, N. M., Dec 1 2004, TRAIL (TNF-Related Apoptosis-Inducing Ligand). p. 81-99 19 p. (Vitamins and Hormones; vol. 67).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice

Hao, C., Song, J. H., Hsi, B., Lewis, J., Song, D. K., Petruk, K. C., Tyrrell, D. L. J. & Kneteman, N. M., Dec 1 2004, In : Cancer Research. 64, 23, p. 8502-8506 5 p.

Research output: Contribution to journalArticle

Open Access
123 Scopus citations
2003

Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells

Yang, B. F., Xiao, C., Roa, W. H., Krammer, P. H. & Hao, C., Feb 28 2003, In : Journal of Biological Chemistry. 278, 9, p. 7043-7050 8 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations