Claire Walczak

  • 6552 Citations
  • 38 h-Index
1993 …2020

Research output per year

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Publications

2020

In vitro FRET- and fluorescence-based assays to study protein conformation and protein-protein interactions in mitosis

Ems-McClung, S. C. & Walczak, C. E., 2020, Methods in Molecular Biology. Humana Press Inc., p. 93-122 30 p. (Methods in Molecular Biology; vol. 2101).

Research output: Chapter in Book/Report/Conference proceedingChapter

RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking

Ems-McClung, S. C., Emch, M., Zhang, S., Mahnoor, S., Weaver, L. N. & Walczak, C. E., Feb 3 2020, In : Journal of Cell Biology. 219, 2

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

A Cyclin A—Myb-MuvB—Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles

Rotelli, M. D., Policastro, R. A., Bolling, A. M., Killion, A. W., Weinberg, A. J., Dixon, M. J., Zentner, G. E., Walczak, C. E., Lilly, M. A. & Calvi, B. R., Jul 2019, In : PLoS Genetics. 15, 7, e1008253.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Cell Division: Tailoring a Swiftly Scaling Spindle

Hartsough, K. E. & Walczak, C. E., Nov 4 2019, In : Current Biology. 29, 21, p. R1135-R1137

Research output: Contribution to journalShort survey

Emerging insights into the function of kinesin-8 proteins in microtubule length regulation

Shrestha, S., Hazelbaker, M., Yount, A. L. & Walczak, C. E., Jan 1 2019, In : Biomolecules. 9, 1, 1.

Research output: Contribution to journalReview article

5 Scopus citations

Self-straining of actively crosslinked microtubule networks

Fürthauer, S., Lemma, B., Foster, P. J., Ems-McClung, S. C., Yu, C. H., Walczak, C. E., Dogic, Z., Needleman, D. J. & Shelley, M. J., Dec 1 2019, In : Nature Physics. 15, 12, p. 1295-1300 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Aurora A activation in mitosis promoted by BuGZ

Huang, Y., Li, T., Ems-McClung, S. C., Walczak, C. E., Prigent, C., Zhu, X., Zhang, X. & Zheng, Y., Jan 1 2018, In : Journal of Cell Biology. 217, 1, p. 107-116 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Spatial regulation of astral microtubule dynamics by Kif18B in PtK cells

Walczak, C. E., Zong, H., Jain, S. & Stout, J. R., Oct 15 2016, In : Molecular Biology of the Cell. 27, 20, p. 3021-3030 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

The far C-terminus of MCAK regulates its conformation and spindle pole focusing

Zong, H., Carnes, S. K., Moe, C., Walczak, C. E. & Ems-McClung, S. C., May 1 2016, In : Molecular Biology of the Cell. 27, 9, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

Chen, S., Stout, J. R., Dharmaiah, S., Yde, S., Calvi, B. R. & Walczak, C. E., Oct 1 2016, In : Molecular Biology of the Cell. 27, 19, p. 2911-2923 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients

Pannu, V., Rida, P. C. G., Ogden, A., Turaga, R. C., Donthamsetty, S., Bowen, N. J., Rudd, K., Gupta, M. V., Reid, M. D., Cantuaria, G., Walczak, C. E. & Aneja, R., 2015, In : Oncotarget. 6, 8, p. 6076-6091 16 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Regulatory mechanisms that control mitotic kinesins

Yount, A. L., Zong, H. & Walczak, C. E., May 15 2015, In : Experimental Cell Research. 334, 1, p. 70-77 8 p.

Research output: Contribution to journalReview article

21 Scopus citations

Spatial gradients controlling spindle assembly

Weaver, L. N. & Walczak, C. E., Feb 1 2015, In : Biochemical Society Transactions. 43, p. 7-12 6 p., 0430007.

Research output: Contribution to journalArticle

7 Scopus citations

The kinesin superfamily

Verhey, K. J., Cochran, J. C. & Walczak, C., Jan 1 2015, Kinesins and Cancer. Sense Publishers, p. 1-26 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

The Ran-GTP gradient spatially regulates XCTK2 in the spindle

Weaver, L. N., Ems-Mcclung, S. C., Chen, S. H. R., Yang, G., Shaw, S. L. & Walczak, C. E., Jun 1 2015, In : Current Biology. 25, 11, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association

Ems-Mcclung, S. C., Hainline, S. G., Devare, J., Zong, H., Cai, S., Carnes, S. K., Shaw, S. L. & Walczak, C. E., Dec 16 2013, In : Current Biology. 23, 24, p. 2491-2499 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H. A., Copenhaver, G. P., Deluca, J. G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J. & 37 others, Harrison, S. C., Heun, P., Hirota, T., Jansen, L. E. T., Karpen, G., Kops, G. J. P. L., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D., Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K. & Cleveland, D. W., Apr 2013, In : Chromosome Research. 21, 2, p. 101-106 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK

Huang, R., Oh, H., Arrendale, A., Martin, V. A., Galan, J., Workman, E. J., Stout, J. R., Walczak, C. E., Tao, W. A., Borch, R. F. & Geahlen, R. L., Jan 1 2013, In : Biochemical Pharmacology. 86, 5, p. 597-611 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Microtubule-depolymerizing kinesins

Walczak, C. E., Gayek, S. & Ohi, R., Oct 1 2013, In : Annual Review of Cell and Developmental Biology. 29, p. 417-441 25 p.

Research output: Contribution to journalReview article

86 Scopus citations
2011

A decade of molecular cell biology: Achievements and challenges

Akhtar, A., Fuchs, E., Mitchison, T., Shaw, R. J., St Johnston, D., Strasser, A., Taylor, S., Walczak, C. & Zerial, M., Oct 1 2011, In : Nature Reviews Molecular Cell Biology. 12, 10, p. 669-674 6 p.

Research output: Contribution to journalReview article

13 Scopus citations

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors

Borysov, S. I., Granic, A., Padmanabhan, J., Walczak, C. E. & Potter, H., May 1 2011, In : Cell Cycle. 10, 9, p. 1397-1410 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation

Weaver, L. N., Ems-McClung, S. C., Stout, J. R., Leblanc, C., Shaw, S. L., Gardner, M. K. & Walczak, C. E., Sep 13 2011, In : Current Biology. 21, 17, p. 1500-1506 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Kif18B interacts with EB1 and controls astral microtubule length during mitosis

Stout, J. R., Yount, A. L., Powers, J. A., LeBlanc, C., Ems-McClung, S. C. & Walczak, C. E., Sep 1 2011, In : Molecular Biology of the Cell. 22, 17, p. 3070-3080 11 p.

Research output: Contribution to journalArticle

58 Scopus citations
2010

A MAP for bundling microtubules

Walczak, C. E. & Shaw, S. L., Aug 1 2010, In : Cell. 142, 3, p. 364-367 4 p.

Research output: Contribution to journalShort survey

42 Scopus citations

Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules

Ems-McClung, S. C. & Walczak, C. E., May 2010, In : Seminars in Cell and Developmental Biology. 21, 3, p. 276-282 7 p.

Research output: Contribution to journalReview article

88 Scopus citations

Mechanisms of chromosome behaviour during mitosis

Walczak, C. E., Cai, S. & Khodjakov, A., Feb 2010, In : Nature Reviews Molecular Cell Biology. 11, 2, p. 91-102 12 p.

Research output: Contribution to journalReview article

147 Scopus citations

Proper Organization of Microtubule Minus Ends Is Needed for Midzone Stability and Cytokinesis

Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E., May 11 2010, In : Current Biology. 20, 9, p. 880-885 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

The Use of Fluorescence Redistribution After Photobleaching for Analysis of Cellular Microtubule Dynamics

Walczak, C., Rizk, R. S. & Shaw, S. L., 2010, C ed. Unknown Publisher. 18 p. (Methods in Cell Biology; vol. 97, no. C)

Research output: Book/ReportBook

7 Scopus citations
2009

Chromosome congression in the absence of kinetochore fibres

Cai, S., O'Connell, C. B., Khodjakov, A. & Walczak, C. E., 2009, In : Nature Cell Biology. 11, 7, p. 832-838 7 p.

Research output: Contribution to journalArticle

113 Scopus citations

Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules

Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E., Mar 1 2009, In : Molecular Biology of the Cell. 20, 5, p. 1348-1359 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

MCAK and paclitaxel have differential effects on spindle microtubule organization and dynamics

Rizk, R. S., Bohannon, K. P., Wetzel, L. A., Powers, J., Shaw, S. L. & Walczak, C. E., Mar 15 2009, In : Molecular Biology of the Cell. 20, 6, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Microtubule binding and disruption and induction of premature senescence by disorazole C 1

Tierno, M. B., Kitchens, C. A., Petrik, B., Graham, T. H., Wipf, P., Xu, F. L., Saunders, W. S., Raccor, B. S., Balachandran, R., Day, B. W., Stout, J. R., Walczak, C. E., Ducruet, A. P., Reese, C. E. & Lazo, J. S., Mar 2009, In : Journal of Pharmacology and Experimental Therapeutics. 328, 3, p. 715-722 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mitotic spindle assembly mechanisms

Heald, R. & Walczak, C. E., Dec 1 2009, The Kinetochore: From Molecular Discoveries to Cancer Therapy. Springer New York, p. 231-268 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
4 Scopus citations

The road less traveled to the spindle equator

Cai, S. & Walczak, C. E., Dec 1 2009, In : Cell Cycle. 8, 23, p. 3791-3793 3 p.

Research output: Contribution to journalShort survey

Open Access
2 Scopus citations
2008

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity

Zhang, X., Ems-McClung, S. C. & Walczak, C. E., Jul 2008, In : Molecular Biology of the Cell. 19, 7, p. 2752-2765 14 p.

Research output: Contribution to journalArticle

93 Scopus citations

Effects of anti-microtubule agents on microtubule organization in cells lacking the kinesin-13 MCAK

Hedrick, D. G., Stout, J. R. & Walczak, C. E., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2146-2156 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Kinetochore Attachment: How the Hec Can a Cell Do It?

Cai, S. & Walczak, C. E., Dec 9 2008, In : Current Biology. 18, 23, p. R1093-R1096

Research output: Contribution to journalShort survey

Mechanisms of Mitotic Spindle Assembly and Function

Walczak, C. & Heald, R., 2008, In : International Review of Cytology. 265, p. 111-158 48 p.

Research output: Contribution to journalArticle

261 Scopus citations

The C-termini of tubulin and the specific geometry of tubulin substrates influence the depolymerization activity of MCAK

Hertzer, K. M. & Walczak, C. E., Sep 1 2008, In : Cell Cycle. 7, 17, p. 2727-2737 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
2007

Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function

Zhang, X., Lan, W., Ems-McClung, S. C., Stukenberg, P. T. & Walczak, C. E., Sep 2007, In : Molecular Biology of the Cell. 18, 9, p. 3264-3276 13 p.

Research output: Contribution to journalArticle

103 Scopus citations

Claire Walczak.

Walczak, C., Jun 19 2007, In : Current biology : CB. 17, 12, p. R440-441

Research output: Contribution to journalArticle

Spindles: One speckle at a time

Shaw, S. L. & Walczak, C. E., Nov 1 2007, In : Nature Cell Biology. 9, 11, p. 1223-1224 2 p.

Research output: Contribution to journalArticle

The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly

Ems-McClung, S. C., Hertzer, K. M., Zhang, X., Miller, M. W. & Walczak, C. E., Jan 2007, In : Molecular Biology of the Cell. 18, 1, p. 282-294 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2006

Chromosome Segregation: Correcting Improperly Attached Chromosomes

Zhang, X. & Walczak, C. E., Sep 5 2006, In : Current Biology. 16, 17, p. R677-R679

Research output: Contribution to journalShort survey

3 Scopus citations

Deciphering protein function during mitosis in PtK cells using RNAi

Stout, J. R., Rizk, R. S., Kline, S. L. & Walczak, C. E., Jun 23 2006, In : BMC Cell Biology. 7, 26.

Research output: Contribution to journalArticle

41 Scopus citations

Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK

Hertzer, K. M., Ems-McClung, S. C., Kline-Smith, S. L., Lipkin, T. G., Gilbert, S. P. & Walczak, C. E., Feb 2006, In : Molecular Biology of the Cell. 17, 2, p. 700-710 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Kinesin-8s: Motoring and depolymerizing

Walczak, C. E., Sep 1 2006, In : Nature Cell Biology. 8, 9, p. 903-905 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Parting company with the chromosome segregation and aneuploidy series

Walczak, C. E., Feb 1 2006, In : Trends in Cell Biology. 16, 2, p. 65-66 2 p.

Research output: Contribution to journalEditorial

2005

CaMKIIγ-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation

Holmfeldt, P., Zhang, X., Stenmark, S., Walczak, C. E. & Gullberg, M., Mar 23 2005, In : EMBO Journal. 24, 6, p. 1256-1266 11 p.

Research output: Contribution to journalArticle

37 Scopus citations