Claire Walczak

  • 6494 Citations
  • 38 h-Index
1993 …2020

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2020

RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking

Ems-McClung, S. C., Emch, M., Zhang, S., Mahnoor, S., Weaver, L. N. & Walczak, C. E., Feb 3 2020, In : Journal of Cell Biology. 219, 2

Research output: Contribution to journalArticle

Open Access
2019

A Cyclin A—Myb-MuvB—Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles

Rotelli, M. D., Policastro, R. A., Bolling, A. M., Killion, A. W., Weinberg, A. J., Dixon, M. J., Zentner, G. E., Walczak, C. E., Lilly, M. A. & Calvi, B. R., Jul 2019, In : PLoS Genetics. 15, 7, e1008253.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Self-straining of actively crosslinked microtubule networks

Fürthauer, S., Lemma, B., Foster, P. J., Ems-McClung, S. C., Yu, C. H., Walczak, C. E., Dogic, Z., Needleman, D. J. & Shelley, M. J., Dec 1 2019, In : Nature Physics. 15, 12, p. 1295-1300 6 p.

Research output: Contribution to journalArticle

2018

Aurora A activation in mitosis promoted by BuGZ

Huang, Y., Li, T., Ems-McClung, S. C., Walczak, C. E., Prigent, C., Zhu, X., Zhang, X. & Zheng, Y., Jan 1 2018, In : Journal of Cell Biology. 217, 1, p. 107-116 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Spatial regulation of astral microtubule dynamics by Kif18B in PtK cells

Walczak, C. E., Zong, H., Jain, S. & Stout, J. R., Oct 15 2016, In : Molecular Biology of the Cell. 27, 20, p. 3021-3030 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

The far C-terminus of MCAK regulates its conformation and spindle pole focusing

Zong, H., Carnes, S. K., Moe, C., Walczak, C. E. & Ems-McClung, S. C., May 1 2016, In : Molecular Biology of the Cell. 27, 9, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

Chen, S., Stout, J. R., Dharmaiah, S., Yde, S., Calvi, B. R. & Walczak, C. E., Oct 1 2016, In : Molecular Biology of the Cell. 27, 19, p. 2911-2923 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients

Pannu, V., Rida, P. C. G., Ogden, A., Turaga, R. C., Donthamsetty, S., Bowen, N. J., Rudd, K., Gupta, M. V., Reid, M. D., Cantuaria, G., Walczak, C. E. & Aneja, R., 2015, In : Oncotarget. 6, 8, p. 6076-6091 16 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Spatial gradients controlling spindle assembly

Weaver, L. N. & Walczak, C. E., Feb 1 2015, In : Biochemical Society Transactions. 43, p. 7-12 6 p., 0430007.

Research output: Contribution to journalArticle

7 Scopus citations

The Ran-GTP gradient spatially regulates XCTK2 in the spindle

Weaver, L. N., Ems-Mcclung, S. C., Chen, S. H. R., Yang, G., Shaw, S. L. & Walczak, C. E., Jun 1 2015, In : Current Biology. 25, 11, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association

Ems-Mcclung, S. C., Hainline, S. G., Devare, J., Zong, H., Cai, S., Carnes, S. K., Shaw, S. L. & Walczak, C. E., Dec 16 2013, In : Current Biology. 23, 24, p. 2491-2499 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H. A., Copenhaver, G. P., Deluca, J. G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J. & 37 others, Harrison, S. C., Heun, P., Hirota, T., Jansen, L. E. T., Karpen, G., Kops, G. J. P. L., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D., Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K. & Cleveland, D. W., Apr 2013, In : Chromosome Research. 21, 2, p. 101-106 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK

Huang, R., Oh, H., Arrendale, A., Martin, V. A., Galan, J., Workman, E. J., Stout, J. R., Walczak, C. E., Tao, W. A., Borch, R. F. & Geahlen, R. L., Jan 1 2013, In : Biochemical Pharmacology. 86, 5, p. 597-611 15 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors

Borysov, S. I., Granic, A., Padmanabhan, J., Walczak, C. E. & Potter, H., May 1 2011, In : Cell Cycle. 10, 9, p. 1397-1410 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation

Weaver, L. N., Ems-McClung, S. C., Stout, J. R., Leblanc, C., Shaw, S. L., Gardner, M. K. & Walczak, C. E., Sep 13 2011, In : Current Biology. 21, 17, p. 1500-1506 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Kif18B interacts with EB1 and controls astral microtubule length during mitosis

Stout, J. R., Yount, A. L., Powers, J. A., LeBlanc, C., Ems-McClung, S. C. & Walczak, C. E., Sep 1 2011, In : Molecular Biology of the Cell. 22, 17, p. 3070-3080 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2010

Proper Organization of Microtubule Minus Ends Is Needed for Midzone Stability and Cytokinesis

Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E., May 11 2010, In : Current Biology. 20, 9, p. 880-885 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2009

Chromosome congression in the absence of kinetochore fibres

Cai, S., O'Connell, C. B., Khodjakov, A. & Walczak, C. E., Jun 16 2009, In : Nature Cell Biology. 11, 7, p. 832-838 7 p.

Research output: Contribution to journalArticle

113 Scopus citations

Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules

Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E., Mar 1 2009, In : Molecular Biology of the Cell. 20, 5, p. 1348-1359 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

MCAK and paclitaxel have differential effects on spindle microtubule organization and dynamics

Rizk, R. S., Bohannon, K. P., Wetzel, L. A., Powers, J., Shaw, S. L. & Walczak, C. E., Mar 15 2009, In : Molecular Biology of the Cell. 20, 6, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Microtubule binding and disruption and induction of premature senescence by disorazole C 1

Tierno, M. B., Kitchens, C. A., Petrik, B., Graham, T. H., Wipf, P., Xu, F. L., Saunders, W. S., Raccor, B. S., Balachandran, R., Day, B. W., Stout, J. R., Walczak, C. E., Ducruet, A. P., Reese, C. E. & Lazo, J. S., Mar 2009, In : Journal of Pharmacology and Experimental Therapeutics. 328, 3, p. 715-722 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
5 Scopus citations
2008

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity

Zhang, X., Ems-McClung, S. C. & Walczak, C. E., Jul 1 2008, In : Molecular Biology of the Cell. 19, 7, p. 2752-2765 14 p.

Research output: Contribution to journalArticle

93 Scopus citations

Effects of anti-microtubule agents on microtubule organization in cells lacking the kinesin-13 MCAK

Hedrick, D. G., Stout, J. R. & Walczak, C. E., Jul 15 2008, In : Cell Cycle. 7, 14, p. 2146-2156 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Mechanisms of Mitotic Spindle Assembly and Function

Walczak, C. & Heald, R., 2008, In : International Review of Cytology. 265, p. 111-158 48 p.

Research output: Contribution to journalArticle

256 Scopus citations

The C-termini of tubulin and the specific geometry of tubulin substrates influence the depolymerization activity of MCAK

Hertzer, K. M. & Walczak, C. E., Sep 1 2008, In : Cell Cycle. 7, 17, p. 2727-2737 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
2007

Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function

Zhang, X., Lan, W., Ems-McClung, S. C., Stukenberg, P. T. & Walczak, C. E., Sep 1 2007, In : Molecular Biology of the Cell. 18, 9, p. 3264-3276 13 p.

Research output: Contribution to journalArticle

102 Scopus citations

Claire Walczak.

Walczak, C., Jun 19 2007, In : Current biology : CB. 17, 12, p. R440-441

Research output: Contribution to journalArticle

Spindles: One speckle at a time

Shaw, S. L. & Walczak, C. E., Nov 1 2007, In : Nature Cell Biology. 9, 11, p. 1223-1224 2 p.

Research output: Contribution to journalArticle

The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly

Ems-McClung, S. C., Hertzer, K. M., Zhang, X., Miller, M. W. & Walczak, C. E., Jan 2007, In : Molecular Biology of the Cell. 18, 1, p. 282-294 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2006

Deciphering protein function during mitosis in PtK cells using RNAi

Stout, J. R., Rizk, R. S., Kline, S. L. & Walczak, C. E., Jun 23 2006, In : BMC Cell Biology. 7, 26.

Research output: Contribution to journalArticle

41 Scopus citations

Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK

Hertzer, K. M., Ems-McClung, S. C., Kline-Smith, S. L., Lipkin, T. G., Gilbert, S. P. & Walczak, C. E., Feb 1 2006, In : Molecular Biology of the Cell. 17, 2, p. 700-710 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Kinesin-8s: Motoring and depolymerizing

Walczak, C. E., Sep 1 2006, In : Nature Cell Biology. 8, 9, p. 903-905 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
2005

CaMKIIγ-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation

Holmfeldt, P., Zhang, X., Stenmark, S., Walczak, C. E. & Gullberg, M., Mar 23 2005, In : EMBO Journal. 24, 6, p. 1256-1266 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2004

Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity

Lan, W., Zhang, X., Kline-Smith, S. L., Rosasco, S. E., Barrett-Wilt, G. A., Shabanowitz, J., Hunt, D. F., Walczak, C. E. & Stukenberg, P. T., Feb 17 2004, In : Current Biology. 14, 4, p. 273-286 14 p.

Research output: Contribution to journalArticle

354 Scopus citations

Depletion of Centromeric MCAK Leads to Chromosome Congression and Segregation Defects Due to Improper Kinetochore Attachments

Kline-Smith, S. L., Khodjakov, A., Hergert, P. & Walczak, C. E., Mar 1 2004, In : Molecular Biology of the Cell. 15, 3, p. 1146-1159 14 p.

Research output: Contribution to journalArticle

214 Scopus citations

Importin α/β and Ran-GTP Regulate XCTK2 Microtubule Binding Through a Bipartite Nuclear Localization Signal

Ems-McClung, S. C., Zheng, Y. & Walczak, C. E., Jan 1 2004, In : Molecular Biology of the Cell. 15, 1, p. 46-57 12 p.

Research output: Contribution to journalArticle

106 Scopus citations

Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase

Rogers, G. C., Rogers, S. L., Schwimmer, T. A., Ems-McClung, S. C., Walczak, C. E., Vale, R. D., Scholey, J. M. & Sharp, D. J., Jan 22 2004, In : Nature. 427, 6972, p. 364-370 7 p.

Research output: Contribution to journalArticle

257 Scopus citations
2002

The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly

Walczak, C. E., Gan, E. C., Desai, A., Mitchison, T. J. & Kline-Smith, S. L., Oct 29 2002, In : Current Biology. 12, 21, p. 1885-1889 5 p.

Research output: Contribution to journalArticle

67 Scopus citations

The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells

Kline-Smith, S. L. & Walczak, C. E., Aug 1 2002, In : Molecular Biology of the Cell. 13, 8, p. 2718-2731 14 p.

Research output: Contribution to journalArticle

133 Scopus citations

XKCM1 acts on a single protofilament and requires the C terminus of tubulin

Niederstrasser, H., Salehi-Had, H., Gan, E. C., Walczak, C. & Nogales, E., Jan 1 2002, In : Journal of molecular biology. 316, 3, p. 817-828 12 p.

Research output: Contribution to journalArticle

62 Scopus citations
2001

Ran hits the ground running

Walczak, C. E., Mar 20 2001, In : Nature Cell Biology. 3, 3, p. E69-E71

Research output: Contribution to journalArticle

15 Scopus citations

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

Wilde, A., Lizarraga, S. B., Zhang, L., Wiese, C., Gliksman, N. R., Walczak, C. E. & Zheng, Y., Mar 20 2001, In : Nature Cell Biology. 3, 3, p. 221-227 7 p.

Research output: Contribution to journalArticle

176 Scopus citations
2000

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

Tournebize, R., Popov, A., Kinoshita, K., Ashford, A. J., Rybina, S., Pozniakovsky, A., Mayer, T. U., Walczak, C. E., Karsenti, E. & Hyman, A. A., Nov 1 2000, In : Nature Cell Biology. 2, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

249 Scopus citations
1999

Kin I kinesins are microtubule-destabilizing enzymes

Desai, A., Verma, S., Mitchison, T. J. & Walczak, C. E., Jan 8 1999, In : Cell. 96, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

549 Scopus citations

Microtubule-based motor function in mitosis

Heald, R. & Walczak, C. E., Apr 1999, In : Current Opinion in Structural Biology. 9, 2, p. 268-274 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Microtubule dynamics in Xenopus egg extracts

Shirasu, M., Yonetani, A. & Walczak, C. E., Mar 15 1999, In : Microscopy Research and Technique. 44, 6, p. 435-445 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

Sharp, D. J., McDonald, K. L., Brown, H. M., Matthies, H. J., Walczak, C., Vale, R. D., Mitchison, T. J. & Scholey, J. M., Jan 11 1999, In : Journal of Cell Biology. 144, 1, p. 125-138 14 p.

Research output: Contribution to journalArticle

230 Scopus citations
1998

[41] Purification of cytoskeletal proteins using peptide antibodies

Field, C. M., Oegema, K., Zheng, Y., Mitchison, T. J. & Walczak, C. E., Jan 1 1998, In : Methods in Enzymology. 298, p. 525-541 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity

Walczak, C. E., Vernos, I., Mitchison, T. J., Karsenti, E. & Heald, R., Jul 30 1998, In : Current Biology. 8, 16, p. 903-913 11 p.

Research output: Contribution to journalArticle

Open Access
300 Scopus citations