Cong Yan

  • 2369 Citations
  • 29 h-Index
1984 …2019

Research output per year

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Publications

  • 2369 Citations
  • 29 h-Index
  • 63 Article
  • 2 Editorial
  • 1 Review article
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Article
2019

Transthyretin stimulates tumor growth through regulation of tumor, immune, and endothelial cells

Lee, C. C., Ding, X., Zhao, T., Wu, L., Perkins, S., Du, H. & Yan, C., Feb 1 2019, In : Journal of Immunology. 202, 3, p. 991-1002 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase– deficient mice

Zhao, T., Ding, X., Yan, C. & Du, H., Nov 24 2017, In : Journal of Biological Chemistry. 292, 47, p. 19198-19208 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation

Tuohetahuntila, M., Molenaar, M. R., Spee, B., Brouwers, J. F., Wubbolts, R., Houweling, M., Yan, C., Du, H., VanderVen, B. C., Vaandrager, A. B. & Helms, J. B., Jul 21 2017, In : Journal of Biological Chemistry. 292, 30, p. 12436-12448 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Rab7 GTPase controls lipid metabolic signaling in myeloidderived suppressor cells

Ding, X., Zhang, W., Zhao, T., Yan, C. & Du, H., Jan 1 2017, In : Oncotarget. 8, 18, p. 30123-30137 15 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., Denstman, F., Xu, X., Altieri, D. C., Du, H., Yan, C. & Gabrilovich, D. I., Feb 16 2016, In : Immunity. 44, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

128 Scopus citations

Critical role of PPARγ in myeloid-derived suppressor cellstimulated cancer cell proliferation and metastasis

Zhao, T., Du, H., Blum, J. S. & Yan, C., Jan 1 2016, In : Oncotarget. 7, 2, p. 1529-1543 15 p.

Research output: Contribution to journalArticle

15 Scopus citations
7 Scopus citations

Lysosomal acid lipase hydrolyzes retinyl ester and affects retinoid turnover

Grumet, L., Eichmann, T. O., Taschler, U., Zierler, K. A., Leopold, C., Moustafa, T., Radovic, B., Romauch, M., Yan, C., Du, H., Haemmerle, G., Zechner, R., Fickert, P., Kratky, D., Zimmermann, R. & Lass, A., Aug 19 2016, In : Journal of Biological Chemistry. 291, 34, p. 17977-17987 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lysosomal acid lipase in mesenchymal stem cell stimulation of tumor growth and metastasis

Zhao, T., Yan, C. & Du, H., Jan 1 2016, In : Oncotarget. 7, 38, p. 61121-61135 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Establishment of lal-/- myeloid lineage cell line that resembles myeloid-derived suppressive cells

Ding, X., Wu, L., Yan, C. & Du, H., Mar 25 2015, In : PloS one. 10, 3, e0121001.

Research output: Contribution to journalArticle

9 Scopus citations

Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal-/- Mice

Du, H., Zhao, T., Ding, X. & Yan, C., Sep 1 2015, In : American Journal of Pathology. 185, 9, p. 2379-2389 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal-/- mice

Zhao, T., Du, H., Ding, X., Walls, K. & Yan, C., May 26 2014, In : Oncogene. 34, 15, p. 1938-1948 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Huang, S. C. C., Everts, B., Ivanova, Y., O'Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W., Love-Gregory, L., Lam, W. Y., O'Neill, C. M., Yan, C., Du, H., Abumrad, N. A., Urban, J. F., Artyomov, M. N., Pearce, E. L. & Pearce, E. J., Sep 2014, In : Nature Immunology. 15, 9, p. 846-855 10 p.

Research output: Contribution to journalArticle

382 Scopus citations
20 Scopus citations

Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions

Zhao, T., Ding, X., Du, H. & Yan, C., Aug 15 2014, In : Journal of Immunology. 193, 4, p. 1942-1953 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Stat3 Downstream Gene Product Chitinase 3-Like 1 Is a Potential Biomarker of Inflammation-induced Lung Cancer in Multiple Mouse Lung Tumor Models and Humans

Yan, C., Ding, X., Wu, L., Yu, M., Qu, P. & Du, H., Apr 22 2013, In : PloS one. 8, 4, e61984.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice

Yan, C., Ding, X., Dasgupta, N., Wu, L. & Du, H., Feb 27 2012, In : PloS one. 7, 2, e30701.

Research output: Contribution to journalArticle

17 Scopus citations

Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J. S., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

57 Scopus citations
8 Scopus citations

Transgenic expression of nonclassically secreted FGF suppresses kidney repair

Kirov, A., Duarte, M., Guay, J., Karolak, M., Yan, C., Oxburgh, L. & Prudovsky, I., May 14 2012, In : PloS one. 7, 5, e36485.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Api6/AIM/Spα/CD5L overexpression in alveolar type II epithelial cells induces spontaneous lung adenocarcinoma

Li, Y., Qu, P., Wu, L., Li, B., Du, H. & Yan, C., Aug 15 2011, In : Cancer Research. 71, 16, p. 5488-5499 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
43 Scopus citations
27 Scopus citations
13 Scopus citations
59 Scopus citations
2010

Critical roles of lysosomal acid lipase in myelopoiesis

Qu, P., Shelley, W. C., Yoder, M. C., Wu, L., Du, H. & Yan, C., May 1 2010, In : American Journal of Pathology. 176, 5, p. 2394-2404 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Critical roles of lysosomal acid lipase in t cell development and function

Qu, P., Du, H., Wilkes, D. S. & Yan, C., Mar 2009, In : American Journal of Pathology. 174, 3, p. 944-956 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition

Qu, P., Du, H., Wang, X. & Yan, C., Oct 13 2009, In : Cancer Research. 69, 18, p. 7252-7261 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Myeloid-specific expression of Api6/AIM/Spα induces systemic inflammation and adenocarcinoma in the lung

Qu, P., Du, H., Li, Y. & Yan, C., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1648-1659 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease

Qu, P., Roberts, J., Li, Y., Albrecht, M., Cummings, O. W., Eble, J. N., Du, H. & Yan, C., Mar 1 2009, In : Lung Cancer. 63, 3, p. 341-347 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
2007
109 Scopus citations

Gene delivery by the hSP-B promoter to lung alveolar type II epithelial cells in LAL-knockout mice through bone marrow mesenchymal stem cells

Yan, C., Lian, X., Dai, Y., Wang, X., Qu, P., White, A., Qin, Y. & Du, H., Oct 1 2007, In : Gene Therapy. 14, 20, p. 1461-1470 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung

Li, Y., Qin, Y., Li, H., Wu, R., Yan, C. & Du, H., Dec 1 2007, In : International Journal of Experimental Pathology. 88, 6, p. 427-436 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice

Yan, C., Lian, X., Li, Y., Dai, Y., White, A., Qin, Y., Li, H., Hume, D. A. & Du, H., Sep 2006, In : American Journal of Pathology. 169, 3, p. 916-926 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
2005
51 Scopus citations

Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury

Lian, X., Qin, Y., Hossain, S. A., Yang, L., White, A., Xu, H., Shipley, J. M., Li, T., Senior, R. M., Du, H. & Yan, C., Jun 1 2005, In : Journal of Immunology. 174, 11, p. 7250-7256 7 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
2004

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung

Lian, X., Yan, C., Yang, L., Xu, Y. & Du, H., Apr 1 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 4 30-4, p. L801-L807

Research output: Contribution to journalArticle

72 Scopus citations

Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1

Yang, L., Yan, D., Bruggeman, M., Du, H. & Yan, C., Oct 5 2004, In : Biochemistry. 43, 39, p. 12489-12497 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-α in regulation of the surfactant protein B gene in the lung

Yang, L., Lian, X., Cowen, A., Xu, H., Du, H. & Yan, C., Jun 1 2004, In : Molecular Endocrinology. 18, 6, p. 1520-1532 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
2003

An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice

Yang, L., Naltner, A., Kreiner, A., Yan, D., Cowen, A., Du, H. & Yan, C., Mar 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 3 28-3, p. L481-L488

Research output: Contribution to journalArticle

14 Scopus citations

Overexpression of dominant negative retinoic acid receptor α causes alveolar abnormality in transgenic neonatal lungs

Yang, L., Naltner, A. & Yan, C., Jul 1 2003, In : Endocrinology. 144, 7, p. 3004-3011 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Peroxisome proliferator-activated receptor γ and ligands inhibit surfactant protein B gene expression in the lung

Yang, L., Yan, D., Yan, C. & Du, H., Sep 19 2003, In : Journal of Biological Chemistry. 278, 38, p. 36841-36847 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells

Yan, C., Naltner, A., Martin, M., Naltner, M., Fangman, J. M. & Gurel, O., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 10967-10972 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2001

Protein-Protein Interaction of Retinoic Acid Receptor α and Thyroid Transcription Factor-1 in Respiratory Epithelial Cells

Yan, C., Naltner, A., Conkright, J. & Ghaffari, M., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21686-21691 6 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations
2000

Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent

Naltner, A., Ghaffari, M., Whitsett, J. A. & Yan, C., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung

Naltner, A., Wert, S., Whitsett, J. A. & Yan, C., Jan 1 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 6 23-6, p. L1066-L1074

Research output: Contribution to journalArticle

33 Scopus citations
1999

Inhibition of hSP-B promoter in respiratory epithelial cells by a dominant negative retinoic acid receptor

Ghaffari, M., Whitsett, J. A. & Yan, C., Mar 1 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 276, 3 20-3, p. L398-L404

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of mouse SP-B gene promoter by AP-1 family members

Sever-Chroneos, Z., Bachurski, C. J., Yan, C. & Whitsett, J. A., Jul 1 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 1 21-1, p. L79-L88

Research output: Contribution to journalArticle

30 Scopus citations
1998

Retinoic acid-receptor activation of SP-B gene transcription in respiratory epithelial cells

Yan, C., Ghaffari, M., Whitsett, J. A., Zeng, X., Sever, Z. & Lin, S., Aug 1 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 2 19-2, p. L239-L246

Research output: Contribution to journalArticle

29 Scopus citations
1997

Hepatocyte nuclear factor-3β limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo

Zhou, L., Dey, C. R., Wert, S. E., Yan, C., Costa, R. H. & Whitsett, J. A., Nov 1 1997, In : Developmental Dynamics. 210, 3, p. 305-314 10 p.

Research output: Contribution to journalArticle

59 Scopus citations