Cong Yan

  • 2242 Citations
  • 29 h-Index
1984 …2019
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Publications 1984 2019

  • 2242 Citations
  • 29 h-Index
  • 65 Article
  • 1 Editorial
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Article
2019
1 Citation (Scopus)

Transthyretin stimulates tumor growth through regulation of tumor, immune, and endothelial cells

Lee, C. C., Ding, X., Zhao, T., Wu, L., Perkins, S., Du, H. & Yan, C., Feb 1 2019, In : Journal of Immunology. 202, 3, p. 991-1002 12 p.

Research output: Contribution to journalArticle

Prealbumin
Lung Neoplasms
Endothelial Cells
Growth
Myeloid Cells
2017
2 Citations (Scopus)

Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase– deficient mice

Zhao, T., Ding, X., Yan, C. & Du, H., Jan 1 2017, In : Journal of Biological Chemistry. 292, 47, p. 19198-19208 11 p.

Research output: Contribution to journalArticle

Sterol Esterase
GTP Phosphohydrolases
Endothelial cells
Tumors
Endothelial Cells
16 Citations (Scopus)

Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation

Tuohetahuntila, M., Molenaar, M. R., Spee, B., Brouwers, J. F., Wubbolts, R., Houweling, M., Yan, C., Du, H., VanderVen, B. C., Vaandrager, A. B. & Helms, J. B., Jan 1 2017, In : Journal of Biological Chemistry. 292, 30, p. 12436-12448 13 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Lysosomes
Chemical activation
Lipids
Degradation
11 Citations (Scopus)

Rab7 GTPase controls lipid metabolic signaling in myeloidderived suppressor cells

Ding, X., Zhang, W., Zhao, T., Yan, C. & Du, H., 2017, In : Oncotarget. 8, 18, p. 30123-30137 15 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Lipids
Sirolimus
Lysosomes
Small Interfering RNA
2016
109 Citations (Scopus)

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., Denstman, F., Xu, X., Altieri, D. C., Du, H., Yan, C. & Gabrilovich, D. I., Feb 16 2016, In : Immunity. 44, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Myeloid Cells
Phosphoric Monoester Hydrolases
Macrophages
Neoplasms
12 Citations (Scopus)

Critical role of PPARγ in myeloid-derived suppressor cellstimulated cancer cell proliferation and metastasis

Zhao, T., Du, H., Blum, J. & Yan, C., 2016, In : Oncotarget. 7, 2, p. 1529-1543 15 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Cell Proliferation
Neoplasm Metastasis
Neoplasms
Cell Movement
6 Citations (Scopus)
Pneumonia
Sterol Esterase
Neoplasm Metastasis
Lung
Neoplasms
15 Citations (Scopus)

Lysosomal acid lipase hydrolyzes retinyl ester and affects retinoid turnover

Grumet, L., Eichmann, T. O., Taschler, U., Zierler, K. A., Leopold, C., Moustafa, T., Radovic, B., Romauch, M., Yan, C., Du, H., Haemmerle, G., Zechner, R., Fickert, P., Kratky, D., Zimmermann, R. & Lass, A., Aug 19 2016, In : Journal of Biological Chemistry. 291, 34, p. 17977-17987 11 p.

Research output: Contribution to journalArticle

Sterol Esterase
Retinoids
Esters
Chylomicrons
Cholesterol Esters
3 Citations (Scopus)

Lysosomal acid lipase in mesenchymal stem cell stimulation of tumor growth and metastasis

Zhao, T., Yan, C. & Du, H., 2016, In : Oncotarget. 7, 38, p. 61121-61135 15 p.

Research output: Contribution to journalArticle

Sterol Esterase
Mesenchymal Stromal Cells
Neoplasm Metastasis
Growth
Neoplasms
2015
7 Citations (Scopus)

Establishment of lal-/- myeloid lineage cell line that resembles myeloid-derived suppressive cells

Ding, X., Wu, L., Yan, C. & Du, H., Mar 25 2015, In : PLoS One. 10, 3, e0121001.

Research output: Contribution to journalArticle

Cell proliferation
Myeloid Cells
suppressor cells
Cells
cell lines
12 Citations (Scopus)

Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal<sup>-/-</sup> Mice

Du, H., Zhao, T., Ding, X. & Yan, C., Sep 1 2015, In : American Journal of Pathology. 185, 9, p. 2379-2389 11 p.

Research output: Contribution to journalArticle

Lysosomes
Lipase
Hepatocytes
Neoplasm Metastasis
Inflammation
5 Citations (Scopus)

Lysosomal acid lipase in cancer

Yan, C., Zhao, T. & Du, H., 2015, In : Oncoscience. 2, 9, p. 727-728 2 p.

Research output: Contribution to journalArticle

Sterol Esterase
PPAR gamma
Neoplasms
Myeloid-Derived Suppressor Cells
2014
25 Citations (Scopus)

Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal<sup>-/-</sup> mice

Zhao, T., Du, H., Ding, X., Walls, K. & Yan, C., May 26 2014, In : Oncogene. 34, 15, p. 1938-1948 11 p.

Research output: Contribution to journalArticle

Sirolimus
Cell Proliferation
Neoplasm Metastasis
Neoplasms
Experimental Melanomas
332 Citations (Scopus)

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Huang, S. C. C., Everts, B., Ivanova, Y., O'Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W., Love-Gregory, L., Lam, W. Y., O'Neill, C. M., Yan, C., Du, H., Abumrad, N. A., Urban, J. F., Artyomov, M. N., Pearce, E. L. & Pearce, E. J., 2014, In : Nature Immunology. 15, 9, p. 846-855 10 p.

Research output: Contribution to journalArticle

Macrophage Activation
Lipolysis
Fatty Acids
Interleukin-4 Receptors
Sterol Esterase
19 Citations (Scopus)
Sirolimus
Lymphocytes
Antigens
Sterol Esterase
Bone Marrow
10 Citations (Scopus)

Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions

Zhao, T., Ding, X., Du, H. & Yan, C., Aug 15 2014, In : Journal of Immunology. 193, 4, p. 1942-1953 12 p.

Research output: Contribution to journalArticle

Endothelial Cells
Sirolimus
Lysosomal acid lipase deficiency
Myeloid-Derived Suppressor Cells
Cell Proliferation
2013
11 Citations (Scopus)

Stat3 Downstream Gene Product Chitinase 3-Like 1 Is a Potential Biomarker of Inflammation-induced Lung Cancer in Multiple Mouse Lung Tumor Models and Humans

Yan, C., Ding, X., Wu, L., Yu, M., Qu, P. & Du, H., Apr 22 2013, In : PLoS One. 8, 4, e61984.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Chitinases
Biomarkers
lung neoplasms
chitinase
2012
17 Citations (Scopus)

Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice

Yan, C., Ding, X., Dasgupta, N., Wu, L. & Du, H., Feb 27 2012, In : PLoS One. 7, 2, e30701.

Research output: Contribution to journalArticle

Sterol Esterase
Knockout Mice
Bone Marrow Cells
bone marrow
Myeloid Cells
54 Citations (Scopus)

Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Myeloid Cells
Immunosuppression
Carcinogenesis
Inflammation
8 Citations (Scopus)
Alveolar Epithelial Cells
bone marrow cells
Stem cells
Mesenchymal Stromal Cells
stem cells
8 Citations (Scopus)

Transgenic expression of nonclassically secreted FGF suppresses kidney repair

Kirov, A., Duarte, M., Guay, J., Karolak, M., Yan, C., Oxburgh, L. & Prudovsky, I., May 14 2012, In : PLoS One. 7, 5, e36485.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 1
Repair
kidneys
Kidney
gene expression
2011
25 Citations (Scopus)

Api6/AIM/Spα/CD5L overexpression in alveolar type II epithelial cells induces spontaneous lung adenocarcinoma

Li, Y., Qu, P., Wu, L., Li, B., Du, H. & Yan, C., Aug 15 2011, In : Cancer Research. 71, 16, p. 5488-5499 12 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Lung
Apoptosis
Doxycycline
Epithelial Cells
43 Citations (Scopus)
Matrix Metalloproteinase 12
Myelopoiesis
Myeloid Cells
Carcinogenesis
Lung
25 Citations (Scopus)
Sterol Esterase
Myeloid Cells
T-Lymphocytes
Myelopoiesis
Thymus Gland
13 Citations (Scopus)
Alveolar Epithelial Cells
Peroxisome Proliferator-Activated Receptors
Inflammation
T-Lymphocytes
Lung
55 Citations (Scopus)
STAT3 Transcription Factor
Doxycycline
Carcinogenesis
Lung
Inflammation
2010
25 Citations (Scopus)

Critical roles of lysosomal acid lipase in myelopoiesis

Qu, P., Shelley, W. C., Yoder, M., Wu, L., Du, H. & Yan, C., May 2010, In : American Journal of Pathology. 176, 5, p. 2394-2404 11 p.

Research output: Contribution to journalArticle

Myelopoiesis
Sterol Esterase
Myeloid Cells
Granulocyte-Macrophage Progenitor Cells
Bone Marrow
2009
33 Citations (Scopus)

Critical roles of lysosomal acid lipase in t cell development and function

Qu, P., Du, H., Wilkes, D. S. & Yan, C., Mar 2009, In : American Journal of Pathology. 174, 3, p. 944-956 13 p.

Research output: Contribution to journalArticle

Sterol Esterase
T-Lymphocytes
Thymus Gland
Cholesterol Esters
T-Cell Antigen Receptor
62 Citations (Scopus)
Matrix Metalloproteinase 12
Emphysema
Epithelial Cells
Lung
Lung Neoplasms
47 Citations (Scopus)

Myeloid-specific expression of Api6/AIM/Spα induces systemic inflammation and adenocarcinoma in the lung

Qu, P., Du, H., Li, Y. & Yan, C., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1648-1659 12 p.

Research output: Contribution to journalArticle

Myeloid Cells
Inflammation
Apoptosis
Myelopoiesis
Lung
64 Citations (Scopus)

Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease

Qu, P., Roberts, J., Li, Y., Albrecht, M., Cummings, O., Eble, J., Du, H. & Yan, C., Mar 2009, In : Lung Cancer. 63, 3, p. 341-347 7 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Biomarkers
Carcinoma
Lung
Lung Neoplasms
2007
105 Citations (Scopus)
Alveolar Epithelial Cells
STAT3 Transcription Factor
Adenocarcinoma
Inflammation
Chemokines
18 Citations (Scopus)

Gene delivery by the hSP-B promoter to lung alveolar type II epithelial cells in LAL-knockout mice through bone marrow mesenchymal stem cells

Yan, C., Lian, X., Dai, Y., Wang, X., Qu, P., White, A., Qin, Y. & Du, H., Oct 2007, In : Gene Therapy. 14, 20, p. 1461-1470 10 p.

Research output: Contribution to journalArticle

Sterol Esterase
Alveolar Epithelial Cells
Mesenchymal Stromal Cells
Knockout Mice
Surface-Active Agents
10 Citations (Scopus)

Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung

Li, Y., Qin, Y., Li, H., Wu, R., Yan, C. & Du, H., Dec 2007, In : International Journal of Experimental Pathology. 88, 6, p. 427-436 10 p.

Research output: Contribution to journalArticle

Sterol Esterase
Surface-Active Agents
Lipids
Lung
Bronchoalveolar Lavage Fluid
2006
48 Citations (Scopus)

Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice

Yan, C., Lian, X., Li, Y., Dai, Y., White, A., Qin, Y., Li, H., Hume, D. A. & Du, H., Sep 2006, In : American Journal of Pathology. 169, 3, p. 916-926 11 p.

Research output: Contribution to journalArticle

Macrophages
Inflammation
Phenotype
Doxycycline
Sterol Esterase
2005
51 Citations (Scopus)
Sterol Esterase
Peroxisomes
Matrix Metalloproteinase 12
Knockout Mice
Inflammation
61 Citations (Scopus)

Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury

Lian, X., Qin, Y., Hossain, S. A., Yang, L., White, A., Xu, H., Shipley, J. M., Li, T., Senior, R. M., Du, H. & Yan, C., Jun 1 2005, In : Journal of Immunology. 174, 11, p. 7250-7256 7 p.

Research output: Contribution to journalArticle

Hyperoxia
Lung Injury
Epithelium
Matrix Metalloproteinase 9
Lung
2004
16 Citations (Scopus)

Alveolus formation: What have we learned from genetic studies?

Yan, C. & Du, H., Oct 2004, In : Journal of Applied Physiology. 97, 4, p. 1543-1548 6 p.

Research output: Contribution to journalArticle

Lung
Lung Diseases
Genetic Models
Respiratory System
Animal Models
71 Citations (Scopus)
Matrix Metalloproteinases
Inflammation
Lung
Sterol Esterase
Lipids
12 Citations (Scopus)

Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1

Yang, L., Yan, D., Bruggeman, M., Du, H. & Yan, C., Oct 5 2004, In : Biochemistry. 43, 39, p. 12489-12497 9 p.

Research output: Contribution to journalArticle

Lysine
Mutation
Acetylation
Nuclear Receptor Coactivators
Nuclear Receptor Coactivator 1
31 Citations (Scopus)

Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-α in regulation of the surfactant protein B gene in the lung

Yang, L., Lian, X., Cowen, A., Xu, H., Du, H. & Yan, C., Jun 2004, In : Molecular Endocrinology. 18, 6, p. 1520-1532 13 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Retinoic Acid Receptors
Surface-Active Agents
Lung
Genes
2003
14 Citations (Scopus)

An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice

Yang, L., Naltner, A., Kreiner, A., Yan, D., Cowen, A., Du, H. & Yan, C., Mar 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 3 28-3

Research output: Contribution to journalArticle

Lac Operon
Transgenic Mice
Epithelial Cells
Gene Expression
Lung
31 Citations (Scopus)

Overexpression of dominant negative retinoic acid receptor α causes alveolar abnormality in transgenic neonatal lungs

Yang, L., Naltner, A. & Yan, C., Jul 1 2003, In : Endocrinology. 144, 7, p. 3004-3011 8 p.

Research output: Contribution to journalArticle

Retinoic Acid Receptors
Doxycycline
Lung
Surface-Active Agents
Alveolar Epithelial Cells
17 Citations (Scopus)

Peroxisome proliferator-activated receptor γ and ligands inhibit surfactant protein B gene expression in the lung

Yang, L., Yan, D., Yan, C. & Du, H., Sep 19 2003, In : Journal of Biological Chemistry. 278, 38, p. 36841-36847 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Gene expression
Surface-Active Agents
Ligands
Lipids
2002
46 Citations (Scopus)

Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells

Yan, C., Naltner, A., Martin, M., Naltner, M., Fangman, J. M. & Gurel, O., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 10967-10972 6 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Genes
Epithelial Cells
Interleukin-11
Respiratory system
2001
45 Citations (Scopus)

Protein-Protein Interaction of Retinoic Acid Receptor α and Thyroid Transcription Factor-1 in Respiratory Epithelial Cells

Yan, C., Naltner, A., Conkright, J. & Ghaffari, M., Jun 15 2001, In : Journal of Biological Chemistry. 276, 24, p. 21686-21691 6 p.

Research output: Contribution to journalArticle

Retinoic Acid Receptors
Epithelial Cells
Proteins
Surface-Active Agents
Tretinoin
2000
56 Citations (Scopus)

Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent

Naltner, A., Ghaffari, M., Whitsett, J. A. & Yan, C., Jan 7 2000, In : Journal of Biological Chemistry. 275, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Tretinoin
Surface-Active Agents
Transcription
Genes
33 Citations (Scopus)

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung

Naltner, A., Wert, S., Whitsett, J. A. & Yan, C., 2000, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 6 23-6

Research output: Contribution to journalArticle

Nuclear Receptor Coactivators
Nuclear Receptor Coactivator 1
CREB-Binding Protein
Lung
Retinoic Acid Receptors
1999
10 Citations (Scopus)
Retinoic Acid Receptors
Surface-Active Agents
Epithelial Cells
Tretinoin
Lung
30 Citations (Scopus)

Regulation of mouse SP-B gene promoter by AP-1 family members

Sever-Chroneos, Z., Bachurski, C. J., Yan, C. & Whitsett, J. A., Jul 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 1 21-1

Research output: Contribution to journalArticle

Transcription Factor AP-1
Surface-Active Agents
Genes
Binding Sites
Protein Binding