Dan Spandau

  • Associate Research Professor of Dermatology, Dermatology
  • 1754 Citations
  • 22 h-Index
1987 …2020

Research output per year

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Publications

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Article
2020

Ex vivo culture of mouse skin activates an interleukin 1 alpha-dependent inflammatory response

Zhou, H. M., Slominski, R. M., Seymour, L. J., Bell, M. C., Dave, P., Atumonye, J., Wright, W., Dawes, A., Griesenauer, B., Paczesny, S., Kaplan, M. H., Spandau, D. F. & Turner, M. J., Jan 1 2020, In : Experimental Dermatology. 29, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

Single Ablative Fractional Resurfacing Laser Treatment For Forearm Actinic Keratoses: 6-Month Follow-Up Data From An Intrapatient Comparison Between Treated and Untreated Sites

Chen, R., Wargo, J. J., Williams, A., Cates, E., Spandau, D. F., Knisely, C. & Travers, J. B., Jan 1 2020, In : Lasers in Surgery and Medicine. 52, 1, p. 84-87 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin

Travers, J. B., Kemp, M. G., Weir, N. M., Cates, E., Alkawar, A. M., Mahajan, A. S. & Spandau, D. F., Jan 1 2019, (Accepted/In press) In : Archives of Dermatological Research.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis

DaSilva-Arnold, S. C., Thyagarajan, A., Seymour, L. J., Yi, Q., Bradish, J. R., Al-Hassani, M., Zhou, H., Perdue, N. J., Nemeth, V., Krbanjevic, A., Serezani, A. P. M., Olson, M. R., Spandau, D. F., Travers, J. B., Kaplan, M. H. & Turner, M. J., Apr 1 2018, In : Archives of Dermatological Research. 310, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2 Scopus citations
2017

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple

Wu, H. J., Oh, J. W., Spandau, D. F., Tholpady, S., Diaz, J., Schroeder, L. J., Offutt, C. D., Glick, A. B., Plikus, M. V., Koyama, S. & Foley, J., Apr 15 2017, In : Development (Cambridge). 144, 8, p. 1498-1509 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2

Collier, A. E., Wek, R. C. & Spandau, D. F., Sep 2017, In : Journal of Investigative Dermatology. 137, 9, p. 1924-1934 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

IL-4 impairs wound healing potential in the skin by repressing fibronectin expression

Serezani, A. P. M., Bozdogan, G., Sehra, S., Walsh, D., Krishnamurthy, P., Sierra Potchanant, E. A., Nalepa, G., Goenka, S., Turner, M. J., Spandau, D. F. & Kaplan, M. H., Jan 1 2017, In : Journal of Allergy and Clinical Immunology. 139, 1, p. 142-151.e5

Research output: Contribution to journalArticle

20 Scopus citations
13 Scopus citations

Ocular Pathology of Oculocerebrorenal Syndrome of Lowe: Novel Mutations and Genotype-Phenotype Analysis

Song, E., Luo, N., Alvarado, J. A., Lim, M., Walnuss, C., Neely, D., Spandau, D., Ghaffarieh, A. & Sun, Y., Dec 1 2017, In : Scientific reports. 7, 1, 1442.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo

Loesch, M. M., Collier, A. E., Southern, D. H., Ward, R. E., Sunil, T., Lewis, D. A., Travers, J. B. & Spandau, D. F., Oct 1 2016, In : Molecular Oncology. 10, 8, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Radiation therapy generates platelet-activating factor agonists

Sahu, R. P., Harrison, K. A., Weyerbacher, J., Murphy, R. C., Konger, R. L., Garrett, J. E., Chin-Sinex, H. J., Johnston, M. E., Dynlacht, J. R., Mendonca, M., McMullen, K., Li, G., Spandau, D. F. & Travers, J. B., Apr 12 2016, In : Oncotarget. 7, 15, p. 20788-20800 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Expansion of specialized epidermis induced by hormonal state and mechanical strain

Wu, H. J., Easwaran, T., Offutt, C. D., Elgar, R. L., Spandau, D. F., Koyama, S. & Foley, J., May 1 2015, In : Mechanisms of Development. 136, p. 73-86 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
9 Scopus citations
2014

Primary cilia signaling mediates intraocular pressure sensation

Luo, N., Conwell, M. D., Chen, X., Kettenhofen, C. I., Westlake, C. J., Cantor, L. B., Wells, C. D., Weinreb, R. N., Corson, T. W., Spandau, D. F., Joos, K. M., Iomini, C., Obukhov, A. G. & Sun, Y., Sep 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 35, p. 12871-12876 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Pten loss induces autocrine FGF signaling to promote skin tumorigenesis

Hertzler-Schaefer, K., Mathew, G., Somani, A. K., Tholpady, S., Kadakia, M. P., Chen, Y., Spandau, D. F. & Zhang, X., Jan 1 2014, In : Cell Reports. 6, 5, p. 818-826 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin

Spandau, D. F., Lewis, D. A., Somani, A. K. & Travers, J. B., Jun 2012, In : Journal of Investigative Dermatology. 132, 6, p. 1591-1596 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Reversing the aging stromal phenotype prevents carcinoma initiation

Lewis, D. A., Travers, J. B., Machado, C., Somani, A. K. & Spandau, D. F., Apr 2011, In : Aging. 3, 4, p. 407-416 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

The effect of chemexfoliation and anti-aging regiments on fibroblast expression of IGF-1: A pilot Study

Zandifar, H., Lewis, D. A., Spandau, D. F., Beeson, W. H. & Travers, J. B., Aug 29 2011, In : Laryngoscope. 121, SUPPL. 5, p. S301

Research output: Contribution to journalArticle

2010

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

Dey, S., Baird, T. D., Zhou, D., Palam, L. R., Spandau, D. F. & Wek, R. C., Oct 22 2010, In : Journal of Biological Chemistry. 285, 43, p. 33165-33174 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

The IGF-1/IGF-1R signaling axis in the skin: A new role for the dermis in aging-associated skin cancer

Lewis, D. A., Travers, J. B., Somani, A. K. & Spandau, D. F., Mar 1 2010, In : Oncogene. 29, 10, p. 1475-1485 11 p.

Research output: Contribution to journalArticle

71 Scopus citations
2008

UVB-induced activation of NF-κB is regulated by the IGF-1R and dependent on p38 MAPK

Lewis, D. A. & Spandau, D. F., Apr 2008, In : Journal of Investigative Dermatology. 128, 4, p. 1022-1029 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53

Lewis, D. A., Yi, Q., Travers, J. B. & Spandau, D. F., Apr 1 2008, In : Molecular Biology of the Cell. 19, 4, p. 1346-1353 8 p.

Research output: Contribution to journalArticle

60 Scopus citations
2007

UVB activation of NF-κB in normal human keratinocytes occurs via a unique mechanism

Lewis, D. A. & Spandau, D. F., May 1 2007, In : Archives of Dermatological Research. 299, 2, p. 93-101 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2006

Aberrant NF-κB activity in HaCaT cells alters their response to UVB signaling

Lewis, D. A., Hengeltraub, S. F., Gao, F. C., Leivant, M. A. & Spandau, D. F., Aug 1 2006, In : Journal of Investigative Dermatology. 126, 8, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2005

A radiation-induced acute apoptosis involving TP53 and BAX precedes the delayed apoptosis and neoplastic transformation of CGL1 human hybrid cells

Mendonca, M. S., Mayhugh, B. M., McDowell, B., Chin-Sinex, H., Smith, M. L., Dynlacht, J. R., Spandau, D. F. & Lewis, D. A., Jun 2005, In : Radiation research. 163, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Decreased incidence of nonmelanoma skin cancer in patients with type 2 diabetes mellitus using insulin: A pilot study

Chuang, T. Y., Lewis, D. A. & Spandau, D. F., Sep 1 2005, In : British Journal of Dermatology. 153, 3, p. 552-557 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage

Marathe, G. K., Johnson, C., Billings, S. D., Southall, M. D., Pei, Y., Spandau, D., Murphy, R. C., Zimmerman, G. A., McIntyre, T. M. & Travers, J. B., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35448-35457 10 p.

Research output: Contribution to journalArticle

70 Scopus citations
2004

Keratin 2e: A marker for murine nipple epidermis

Mahler, B., Gocken, T., Brojan, M., Childress, S., Spandau, D. F. & Foley, J., May 18 2004, In : Cells Tissues Organs. 176, 4, p. 169-177 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Hiatt, K., Ingram, D. A., Huddleston, H., Spandau, D. F., Kapur, R. & Clapp, D. W., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes

Cho, Y. M., Lewis, D. A., Koltz, P. F., Richard, V., Gocken, T. A., Rosol, T. J., Konger, R. L., Spandau, D. F. & Foley, J., Apr 1 2004, In : Journal of Endocrinology. 181, 1, p. 179-190 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2003

Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors: An In Vivo Xenograft Model of Keratoacanthoma

Billings, S. D., Southall, M. D., Li, T., Cook, P. W., Baldridge, L. A., Moores, W. B., Spandau, D. F., Foley, J. G. & Travers, J. B., Dec 2003, In : American Journal of Pathology. 163, 6, p. 2451-2458 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis

Lewis, D. A., Zweig, B., Hurwitz, S. A. & Spandau, D. F., Mar 1 2003, In : Journal of Investigative Dermatology. 120, 3, p. 483-488 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines

Li, T., Southall, M. D., Yi, Q., Pei, Y., Lewis, D., Al-Hassani, M., Spandau, D. & Travers, J. B., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16614-16621 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

UVB-induced apoptosis in normal human keratinocytes: Role of the erbB receptor family

Lewis, D. A., Hurwitz, S. A. & Spandau, D. F., Apr 1 2003, In : Experimental Cell Research. 284, 2, p. 314-325 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2002

E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis

Zhang, B., Spandau, D. F. & Roman, A., 2002, In : Journal of virology. 76, 1, p. 220-231 12 p.

Research output: Contribution to journalArticle

83 Scopus citations

Effect of Ultraviolet B Radiation and 100 Hz Electromagnetic Fields on Proliferation and DNA Synthesis of Jurkat Cells

Nindl, G., Hughes, E. F., Johnson, M. T., Spandau, D. F., Vesper, D. N. & Balcavage, W. X., Sep 1 2002, In : Bioelectromagnetics. 23, 6, p. 455-463 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
48 Scopus citations
2001

A system for simultaneous ultraviolet light and electromagnetic field exposure in in vitro experiments

Vesper, D. N., Waite, G., Johnson, M. T., Spandau, D. F., Swez, J. A. & Balcavage, W. X., May 9 2001, In : Biomedical Sciences Instrumentation. 37, p. 221-226 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
37 Scopus citations
2000
21 Scopus citations

Quantitative analysis of UVB-induced apoptosis in human epidermis

Hurwitz, S. A. & Spandau, D. F., Jun 2000, In : Experimental Dermatology. 9, 3, p. 185-191 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Use of enhanced green fluorescent protein to monitor retroviral-mediated gene therapy in human keratinocytes

Spandau, D. F., Marques, M., Bierhuizen, M., Wagemaker, G., Hurwitz, S., Pei, Y., Breese, R. & Travers, J. B., Aug 2000, In : Experimental Dermatology. 9, 4, p. 252-257 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
1999

Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation

Kuhn, C., Hurwitz, S. A., Kumar, M. G., Cotton, J. & Spandau, D. F., 1999, In : International Journal of Cancer. 80, 3, p. 431-438 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Subphysiological concentrations of extracellular calcium sensitize normal human keratinocytes to UVB-induced apoptosis

Kumar, M. G., Hurwitz, S. A., Cotton, J. & Spandau, D. F., Feb 2 1999, In : Archives of Dermatological Research. 291, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
1998

Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line

Barber, L. A., Spandau, D. F., Rathman, S. C., Murphy, R. C., Johnson, C. A., Kelley, S. W., Hurwitz, S. A. & Travers, J. B., Jul 24 1998, In : Journal of Biological Chemistry. 273, 30, p. 18891-18897 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
1997

Ultraviolet B-radiation dose influences the induction of apoptosis and p53 in human keratinocytes

Cotton, J. & Spandau, D. F., Feb 13 1997, In : Radiation research. 147, 2, p. 148-155 8 p.

Research output: Contribution to journalArticle

80 Scopus citations
1996
15 Scopus citations
1995

p53-binding proteins in squamous cell carcinoma and normal human keratinocytes

Kumar, M. G. & Spandau, D. F., Jan 1 1995, In : Cell Growth and Differentiation. 6, 12, p. 1601-1608 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Effect of Phosphorylation on the Antigenic Reactivity of p53 in Cultured Human Keratinocytes

Kumar, M. & Spandau, D. F., Jan 1 1995, In : Biochemical and Biophysical Research Communications. 214, 2, p. 744-753 10 p.

Research output: Contribution to journalArticle

7 Scopus citations