Dan Spandau

  • Associate Research Professor of Dermatology, Dermatology
  • 1585 Citations
  • 21 h-Index
1987 …2019
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Publications 1987 2018

  • 1585 Citations
  • 21 h-Index
  • 58 Article
  • 2 Review article
  • 1 Chapter
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Article
2018

Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis

DaSilva-Arnold, S. C., Thyagarajan, A., Seymour, L. J., Yi, Q., Bradish, J. R., Al-Hassani, M., Zhou, H., Perdue, N. J., Nemeth, V., Krbanjevic, A., Serezani, A. P. M., Olson, M. R., Spandau, D., Travers, J., Kaplan, M. & Turner, M. J., Jan 24 2018, (Accepted/In press) In : Archives of Dermatological Research. p. 1-11 11 p.

Research output: Contribution to journalArticle

Atopic Dermatitis
Keratinocytes
STAT6 Transcription Factor
Keratin-5
Skin
1 Citation (Scopus)

Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes

Collier, A. E., Spandau, D. & Wek, R., Jan 1 2018, In : Molecular Biology of the Cell. 29, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

Keratinocytes
DNA Repair
Messenger RNA
Protein Biosynthesis
Cytoprotection
2017
1 Citation (Scopus)

Estrogen modulates mesenchyme-epidermis interactions in the adult nipple

Wu, H. J., Oh, J. W., Spandau, D., Tholpady, S., Diaz, J., Schroeder, L. J., Offutt, C. D., Glick, A. B., Plikus, M. V., Koyama, S. & Foley, J., Apr 15 2017, In : Development (Cambridge). 144, 8, p. 1498-1509 12 p.

Research output: Contribution to journalArticle

Nipples
Parathyroid Hormone-Related Protein
Mesoderm
Epidermis
Estrogens
6 Citations (Scopus)

Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2

Collier, A. E., Wek, R. & Spandau, D., Sep 1 2017, In : Journal of Investigative Dermatology. 137, 9, p. 1924-1934 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Keratinocytes
Phosphorylation
Polyribosomes
Epidermis
6 Citations (Scopus)
Somatomedin Receptors
Automatic teller machines
Somatomedins
Keratinocytes
Phosphotransferases
2 Citations (Scopus)

Ocular Pathology of Oculocerebrorenal Syndrome of Lowe: Novel Mutations and Genotype-Phenotype Analysis

Song, E., Luo, N., Alvarado, J. A., Lim, M., Walnuss, C., Neely, D., Spandau, D., Ghaffarieh, A. & Sun, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 1442.

Research output: Contribution to journalArticle

Oculocerebrorenal Syndrome
Genotype
Pathology
Phenotype
Mutation
2016
7 Citations (Scopus)

Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo

Loesch, M. M., Collier, A. E., Southern, D. H., Ward, R. E., Tholpady, S. S., Lewis, D. A., Travers, J. & Spandau, D., Mar 4 2016, (Accepted/In press) In : Molecular Oncology.

Research output: Contribution to journalArticle

Somatomedin Receptors
Keratinocytes
DNA Damage
DNA Repair
Geriatrics
15 Citations (Scopus)

Radiation therapy generates platelet-activating factor agonists

Sahu, R. P., Harrison, K. A., Weyerbacher, J., Murphy, R. C., Konger, R., Garrett, J. E., Chin-Sinex, H. J., Johnston, M. E., Dynlacht, J., Mendonca, M., McMullen, K., Li, G., Spandau, D. & Travers, J., Apr 12 2016, In : Oncotarget. 7, 15, p. 20788-20800 13 p.

Research output: Contribution to journalArticle

Platelet Activating Factor
Radiotherapy
Neoplasms
Immunity
Lipids
2015
2 Citations (Scopus)

Expansion of specialized epidermis induced by hormonal state and mechanical strain

Wu, H. J., Easwaran, T., Offutt, C. D., Elgar, R. L., Spandau, D., Koyama, S. & Foley, J., May 1 2015, In : Mechanisms of Development. 136, p. 73-86 14 p.

Research output: Contribution to journalArticle

Nipples
Epidermis
Connective Tissue
Skin
Relaxin
15 Citations (Scopus)

IL-4 impairs wound healing potential in the skin by repressing fibronectin expression

Serezani, A. P. M., Bozdogan, G., Sehra, S., Walsh, D., Krishnamurthy, P., Sierra Potchanant, E. A., Nalepa, G., Goenka, S., Turner, M. J., Spandau, D. & Kaplan, M., Oct 23 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Keratinocytes
Fibronectins
Interleukin-4
Wound Healing
Atopic Dermatitis
2 Citations (Scopus)

Important implications and new uses of ablative lasers in dermatology: Fractional carbon dioxide laser prevention of skin cancer

Jagdeo, J. R., Brody, N. I., Spandau, D. & Travers, J., Mar 15 2015, In : Dermatologic Surgery. 41, 3, p. 387-389 3 p.

Research output: Contribution to journalArticle

Radiation-Induced Neoplasms
Skin Aging
Gas Lasers
Laser Therapy
Skin Neoplasms
9 Citations (Scopus)
Activating Transcription Factor 4
Keratinocytes
Transcription Factor CHOP
Phosphotransferases
Apoptosis
2014
34 Citations (Scopus)

Primary cilia signaling mediates intraocular pressure sensation

Luo, N., Conwell, M. D., Chen, X., Kettenhofen, C. I., Westlake, C. J., Cantor, L., Wells, C., Weinreb, R. N., Corson, T., Spandau, D., Joos, K. M., Iomini, C., Obukhov, A. & Sun, Y., Sep 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 35, p. 12871-12876 6 p.

Research output: Contribution to journalArticle

Cilia
Intraocular Pressure
TRPV Cation Channels
Trabecular Meshwork
Oculocerebrorenal Syndrome
18 Citations (Scopus)

Pten loss induces autocrine FGF signaling to promote skin tumorigenesis

Hertzler-Schaefer, K., Mathew, G., Somani, A-K., Tholpady, S., Kadakia, M. P., Chen, Y., Spandau, D. & Zhang, X., 2014, In : Cell Reports. 6, 5, p. 818-826 9 p.

Research output: Contribution to journalArticle

Autocrine Communication
Skin
Carcinogenesis
Tumors
Chemical activation
8 Citations (Scopus)

Skin resurfacing procedures: New and emerging options

Loesch, M. M., Somani, A-K., Kingsley, M., Travers, J. & Spandau, D., Aug 28 2014, In : Clinical, Cosmetic and Investigational Dermatology. 7, p. 231-241 11 p.

Research output: Contribution to journalArticle

Skin
Pathology
Therapeutics
2013
11 Citations (Scopus)

Fibroblast senescence and squamous cell carcinoma: How wounding therapies could be protective

Travers, J., Spandau, D., Lewis, D. A., Machado, C., Kingsley, M., Mousdicas, N. & Somani, A-K., Jul 2013, In : Dermatologic Surgery. 39, 7, p. 967-973 7 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Fibroblasts
Skin
Somatomedins
Ultraviolet Rays
2012
14 Citations (Scopus)

Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin

Spandau, D., Lewis, D. A., Somani, A-K. & Travers, J., Jun 2012, In : Journal of Investigative Dermatology. 132, 6, p. 1591-1596 6 p.

Research output: Contribution to journalArticle

Geriatrics
Skin Neoplasms
Solar System
Skin
Lasers
2011
31 Citations (Scopus)

Reversing the aging stromal phenotype prevents carcinoma initiation

Lewis, D. A., Travers, J., Machado, C., Somani, A-K. & Spandau, D., Apr 2011, In : Aging. 3, 4, p. 407-416 10 p.

Research output: Contribution to journalArticle

Geriatrics
Carcinoma
Phenotype
Fibroblasts
Skin

The effect of chemexfoliation and anti-aging regiments on fibroblast expression of IGF-1: A pilot Study

Zandifar, H., Lewis, D. A., Spandau, D., Beeson, W. H. & Travers, J., 2011, In : Laryngoscope. 121, SUPPL. 5

Research output: Contribution to journalArticle

Chemexfoliation
Insulin-Like Growth Factor I
Fibroblasts
Skin
Antioxidants
2010
105 Citations (Scopus)

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

Dey, S., Baird, T. D., Zhou, D., Palam, L. R., Spandau, D. & Wek, R., Oct 22 2010, In : Journal of Biological Chemistry. 285, 43, p. 33165-33174 10 p.

Research output: Contribution to journalArticle

Apoptosis
Endoplasmic Reticulum Stress
Protein Biosynthesis
Regulator Genes
Transcriptome
59 Citations (Scopus)

The IGF-1/IGF-1R signaling axis in the skin: A new role for the dermis in aging-associated skin cancer

Lewis, D. A., Travers, J., Somani, A-K. & Spandau, D., Mar 2010, In : Oncogene. 29, 10, p. 1475-1485 11 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Skin Neoplasms
Somatomedins
Dermis
Keratinocytes
2009
22 Citations (Scopus)

A new paradigm for the role of aging in the development of skin cancer

Lewis, D. A., Travers, J. & Spandau, D., Mar 2009, In : Journal of Investigative Dermatology. 129, 3, p. 787-791 5 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Fibroblasts
Skin
Aging of materials
Ultraviolet Rays
2008
22 Citations (Scopus)

UVB-induced activation of NF-κB is regulated by the IGF-1R and dependent on p38 MAPK

Lewis, D. A. & Spandau, D., Apr 2008, In : Journal of Investigative Dermatology. 128, 4, p. 1022-1029 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Keratinocytes
Chemical activation
Irradiation
Transcription Factors
49 Citations (Scopus)

UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53

Lewis, D. A., Yi, Q., Travers, J. & Spandau, D., Apr 2008, In : Molecular Biology of the Cell. 19, 4, p. 1346-1353 8 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Keratinocytes
Apoptosis
Cyclin-Dependent Kinases
Sunlight
2007
21 Citations (Scopus)

UVB activation of NF-κB in normal human keratinocytes occurs via a unique mechanism

Lewis, D. A. & Spandau, D., May 2007, In : Archives of Dermatological Research. 299, 2, p. 93-101 9 p.

Research output: Contribution to journalArticle

Ultraviolet Rays
Keratinocytes
Tumor Necrosis Factor-alpha
Cell Survival
Homeostasis
2006
39 Citations (Scopus)

Aberrant NF-κB activity in HaCaT cells alters their response to UVB signaling

Lewis, D. A., Hengeltraub, S. F., Gao, F. C., Leivant, M. A. & Spandau, D., Aug 2006, In : Journal of Investigative Dermatology. 126, 8, p. 1885-1892 8 p.

Research output: Contribution to journalArticle

Keratinocytes
Phosphorylation
Transcription Factors
Experiments
Chemical activation
2005
12 Citations (Scopus)

A radiation-induced acute apoptosis involving TP53 and BAX precedes the delayed apoptosis and neoplastic transformation of CGL1 human hybrid cells

Mendonca, M., Mayhugh, B. M., McDowell, B., Chin-Sinex, H., Smith, M. L., Dynlacht, J., Spandau, D. & Lewis, D. A., Jun 2005, In : Radiation Research. 163, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

Hybrid Cells
apoptosis
Radiation
Apoptosis
radiation
24 Citations (Scopus)

Decreased incidence of nonmelanoma skin cancer in patients with type 2 diabetes mellitus using insulin: A pilot study

Chuang, T. Y., Lewis, D. A. & Spandau, D., Sep 2005, In : British Journal of Dermatology. 153, 3, p. 552-557 6 p.

Research output: Contribution to journalArticle

Skin Neoplasms
Type 2 Diabetes Mellitus
Insulin
Incidence
Somatomedin Receptors
64 Citations (Scopus)

Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage

Marathe, G. K., Johnson, C., Billings, S. D., Southall, M. D., Pei, Y., Spandau, D., Murphy, R. C., Zimmerman, G. A., McIntyre, T. M. & Travers, J., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35448-35457 10 p.

Research output: Contribution to journalArticle

Platelet Activating Factor
Ultraviolet Rays
Phospholipids
Radiation
Skin
2004
13 Citations (Scopus)

Keratin 2e: A marker for murine nipple epidermis

Mahler, B., Gocken, T., Brojan, M., Childress, S., Spandau, D. & Foley, J., 2004, In : Cells Tissues Organs. 176, 4, p. 169-177 9 p.

Research output: Contribution to journalArticle

Keratin-2
Nipples
Parathyroid Hormone-Related Protein
Epidermis
Skin
19 Citations (Scopus)

Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Hiatt, K., Ingram, D., Huddleston, H., Spandau, D., Kapur, R. & Clapp, D., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

CD95 Antigens
Myeloid Cells
Tumor Suppressor Genes
Mast Cells
Stem Cell Factor
20 Citations (Scopus)

Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes

Cho, Y. M., Lewis, D. A., Koltz, P. F., Richard, V., Gocken, T. A., Rosol, T. J., Konger, R., Spandau, D. & Foley, J., Apr 2004, In : Journal of Endocrinology. 181, 1, p. 179-190 12 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Keratinocytes
Epidermal Growth Factor
Ligands
Gene Expression
2003
22 Citations (Scopus)

Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors: An In Vivo Xenograft Model of Keratoacanthoma

Billings, S. D., Southall, M. D., Li, T., Cook, P. W., Baldridge, L., Moores, W. B., Spandau, D., Foley, J. & Travers, J., Dec 2003, In : American Journal of Pathology. 163, 6, p. 2451-2458 8 p.

Research output: Contribution to journalArticle

Keratoacanthoma
Heterografts
Neoplasms
Squamous Cell Carcinoma
Basal Cell Carcinoma
17 Citations (Scopus)

Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis

Lewis, D. A., Zweig, B., Hurwitz, S. A. & Spandau, D., Mar 1 2003, In : Journal of Investigative Dermatology. 120, 3, p. 483-488 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Apoptosis
Protein-Tyrosine Kinases
Chemical activation
Cells
26 Citations (Scopus)

The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines

Li, T., Southall, M. D., Yi, Q., Pei, Y., Lewis, D., Al-Hassani, M., Spandau, D. & Travers, J., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16614-16621 8 p.

Research output: Contribution to journalArticle

Chemotherapy
Platelet Activating Factor
Cells
Apoptosis
Carcinoma
19 Citations (Scopus)

UVB-induced apoptosis in normal human keratinocytes: Role of the erbB receptor family

Lewis, D. A., Hurwitz, S. A. & Spandau, D., Apr 1 2003, In : Experimental Cell Research. 284, 2, p. 316-327 12 p.

Research output: Contribution to journalArticle

Keratinocytes
Apoptosis
Protein-Tyrosine Kinases
ErbB Receptors
Bleomycin
2002
75 Citations (Scopus)

E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis

Zhang, B., Spandau, D. & Roman, A., 2002, In : Journal of Virology. 76, 1, p. 220-231 12 p.

Research output: Contribution to journalArticle

Foreskin
Papillomaviridae
keratinocytes
Keratinocytes
apoptosis
16 Citations (Scopus)

Effect of Ultraviolet B Radiation and 100 Hz Electromagnetic Fields on Proliferation and DNA Synthesis of Jurkat Cells

Nindl, G., Hughes, E. F., Johnson, M. T., Spandau, D., Vesper, D. N. & Balcavage, W. X., Sep 2002, In : Bioelectromagnetics. 23, 6, p. 455-463 9 p.

Research output: Contribution to journalArticle

Electromagnetic Fields
Jurkat Cells
Ultraviolet Rays
ultraviolet radiation
Radiation
43 Citations (Scopus)
Platelet Activating Factor
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor Receptor
Cell Proliferation
2001
2 Citations (Scopus)

A system for simultaneous ultraviolet light and electromagnetic field exposure in in vitro experiments

Vesper, D. N., Nindl, G., Johnson, M. T., Spandau, D., Swez, J. A. & Balcavage, W. X., 2001, In : Biomedical Sciences Instrumentation. 37, p. 221-226 6 p.

Research output: Contribution to journalArticle

Electromagnetic Fields
Ultraviolet Rays
Electromagnetic fields
Vents
Experiments
36 Citations (Scopus)
Tumor Necrosis Factor-alpha
Apoptosis
Ligands
Chemical activation
G-Protein-Coupled Receptors
2000
21 Citations (Scopus)
Interleukin-8
Radiation
Platelet Activating Factor
KB Cells
Cytokines
19 Citations (Scopus)

Quantitative analysis of UVB-induced apoptosis in human epidermis

Hurwitz, S. A. & Spandau, D., Jun 2000, In : Experimental Dermatology. 9, 3, p. 185-191 7 p.

Research output: Contribution to journalArticle

Epidermis
Caspase 3
Apoptosis
Chemical analysis
Chemical activation
5 Citations (Scopus)

Use of enhanced green fluorescent protein to monitor retroviral-mediated gene therapy in human keratinocytes

Spandau, D., Marques, M., Bierhuizen, M., Wagemaker, G., Hurwitz, S., Pei, Y., Breese, R. & Travers, J., Aug 2000, In : Experimental Dermatology. 9, 4, p. 252-257 6 p.

Research output: Contribution to journalArticle

Gene therapy
Keratinocytes
Genetic Therapy
Gene transfer
Cells
1999
85 Citations (Scopus)

Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation

Kuhn, C., Hurwitz, S. A., Kumar, M. G., Cotton, J. & Spandau, D., 1999, In : International Journal of Cancer. 80, 3, p. 431-438 8 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
IGF Type 1 Receptor
Keratinocytes
Apoptosis
DNA Damage
16 Citations (Scopus)

Subphysiological concentrations of extracellular calcium sensitize normal human keratinocytes to UVB-induced apoptosis

Kumar, M. G., Hurwitz, S. A., Cotton, J. & Spandau, D., 1999, In : Archives of Dermatological Research. 291, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Keratinocytes
Apoptosis
Calcium
Cell Death
Fluorescein-5-isothiocyanate
1998
65 Citations (Scopus)

Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line

Barber, L. A., Spandau, D., Rathman, S. C., Murphy, R. C., Johnson, C. A., Kelley, S. W., Hurwitz, S. A. & Travers, J., Jul 24 1998, In : Journal of Biological Chemistry. 273, 30, p. 18891-18897 7 p.

Research output: Contribution to journalArticle

Platelet Activating Factor
Cells
Radiation
Apoptosis
Cell Line
1997
77 Citations (Scopus)

Ultraviolet B-radiation dose influences the induction of apoptosis and p53 in human keratinocytes

Cotton, J. & Spandau, D., 1997, In : Radiation Research. 147, 2, p. 148-155 8 p.

Research output: Contribution to journalArticle

keratinocytes
apoptosis
Keratinocytes
ultraviolet radiation
induction
1996
15 Citations (Scopus)
Cell-Matrix Junctions
Intercellular Junctions
Intermediate Filaments
Vimentin
Keratins
1995
5 Citations (Scopus)

p53-binding proteins in squamous cell carcinoma and normal human keratinocytes

Kumar, M. G. & Spandau, D., 1995, In : Cell Growth and Differentiation. 6, 12, p. 1601-1608 8 p.

Research output: Contribution to journalArticle

Keratinocytes
Squamous Cell Carcinoma
Carrier Proteins
Proteins
Neoplasms