David Crabb

  • 9474 Citations
  • 49 h-Index
1976 …2019
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Publications 1976 2019

2019

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis

Li, W., Lin, E. L., Liangpunsakul, S., Lan, J., Chalasani, S., Rane, S., Puri, P., Kamath, P. S., Sanyal, A. J., Shah, V. H., Radaeva, S., Crabb, D., Chalasani, N. & Yu, A., Jun 1 2019, In : Clinical and translational gastroenterology. 10, 6, p. e00052

Research output: Contribution to journalArticle

Open Access
Alcohol Abstinence
Alcoholic Hepatitis
HLA Antigens
Blood Cells
Mucosal-Associated Invariant T Cells

Drug-induced liver injury

Chalasani, N. & Crabb, D., Jan 1 2019, In : Gastroenterology and Hepatology. 15, 1, p. 35-37 3 p.

Research output: Contribution to journalComment/debate

Chemical and Drug Induced Liver Injury
1 Citation (Scopus)

Introducing the 2019 American Association for the Study of Liver Diseases Guidance on Alcohol-Related Liver Disease

Lucey, M. R., Im, G. Y., Mellinger, J. L., Szabo, G. & Crabb, D., Jan 1 2019, (Accepted/In press) In : Liver Transplantation.

Research output: Contribution to journalEditorial

Liver Diseases
Alcohols
2018

An Initial Assessment of the Utility of Validated Alcohol and Drug Screening Tools in Predicting 30-Day Readmission to Adult General Medicine Wards

Gerke, S. P., Agley, J. D., Wilson, C., Gassman, R. A., Forys, P. & Crabb, D., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Quality.

Research output: Contribution to journalArticle

Patients' Rooms
Preclinical Drug Evaluations
Alcohols
Medicine
Substance Abuse Detection

Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease

Chang, B., Hao, S., Zhang, L., Gao, M., Sun, Y., Huang, A., Teng, G., Li, B., Crabb, D., Kusumanchi, P., Wang, L., Liangpunsakul, S. & Zou, Z., Jan 1 2018, (Accepted/In press) In : American Journal of the Medical Sciences.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Aldehyde Dehydrogenase
Alcohols
Odds Ratio
Alcohol Dehydrogenase
1 Citation (Scopus)
Alcoholic Liver Diseases
Liver
Substance-Related Disorders
Psychiatry
Liver Diseases
1 Citation (Scopus)

Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis

Samala, N., Lourens, S. G., Shah, V. H., Kamath, P. S., Sanyal, A. J., Crabb, D., Tang, Q., Radaeva, S., Liangpunsakul, S. & Chalasani, N., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Post-Traumatic Stress Disorders
Alcohol Drinking
Alcohols
Liver
1 Citation (Scopus)

Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers

Plawecki, M. H., White, K., Kosobud, A., Grahame, N., Zimmermann, U. S., Crabb, D. & O'Connor, S., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Sex Characteristics
Motivation
Young Adult
Alcohols
Drinking
19 Citations (Scopus)

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

Puri, P., Liangpunsakul, S., Christensen, J. E., Shah, V. H., Kamath, P. S., Gores, G. J., Walker, S., Comerford, M., Katz, B., Borst, A., Yu, A., Kumar, D. P., Mirshahi, F., Radaeva, S., Chalasani, N., Crabb, D. & Sanyal, A. J., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Metagenomics
Microbiota
Drinking
Fusobacteria
3 Citations (Scopus)

‘Asking’ but Not ‘Screening’: Assessing Physicians’ and Nurses’ Substance-Related Clinical Behaviors

Agley, J., Carlson, J. M., McNelis, A. M., Gassman, R. A., Schwindt, R., Crabb, D. & Vannerson, J., Feb 14 2018, (Accepted/In press) In : Substance Use and Misuse. p. 1-6 6 p.

Research output: Contribution to journalArticle

Referral and Consultation
nurse
Nurses
physician
Physicians
2017
7 Citations (Scopus)

Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study

Li, W., Amet, T., Xing, Y., Yang, D., Liangpunsakul, S., Puri, P., Kamath, P. S., Sanyal, A. J., Shah, V. H., Katz, B., Radaeva, S., Crabb, D., Chalasani, N. & Yu, A., Aug 1 2017, In : Hepatology. 66, 2, p. 575-590 16 p.

Research output: Contribution to journalArticle

Alcohol Abstinence
Alcoholic Hepatitis
Observational Studies
Prospective Studies
Chemokine CCL22
2 Citations (Scopus)

An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis

Beaudoin, J. J., Long, N., Liangpunsakul, S., Puri, P., Kamath, P. S., Shah, V., Sanyal, A. J., Crabb, D., Chalasani, N. & Urban, T. J., Aug 3 2017, (Accepted/In press) In : Scandinavian Journal of Gastroenterology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Genome
Genome-Wide Association Study
Genes
Alcoholic Liver Cirrhosis
2 Citations (Scopus)

Challenges in Patient Enrollment and Retention in Clinical Studies for Alcoholic Hepatitis: Experience of the TREAT Consortium

Comerford, M., Lourens, S., Liangpunsakul, S., Chalasani, N., Sanyal, A. J., Shah, V. H., Kamath, P. S., Puri, P., Katz, B., Radaeva, S. & Crabb, D., 2017, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Screening
Observational Studies
Refusal to Participate
Demography
8 Citations (Scopus)

Effects and Durability of an SBIRT Training Curriculum for First-Year MSW Students

Carlson, J. M., Agley, J., Gassman, R. A., McNelis, A. M., Schwindt, R., Vannerson, J., Crabb, D. & Khaja, K., Apr 3 2017, In : Journal of Social Work Practice in the Addictions. 17, 1-2, p. 135-149 15 p.

Research output: Contribution to journalArticle

first-year student
Curriculum
Referral and Consultation
alcohol
Alcohols

In Memoriam—Lawrence Lumeng, MD: Researcher, Clinician, Leader, Mentor, Family Man, and Friend

Chalasani, N., Crabb, D. & Rex, D., Oct 1 2017, In : Gastroenterology. 153, 4, p. 873-874 2 p.

Research output: Contribution to journalEditorial

Mentors
Research Personnel

Lawrence Lumeng, MD: Researcher, Clinician, Leader, Mentor - In Memoriam

Crabb, D. W., Mcbride, W. J., Grahame, N. J., Bell, R. L. & Kareken, D. A., 2017, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Mentors
Research Personnel
2016
5 Citations (Scopus)

Early Detection of Alcoholic Liver Disease: Are We a Step Closer?

Liangpunsakul, S. & Crabb, D., Jan 1 2016, In : Gastroenterology. 150, 1, p. 29-31 3 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Alcoholic Liver Cirrhosis
Alcoholic Liver Diseases
16 Citations (Scopus)

Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis

Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium, Dec 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 12, p. 1831-1838.e3

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Alcohol Drinking
Body Weight
Drinking
Body Mass Index
12 Citations (Scopus)

If you teach it, they will screen: Advanced practice nursing students’ use of screening and brief intervention in the clinical setting

Agley, J., McNelis, A. M., Carlson, J. M., Schwindt, R., Clark, C. A., Kent, K. A., Lay, K., Gassman, R. A. & Crabb, D., Apr 1 2016, In : Journal of Nursing Education. 55, 4, p. 231-235 5 p.

Research output: Contribution to journalArticle

Advanced Practice Nursing
Nursing Students
Family Nurse Practitioners
nursing
Referral and Consultation
86 Citations (Scopus)

Standard Definitions and Common Data Elements for Clinical Trials in Patients with Alcoholic Hepatitis: Recommendation from the NIAAA Alcoholic Hepatitis Consortia

Crabb, D., Bataller, R., Chalasani, N., Kamath, P. S., Lucey, M., Mathurin, P., McClain, C., McCullough, A., Mitchell, M. K. C., Morgan, T. R., Nagy, L., Radaeva, S., Sanyal, A., Shah, V. & Szabo, G., Apr 1 2016, In : Gastroenterology. 150, 4, p. 785-790 6 p.

Research output: Contribution to journalArticle

Severity of Illness Index
National Institute on Alcohol Abuse and Alcoholism (U.S.)
Endpoint Determination
Alcoholic Hepatitis
Research Design
2015
11 Citations (Scopus)

Novel serum biomarkers for detection of excessive alcohol use

Liangpunsakul, S., Lai, X., Ross, R. A., Yu, Z., Modlik, E., Westerhold, C., Heathers, L., Paul, R., O'Connor, S., Crabb, D. & Witzmann, F., Mar 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 3, p. 556-565 10 p.

Research output: Contribution to journalArticle

Biomarkers
Alcohols
Serum
Erythrocyte Indices
Alanine Transaminase
1 Citation (Scopus)

Pathogenesis of alcoholic liver disease

Arteel, G. E. & Crabb, D., Jan 1 2015, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside. Springer International Publishing, p. 41-69 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alcoholic Liver Diseases
Fibrosis
Liver
Alcoholic Fatty Liver
Inflammation
16 Citations (Scopus)

The Utility of Commonly Used Laboratory Tests to Screen for Excessive Alcohol Use in Clinical Practice

Gough, G., Heathers, L., Puckett, D., Westerhold, C., Ren, X., Yu, Z., Crabb, D. & Liangpunsakul, S., Aug 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 8, p. 1493-1500 8 p.

Research output: Contribution to journalArticle

Alcohols
Aspartate Aminotransferases
Alanine Transaminase
Transferases
Alcoholic Liver Cirrhosis
2014
9 Citations (Scopus)

Assessing the relationship between medical residents' perceived barriers to SBIRT implementation and their documentation of SBIRT in clinical practice

Agley, J., Gassman, R. A., Vannerson, J. & Crabb, D., 2014, In : Public Health. 128, 8, p. 755-758 4 p.

Research output: Contribution to journalArticle

Physicians' Practice Patterns
Attitude of Health Personnel
health worker
Internship and Residency
Documentation
4 Citations (Scopus)
alcohol consumption
Nonesterified Fatty Acids
Adipocytes
Alcohol Drinking
Adipose Tissue

Metabolism

Plawecki, M. H. & Crabb, D., 2014, In : Handbook of Clinical Neurology. 125, p. 55-69 15 p.

Research output: Contribution to journalArticle

Ethanol
Pharmacokinetics
Enzymes
Metabolic Networks and Pathways
Nervous System
2013
16 Citations (Scopus)

Activation of carbohydrate response element-binding protein by ethanol

Liangpunsakul, S., Ross, R. A. & Crabb, D., Feb 2013, In : Journal of Investigative Medicine. 61, 2, p. 270-277 8 p.

Research output: Contribution to journalArticle

Response Elements
Carrier Proteins
Ethanol
Chemical activation
Carbohydrates
13 Citations (Scopus)

Chronic Free-Choice Drinking in Crossed High Alcohol Preferring Mice Leads to Sustained Blood Ethanol Levels and Metabolic Tolerance Without Evidence of Liver Damage

Matson, L., Liangpunsakul, S., Crabb, D., Buckingham, A., Ross, R. A., Halcomb, M. & Grahame, N., Feb 2013, In : Alcoholism: Clinical and Experimental Research. 37, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

Liver
Drinking
Blood
Ethanol
Alcohols
2012
10 Citations (Scopus)

Alcohol Exposure Rate Control Through Physiologically Based Pharmacokinetic Modeling

Plawecki, M. H., Zimmermann, U. S., Vitvitskiy, V., Doerschuk, P. C., Crabb, D. & O'Connor, S., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 530-542 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Alcohols
Trajectories
Intravenous Infusions
Design of experiments
40 Citations (Scopus)
Sphingomyelin Phosphodiesterase
Imipramine
Ceramides
Ethanol
Acids
2011
61 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
AMP-Activated Protein Kinases
Hepatocellular Carcinoma
rosiglitazone
Metformin
30 Citations (Scopus)
Fanconi Anemia
Acetaldehyde
Metabolism
DNA Damage
Ethanol
11 Citations (Scopus)

Ethanol impairs differentiation of human adipocyte stromal cells in culture

Crabb, D., Zeng, Y., Liangpunsakul, S., Jones, R. & Considine, R., Sep 2011, In : Alcoholism: Clinical and Experimental Research. 35, 9, p. 1584-1592 9 p.

Research output: Contribution to journalArticle

Stromal Cells
Adipocytes
Ethanol
Cell Culture Techniques
Tissue
34 Citations (Scopus)

Ethanol-Induced Alterations in Fatty Acid-Related Lipids in Serum and Tissues in Mice

Zhao, Z., Yu, M., Crabb, D., Xu, Y. & Liangpunsakul, S., Feb 2011, In : Alcoholism: Clinical and Experimental Research. 35, 2, p. 229-234 6 p.

Research output: Contribution to journalArticle

Ethanol
Fatty Acids
Tissue
Lipids
Serum
17 Citations (Scopus)

Ethanol Metabolism by HeLa Cells Transduced With Human Alcohol Dehydrogenase Isoenzymes: Control of the Pathway by Acetaldehyde Concentration

Matsumoto, M., Cyganek, I., Sanghani, P. C., Cho, W. K., Liangpunsakul, S. & Crabb, D., Jan 2011, In : Alcoholism: Clinical and Experimental Research. 35, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Acetaldehyde
Alcohol Dehydrogenase
HeLa Cells
Metabolism
Isoenzymes
2010
100 Citations (Scopus)

Alcohol consumption and ethyl carbamate

Allen, N., Anderson, L. M., Beland, F. A., Bénichou, J., Beral, V., Bloomfield, K., Brooks, P. J., Cai, L., Cho, S. I., Crabb, D., Eriksson, P., Gapstur, S. M., Gmel, G., Griciute, L. L., Kono, S., Lachenmeier, D. W., La Vecchia, C., Marques, M. M., Miller, A. B., Rehm, J. & 41 others, Rehn-Mendoza, N., Rusyn, I., Seitz, H. K., Weiderpass, E., Willett, W. C., Yokoyama, A., Zhang, Z. F., Huici-Montagud, A., Altieri, A., Baan, R., Balbo, S., Berthiller, J., Bouvard, V., Brennan, P., Cogliano, V. J., El Ghissassi, F., Ferrari, P., Franceschi, S., Gaudin, N., Grosse, Y., Hashibe, M., Islami, F., Lee, Y. C. A., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Tong, W. M., Egraz, S., Javin, M., Kajo, B., Lézère, M., Lorenzen-Augros, H., Benbrahim-Tallaa, L., Freeman, C., Guha, N., Galichet, L., Hameau, A. S., Moutinho, S. & Russell, D., 2010, In : IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 96, p. 1-1379 1379 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
AMP-Activated Protein Kinases
Ceramides
Protein Phosphatase 2
Ethanol
Phosphorylation
37 Citations (Scopus)

Relationship among alcohol intake, body fat, and physical activity: A population-based study

Liangpunsakul, S., Crabb, D. & Qi, R., Sep 2010, In : Annals of Epidemiology. 20, 9, p. 670-675 6 p.

Research output: Contribution to journalArticle

Adipose Tissue
Alcohols
Exercise
Alcohol Drinking
Nutrition Surveys
22 Citations (Scopus)
Erythrocyte Indices
gamma-Glutamyltransferase
Apolipoprotein A-I
Apolipoproteins B
Aspartate Aminotransferases
95 Citations (Scopus)

The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis

Sozio, M. S., Liangpunsakul, S. & Crabb, D., 2010, In : Seminars in Liver Disease. 30, 4, p. 378-390 13 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Fatty Acids
Liver
Lipids
Alcoholic Fatty Liver
2009
2 Citations (Scopus)

Alcoholic Liver Diseases

Liangpunsakul, S. & Crabb, D., Feb 17 2009, Textbook of Gastroenterology, Fifth Edition. Blackwell Publishing Ltd., Vol. 2. p. 2247-2273 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alcoholic Liver Diseases
Alcohol Dehydrogenase
18 Citations (Scopus)

A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS

Lai, X., Liangpunsakul, S., Crabb, D., Ringham, H. N. & Witzmann, F., Jun 2009, In : Electrophoresis. 30, 12, p. 2207-2214 8 p.

Research output: Contribution to journalArticle

Workflow
Biomarkers
Proteomics
Alcoholism
Blood Proteins
13 Citations (Scopus)

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase

Liangpunsakul, S., Wou, S. E., Wineinger, K. D., Zeng, Y., Cyganek, I., Jayaram, H. N. & Crabb, D., May 1 2009, In : Archives of Biochemistry and Biophysics. 485, 1, p. 10-15 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Adenosine Monophosphate
Protein Kinases
Chemical activation
Peroxisome Proliferator-Activated Receptors
3 Citations (Scopus)

Serum proteomic profiles in subjects with heavy alcohol abuse

Liangpunsakul, S., Lai, X., Ringham, H. N., Crabb, D. & Witzmann, F., May 2009, In : Journal of Proteomics and Bioinformatics. 2, 5, p. 236-243 8 p.

Research output: Contribution to journalArticle

Proteomics
Alcoholism
Alcohols
Alcohol Drinking
Mass Spectrometry
2008
140 Citations (Scopus)

Alcohol and lipid metabolism

Sozio, M. & Crabb, D., Jul 2008, In : American Journal of Physiology - Endocrinology and Metabolism. 295, 1

Research output: Contribution to journalArticle

Lipid Metabolism
Alcohols
Alcoholic Liver Diseases
Endoplasmic Reticulum Stress
Adipokines
34 Citations (Scopus)

Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation

Liangpunsakul, S., Wou, S. E., Zeng, Y., Ross, R. A., Jayaram, H. N. & Crabb, D., Dec 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 6

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Hydrogen Peroxide
Ethanol
Phosphorylation
Protein Phosphatase 2
2007
29 Citations (Scopus)

Acetaldehyde generating enzyme systems: Roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes

Crabb, D. & Liangpunsakul, S., 2007, Novartis Foundation Symposium. Vol. 285. p. 4-16 13 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cytochrome P-450 CYP2E1
Acetaldehyde
Alcohol Dehydrogenase
Catalase
Enzymes
15 Citations (Scopus)

Alcoholic myopathy and acetaldehyde

Preedy, V. R., Crabb, D., Farrés, J. & Emery, P. W., 2007, Novartis Foundation Symposium. Vol. 285. p. 158-177 20 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Acetaldehyde
Muscle Proteins
Muscular Diseases
Alcohols
Cyanamide
13 Citations (Scopus)

Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population

Fischer, M., Wetherill, L. F., Carr, L. G., You, M. & Crabb, D., Oct 2007, In : Alcoholism: Clinical and Experimental Research. 31, 10, p. 1654-1659 6 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Polymorphism
Alcohol Drinking
Alcohols
Alleles

Discussion

Eriksson, C. J. P., Preedy, V. R., Albano, E., Salaspuro, M., Seitz, H. K., Emery, P., Apte, M. V., Shukla, S. D., Worrall, S., Thornalley, P. J., Rao, R. K., Niemelä, O., Crabb, D. & Ren, J., 2007, Novartis Foundation Symposium. Vol. 285. p. 177-182 6 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution