David Crabb

  • 9859 Citations
  • 50 h-Index
1976 …2020

Research output per year

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Publications

2007

Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population

Fischer, M., Wetherill, L. F., Carr, L. G., You, M. & Crabb, D. W., Oct 1 2007, In : Alcoholism: Clinical and Experimental Research. 31, 10, p. 1654-1659 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Discussion

Preedy, V. R., Salaspuro, M., Morris, J. B., Seitz, H. K., Apte, M. V., Rao, R. K., Eriksson, C. J. P., Emery, P., Salaspuro, V., Crabb, D. W., Albano, E., Okamura, T. & Ren, J., Dec 1 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 89-96 8 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Crabb, D. W., Seitz, H. K., Emery, P., Worrall, S., Thornalley, P. J., Rao, R. K., Shukla, S. D., Apte, M. V., Deitrich, R. A., Salaspuro, M., Yin, S. J., Ren, J., Okamura, T., Eriksson, C. J. P., Preedy, V. R. & Albano, E., 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 119-124 6 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Deitrich, R. A., Crabb, D. W., Salaspuro, M., Peter Eriksson, C. J., Apte, M. V., Emery, P., Niemelä, O., Worrall, S., Thornalley, P. J., Albano, E., Seitz, H. K. & Shukla, S. D., 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 16-22 7 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Salaspuro, M., Matsuse, H., Morris, J. B., Apte, M. V., Eriksson, C. J. P., Rao, R. K., Deitrich, R. A., Niemelä, O., Thornalley, P. J., Emery, P., Crabb, D. W. & Yin, S. J., 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 106-109 4 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Albano, E., Apte, M. V., Ren, J., Seitz, H. K., Preedy, V. R., Peter Eriksson, C. J., Rao, R. K., Shukla, S. D., Niemelä, O., Crabb, D. W. & Aranda, A., Dec 1 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 211-216 6 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Crabb, D. W., Yin, S. J., Apte, M. V., Emery, P., Preedy, V. R., Peter Eriksson, C. J., Salaspuro, M., Quertemont, E., Deitrich, R. A. & Okamura, T., Dec 1 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 63-68 6 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Eriksson, C. J. P., Preedy, V. R., Albano, E., Salaspuro, M., Seitz, H. K., Emery, P., Apte, M. V., Shukla, S. D., Worrall, S., Thornalley, P. J., Rao, R. K., Niemelä, O., Crabb, D. W. & Ren, J., 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 177-182 6 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Discussion

Seitz, H. K., Deitrich, R. A., Peter Eriksson, C. J., Apte, M. V., Preedy, V. R., Morris, J. B., Albano, E., Worrall, S., Emery, P., Ren, J., Crabb, D. W., Salaspuro, M., Quertemont, E., Thornalley, P. J., Rao, R. K., Aranda, A., Okamura, T., Shukla, S. D., Niemelä, O. & Jamal, M., 2007, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide. p. 40-51 12 p. (Novartis Foundation Symposium; vol. 285).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2006

Acetaldehyde Inhibits PPARγ via H2O2-Mediated c-Abl Activation in Human Hepatic Stellate Cells

Ceni, E., Crabb, D. W., Foschi, M., Mello, T., Tarocchi, M., Patussi, V., Moraldi, L., Moretti, R., Milani, S., Surrenti, C. & Galli, A., Oct 2006, In : Gastroenterology. 131, 4, p. 1235-1252 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Alcohol and lipid metabolism

Crabb, D. W. & Liangpunsakul, S., Oct 2006, In : Journal of Gastroenterology and Hepatology (Australia). 21, SUPPL. 3, p. S56-S60

Research output: Contribution to journalArticle

81 Scopus citations

Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism

McClintick, J. N., Crabb, D. W., Tian, H., Pinaire, J., Smith, J. R., Jerome, R. E. & Edenberg, H. J., May 1 2006, In : Journal of Nutritional Biochemistry. 17, 5, p. 345-355 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol

Bell, R. L., Kimpel, M. W., Rodd, Z. A., Strother, W. N., Bai, F., Peper, C. L., Mayfield, R. D., Lumeng, L., Crabb, D. W., McBride, W. J. & Witzmann, F. A., Aug 1 2006, In : Alcohol. 40, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

51 Scopus citations
2005

Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells

Ceni, E., Mello, T., Tarocchi, M., Crabb, D. W., Caldini, A., Invernizzi, P., Surrenti, C., Milani, S. & Galli, A., Feb 28 2005, In : World Journal of Gastroenterology. 11, 8, p. 1122-1130 9 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice

You, M., Considine, R. V., Leone, T. C., Kelly, D. P. & Crabb, D. W., Sep 1 2005, In : Hepatology. 42, 3, p. 568-577 10 p.

Research output: Contribution to journalArticle

206 Scopus citations
2004
11 Scopus citations

Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARγ independent mechanisms

Galli, A., Ceni, E., Crabb, D. W., Mello, T., Salzano, R., Grappone, C., Milani, S., Surrenti, E., Surrenti, C. & Casini, A., Nov 1 2004, In : Gut. 53, 11, p. 1688-1697 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Molecular mechanisms of alcoholic fatty liver: Role of sterol regulatory element-binding proteins

You, M. & Crabb, D. W., Aug 1 2004, In : Alcohol. 34, 1, p. 39-43 5 p.

Research output: Contribution to journalArticle

90 Scopus citations

Molecular mechanisms of alcoholic fatty liver: Role of peroxisome proliferator-activated receptor alpha

Crabb, D. W., Galli, A., Fischer, M. & You, M., Aug 1 2004, In : Alcohol. 34, 1, p. 35-38 4 p.

Research output: Contribution to journalArticle

102 Scopus citations

Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology

Crabb, D. W., Matsumoto, M., Chang, D. & You, M., Feb 1 2004, In : Proceedings of the Nutrition Society. 63, 1, p. 49-63 15 p.

Research output: Contribution to journalArticle

319 Scopus citations
180 Scopus citations
259 Scopus citations

The role of AMP-activated protein kinase in the action of ethanol in the liver

You, M., Matsumoto, M., Pacold, C. M., Cho, W. K. & Crabb, D. W., Dec 2004, In : Gastroenterology. 127, 6, p. 1798-1808 11 p.

Research output: Contribution to journalArticle

299 Scopus citations
2003

Does Leptin Play a Role in the Pathogenesis of Human Nonalcoholic Steatohepatitis?

Chalasani, N., Crabb, D. W., Cummings, O. W., Kwo, P. Y., Asghar, A., Pandya, P. K. & Considine, R. V., Dec 2003, In : American Journal of Gastroenterology. 98, 12, p. 2771-2776 6 p.

Research output: Contribution to journalArticle

125 Scopus citations

Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis

Chalasani, N., Christopher Gorski, J., Asghar, M. S., Asghar, A., Foresman, B., Hall, S. D. & Crabb, D. W., Mar 1 2003, In : Hepatology. 37, 3, p. 544-550 7 p.

Research output: Contribution to journalArticle

263 Scopus citations

Identification of a Retinoid Receptor Response Element in the Human Aldehyde Dehydrogenase-2 Promoter

Pinaire, J., Chou, W. Y., Morton, M., You, M., Zeng, Y., Cho, W. K., Galli, A., Everett, L., Breen, H., Dumaual, N., Smith, J. R. & Crabb, D., Dec 2003, In : Alcoholism: Clinical and Experimental Research. 27, 12, p. 1860-1866 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats

Witzmann, F. A., Li, J., Strother, W. N., McBride, W. J., Hunter, L., Crabb, D. W., Lumeng, L. & Li, T. K., Jul 1 2003, In : Proteomics. 3, 7, p. 1335-1344 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Metabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatohepatitis

Chalasani, N., Deeg, M. A., Persohn, S. & Crabb, D. W., Aug 1 2003, In : American Journal of Gastroenterology. 98, 8, p. 1849-1855 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Nutritional modulation of the expression of alcohol and aldehyde dehydrogenases and alcohol metabolism

You, M. & Crabb, D., Jan 1 2003, Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake. CRC Press, p. 173-186 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

202 Scopus citations

Reproducibility of oligonucleotide arrays using small samples

McClintick, J. N., Jerome, R. E., Nicholson, C. R., Crabb, D. W. & Edenberg, H. J., Jan 30 2003, In : BMC genomics. 4, 4.

Research output: Contribution to journalArticle

79 Scopus citations
2002

Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro

Galli, A., Crabb, D. W., Ceni, E., Salzano, R., Mello, T., Svegliati-Baroni, G., Ridolfi, F., Trozzi, L., Surrenti, C. & Casini, A., Jan 1 2002, In : Gastroenterology. 122, 7, p. 1924-1940 17 p.

Research output: Contribution to journalArticle

361 Scopus citations

Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP).

You, M., Fischer, M., Deeg, M. A. & Crabb, D. W., Aug 9 2002, In : The Journal of biological chemistry. 277, 32, p. 29342-29347 6 p.

Research output: Contribution to journalArticle

Open Access
351 Scopus citations

Genetics of ethanol metabolism and alcoholic liver disease

Kwo, P. & Crabb, D. W., Jan 1 2002, Ethanol and the Liver: Mechanisms and Management. CRC Press, p. 95-129 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
24 Scopus citations
2001

Alcohol and retinoids

Crabb, D. W., Pinairs, J., Hasanadka, R., Fang, M., Leo, M. A., Lieber, C. S., Tsukamoto, H., Motomura, K., Miyahara, T., Ohata, M., Bosron, W., Sanghani, S., Kedishvili, N., Shiraishi, H., Yokoyama, H., Miyagi, M., Ishii, H., Bergheim, I., Menzl, I., Parlesak, A. & 1 others, Bode, C., 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 207S-217S

Research output: Contribution to journalArticle

26 Scopus citations

Alcoholic liver disease

Lumeng, L. & Crabb, D. W., May 5 2001, In : Current Opinion in Gastroenterology. 17, 3, p. 211-220 10 p.

Research output: Contribution to journalReview article

25 Scopus citations

Genetic and environmental influences on alcohol metabolism in humans

Li, T. K., Yin, S. J., Crabb, D. W., O'Connor, S. & Ramchandani, V. A., Jan 1 2001, In : Alcoholism: Clinical and Experimental Research. 25, 1, p. 136-144 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Peroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo

Crabb, D. W., Pinaire, J., Chou, W. Y., Sissom, S., Peters, J. M., Harris, R. A. & Stewart, M., Jan 1 2001, In : Alcoholism: Clinical and Experimental Research. 25, 7, p. 945-952 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
151 Scopus citations

Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism

Donohue, J., Clemens, D. L., Galli, A., Crabb, D., Nieto, N., Kato, J. & Barve, S. S., 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 87S-93S

Research output: Contribution to journalArticle

15 Scopus citations
2000

Alcoholic liver disease

Lumeng, L. & Crabb, D. W., Dec 1 2000, In : Current Opinion in Gastroenterology. 16, 3, p. 208-218 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Effects of vitamin A deficiency on rat liver alcohol dehydrogenase expression and alcohol elimination rate in rats

Pinaire, J., Smith, J. R., Cho, W. K. & Crabb, D. W., Jan 1 2000, In : Alcoholism: Clinical and Experimental Research. 24, 12, p. 1759-1764 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mammalian 3-hydroxyisobutyrate dehydrogenase

Hawes, J. W., Crabb, D. W., Chan, R. J., Rougraff, P. M., Paxton, R. & Harris, R. A., Jan 1 2000, In : Methods in Enzymology. 324, p. 218-228 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peroxisome proliferator-activated receptor γ transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells

Galli, A., Crabb, D., Price, D., Ceni, E., Salzano, R., Surrenti, C. & Casini, A., Jan 1 2000, In : Hepatology. 31, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

189 Scopus citations

The retinoid X receptor response element in the human aldehyde dehydrogenase 2 promoter is antagonized by the chicken ovalbumin upstream promoter family of orphan receptors

Pinaire, J., Hasanadka, R., Fang, M., Chou, W. Y., Stewart, M. J., Kruijer, W. & Crabb, D., Aug 1 2000, In : Archives of Biochemistry and Biophysics. 380, 1, p. 192-200 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease

Everett, L., Galli, A. & Crabb, D., 2000, In : Liver. 20, 3, p. 191-199 9 p.

Research output: Contribution to journalReview article

102 Scopus citations

Alcohol and medication interactions

Weathermon, R. & Crabb, D. W., Dec 1 1999, In : Alcohol Research and Health. 23, 1, p. 40-54 15 p.

Research output: Contribution to journalArticle

206 Scopus citations

Alcohol's influences on various disease states

Weathermon, R. & Crabb, D. W., Dec 1 1999, In : Alcohol Research and Health. 23, 1, p. 52-53 2 p.

Research output: Contribution to journalArticle