David Crabb

  • 9859 Citations
  • 50 h-Index
1976 …2020

Research output per year

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Publications

1999

An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): Effects of the sequence variant on transcription factor binding and promoter strength

Chou, W. Y., Stewart, M. J., Carr, L. G., Zheng, D., Stewart, T. R., Williams, A., Pinaire, J. & Crabb, D. W., Jun 1 1999, In : Alcoholism: Clinical and Experimental Research. 23, 6, p. 963-968 6 p.

Research output: Contribution to journalReview article

49 Scopus citations

High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells

Galli, A., Price, D. & Crabb, D., Jan 1 1999, In : Hepatology. 29, 4, p. 1164-1170 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

Pathogenesis of alcoholic liver disease: Newer mechanisms of injury

Crabb, D. W., Jan 1 1999, In : Keio Journal of Medicine. 48, 4, p. 184-188 5 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations
17 Scopus citations
1998

Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4

Stewart, M. J., Dipple, K. M., Estonius, M., Nakshatri, H., Everett, L. M. & Crabb, D. W., Aug 20 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1399, 2-3, p. 181-186 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
24 Scopus citations

Studies on the enzymology of aldehyde dehydrogenase-2 in genetically modified HeLa cells

Crabb, D. & Xiao, Q., Jan 1 1998, In : Alcoholism: Clinical and Experimental Research. 22, 4, p. 780-781 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
1997

A direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene

Chan, R. M., Stewart, M. J. & Crabb, D. W., Apr 1 1997, In : Molecular Brain Research. 45, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

A new instrument for measuring patient utilities for colorectal cancer outcome states

Ness, R., Crabb, D., Holmes, A., Klein, R., Rex, D. & Dittus, R., Jan 1 1997, In : Gastrointestinal endoscopy. 45, 4, p. AB113

Research output: Contribution to journalArticle

First pass metabolism of ethanol: gastric or hepatic, mountain or molehill?

Crabb, D. W., May 1997, In : Hepatology (Baltimore, Md.). 25, 5, p. 1292-1294 3 p.

Research output: Contribution to journalArticle

18 Scopus citations

Structural and mechanistic aspects of a new family of dehydrogenases, the β-hydroxy acid dehydrogenases

Hawes, J. W., Harper, E. T., Crabb, D. W. & Harris, R. A., Apr 1 1997, In : Advances in experimental medicine and biology. 414, p. 395-402 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Studies on the dominant negative effect of the ALDH2*2 allele

Xiao, Q., Weiner, H. & Crabb, D., Apr 1 1997, In : Advances in experimental medicine and biology. 414, p. 187-194 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
1996

Catabolism of isobutyrate by colonocytes

Jaskiewicz, J., Zhao, Y., Hawes, J. W., Shimomura, Y., Crabb, D. W. & Harris, R. A., Mar 15 1996, In : Archives of Biochemistry and Biophysics. 327, 2, p. 265-270 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
1 Scopus citations

Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues

Stewart, M. J., Malek, K. & Crabb, D. W., Jan 1 1996, In : Journal of Investigative Medicine. 44, 2, p. 42-46 5 p.

Research output: Contribution to journalArticle

118 Scopus citations

Gene regulation of alcohol metabolizing enzymes

Crabb, D. W. & Edenberg, H. J., Dec 5 1996, In : Alcoholism: Clinical and Experimental Research. 20, 8 SUPPL., p. 113A-116A

Research output: Contribution to journalArticle

3 Scopus citations

Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as Δ4-3-ketosteroid 5β-reductase

Zhu, Y., Fillenwarth, M. J., Crabb, D., Lumeng, L. & Lin, R. C., Jan 1 1996, In : Hepatology. 23, 1, p. 115-122 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
35 Scopus citations
Open Access
71 Scopus citations

The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene

Stewart, M. J., Dipple, K. M., Stewart, T. R. & Crabb, D. W., Sep 16 1996, In : Gene. 173, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1995

A new family of protein kinases- The mitochondrial protein kinases

Harris, R. A., Popov, K. M., Zhao, Y., Kedishvili, N. Y., Shimomura, Y. & Crabb, D. W., 1995, In : Advances in Enzyme Regulation. 35, C, p. 147-158,IN17,159-162

Research output: Contribution to journalArticle

63 Scopus citations

Chemical Modification and Site-Directed Mutagenesis Studies of Rat 3-Hydroxyisobutyrate Dehydrogenase

Hawes, J. W., Crabb, D. W., Chan, R. M., Harris, R. A. & Rougraff, P. M., Sep 1 1995, In : Biochemistry. 34, 13, p. 4231-4237 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ethanol oxidizing enzymes: Roles in alcohol metabolism and alcoholic liver disease

Crabb, D. W., Jan 1 1995, In : Progress in Liver Diseases. 13, p. 151-172 22 p.

Research output: Contribution to journalReview article

65 Scopus citations
16 Scopus citations

Molecular cloning of the E1 beta subunit of the rat branched chain alpha-ketoacid dehydrogenase.

Zhao, Y., Kuntz, M. J., Harris, R. & Crabb, D., Jan 25 1995, In : Biochimica et Biophysica Acta - General Subjects. 1260, 2, p. 243 1 p.

Research output: Contribution to journalArticle

The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells

Xiao, Q., Weiner, H., Johnston, T. & Crabb, D. W., Nov 1995, In : Journal of Clinical Investigation. 96, 5, p. 2180-2186 7 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme

Stewart, M. J., Malek, K., Xiao, Q., Dipple, K. M. & Crabb, D. W., Jun 6 1995, In : Biochemical and Biophysical Research Communications. 211, 1, p. 144-151 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
1994

17β-Estradiol inhibits expression of human interleukin-6 promoter- reporter constructs by a receptor-dependent mechanism

Pottratz, S. T., Bellido, T., Mocharia, H., Crabb, D. & Manolagas, S. C., 1994, In : Journal of Clinical Investigation. 93, 3, p. 944-950 7 p.

Research output: Contribution to journalArticle

Open Access
239 Scopus citations
13 Scopus citations

Characterization of the 5'-flanking sequence of rat class I alcohol dehydrogenase gene

Cortese, J. F., Majewski, J. L., Crabb, D. W., Edenberg, H. J. & Yang, V. W., Jan 1 1994, In : Journal of Biological Chemistry. 269, 34, p. 21898-21906 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genetic aspects and risk factors in alcoholism and alcoholic liver disease

Lumeng, L. & Crabb, D. W., Aug 1994, In : Gastroenterology. 107, 2, p. 572-578 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long‐term system for study of liver‐specific gene expression

Chen, L., Davis, G. J., Crabb, D. W. & Lumeng, L., Apr 1994, In : Hepatology. 19, 4, p. 989-998 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Low Frequency of the ADH2*2 Allele among Atayal Natives of Taiwan with Alcohol Use Disorders

Thomasson, H. R., Crabb, D. W., Edenberg, H. J., Li, TK. K., Hwu, HG. G., Chen, CC. C., Yeh, EK. K. & Yin, SJ. J., Jun 1994, In : Alcoholism: Clinical and Experimental Research. 18, 3, p. 640-643 4 p.

Research output: Contribution to journalArticle

131 Scopus citations
3 Scopus citations

Site-directed mutagenesis of phosphorylation sites of the branched chain α-ketoacid dehydrogenase complex

Zhao, Y., Hawes, J., Popov, K. M., Jaskiewicz, J., Shimomura, Y., Crabb, D. W. & Harris, R. A., Jul 15 1994, In : Journal of Biological Chemistry. 269, 28, p. 18583-18587 5 p.

Research output: Contribution to journalArticle

36 Scopus citations
1993

Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism

Thomasson, H. R., Crabb, D. W., Edenberg, H. J. & Li, T. K., Mar 1 1993, In : Behavior Genetics. 23, 2, p. 131-136 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Alcohol dehydrogenase polymorphisms and predisposition to alcoholic cirrhosis

Day, C. P., James, O. F. W., Bassendine, M. F., Crabb, D. W., Li, TK. K., Poupon, R. E., Ward, P. & Balkau, B., Jul 1993, In : Hepatology. 18, 1, p. 230-232 3 p.

Research output: Contribution to journalLetter

25 Scopus citations

Alcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes

Crabb, D. W., Dipple, K. M. & Thomasson, H. R., Sep 1993, In : The Journal of Laboratory and Clinical Medicine. 122, 3, p. 234-240 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Detection of a CA Repeat Polymorphism in the Rat Class I Alcohol Dehydrogenase Gene

Carr, L. G., Koivisto, T., Eriksson, C. J. P. & Crabb, D. W., Feb 1993, In : Alcoholism: Clinical and Experimental Research. 17, 1, p. 107-109 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of ethanol on urinary acidification and on gluconeogenesis by isolated renal tubules

Crabb, D. W. & Sidhu, R., Oct 1993, In : Metabolism. 42, 10, p. 1249-1254 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney

Dipple, K. M., Qulali, M., Ross, R. A. & Crabb, D. W., Apr 1993, In : Hepatology. 17, 4, p. 701-706 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Evolutionary relationships of branched chain and non-specific alcohol and aldehyde dehydrogenases

Crabb, D., Kedishvili, N. Y., Popov, K. M., Rougraff, P., Zhao, Y. & Harris, R., 1993, Advances in Experimental Medicine and Biology. Vol. 328. p. 523-532 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Modulation of hepatic and renal alcohol dehydrogenase activity and mRNA by steroid hormones in vivo

Qulali, M., Dipple, K. M. & Crabb, D., 1993, Advances in Experimental Medicine and Biology. Vol. 328. p. 581-590 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Molecular cloning of the branched-chain α-keto acid dehydrogenase kinase and the CoA-dependent methylmalonate semialdehyde dehydrogenase

Harris, R. A., Popov, K. M., Kedishvili, N. Y., Zhao, Y., Shimomura, Y., Robbins, B. & Crabb, D. W., 1993, In : Advances in Enzyme Regulation. 33, C, p. 255-258 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases

Popov, K. M., Kedishvili, N. Y., Zhao, Y., Shimomura, Y., Crabb, D. W. & Harris, R. A., Jan 1 1993, In : Journal of Biological Chemistry. 268, 35, p. 26602-26606 5 p.

Research output: Contribution to journalArticle

120 Scopus citations
22 Scopus citations