Diane Janowicz

  • 500 Citations
  • 14 h-Index
20042019
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Publications 2004 2019

  • 500 Citations
  • 14 h-Index
  • 30 Article
  • 2 Chapter
2019

A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HGBA vaccine efficacy trials

Leduc, I., Fortney, K. R., Janowicz, D., Zwickl, B., Ellinger, S., Katz, B., Lin, H., Dong, Q. & Spinola, S., Jan 1 2019, In : Infection and Immunity. 87, 7, e00112.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Vaccines
Alleles
Skin Ulcer
Hemoglobins

Determination of an interaction network between an extracellular bacterial pathogen and the human host

Griesenauer, B., Tran, T., Fortney, K. R., Janowicz, D., Johnson, P., Gao, H., Barnes, S., Wilson, L. S., Liu, Y. & Spinola, S., May 1 2019, In : mBio. 10, 3, e01193-19.

Research output: Contribution to journalArticle

Open Access
Haemophilus ducreyi
Anaerobiosis
Metabolomics
Ascorbic Acid
RNA Sequence Analysis
2018

Chancroid

Bauer, M. & Janowicz, D., Jan 1 2018, Diagnostics to Pathogenomics of Sexually Transmitted Infections. wiley, p. 277-291 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chancroid
Haemophilus ducreyi
Ulcer
Haemophilus Infections
Coitus
2016
7 Citations (Scopus)

HIV transmission and injection drug use: Lessons from the Indiana outbreak

Janowicz, D., Jul 1 2016, In : Topics in antiviral medicine. 24, 2, p. 90-92 3 p.

Research output: Contribution to journalArticle

Disease Outbreaks
HIV
Injections
Pharmaceutical Preparations
Contact Tracing
2015
10 Citations (Scopus)

DksA and (p)ppGpp have unique and overlapping contributions to Haemophilus ducreyi pathogenesis in humans

Holley, C. L., Zhang, X., Fortney, K. R., Ellinger, S., Johnson, P., Baker, B., Liu, Y., Janowicz, D., Katz, B., Munson, R. S. & Spinola, S., 2015, In : Infection and Immunity. 83, 8, p. 3281-3292 12 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Genes
Virulence
RNA Sequence Analysis
Foreskin
7 Citations (Scopus)

Phosphoethanolamine transferase LptA in haemophilus ducreyi modifies lipid a and contributes to human defensin resistance in vitro

Trombley, M. P., Post, D. M. B., Rinker, S. D., Reinders, L. M., Fortney, K. R., Zwickl, B. W., Janowicz, D., Baye, F. M., Katz, B., Spinola, S. & Bauer, M., Apr 22 2015, In : PLoS One. 10, 4, e0124373.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Defensins
Transferases
transferases
lipooligosaccharides
45 Citations (Scopus)

The human skin microbiome associates with the outcome of and is influenced by bacterial infection

Van Rensburg, J. J., Lin, H., Gao, X., Toh, E., Fortney, K. R., Ellinger, S., Zwickl, B., Janowicz, D., Katz, B., Nelson, D. E., Dong, Q. & Spinolaa, S. M., 2015, In : mBio. 6, 5, e01315-15.

Research output: Contribution to journalArticle

Microbiota
Bacterial Infections
Haemophilus ducreyi
Skin
Volunteers
2014
5 Citations (Scopus)

A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes

Holley, C., Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D., Ellinger, S., Zwickl, B., Katz, B. & Spinola, S., 2014, In : Infection and Immunity. 82, 8, p. 3492-3502 11 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Phenotype
Virulence
Oxidative Stress
Chancroid

Haemophilus ducreyi: Chancroid

Humphreys, T. L. & Janowicz, D., Nov 26 2014, Molecular Medical Microbiology: Second Edition. Elsevier Ltd, Vol. 3. p. 1437-1447 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Haemophilus ducreyi
Chancroid
Ulcer
Fluoroquinolones
Macrolides
7 Citations (Scopus)

Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase

Gangaiah, D., Labandeira-Rey, M., Zhang, X., Fortney, K. R., Ellinger, S., Zwickl, B., Baker, B., Liu, Y., Janowicz, D., Katz, B., Brautigam, C. A., Munson, R. S., Hansen, E. J. & Spinola, S., Feb 11 2014, In : mBio. 5, 1, e01081-13.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Genes
Down-Regulation
Sigma Factor
1 Citation (Scopus)

Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection

Janowicz, D., Zwickl, B. W., Fortney, K. R., Katz, B. & Bauer, M., Jun 24 2014, In : BMC Microbiology. 14, 1, 166.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Haemophilus Infections
Virulence
Membrane Proteins
Lipoproteins
2013
11 Citations (Scopus)

Carbon storage regulator a contributes to the virulence of haemophilus ducreyi in humans by multiple mechanisms

Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D., Ellinger, S., Zwickl, B., Katz, B. & Spinola, S., Feb 2013, In : Infection and Immunity. 81, 2, p. 608-617 10 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Carbon
Foreskin
Bacteria
2012
12 Citations (Scopus)

Permeases of the sap transporter are required for cathelicidin resistance and virulence of haemophilus ducreyi in humans

Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Katz, B., Janowicz, D., Spinola, S. & Bauer, M., Nov 1 2012, In : Journal of Infectious Diseases. 206, 9, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Membrane Transport Proteins
Virulence
Volunteers
Defensins
5 Citations (Scopus)

Sialylation of lipooligosaccharides is dispensable for the virulence of haemophilus ducreyi in humans

Spinola, S., Li, W., Fortney, K. R., Janowicz, D., Zwickl, B., Katz, B. & Munson, R. S., Feb 2012, In : Infection and Immunity. 80, 2, p. 679-687 9 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Sialyltransferases
Glycolipids
N-Acetylneuraminic Acid
2011
15 Citations (Scopus)

A Haemophilus ducreyi CpxR deletion mutant is virulent in human volunteers

Labandeira-Rey, M., Dodd, D., Fortney, K. R., Zwickl, B., Katz, B., Janowicz, D., Spinola, S. & Hansen, E. J., Jun 15 2011, In : Journal of Infectious Diseases. 203, 12, p. 1859-1865 7 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Volunteers
Virulence
Virulence Factors
Chancroid
14 Citations (Scopus)

Expression of the Flp proteins by Haemophilus ducreyi is necessary for virulence in human volunteers

Janowicz, D., Cooney, S. A., Walsh, J., Baker, B., Katz, B., Fortney, K. R., Zwickl, B. W., Ellinger, S. & Munson, R. S., 2011, In : BMC Microbiology. 11, 208.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Volunteers
Foreskin
Fimbriae Proteins
2010
37 Citations (Scopus)

Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans

Spinola, S., Fortney, K. R., Baker, B., Janowicz, D., Zwickl, B., Katz, B., Blick, R. J. & Munson, R. S., Sep 2010, In : Infection and Immunity. 78, 9, p. 3898-3904 7 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Phosphoric Monoester Hydrolases
Down-Regulation
Periplasm
Operon
23 Citations (Scopus)

Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans

Mount, K. L. B., Townsend, C. A., Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Janowicz, D., Spinola, S., Katz, B. & Bauer, M., Mar 2010, In : Infection and Immunity. 78, 3, p. 1176-1184 9 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Defensins
Peptides
Haemophilus influenzae
19 Citations (Scopus)

Host-pathogen interplay of Haemophilus ducreyi

Janowicz, D., Li, W. & Bauer, M., Feb 2010, In : Current Opinion in Infectious Diseases. 23, 1, p. 64-69 6 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Haemophilus Infections
Virulence Factors
Virulence
Chancroid
11 Citations (Scopus)

Role played by CD4+FOXP3+ regulatory T cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers

Li, W., Tenner-Racz, K., Racz, P., Janowicz, D., Fortney, K. R., Katz, B. & Spinola, S., Jun 15 2010, In : Journal of Infectious Diseases. 201, 12, p. 1839-1848 10 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Regulatory T-Lymphocytes
Volunteers
T-Lymphocytes
Infection
2009
22 Citations (Scopus)

A fibrinogen-binding lipoprotein contributes to the virulence of Haemophilus ducreyi in humans

Bauer, M., Townsend, C. A., Doster, R. S., Fortney, K. R., Zwickl, B. W., Katz, B., Spinola, S. & Janowicz, D., Mar 1 2009, In : Journal of Infectious Diseases. 199, 5, p. 684-692 9 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Fibrinogen
Lipoproteins
Virulence
Carrier Proteins
53 Citations (Scopus)
Haemophilus ducreyi
Volunteers
Infection
Chancroid
Hypertrophic Cicatrix
12 Citations (Scopus)

Inactivation of the haemophilus ducreyi luxS gene affects the virulence of this pathogen in human subjects

Labandeira-Rey, M., Janowicz, D., Blick, R. J., Fortney, K. R., Zwickl, B., Katz, B., Spinola, S. & Hansen, E. J., Aug 1 2009, In : Journal of Infectious Diseases. 200, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Genes
Chancroid
Confidence Intervals
16 Citations (Scopus)

Mechanism of human natural killer cell activation by haemophilus ducreyi

Li, W., Janowicz, D., Fortney, K. R., Katz, B. & Spinola, S., Aug 15 2009, In : Journal of Infectious Diseases. 200, 4, p. 590-598 9 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Natural Killer Cells
Interleukin-18
Interleukin-12
Dendritic Cells
2008
23 Citations (Scopus)

Identification of Haemophilus ducreyi genes expressed during human infection

Bauer, M., Fortney, K. R., Harrison, A., Janowicz, D., Munson, R. S. & Spinola, S., Apr 2008, In : Microbiology. 154, 4, p. 1152-1160 9 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Infection
Genes
Volunteers
Virulence
2007
20 Citations (Scopus)

Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers

Humphreys, T. L., Li, L., Li, X., Janowicz, D., Fortney, K. R., Zhao, Q., Li, W., McClintick, J., Katz, B., Wilkes, D. S., Edenberg, H. & Spinola, S., Dec 2007, In : Infection and Immunity. 75, 12, p. 5686-5697 12 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Haemophilus Infections
Langerhans Cells
Dendritic Cells
Volunteers
11 Citations (Scopus)

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication

Janowicz, D., Tenner-Racz, K., Racz, P., Humphreys, T. L., Schnizlein-Bick, C., Fortney, K. R., Zwickl, B., Katz, B., Campbell, J. J., Ho, D. D. & Spinola, S., May 15 2007, In : Journal of Infectious Diseases. 195, 10, p. 1443-1451 9 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
HIV
Infection
CD4 Lymphocyte Count
HIV Infections
2006
19 Citations (Scopus)

A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers

Janowicz, D., Leduc, I., Fortney, K. R., Katz, B., Elkins, C. & Spinola, S., Feb 2006, In : Infection and Immunity. 74, 2, p. 1394-1397 4 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Lectins
Volunteers
Serum
Confidence Intervals
25 Citations (Scopus)

Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid

Fulcher, R. A., Cole, L. E., Janowicz, D., Toffer, K. L., Fortney, K. R., Katz, B., Orndorff, P. E., Spinola, S. & Kawula, T. H., May 2006, In : Infection and Immunity. 74, 5, p. 2651-2658 8 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Chancroid
Virulence
Membrane Proteins
Swine
13 Citations (Scopus)

Expression of OmpP2A and OmpP2B is not required for pustule formation by Haemophilus ducreyi in human volunteers

Janowicz, D., Luke, N. R., Fortney, K. R., Katz, B., Campagnari, A. A. & Spinola, S., Mar 2006, In : Microbial Pathogenesis. 40, 3, p. 110-115 6 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Volunteers
Porins
Virulence
Bacteria
2005
20 Citations (Scopus)

Successful treatment of CMV ventriculitis immune reconstitution syndrome [4]

Janowicz, D., Johnson, R. M. & Gupta, S., Jun 2005, In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 6, p. 891-892 2 p.

Research output: Contribution to journalArticle

Immune Reconstitution Inflammatory Syndrome
Pneumocystis Infections
Anti-HIV Agents
Bacterial Pneumonia
Pneumocystis carinii
2004
37 Citations (Scopus)

Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers

Janowicz, D., Fortney, K. R., Katz, B., Latimer, J. L., Deng, K., Hansen, E. J. & Spinola, S., Aug 2004, In : Infection and Immunity. 72, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Virulence
Volunteers
Confidence Intervals
Phagocytosis