Diane Janowicz &ndash; Publications

Article

A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes

Holley, C., Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D., Ellinger, S., Zwickl, B., Katz, B. & Spinola, S., 2014, In : Infection and Immunity. 82, 8, p. 3492-3502 11 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Phenotype

Virulence

Oxidative Stress

Chancroid

A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HGBA vaccine efficacy trials

Leduc, I., Fortney, K. R., Janowicz, D., Zwickl, B., Ellinger, S., Katz, B., Lin, H., Dong, Q. & Spinola, S., Jan 1 2019, In : Infection and Immunity. 87, 7, e00112.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Vaccines

Alleles

Skin Ulcer

Hemoglobins

38 Citations (Scopus)

Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans

Spinola, S., Fortney, K. R., Baker, B., Janowicz, D., Zwickl, B., Katz, B., Blick, R. J. & Munson, R. S., Sep 2010, In : Infection and Immunity. 78, 9, p. 3898-3904 7 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Phosphoric Monoester Hydrolases

Down-Regulation

Periplasm

Operon

19 Citations (Scopus)

A DltA mutant of Haemophilus ducreyi is partially attenuated in its ability to cause pustules in human volunteers

Janowicz, D., Leduc, I., Fortney, K. R., Katz, B., Elkins, C. & Spinola, S., Feb 2006, In : Infection and Immunity. 74, 2, p. 1394-1397 4 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Lectins

Volunteers

Serum

Confidence Intervals

23 Citations (Scopus)

A fibrinogen-binding lipoprotein contributes to the virulence of Haemophilus ducreyi in humans

Bauer, M., Townsend, C. A., Doster, R. S., Fortney, K. R., Zwickl, B. W., Katz, B., Spinola, S. & Janowicz, D., Mar 1 2009, In : Journal of Infectious Diseases. 199, 5, p. 684-692 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Fibrinogen

Lipoproteins

Virulence

Carrier Proteins

15 Citations (Scopus)

A Haemophilus ducreyi CpxR deletion mutant is virulent in human volunteers

Labandeira-Rey, M., Dodd, D., Fortney, K. R., Zwickl, B., Katz, B., Janowicz, D., Spinola, S. & Hansen, E. J., Jun 15 2011, In : Journal of Infectious Diseases. 203, 12, p. 1859-1865 7 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Volunteers

Virulence

Virulence Factors

Chancroid

12 Citations (Scopus)

Carbon storage regulator a contributes to the virulence of haemophilus ducreyi in humans by multiple mechanisms

Gangaiah, D., Li, W., Fortney, K. R., Janowicz, D., Ellinger, S., Zwickl, B., Katz, B. & Spinola, S., Feb 2013, In : Infection and Immunity. 81, 2, p. 608-617 10 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Carbon

Foreskin

Bacteria

Determination of an interaction network between an extracellular bacterial pathogen and the human host

Griesenauer, B., Tran, T., Fortney, K. R., Janowicz, D., Johnson, P., Gao, H., Barnes, S., Wilson, L. S., Liu, Y. & Spinola, S., May 1 2019, In : mBio. 10, 3, e01193-19.

Research output: Contribution to journal › Article

Open Access

Haemophilus ducreyi

Anaerobiosis

Metabolomics

Ascorbic Acid

RNA Sequence Analysis

12 Citations (Scopus)

DksA and (p)ppGpp have unique and overlapping contributions to Haemophilus ducreyi pathogenesis in humans

Holley, C. L., Zhang, X., Fortney, K. R., Ellinger, S., Johnson, P., Baker, B., Liu, Y., Janowicz, D., Katz, B., Munson, R. S. & Spinola, S., 2015, In : Infection and Immunity. 83, 8, p. 3281-3292 12 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Genes

Virulence

RNA Sequence Analysis

Foreskin

20 Citations (Scopus)

Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers

Humphreys, T. L., Li, L., Li, X., Janowicz, D., Fortney, K. R., Zhao, Q., Li, W., McClintick, J., Katz, B., Wilkes, D. S., Edenberg, H. & Spinola, S., Dec 2007, In : Infection and Immunity. 75, 12, p. 5686-5697 12 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Haemophilus Infections

Langerhans Cells

Dendritic Cells

Volunteers

55 Citations (Scopus)

Experimental infection of human volunteers with Haemophilus ducreyi: Fifteen years of clinical data and experience

Janowicz, D., Ofner, S., Katz, B. & Spinola, S., Jun 1 2009, In : Journal of Infectious Diseases. 199, 11, p. 1671-1679 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Volunteers

Infection

Chancroid

Hypertrophic Cicatrix

11 Citations (Scopus)

Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication

Janowicz, D., Tenner-Racz, K., Racz, P., Humphreys, T. L., Schnizlein-Bick, C., Fortney, K. R., Zwickl, B., Katz, B., Campbell, J. J., Ho, D. D. & Spinola, S., May 15 2007, In : Journal of Infectious Diseases. 195, 10, p. 1443-1451 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

HIV

Infection

CD4 Lymphocyte Count

HIV Infections

28 Citations (Scopus)

Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid

Fulcher, R. A., Cole, L. E., Janowicz, D., Toffer, K. L., Fortney, K. R., Katz, B., Orndorff, P. E., Spinola, S. & Kawula, T. H., May 2006, In : Infection and Immunity. 74, 5, p. 2651-2658 8 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Chancroid

Virulence

Membrane Proteins

Swine

13 Citations (Scopus)

Expression of OmpP2A and OmpP2B is not required for pustule formation by Haemophilus ducreyi in human volunteers

Janowicz, D., Luke, N. R., Fortney, K. R., Katz, B., Campagnari, A. A. & Spinola, S., Mar 2006, In : Microbial Pathogenesis. 40, 3, p. 110-115 6 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Volunteers

Porins

Virulence

Bacteria

15 Citations (Scopus)

Expression of the Flp proteins by Haemophilus ducreyi is necessary for virulence in human volunteers

Janowicz, D., Cooney, S. A., Walsh, J., Baker, B., Katz, B., Fortney, K. R., Zwickl, B. W., Ellinger, S. & Munson, R. S., 2011, In : BMC Microbiology. 11, 208.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Volunteers

Foreskin

Fimbriae Proteins

39 Citations (Scopus)

Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers

Janowicz, D., Fortney, K. R., Katz, B., Latimer, J. L., Deng, K., Hansen, E. J. & Spinola, S., Aug 2004, In : Infection and Immunity. 72, 8, p. 4528-4533 6 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Volunteers

Confidence Intervals

Phagocytosis

8 Citations (Scopus)

Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase

Gangaiah, D., Labandeira-Rey, M., Zhang, X., Fortney, K. R., Ellinger, S., Zwickl, B., Baker, B., Liu, Y., Janowicz, D., Katz, B., Brautigam, C. A., Munson, R. S., Hansen, E. J. & Spinola, S., Feb 11 2014, In : mBio. 5, 1, e01081-13.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Genes

Down-Regulation

Sigma Factor

23 Citations (Scopus)

Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans

Mount, K. L. B., Townsend, C. A., Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Janowicz, D., Spinola, S., Katz, B. & Bauer, M., Mar 2010, In : Infection and Immunity. 78, 3, p. 1176-1184 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Defensins

Peptides

Haemophilus influenzae

7 Citations (Scopus)

HIV transmission and injection drug use: Lessons from the Indiana outbreak

Janowicz, D., Jul 1 2016, In : Topics in antiviral medicine. 24, 2, p. 90-92 3 p.

Research output: Contribution to journal › Article

Disease Outbreaks

HIV

Injections

Pharmaceutical Preparations

Contact Tracing

19 Citations (Scopus)

Host-pathogen interplay of Haemophilus ducreyi

Janowicz, D., Li, W. & Bauer, M., Feb 2010, In : Current Opinion in Infectious Diseases. 23, 1, p. 64-69 6 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Haemophilus Infections

Virulence Factors

Virulence

Chancroid

24 Citations (Scopus)

Identification of Haemophilus ducreyi genes expressed during human infection

Bauer, M., Fortney, K. R., Harrison, A., Janowicz, D., Munson, R. S. & Spinola, S., Apr 2008, In : Microbiology. 154, 4, p. 1152-1160 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Infection

Genes

Volunteers

Virulence

12 Citations (Scopus)

Inactivation of the haemophilus ducreyi luxS gene affects the virulence of this pathogen in human subjects

Labandeira-Rey, M., Janowicz, D., Blick, R. J., Fortney, K. R., Zwickl, B., Katz, B., Spinola, S. & Hansen, E. J., Aug 1 2009, In : Journal of Infectious Diseases. 200, 3, p. 409-416 8 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Genes

Chancroid

Confidence Intervals

16 Citations (Scopus)

Mechanism of human natural killer cell activation by haemophilus ducreyi

Li, W., Janowicz, D., Fortney, K. R., Katz, B. & Spinola, S., Aug 15 2009, In : Journal of Infectious Diseases. 200, 4, p. 590-598 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Natural Killer Cells

Interleukin-18

Interleukin-12

Dendritic Cells

1 Citation (Scopus)

Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection

Janowicz, D., Zwickl, B. W., Fortney, K. R., Katz, B. & Bauer, M., Jun 24 2014, In : BMC Microbiology. 14, 1, 166.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Haemophilus Infections

Virulence

Membrane Proteins

Lipoproteins

12 Citations (Scopus)

Permeases of the sap transporter are required for cathelicidin resistance and virulence of haemophilus ducreyi in humans

Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Katz, B., Janowicz, D., Spinola, S. & Bauer, M., Nov 1 2012, In : Journal of Infectious Diseases. 206, 9, p. 1407-1414 8 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Membrane Transport Proteins

Virulence

Volunteers

Defensins

7 Citations (Scopus)

Phosphoethanolamine transferase LptA in haemophilus ducreyi modifies lipid a and contributes to human defensin resistance in vitro

Trombley, M. P., Post, D. M. B., Rinker, S. D., Reinders, L. M., Fortney, K. R., Zwickl, B. W., Janowicz, D., Baye, F. M., Katz, B., Spinola, S. & Bauer, M., Apr 22 2015, In : PLoS One. 10, 4, e0124373.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Defensins

Transferases

transferases

lipooligosaccharides

11 Citations (Scopus)

Role played by CD4⁺FOXP3⁺ regulatory T cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers

Li, W., Tenner-Racz, K., Racz, P., Janowicz, D., Fortney, K. R., Katz, B. & Spinola, S., Jun 15 2010, In : Journal of Infectious Diseases. 201, 12, p. 1839-1848 10 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Regulatory T-Lymphocytes

Volunteers

T-Lymphocytes

Infection

5 Citations (Scopus)

Sialylation of lipooligosaccharides is dispensable for the virulence of haemophilus ducreyi in humans

Spinola, S., Li, W., Fortney, K. R., Janowicz, D., Zwickl, B., Katz, B. & Munson, R. S., Feb 2012, In : Infection and Immunity. 80, 2, p. 679-687 9 p.

Research output: Contribution to journal › Article

Haemophilus ducreyi

Virulence

Sialyltransferases

Glycolipids

N-Acetylneuraminic Acid

20 Citations (Scopus)

Successful treatment of CMV ventriculitis immune reconstitution syndrome [4]

Janowicz, D., Johnson, R. M. & Gupta, S., Jun 2005, In : Journal of Neurology, Neurosurgery and Psychiatry. 76, 6, p. 891-892 2 p.

Research output: Contribution to journal › Article

Immune Reconstitution Inflammatory Syndrome

Pneumocystis Infections

Anti-HIV Agents

Bacterial Pneumonia

Pneumocystis carinii

46 Citations (Scopus)

The human skin microbiome associates with the outcome of and is influenced by bacterial infection

Van Rensburg, J. J., Lin, H., Gao, X., Toh, E., Fortney, K. R., Ellinger, S., Zwickl, B., Janowicz, D., Katz, B., Nelson, D. E., Dong, Q. & Spinolaa, S. M., 2015, In : mBio. 6, 5, e01315-15.

Research output: Contribution to journal › Article

Microbiota

Bacterial Infections

Haemophilus ducreyi

Skin

Volunteers