Edward Srour

  • 8007 Citations
  • 49 h-Index
1985 …2020

Research output per year

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Publications

2020

Megakaryocytes promote osteoclastogenesis in aging

Kanagasabapathy, D., Blosser, R. J., Maupin, K. A., Hong, J. M., Alvarez, M., Ghosh, J., Mohamad, S. F., Aguilar-Perez, A., Srour, E. F., Kacena, M. A. & Bruzzaniti, A., Jul 31 2020, In : Aging. 12, 14, p. 15121-15133 13 p.

Research output: Contribution to journalArticle

2019

Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass

Maupin, K. A., Himes, E. R., Plett, A. P., Chua, H. L., Singh, P., Ghosh, J., Mohamad, S. F., Abeysekera, I., Fisher, A., Sampson, C., Hong, J. M., Childress, P., Alvarez, M., Srour, E. F., Bruzzaniti, A., Pelus, L. M., Orschell, C. M. & Kacena, M. A., Oct 2019, In : Bone. 127, p. 452-459 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

CD166 Engagement Augments Mouse and Human Hematopoietic Progenitor Function via Activation of Stemness and Cell Cycle Pathways

Zhang, J., Ghosh, J., Mohamad, S. F., Zhang, C., Huang, X., Capitano, M. L., Gunawan, A. M., Cooper, S., Guo, B., Cai, Q., Broxmeyer, H. E. & Srour, E. F., Oct 1 2019, In : STEM CELLS. 37, 10, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isolation and identification of murine bone marrow-derived macrophages and osteomacs from neonatal and adult mice

Ghosh, J., Mohamad, S. F. & Srour, E. F., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 181-193 13 p. (Methods in Molecular Biology; vol. 2002).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis

Alvarez, M. B., Xu, L. L., Childress, P. J., Maupin, K. A., Mohamad, S. F., Chitteti, B. R., Himes, E., Olivos, D. J., Cheng, Y. H., Conway, S. J., Srour, E. F. & Kacena, M. A., May 15 2018, In : Stem Cells and Development. 27, 10, p. 671-682 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Research letter: Absence of cardiomyocyte differentiation following transplantation of adult cardiac-resident Sca-1+ cells into infarcted mouse hearts

Soonpaa, M. H., Lafontant, P. J., Reuter, S., Scherschel, J. A., Srour, E. F., Zaruba, M. M., Rubart-Von Der Lohe, M. & Field, L. J., 2018, In : Circulation. 138, 25, p. 2963-2966 4 p.

Research output: Contribution to journalLetter

4 Scopus citations

Tamm-Horsfall protein regulates mononuclear phagocytes in the kidney

Micanovic, R., Khan, S., Janosevic, D., Lee, M. E., Hato, T., Srour, E. F., Winfree, S., Ghosh, J., Tong, Y., Rice, S. E., Dagher, P. C., Wu, X. R. & El-Achkar, T. M., Mar 2018, In : Journal of the American Society of Nephrology. 29, 3, p. 841-856 16 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Clinkenbeard, E. L., Hanudel, M. R., Stayrook, K. R., Appaiah, H. N., Farrow, E. G., Cass, T. A., Summers, L. J., Ip, C. S., Hum, J. M., Thomas, J. C., Ivan, M., Richine, B. M., Chan, R. J., Clemens, T. L., Schipani, E., Sabbagh, Y., Xu, L., Srour, E. F., Alvarez, M. B., Kacena, M. A. & 4 others, Salusky, I. B., Ganz, T., Nemeth, E. & White, K. E., Oct 27 2017, In : Haematologica. 102, 11, p. e427-e430

Research output: Contribution to journalLetter

38 Scopus citations

Individualized breast cancer characterization through single-cell analysis of tumor and adjacent normal cells

Anjanappa, M., Cardoso, A., Cheng, L., Mohamad, S., Gunawan, A., Rice, S., Dong, Y., Li, L., Sandusky, G. E., Srour, E. F. & Nakshatri, H., May 15 2017, In : Cancer Research. 77, 10, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype

Olivos, D. J., Alvarez, M., Cheng, Y. H., Hooker, R. A., Ciovacco, W. A., Bethel, M., McGough, H., Yim, C., Chitteti, B. R., Eleniste, P. P., Horowitz, M. C., Srour, E. F., Bruzzaniti, A., Fuchs, R. K. & Kacena, M. A., Aug 1 2017, In : Journal of Cellular Biochemistry. 118, 8, p. 2231-2240 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

Mohamad, S. F., Xu, L., Ghosh, J., Childress, P. J., Abeysekera, I., Himes, E. R., Wu, H., Alvarez, M. B., Davis, K. M., Aguilar-Perez, A., Hong, J. M., Bruzzaniti, A., Kacena, M. A. & Srour, E. F., Dec 12 2017, In : Blood Advances. 1, 26, p. 2520-2528 9 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

P190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

Hinge, A., Xu, J., Javier, J., Mose, E., Kumar, S., Kapur, R., Srour, E. F., Malik, P., Aronow, B. J. & Filippi, M. D., Feb 8 2017, In : Nature communications. 8, 14382.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Cell adhesion molecule CD166 drives malignant progression and osteolytic disease in multiple myeloma

Xu, L., Mohammad, K. S., Wu, H., Crean, C., Poteat, B., Cheng, Y., Cardoso, A. A., Machal, C., Hanenberg, H., Abonour, R., Kacena, M. A., Chirgwin, J., Suvannasankha, A. & Srour, E. F., Dec 1 2016, In : Cancer Research. 76, 23, p. 6901-6910 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis

Meijome, T. E., Baughman, J. T., Hooker, R. A., Cheng, Y. H., Ciovacco, W. A., Balamohan, S. M., Srinivasan, T. L., Chitteti, B. R., Eleniste, P. P., Horowitz, M. C., Srour, E. F., Bruzzaniti, A., Fuchs, R. K. & Kacena, M. A., Apr 1 2016, In : Journal of Cellular Biochemistry. 117, 4, p. 959-969 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

Silberstein, L., Goncalves, K. A., Kharchenko, P. V., Turcotte, R., Kfoury, Y., Mercier, F., Baryawno, N., Severe, N., Bachand, J., Spencer, J. A., Papazian, A., Lee, D., Chitteti, B. R., Srour, E. F., Hoggatt, J., Tate, T., Lo Celso, C., Ono, N., Nutt, S., Heino, J. & 6 others, Sipilä, K., Shioda, T., Osawa, M., Lin, C. P., Hu, G. F. & Scadden, D. T., Oct 6 2016, In : Cell Stem Cell. 19, 4, p. 530-543 14 p.

Research output: Contribution to journalArticle

49 Scopus citations
2015

Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis

Hooker, R. A., Chitteti, B. R., Egan, P. H., Cheng, Y. H., Himes, E. R., Meijome, T., Srour, E. F., Fuchs, R. K. & Kacena, M. A., Jan 1 2015, In : Journal of Musculoskeletal Neuronal Interactions. 15, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen

Capitano, M. L., Chitteti, B. R., Cooper, S., Srour, E. F., Bartke, A. & Broxmeyer, H. E., Jun 1 2015, In : Blood Cells, Molecules, and Diseases. 55, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Novel Role for Thrombopoietin in Regulating Osteoclast Development in Humans and Mice

Bethel, M., Barnes, C. L. T., Taylor, A. F., Cheng, Y. H., Chitteti, B. R., Horowitz, M. C., Bruzzaniti, A., Srour, E. F. & Kacena, M. A., Sep 1 2015, In : Journal of cellular physiology. 230, 9, p. 2142-2151 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H. E., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

135 Scopus citations

Expansion of prostate epithelial progenitor cells after inflammation of the mouse prostate

Wang, L., Zoetemelk, M., Chitteti, B. R., Ratliff, T. L., Myers, J. D., Srour, E. F., Broxmeyer, H. & Jerde, T. J., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1421-F1430

Research output: Contribution to journalArticle

8 Scopus citations

Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6

Xie, J., Broxmeyer, H. E., Feng, D., Schweitzer, K. S., Yi, R., Cook, T. G., Chitteti, B. R., Barwinska, D., Traktuev, D. O., Van Demark, M. J., Justice, M. J., Ou, X., Srour, E. F., Prockop, D. J., Petrache, I. & March, K. L., Feb 1 2015, In : STEM CELLS. 33, 2, p. 468-478 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts

Chitteti, B. R., Kacena, M., Voytik-Harbin, S. L. & Srour, E., Oct 1 2015, In : Journal of Immunological Methods. 425, p. 108-113 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation

Zeng, Y., Broxmeyer, H. E., Staser, K., Chitteti, B. R., Park, S. J., Hahn, S., Cooper, S., Sun, Z., Jiang, L., Yang, X., Yuan, J., Kosoff, R., Sandusky, G., Srour, E. F., Chernoff, J. & Clapp, D. W., May 1 2015, In : STEM CELLS. 33, 5, p. 1630-1641 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Signaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells

Cheng, Y. H., Streicher, D. A., Waning, D. L., Chitteti, B. R., Gerard-O'Riley, R., Horowitz, M. C., Bidwell, J. P., Pavalko, F. M., Srour, E. F., Mayo, L. D. & Kacena, M. A., Mar 1 2015, In : Journal of cellular physiology. 230, 3, p. 578-586 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tamm-horsfall protein regulates granulopoiesis and systemic neutrophil homeostasis

Micanovic, R., Chitteti, B. R., Dagher, P. C., Srour, E. F., Khan, S., Hato, T., Lyle, A., Tong, Y., Wu, X. R. & El-Achkar, T. M., Sep 1 2015, In : Journal of the American Society of Nephrology. 26, 9, p. 2172-2182 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche

Chitteti, B. R., Kobayashi, M., Cheng, Y., Zhang, H., Poteat, B. A., Broxmeyer, H. E., Pelus, L. M., Hanenberg, H., Zollman, A., Kamocka, M. M., Carlesso, N., Cardoso, A. A., Kacena, M. A. & Srour, E. F., Jul 24 2014, In : Blood. 124, 4, p. 519-529 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cell cycle measurement of mouse hematopoietic stem/progenitor cells

Chitteti, B. R. & Srour, E. F., 2014, Hematopoietic Stem Cell Protocols. Humana Press Inc., p. 65-78 14 p. (Methods in Molecular Biology; vol. 1185).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Nonmarrow hematopoiesis occurs in a hyaluronic-acid-rich node and duct system in mice

Hwang, S., Lee, S. J., Park, S. H., Chitteti, B. R., Srour, E. F., Cooper, S., Hangoc, G., Broxmeyer, H. E. & Kwon, B. S., Nov 1 2014, In : Stem cells and development. 23, 21, p. 2661-2671 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

108 Scopus citations
2013

CD166 and regulation of hematopoiesis

Chitteti, B. R., Bethel, M., Kacena, M. A. & Srour, E. F., Jul 1 2013, In : Current opinion in hematology. 20, 4, p. 273-280 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

Differential stem-and progenitor-cell trafficking by prostaglandin e 2

Hoggatt, J., Mohammad, K. S., Singh, P., Hoggatt, A. F., Chitteti, B. R., Speth, J. M., Hu, P., Poteat, B. A., Stilger, K. N., Ferraro, F., Silberstein, L., Wong, F. K., Farag, S. S., Czader, M., Milne, G. L., Breyer, R. M., Serezani, C. H., Scadden, D. T., Guise, T. A., Srour, E. F. & 1 others, Pelus, L. M., Mar 21 2013, In : Nature. 495, 7441, p. 365-369 5 p.

Research output: Contribution to journalArticle

86 Scopus citations

Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function

Chitteti, B. R., Cheng, Y. H., Kacena, M. A. & Srour, E. F., May 1 2013, In : Bone. 54, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

In Vitro Construction of 2D and 3D simulations of the murine hematopoietic niche

Reddy Chitteti, B., Bethel, M., Voytik-Harbin, S. L., Kacena, M. A. & Srour, E. F., 2013, Stem Cell Niche: Methods and Protocols. Humana Press Inc., p. 43-56 14 p. (Methods in Molecular Biology; vol. 1035).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation

Cheng, Y. H., Hooker, R. A., Nguyen, K., Gerard-O'Riley, R., Waning, D. L., Chitteti, B. R., Meijome, T. E., Chua, H. L., Plett, A. P., Orschell, C. M., Srour, E. F., Mayo, L. D., Pavalko, F. M., Bruzzaniti, A. & Kacena, M. A., Jun 2013, In : Journal of Bone and Mineral Research. 28, 6, p. 1434-1445 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

The changing balance between osteoblastogenesis and adipogenesis in aging and its impact on hematopoiesis

Bethel, M., Chitteti, B. R., Srour, E. F. & Kacena, M. A., Jun 1 2013, In : Current Osteoporosis Reports. 11, 2, p. 99-106 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012

Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors

Broxmeyer, H. E., Srour, E. F., Cooper, S., Wallace, C. T., Hangoc, G. & Youn, B. S., Jan 15 2012, In : Blood Cells, Molecules, and Diseases. 48, 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis

Broxmeyer, H. E., Hoggatt, J., O'leary, H. A., Mantel, C., Chitteti, B. R., Cooper, S., Messina-Graham, S., Hangoc, G., Farag, S., Rohrabaugh, S. L., Ou, X., Speth, J., Pelus, L. M., Srour, E. F. & Campbell, T. B., Dec 1 2012, In : Nature Medicine. 18, 12, p. 1786-1796 11 p.

Research output: Contribution to journalArticle

129 Scopus citations
2011

Genomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells

Chitteti, B. R., Liu, Y. & Srour, E. F., 2011, In : PloS one. 6, 3, e17498.

Research output: Contribution to journalArticle

8 Scopus citations

Hematopoietic cell regulation of osteoblast proliferation and differentiation

Bethel, M., Srour, E. F. & Kacena, M. A., Jun 1 2011, In : Current osteoporosis reports. 9, 2, p. 96-102 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells

Cheng, Y. H., Chitteti, B. R., Streicher, D. A., Morgan, J. A., Rodriguez-Rodriguez, S., Carlesso, N., Srour, E. F. & Kacena, M. A., May 2011, In : Journal of Bone and Mineral Research. 26, 5, p. 1111-1121 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Regulation of murine hematopoietic stem cell quiescence by Dmtf1

Kobayashi, M. & Srour, E. F., Dec 15 2011, In : Blood. 118, 25, p. 6562-6571 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., Jun 16 2011, In : Blood. 117, 24, p. 6509-6519 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Kondo, T., Matsuoka, A. J., Shimomura, A., Koehler, K. R., Chan, R. J., Miller, J. M., Srour, E. F. & Hashino, E., May 2011, In : STEM CELLS. 29, 5, p. 836-846 11 p.

Research output: Contribution to journalArticle

64 Scopus citations
2010

Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice

Xue, X., Pech, N. K., Shelley, W. C., Srour, E. F., Yoder, M. C. & Dinauer, M. C., Dec 9 2010, In : Blood. 116, 24, p. 5419-5422 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential

Estes, M. L., Mund, J. A., Mead, L. E., Prater, D. N., Cai, S., Wang, H., Pollok, K. E., Murphy, M. P., An, C. S. T., Srour, E. F., Ingram, D. A. & Case, J., Sep 2010, In : Cytometry Part A. 77, 9, p. 831-839 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

CCR7 alters hematopoietic potential

Srour, E. F., Dec 9 2010, In : Blood. 116, 24, p. 5086-5087 2 p.

Research output: Contribution to journalComment/debate

Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function

Chitteti, B. R., Cheng, Y. H., Poteat, B., Rodriguez-Rodriguez, S., Goebel, W. S., Carlesso, N., Kacena, M. A. & Srour, E. F., Apr 22 2010, In : Blood. 115, 16, p. 3239-3248 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function

Chitteti, B. R., Cheng, Y. H., Streicher, D. A., Rodriguez-Rodriguez, S., Carlesso, N., Srour, E. F. & Kacena, M. A., Oct 1 2010, In : Journal of Cellular Biochemistry. 111, 2, p. 284-294 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24- Phenotype

Bhat-Nakshatri, P., Appaiah, H., Ballas, C., Pick-Franke, P., Goulet, R., Badve, S., Srour, E. F. & Nakshatri, H., Aug 6 2010, In : BMC Cancer. 10, 411.

Research output: Contribution to journalArticle

117 Scopus citations
2009

Breast cancer stem cells and intrinsic subtypes: Controversies rage on

Nakshatri, H., Srour, E. F. & Badve, S., 2009, In : Current Stem Cell Research and Therapy. 4, 1, p. 50-60 11 p.

Research output: Contribution to journalReview article

106 Scopus citations