Elliot Androphy

  • 9871 Citations
  • 52 h-Index
1978 …2020

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2020

Human papillomavirus 31 tyrosine 102 regulates interaction with E2 binding partners and episomal maintenance

Gilson, T., Culleton, S., Xie, F., DeSmet, M. & Androphy, E. J., Aug 1 2020, In : Journal of virology. 94, 16, e01227-20.

Research output: Contribution to journalArticle

Phosphorylation of the human papillomavirus E2 protein at tyrosine 138 regulates episomal replication

Jose, L., Androphy, E. J. & DeSmet, M., Jul 1 2020, In : Journal of virology. 94, 14, e00488-20.

Research output: Contribution to journalArticle

2019

Abnormal Golgi morphology and decreased COPI function in cells with low levels of SMN

Custer, S. K., Foster, J. N., Astroski, J. W. & Androphy, E. J., Mar 1 2019, In : Brain research. 1706, p. 135-146 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Acetylation of E2 by p300 mediates topoisomerase entry at the papillomavirus replicon

Thomas, Y. & Androphy, E. J., Jan 1 2019, In : Journal of virology. 93, 7, e02224.

Research output: Contribution to journalArticle

5 Scopus citations

Interaction between alpha-COP and SMN ameliorates disease phenotype in a mouse model of spinal muscular atrophy

Custer, S. K., Astroski, J. W., Li, H. X. & Androphy, E. J., Jun 25 2019, In : Biochemical and Biophysical Research Communications. 514, 2, p. 530-537 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Intraperitoneal delivery of a novel drug‐like compound improves disease severity in severe and intermediate mouse models of Spinal Muscular Atrophy

Osman, E. Y., Rietz, A., Kline, R. A., Cherry, J. J., Hodgetts, K. J., Lorson, C. L. & Androphy, E. J., Dec 1 2019, In : Scientific reports. 9, 1, 1633.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Phosphorylation of a conserved tyrosine in the papillomavirus e2 protein regulates BRD4 binding and viral replication

DeSmet, M., Jose, L., Isaq, N. & Androphy, E. J., May 1 2019, In : Journal of virology. 93, 10, e01801-18.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Human papillomavirus replication regulation by acetylation of a conserved lysine in the E2 protein

Thomas, Y. & Androphy, E. J., Feb 1 2018, In : Journal of virology. 92, 3, e01912-17.

Research output: Contribution to journalArticle

7 Scopus citations

Metagenomic discovery of 83 new human papillomavirus types in patients with immunodeficiency

Pastrana, D. V., Peretti, A., Welch, N. L., Borgogna, C., Olivero, C., Badolato, R., Notarangelo, L. D., Gariglio, M., FitzGerald, P. C., McIntosh, C. E., Reeves, J., Starrett, G. J., Bliskovsky, V., Velez, D., Brownell, I., Yarchoan, R., Wyvill, K. M., Uldrick, T. S., Maldarelli, F., Lisco, A. & 12 others, Sereti, I., Gonzalez, C. M., Androphy, E. J., McBride, A. A., Van Doorslaer, K., Garcia, F., Dvoretzky, I., Liu, J. S., Han, J., Murphy, P. M., McDermott, D. H. & Buck, C. B., Nov 1 2018, In : mSphere. 3, 6, e00645-18.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors

DeSmet, M., Kanginakudru, S., Jose, L., Xie, F., Gilson, T. & Androphy, E. J., Aug 2018, In : Virology. 521, p. 62-68 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Association of human papillomavirus 16 E2 with Rad50-interacting protein 1 enhances viral DNA replication

Campos-León, K., Wijendra, K., Siddiqa, A., Pentland, I., Feeney, K. M., Knapman, A., Davies, R., Androphy, E. J. & Parish, J. L., 2017, In : Journal of virology. 91, 5, e02305-16.

Research output: Contribution to journalArticle

5 Scopus citations

Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy

Rietz, A., Li, H., Quist, K. M., Cherry, J. J., Lorson, C. L., Burnett, B. G., Kern, N. L., Calder, A. N., Fritsche, M., Lusic, H., Boaler, P. J., Choi, S., Xing, X., Glicksman, M. A., Cuny, G. D., Androphy, E. J. & Hodgetts, K. J., Jun 8 2017, In : Journal of Medicinal Chemistry. 60, 11, p. 4594-4610 17 p.

Research output: Contribution to journalArticle

5 Scopus citations

In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels

Cherry, J. J., Didonato, C. J., Androphy, E. J., Calo, A., Potter, K., Custer, S. K., Du, S., Foley, T. L., Gopalsamy, A., Reedich, E. J., Gordo, S. M., Gordon, W., Hosea, N., Jones, L. H., Krizay, D. K., Larosa, G., Li, H., Mathur, S., Menard, C. A., Patel, P. & 5 others, Ramos-Zayas, R., Rietz, A., Rong, H., Zhang, B. & Tones, M. A., Sep 2017, In : PloS one. 12, 9, e0185079.

Research output: Contribution to journalArticle

7 Scopus citations

Kinase activity of fibroblast growth factor receptor 3 regulates activity of the papillomavirus E2 protein

Xie, F., DeSmet, M., Kanginakudru, S., Jose, L., Culleton, S. P., Gilson, T., Li, C. & Androphy, E., Oct 1 2017, In : Journal of Virology. 91, 20, e01066-17.

Research output: Contribution to journalArticle

6 Scopus citations

Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers

Choi, S., Calder, A. N., Miller, E. H., Anderson, K. P., Fiejtek, D. K., Rietz, A., Li, H., Cherry, J. J., Quist, K. M., Xing, X., Glicksman, M. A., Cuny, G. D., Lorson, C. L., Androphy, E. A. & Hodgetts, K. J., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5144-5148 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phosphorylation of the bovine papillomavirus E2 protein on tyrosine regulates its transcription and replication functions

Culleton, S. P., Kanginakudru, S., DeSmet, M., Gilson, T., Xie, F., Wu, S. Y., Chiang, C. M., Qi, G., Wang, M. & Androphy, E. J., 2017, In : Journal of virology. 91, 2, e01854-16.

Research output: Contribution to journalArticle

7 Scopus citations

SMN deficiency negatively impacts red pulp macrophages and spleen development in mouse models of spinal muscular atrophy

Khairallah, M. T., Astroski, J., Custer, S. K., Androphy, E. J., Franklin, C. L. & Lorson, C. L., Mar 1 2017, In : Human molecular genetics. 26, 5, p. 932-941 10 p., ddx008.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Altered mRNA splicing in SMN-depleted motor neuron-like cells

Custer, S. K., Gilson, T. D., Li, H., Todd, A. G., Astroski, J. W., Lin, H., Liu, Y. & Androphy, E. J., Oct 2016, In : PloS one. 11, 10, e0163954.

Research output: Contribution to journalArticle

8 Scopus citations

Human papillomavirus oncogenic E6 protein regulates human β-defensin 3 (hBD3) expression via the tumor suppressor protein p53

DasGupta, T., Nweze, E. I., Yue, H., Wang, L., Jin, J., Ghosh, S. K., Kawsar, H. I., Zender, C., Androphy, E. J., Weinberg, A., McCormick, T. S. & Jin, G., May 10 2016, In : Oncotarget. 7, 19, p. 27430-27444 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular probing of the HPV-16 E6 protein alpha helix binding groove with small molecule inhibitors

Rietz, A., Petrov, D. P., Bartolowits, M., DeSmet, M., Davisson, V. J. & Androphy, E. J., Feb 2016, In : PloS one. 11, 2, e0149845.

Research output: Contribution to journalArticle

10 Scopus citations

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2

DeSmet, M., Kanginakudru, S., Rietz, A., Wu, W. H., Roden, R. & Androphy, E. J., Oct 2016, In : PLoS pathogens. 12, 10, e1005934.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication

Kanginakudru, S., DeSmet, M., Thomas, Y., Morgan, I. M. & Androphy, E. J., Apr 1 2015, In : Virology. 478, p. 129-136 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth

Li, H., Custer, S. K., Gilson, T., Hao, L. T., Beattie, C. E. & Androphy, E. J., 2015, In : Human molecular genetics. 24, 25, p. 7295-7307 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy

Custer, S. K. & Androphy, E. J., Jul 2014, In : Molecular and Cellular Neuroscience. 61, p. 133-140 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Acetylation of conserved lysines in bovine papillomavirus E2 by p300

Quinlan, E. J., Culleton, S. P., Wu, S. Y., Chiang, C. M. & Androphy, E. J., Feb 2013, In : Journal of virology. 87, 3, p. 1497-1507 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation

Lakhter, A. J., Sahu, R. P., Sun, Y., Kaufmann, W. K., Androphy, E. J., Travers, J. B. & Naidu, S. R., Sep 2013, In : Journal of Investigative Dermatology. 133, 9, p. 2247-2254 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

COPI transport complexes bind to specific RNAs in neuronal cells

Todd, A. G., Lin, H., Ebert, A. D., Liu, Y. & Androphy, E. J., Feb 1 2013, In : Human molecular genetics. 22, 4, p. 729-736 8 p., dds480.

Research output: Contribution to journalArticle

29 Scopus citations

Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle proteina α-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy

Custer, S. K., Todd, A. G., Singh, N. N. & Androphy, E. J., Oct 1 2013, In : Human molecular genetics. 22, 20, p. 4043-4052 10 p., ddt254.

Research output: Contribution to journalArticle

28 Scopus citations

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

Cherry, J. J., Osman, E. Y., Evans, M. C., Choi, S., Xing, X., Cuny, G. D., Glicksman, M. A., Lorson, C. L. & Androphy, E. J., Jul 2013, In : EMBO Molecular Medicine. 5, 7, p. 1103-1118 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function

Cherry, J. J., Rietz, A., Malinkevich, A., Liu, Y., Xie, M., Bartolowits, M., Davisson, V. J., Baleja, J. D. & Androphy, E. J., Dec 23 2013, In : PloS one. 8, 12, e84506.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay

Cherry, J. J., Evans, M. C., Ni, J., Cuny, G. D., Glicksman, M. A. & Androphy, E. J., Apr 2012, In : Journal of Biomolecular Screening. 17, 4, p. 481-495 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy

Naidu, S. R., Lakhter, A. J. & Androphy, E. J., Jul 15 2012, In : Cell Cycle. 11, 14, p. 2717-2728 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3

Love, I. M., Sekaric, P., Shi, D., Grossman, S. R. & Androphy, E. J., Jul 1 2012, In : Cell Cycle. 11, 13, p. 2458-2466 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Transcriptional Repression of E-Cadherin by Human Papillomavirus Type 16 E6

D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M. & Hibma, M. H., Nov 26 2012, In : PloS one. 7, 11, e48954.

Research output: Contribution to journalArticle

51 Scopus citations
2011

Differential regulation of the SMN2 gene by individual HDAC proteins

Evans, M. C., Cherry, J. J. & Androphy, E. J., Oct 14 2011, In : Biochemical and Biophysical Research Communications. 414, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Discovery, synthesis, and biological evaluation of novel SMN protein modulators

Xiao, J., Marugan, J. J., Zheng, W., Titus, S., Southall, N., Cherry, J. J., Evans, M., Androphy, E. J. & Austin, C. P., Sep 22 2011, In : Journal of Medicinal Chemistry. 54, 18, p. 6215-6233 19 p.

Research output: Contribution to journalArticle

32 Scopus citations

The COPI vesicle complex binds and moves with survival motor neuron within axons

Peter, C. J., Evans, M., Thayanithy, V., Taniguchi-Ishigaki, N., Bach, I., Kolpak, A., Bassell, G. J., Rossoll, W., Lorson, C. L., Bao, Z. Z. & Androphy, E. J., May 1 2011, In : Human molecular genetics. 20, 9, p. 1701-1711 11 p., ddr046.

Research output: Contribution to journalArticle

54 Scopus citations
2010

Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function

Mallappa, C., Nasipak, B. T., Etheridge, L., Androphy, E. J., Jones, S. N., Sagerström, C. G., Ohkawa, Y. & Imbalzano, A. N., Jul 2010, In : Molecular and cellular biology. 30, 13, p. 3176-3186 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Valproate and bone loss: ITRAQ proteomics show that valproate reduces collagens and osteonectin in SMA cells

Fuller, H. R., Man, N. T., Lam, L. T., Shamanin, V. A., Androphy, E. J. & Morris, G. E., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4228-4233 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Determinants of Stability for the E6 Protein of Papillomavirus Type 16

Liu, Y., Cherry, J. J., Dineen, J. V., Androphy, E. J. & Baleja, J. D., Mar 6 2009, In : Journal of molecular biology. 386, 4, p. 1123-1137 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

TaxlBPl interacts with papillomavirus E2 and regulates E2-dependent transcription and stability

Wang, X., Naidu, S. R., Sverdrup, F. & Androphy, E. J., Mar 2009, In : Journal of virology. 83, 5, p. 2274-2284 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells

Naidu, S. R., Love, I. M., Imbalzano, A. N., Grossman, S. R. & Androphy, E. J., Jul 9 2009, In : Oncogene. 28, 27, p. 2492-2501 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle

Melanson, S. M. & Androphy, E. J., Oct 25 2009, In : Virology. 393, 2, p. 258-264 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2008

Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT

Sekaric, P., Cherry, J. J. & Androphy, E. J., Jan 2008, In : Journal of virology. 82, 1, p. 71-76 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
17 Scopus citations
2007

hAda3 regulates p14ARF-induced p53 acetylation and senescence

Sekaric, P., Shamanin, V. A., Luo, J. & Androphy, E. J., Sep 20 2007, In : Oncogene. 26, 43, p. 6261-6268 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Interaction of papillomavirus E2 protein with the Brm chromatin remodeling complex leads to enhanced transcriptional activation

Kumar, R. A., Naidu, S. R., Wang, X., Imbalzano, A. N. & Androphy, E. J., Mar 2007, In : Journal of virology. 81, 5, p. 2213-2220 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mitotic kinesin-like protein 2 binds and colocalizes with papillomavirus E2 during mitosis

Yu, T., Peng, Y. C. & Androphy, E. J., Feb 2007, In : Journal of virology. 81, 4, p. 1736-1745 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes

Singh, N. N., Singh, R. N. & Androphy, E. J., Jan 2007, In : Nucleic acids research. 35, 2, p. 371-389 19 p.

Research output: Contribution to journalArticle

133 Scopus citations
2006

ChlR1 Is Required for Loading Papillomavirus E2 onto Mitotic Chromosomes and Viral Genome Maintenance

Parish, J. L., Bean, A. M., Park, R. B. & Androphy, E. J., Dec 28 2006, In : Molecular Cell. 24, 6, p. 867-876 10 p.

Research output: Contribution to journalArticle

76 Scopus citations