Elliot Rosen

  • 2934 Citations
  • 26 h-Index
1979 …2013
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Publications 1979 2013

  • 2934 Citations
  • 26 h-Index
  • 64 Article
  • 3 Conference contribution
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Article
2013
22 Citations (Scopus)

Fibrin Networks Regulate Protein Transport during Thrombus Development

Kim, O. V., Xu, Z., Rosen, E. & Alber, M. S., Jun 2013, In : PLoS Computational Biology. 9, 6, e1003095.

Research output: Contribution to journalArticle

protein transport
fibrin
Protein Transport
Platelets
Fibrin
2012
16 Citations (Scopus)

Mechano-rheological properties of the murine thrombus determined via nanoindentation and finite element modeling

Slaboch, C. L., Alber, M. S., Rosen, E. & Ovaert, T. C., Jun 2012, In : Journal of the Mechanical Behavior of Biomedical Materials. 10, p. 75-86 12 p.

Research output: Contribution to journalArticle

Nanoindentation
Blood
Elastic moduli
Public health
Medical problems
20 Citations (Scopus)

Multiscale Model of Fibrin Accumulation on the Blood Clot Surface and Platelet Dynamics

Xu, Z., Christley, S., Lioi, J., Kim, O., Harvey, C., Sun, W., Rosen, E. & Alber, M., 2012, In : Methods in Cell Biology. 110, p. 367-388 22 p.

Research output: Contribution to journalArticle

Fibrin
Thrombosis
Blood Platelets
Growth
Thrombin
22 Citations (Scopus)

Multiscale models of thrombogenesis

Xu, Z., Kim, O., Kamocka, M., Rosen, E. & Alber, M., 2012, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 4, 3, p. 237-246 10 p.

Research output: Contribution to journalArticle

Thrombosis
Blood
Platelets
Fibrin
Blood vessels
2011
45 Citations (Scopus)

Computational approaches to studying thrombus development

Xu, Z., Kamocka, M., Alber, M. & Rosen, E., Mar 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 3, p. 500-505 6 p.

Research output: Contribution to journalArticle

Thrombosis
Biological Models
Hemostasis
Platelet Activation
Fibrinogen
28 Citations (Scopus)

Correlation between fibrin network structure and mechanical properties: An experimental and computational analysis

Kim, E., Kim, O. V., MacHlus, K. R., Liu, X., Kupaev, T., Lioi, J., Wolberg, A. S., Chen, D. Z., Rosen, E., Xu, Z. & Alber, M., May 21 2011, In : Soft Matter. 7, 10, p. 4983-4992 10 p.

Research output: Contribution to journalArticle

fibrin
Fibrin
mechanical properties
Mechanical properties
Fibers
25 Citations (Scopus)

Modelling platelet-blood flow interaction using the subcellular element Langevin method

Sweet, C. R., Chatterjee, S., Xu, Z., Bisordi, K., Rosen, E. & Alber, M., Dec 7 2011, In : Journal of the Royal Society Interface. 8, 65, p. 1760-1771 12 p.

Research output: Contribution to journalArticle

Flow interactions
Platelets
Blood
Blood Platelets
Fluids
29 Citations (Scopus)

Pro-inflammatory angiogenesis is mediated by p38 MAP kinase.

Rajashekhar, G., Kamocka, M., Marin, A., Suckow, M. A., Wolter, W. R., Badve, S., Sanjeevaiah, A. R., Pumiglia, K., Rosen, E. & Clauss, M., Mar 2011, In : Journal of Cellular Physiology. 226, 3, p. 800-808 9 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Endothelial cells
Endothelial Cells
Chemical activation
Tumors
2010
76 Citations (Scopus)

A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade

Xu, Z., Lioi, J., Mu, J., Kamocka, M., Liu, X., Chen, D. Z., Rosen, E. & Alber, M., May 5 2010, In : Biophysical Journal. 98, 9, p. 1723-1732 10 p.

Research output: Contribution to journalArticle

Factor VII
Blood Coagulation
Thrombosis
Thromboplastin
Thrombin
1 Citation (Scopus)

Erratum: A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade (Biophysical Journal (2010) 98 (1723-1732))

Xu, Z., Lioi, J., Mu, J., Kamocka, M., Liu, X., Chen, D. Z., Rosen, E. & Alber, M., Oct 6 2010, In : Biophysical Journal. 99, 7, p. 2384-2385 2 p.

Research output: Contribution to journalArticle

Blood Coagulation
Thrombosis
10 Citations (Scopus)

Segmentation, reconstruction, and analysis of blood thrombus formation in 3D 2-photon microscopy images

Mu, J., Liu, X., Kamocka, M., Xu, Z., Alber, M. S., Rosen, E. & Chen, D. Z., 2010, In : Eurasip Journal on Advances in Signal Processing. 2010, 147216.

Research output: Contribution to journalArticle

Microscopic examination
Blood
Photons
Blood vessels
Coagulation
39 Citations (Scopus)

Two-photon intravital imaging of thrombus development

Kamocka, M., Mu, J., Liu, X., Chen, N., Zollman, A., Sturonas-Brown, B., Dunn, K., Xu, Z., Chen, D. Z., Alber, M. S. & Rosen, E., 2010, In : Journal of Biomedical Optics. 15, 1, 016020.

Research output: Contribution to journalArticle

blood cells
Blood
Photons
platelets
fibrin
2009
74 Citations (Scopus)

Study of blood flow impact on growth of thrombi using a multiscale model

Xu, Z., Chen, N., Shadden, S. C., Marsden, J. E., Kamocka, M., Rosen, E. & Alber, M., 2009, In : Soft Matter. 5, 4, p. 769-779 11 p.

Research output: Contribution to journalArticle

multiscale models
blood flow
platelets
Blood
Platelets
2008
111 Citations (Scopus)

A multiscale model of thrombus development

Xu, Z., Chen, N., Kamocka, M., Rosen, E. & Alber, M., Jul 6 2008, In : Journal of the Royal Society Interface. 5, 24, p. 705-722 18 p.

Research output: Contribution to journalArticle

Platelets
Thrombosis
Blood
Blood Platelets
Fibrinogen
15 Citations (Scopus)

Identifying and genotyping transgene integration loci

Liang, Z., Breman, A. M., Grimes, B. & Rosen, E., Oct 2008, In : Transgenic Research. 17, 5, p. 979-983 5 p.

Research output: Contribution to journalArticle

Transgenes
genotyping
transgenes
loci
mice
77 Citations (Scopus)

IFATS collection: Adipose stromal cell differentiation is reduced by endothelial cell contact and paracrine communication: Role of canonical Wnt signaling

Rajashekhar, G., Traktuev, D., Roell, W. C., Johnstone, B. H., Merfeld-Clauss, S., Van Natta, B., Rosen, E., March, K. L. & Clauss, M., Oct 2008, In : Stem Cells. 26, 10, p. 2674-2681 8 p.

Research output: Contribution to journalArticle

Paracrine Communication
Stromal Cells
Cell Communication
Adipogenesis
Cell Differentiation
1 Citation (Scopus)

Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X

Kamocka, M., Pollard, M., Suckow, M., Mielicki, W. P. & Rosen, E., Jun 2008, In : Comparative Medicine. 58, 3, p. 282-286 5 p.

Research output: Contribution to journalArticle

cancer procoagulant
Factor X
prostatic neoplasms
coagulation
Rats
2007
1 Citation (Scopus)
cancer procoagulant
Chorion
Amnion
Prostatic Neoplasms
Swine

In utero as a potential location for cell transplantation

Suckow, M. A. & Rosen, E., 2007, In : Journal of Organ Dysfunction. 3, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

Cell Transplantation
Factor X Deficiency
Factor X
Immune Tolerance
Gonads
15 Citations (Scopus)

Prevention of human PC-346C prostate cancer growth in mice by a xenogeneic tissue vaccine

Suckow, M. A., Rosen, E., Wolter, W. R., Sailes, V., Jeffrey, R. & Tenniswood, M., Aug 2007, In : Cancer Immunology Immunotherapy. 56, 8, p. 1275-1283 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Vaccines
Growth
Immunity
Glutaral
154 Citations (Scopus)

Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization

Cai, L., Johnstone, B. H., Cook, T. G., Liang, Z., Traktuev, D., Cornetta, K., Ingram, D., Rosen, E. & March, K. L., Dec 2007, In : Stem Cells. 25, 12, p. 3234-3243 10 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Stromal Cells
Stem Cells
Reperfusion
Green Fluorescent Proteins
5 Citations (Scopus)

Tissue vaccines for cancer

Suckow, M. A., Heinrich, J. & Rosen, E., Dec 2007, In : Expert Review of Vaccines. 6, 6, p. 925-937 13 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Vaccines
Neoplasms
Antigens
Stromal Cells
2 Citations (Scopus)

Vaccination against prostate cancer using a live tissue factor deficient cell line in Lobund-Wistar rats

Heinrich, J. E., Pollard, M., Wolter, W. A., Liang, Z., Song, H., Rosen, E. & Suckow, M. A., May 2007, In : Cancer Immunology Immunotherapy. 56, 5, p. 725-730 6 p.

Research output: Contribution to journalArticle

Thromboplastin
Wistar Rats
Prostatic Neoplasms
Vaccination
Cell Line
2006
5 Citations (Scopus)
Modifier Genes
Hemostatics
Phenotype
Alleles
Breeding
2005
33 Citations (Scopus)

Generation of genetically-altered mice producing very low levels of coagulation factor VII

Rosen, E., Xu, H., Liang, Z., Martin, A. J., Suckow, M. & Castellino, F. J., Sep 2005, In : Thrombosis and Haemostasis. 94, 3, p. 493-497 5 p.

Research output: Contribution to journalArticle

Factor VII
Trans-Activators
Tetracycline
Thrombin
Genes
59 Citations (Scopus)

Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities

Lay, A. J., Liang, Z., Rosen, E. & Castellino, F. J., Jun 2005, In : Journal of Clinical Investigation. 115, 6, p. 1552-1561 10 p.

Research output: Contribution to journalArticle

Protein C Deficiency
Protein C
Mothers
Phenotype
Inflammation
2 Citations (Scopus)

Tissue distribution of fetal liver cells following in utero transplantation in mice

Suckow, M. A., Zollman, A., Cornelissen, I., Casad, M., Roahrig, J., Castellino, F. J. & Rosen, E., Dec 2005, In : Experimental Biology and Medicine. 230, 11, p. 860-864 5 p.

Research output: Contribution to journalArticle

Tissue Distribution
Galactosidases
Liver
Transplantation
Tissue
2003
477 Citations (Scopus)

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Cheng, T., Liu, D., Griffin, J. H., Fernández, J. A., Castellino, F., Rosen, E., Fukudome, K. & Zlokovic, B. V., Mar 1 2003, In : Nature Medicine. 9, 3, p. 338-342 5 p.

Research output: Contribution to journalArticle

Protein C
Endothelium
Brain
Apoptosis
PAR-1 Receptor
17 Citations (Scopus)

In utero transplantation of wild-type fetal liver cells rescues factor X-deficient mice from fatal neonatal bleeding diatheses

Rosen, E., Cornelissen, I., Liang, Z., Zollman, A., Casad, M., Roahrig, J., Suckow, M. & Castellino, F. J., Jan 2003, In : Journal of Thrombosis and Haemostasis. 1, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

Factor X
Disease Susceptibility
Transplantation
Hemorrhage
Liver
2002
106 Citations (Scopus)

FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse

Rosen, E., Gailani, D. & Castellino, F. J., 2002, In : Thrombosis and Haemostasis. 87, 4, p. 774-776 3 p.

Research output: Contribution to journalArticle

Ferrous Compounds
Carotid Artery Thrombosis
Factor XI
Carotid Artery Injuries
Enzyme Activation
12 Citations (Scopus)

Gene targeting in hemostasis. Factor X.

Rosen, E., 2002, In : Frontiers in Bioscience. 7

Research output: Contribution to journalArticle

Factor X
Gene Targeting
Hemostasis
Genes
Factor X Deficiency
44 Citations (Scopus)

Mice with a severe deficiency of the endothelial Protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge

Castellino, F. J., Liang, Z., Volkir, S. P., Haalboom, E., Martin, J. A., Sandoval-Cooper, M. J. & Rosen, E., Sep 2002, In : Thrombosis and Haemostasis. 88, 3, p. 462-472 11 p.

Research output: Contribution to journalArticle

Protein C Deficiency
Thrombosis
Genes
Carotid Artery Thrombosis
Thrombomodulin
83 Citations (Scopus)

Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction

Pawlinski, R., Fernandes, A., Kehrle, B., Pedersen, B., Parry, G., Erlich, J., Pyo, R., Gutstein, D., Zhang, J., Castellino, F., Melis, E., Carmeliet, P., Baretton, G., Luther, T., Taubman, M., Rosen, E. & Mackman, N., Nov 26 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 24, p. 15333-15338 6 p.

Research output: Contribution to journalArticle

Left Ventricular Dysfunction
Thromboplastin
Fibrosis
Hemosiderin
Hemorrhage
2001
34 Citations (Scopus)

Development of pulmonary fibrosis in fibrinogen-deficient mice

Wilberding, J. A., Ploplis, V. A., McLennan, L., Liang, Z., Cornelissen, I., Feldman, M., Deford, M. E., Rosen, E. & Castellino, F. J., 2001, In : Annals of the New York Academy of Sciences. 936, p. 542-548 7 p.

Research output: Contribution to journalArticle

Pulmonary Fibrosis
Fibrinogen
Bleomycin
Animals
Collagen
110 Citations (Scopus)

Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulationdependent thrombi

Rosen, E., Raymond, S., Zollman, A., Noria, F., Sandoval-Cooper, M., Shulman, A., Merz, J. L. & Castellino, F. J., 2001, In : American Journal of Pathology. 158, 5, p. 1613-1622 10 p.

Research output: Contribution to journalArticle

Vascular System Injuries
Lasers
Thrombosis
Blood Platelets
Lighting
30 Citations (Scopus)

The characterization of mice with a targeted combined deficiency of protein C and factor XI

Chan, J. C. Y., Ganopolsky, J. G., Cornelissen, I., Suckow, M. A., Sandoval-Cooper, M. J., Brown, E. C., Noria, F., Gailani, D., Rosen, E., Ploplis, V. A. & Castellino, F. J., 2001, In : American Journal of Pathology. 158, 2, p. 469-479 11 p.

Research output: Contribution to journalArticle

Factor XI
Protein C Deficiency
Fibrin
Thoracic Cavity
Protein C
2000

A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice

Ploplis, V. A., Wilberding, J., Cornelissen, I., Defokdm, E., Uang, Z., Rosen, E. & Castellino, F. J., 2000, In : Fibrinolysis and Proteolysis. 14, SUPPL. 1, p. 11 1 p.

Research output: Contribution to journalArticle

Afibrinogenemia
Pulmonary Fibrosis
Fibrin
Fibrinogen
Bleomycin
69 Citations (Scopus)

A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice

Ploplis, V. A., Wilberding, J., McLennan, L., Liang, Z., Cornelissen, I., Deford, M. E., Rosen, E. & Castellino, F. J., 2000, In : American Journal of Pathology. 157, 3, p. 703-708 6 p.

Research output: Contribution to journalArticle

Afibrinogenemia
Pulmonary Fibrosis
Fibrinogen
Fibrin
Acute Lung Injury
121 Citations (Scopus)

Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice

Dewerchin, M., Liang, Z., Moons, L., Carmeliet, P., Castellino, F. J., Collen, D. & Rosen, E., 2000, In : Thrombosis and Haemostasis. 83, 2, p. 185-190 6 p.

Research output: Contribution to journalArticle

Coagulation Protein Disorders
Factor X Deficiency
Factor X
Hemorrhage
Embryonic Structures
4 Citations (Scopus)

Cloning and characterization of the murine coagulation factor X gene

Cooper, A., Liang, Z., Castellino, F. J. & Rosen, E., 2000, In : Thrombosis and Haemostasis. 83, 5, p. 732-735 4 p.

Research output: Contribution to journalArticle

Factor X
Organism Cloning
Exons
Genes
Serine Proteases
Insertional Mutagenesis
Tetracycline
Genes
Switches
Transcription
1999
38 Citations (Scopus)

Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit

Chan, J. C. Y., Carmeliet, P., Moons, L., Rosen, E., Huang, Z. F., Broze, G. J., Collen, D. & Castellino, F. J., Feb 1999, In : Journal of Clinical Investigation. 103, 4, p. 475-482 8 p.

Research output: Contribution to journalArticle

Factor VII Deficiency
Alleles
Genotype
lipoprotein-associated coagulation inhibitor
Embryonic Structures
12 Citations (Scopus)

Nucleotide structure and characterization of the murine gene encoding the endothelial cell protein C receptor

Liang, Z., Rosen, E. & Castellino, F. J., 1999, In : Thrombosis and Haemostasis. 81, 4, p. 585-588 4 p.

Research output: Contribution to journalArticle

Nucleotides
Genes
Exons
Introns
Centrosome
1998
19 Citations (Scopus)

Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene

Stauffer, D. R., Chukwumezie, B. N., Wilberding, J. A., Rosen, E. & Castellino, F. J., Jan 23 1998, In : Journal of Biological Chemistry. 273, 4, p. 2277-2287 11 p.

Research output: Contribution to journalArticle

Transcriptional Regulatory Elements
Factor VII
Genetic Promoter Regions
CCAAT-Enhancer-Binding Proteins
Base Pairing
5 Citations (Scopus)

Chromosomal arrangement of the murine coagulation factor VII and factor X genes [6]

Liang, Z., Cooper, A., Rosen, E. & Castellino, F. J., 1998, In : Thrombosis and Haemostasis. 80, 3, p. 524-525 2 p.

Research output: Contribution to journalArticle

Factor X
Factor VII
Chromosome Mapping
Genome
Genes
9 Citations (Scopus)

Cloning and characterization of a cDNA encoding murine coagulation factor X

Liang, Z., Cooper, A., DeFord, M. E., Carmeliet, P., Collen, D., Castellino, F. J. & Rosen, E., Jul 1998, In : Thrombosis and Haemostasis. 80, 1, p. 87-91 5 p.

Research output: Contribution to journalArticle

Factor X
Organism Cloning
Complementary DNA
Messenger RNA
Initiator Codon
131 Citations (Scopus)

Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice

Jalbert, L. R., Rosen, E., Moons, L., Chan, J. C. Y., Carmeliet, P., Collen, D. & Castellino, F. J., Oct 15 1998, In : Journal of Clinical Investigation. 102, 8, p. 1481-1488 8 p.

Research output: Contribution to journalArticle

Protein C
Anticoagulants
Protein C Deficiency
Proteins
Fibrinogen
9 Citations (Scopus)

Nucleotide structure and characterization of the murine gene encoding anticoagulant protein C

Jalbert, L. R., Rosen, E., Lissens, A., Carmeliet, P., Collen, D. & Castellino, F. J., Feb 1998, In : Thrombosis and Haemostasis. 79, 2, p. 310-316 7 p.

Research output: Contribution to journalArticle

Protein C
Anticoagulants
Exons
Nucleotides
Terminator Codon
1997
163 Citations (Scopus)

Mice lacking factor VII develop normally but suffer fatal perinatal bleeding

Rosen, E., Chan, J. C. Y., Idusogie, E., Clotman, F., Vlasuk, G., Luther, T., Jalbert, L. R., Albrecht, S., Zhong, L., Lissens, A., Schoonjans, L., Moons, L., Collen, D., Castellino, F. J. & Carmeliet, P., Nov 20 1997, In : Nature. 390, 6657, p. 290-294 5 p.

Research output: Contribution to journalArticle

Factor VII
Thromboplastin
Hemorrhage
Embryonic Structures
Fibrin
1996
20 Citations (Scopus)

Characterization of a cDNA encoding murine coagulation factor VII

Idusogie, E., Rosen, E., Geng, J. P., Carmeliet, P., Collen, D. & Castellino, F. J., Mar 1996, In : Thrombosis and Haemostasis. 75, 3, p. 481-487 7 p.

Research output: Contribution to journalArticle

Factor VII
Nucleotides
Complementary DNA
Messenger RNA
Initiator Codon