Frank Witzmann

  • 4076 Citations
  • 36 h-Index
1979 …2020

Research output per year

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Publications

2020

A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones

Makki, M. S., Winfree, S., Lingeman, J. E., Witzmann, F. A., Worcester, E. M., Krambeck, A. E., Coe, F. L., Evan, A. P., Bledsoe, S., Bergsland, K. J., Khochare, S., Barwinska, D., Williams, J. C. & El-Achkar, T. M., May 2020, In : Kidney International Reports. 5, 5, p. 663-677 15 p.

Research output: Contribution to journalArticle

Open Access
2019

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

LaFavers, K. A., Macedo, E., Garimella, P. S., Lima, C., Khan, S., Myslinski, J., McClintick, J., Witzmann, F. A., Winfree, S., Phillips, C. L., Hato, T., Dagher, P. C., Wu, X. R., El-Achkar, T. M. & Micanovic, R., Oct 2 2019, In : Science translational medicine. 11, 512, eaaw3639.

Research output: Contribution to journalArticle

5 Scopus citations
2018

A possible chemo-biodescriptor framework for the prediction of toxicity of nanosubstances: An integrated computational approach

Vracko, M., Witzmann, F. & Basak, S. C., Mar 1 2018, In : Current Computer-Aided Drug Design. 14, 1, p. 2-4 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation

Shugg, T., Johnson, D. E., Shao, M., Lai, X., Witzmann, F., Cummins, T. R., Rubart-Von-der Lohe, M., Hudmon, A. & Overholser, B. R., Jun 2018, In : Heart Rhythm. 15, 6, p. 895-904 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
1 Scopus citations

Exogenous gene transmission of isocitrate dehydrogenase 2 mimics ischemic preconditioning protection

Kolb, A. L., Corridon, P. R., Zhang, S., Xu, W., Witzmann, F., Collett, J. A., Rhodes, G. J., Winfree, S., Bready, D., Pfeffenberger, Z. J., Pomerantz, J. M., Hato, T., Nagami, G. T., Molitoris, B., Basile, D., Atkinson, S. J. & Bacallao, R., Apr 1 2018, In : Journal of the American Society of Nephrology. 29, 4, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes

Witzmann, F. A. & Monteiro-Riviere, N. A., Jan 1 2017, Nanomedicine in Cancer. Pan Stanford Publishing Pte. Ltd., p. 461-485 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Cancer and chemotherapy contribute to muscle loss by activating common signaling pathways

Barreto, R., Mandili, G., Witzmann, F. A., Novelli, F., Zimmers, T. A. & Bonetto, A., Oct 19 2016, In : Frontiers in Physiology. 7, OCT, 472.

Research output: Contribution to journalArticle

37 Scopus citations

Delineation of molecular pathways involved in cardiomyopathies caused by Troponin T Mutations

Gilda, J. E., Lai, X., Witzmann, F. & Gomes, A. V., Jun 1 2016, In : Molecular and Cellular Proteomics. 15, 6, p. 1962-1981 20 p.

Research output: Contribution to journalArticle

5 Scopus citations

Editorial

Basak, S. C., Vračko, M. & Witzmann, F., Dec 1 2016, In : Current Computer-Aided Drug Design. 12, 4, p. 253-254 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Label-free proteomic methodology for the analysis of human kidney stone matrix composition

Witzmann, F. A., Evan, A. P., Coe, F. L., Worcester, E. M., Lingeman, J. E. & Williams, J. C., Jan 1 2016, In : Proteome Science. 14, 1, 4.

Research output: Contribution to journalArticle

6 Scopus citations
8 Scopus citations

Proximal tubules have the capacity to regulate uptake of albumin

Wagner, M. C., Campos-Bilderback, S. B., Chowdhury, M., Flores, B., Lai, X., Myslinski, J., Pandit, S., Sandoval, R. M., Wean, S. E., Wei, Y., Satlin, L. M., Wiggins, R. C., Witzmann, F. A. & Molitoris, B. A., Feb 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 482-494 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
2015

Distinctive and pervasive alterations in aqueous humor protein composition following different types of glaucoma surgery

Rosenfeld, C., Price, M. O., Lai, X., Witzmann, F. A. & Price, F. W., Aug 25 2015, In : Molecular vision. 21, p. 911-918 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K. S., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L. E., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F. A., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T. A., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

128 Scopus citations

Novel serum biomarkers for detection of excessive alcohol use

Liangpunsakul, S., Lai, X., Ross, R. A., Yu, Z., Modlik, E., Westerhold, C., Heathers, L., Paul, R., O'Connor, S., Crabb, D. W. & Witzmann, F., Mar 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 3, p. 556-565 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Proteomic profiling of hematopoietic stem/progenitor cells after a whole body exposure of CBA/CaJ mice to titanium (48Ti) ions

Rithidech, K. N., Tungjai, M., Jangiam, W., Honikel, L., Gordon, C., Lai, X. & Witzmann, F., Sep 1 2015, In : Proteomes. 3, 3, p. 132-159 28 p.

Research output: Contribution to journalArticle

2 Scopus citations

Proteomic profiling of human sera for discovery of potential biomarkers to monitor abstinence from alcohol abuse

Lai, X., Liangpunsakul, S., Li, K. & Witzmann, F. A., Feb 1 2015, In : ELECTROPHORESIS. 36, 4, p. 556-563 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014
5 Scopus citations

Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice

Domenighetti, A. A., Chu, P. H., Wu, T., Sheikh, F., Gokhin, D. S., Guo, L. T., Cui, Z., Peter, A. K., Christodoulou, D. C., Parfenov, M. G., Gorham, J. M., Li, D. Y., Banerjee, I., Lai, X., Witzmann, F. A., Seidman, C. E., Seidman, J. G., Gomes, A. V., Shelton, G. D., Lieber, R. L. & 1 others, Chen, J., Jan 2014, In : Human molecular genetics. 23, 1, p. 209-225 17 p., ddt412.

Research output: Contribution to journalArticle

28 Scopus citations

Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns

Tilton, S. C., Karin, N. J., Tolic, A., Xie, Y., Lai, X., Hamilton, R. F., Waters, K. M., Holian, A., Witzmann, F. A. & Orr, G., Aug 1 2014, In : Nanotoxicology. 8, 5, p. 533-548 16 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

Bioinformatic analysis of differential protein expression in Calu-3 cells exposed to carbon nanotubes

Li, P., Lai, X., Witzmann, F. A. & Blazer-Yost, B. L., Dec 1 2013, In : Proteomes. 1, 3, p. 219-239 21 p.

Research output: Contribution to journalArticle

8 Scopus citations

Comparison of nanotube-protein corona composition in cell culture media

Shannahan, J. H., Brown, J. M., Chen, R., Ke, P. C., Lai, X., Mitra, S. & Witzmann, F. A., Jun 24 2013, In : Small. 9, 12, p. 2171-2181 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease

Prince, K. L., Colvin, S. C., Park, S., Lai, X., Witzmann, F. A. & Rhodes, S. J., Feb 1 2013, In : Endocrinology. 154, 2, p. 738-748 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: The NIEHS Nano go consortium

Xia, T., Hamilton, R. F., Bonner, J. C., Crandall, E. D., Elder, A., Fazlollahi, F., Girtsman, T. A., Kim, K., Mitra, S., Ntim, S. A., Orr, G., Tagmount, M., Taylor, A. J., Telesca, D., Tolic, A., Vulpe, C. D., Walker, A. J., Wang, X., Witzmann, F. A., Wu, N. & 4 others, Xie, Y., Zink, J. I., Nel, A. & Holian, A., Jun 1 2013, In : Environmental Health Perspectives. 121, 6, p. 683-690 8 p.

Research output: Contribution to journalArticle

124 Scopus citations

LHX3 Interacts with Inhibitor of Histone Acetyltransferase Complex Subunits LANP and TAF-1β to Modulate Pituitary Gene Regulation

Hunter, C. S., Malik, R. E., Witzmann, F. A. & Rhodes, S. J., Jul 4 2013, In : PloS one. 8, 7, e68898.

Research output: Contribution to journalArticle

7 Scopus citations

Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: Influence of obesity

Owen, M. K., Witzmann, F. A., Mckenney, M. L., Lai, X., Berwick, Z. C., Moberly, S. P., Alloosh, M., Sturek, M. & Tune, J. D., Jul 2 2013, In : Circulation. 128, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

88 Scopus citations
19 Scopus citations

Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture

Lai, X., Agarwal, M., Lvov, Y. M., Pachpande, C., Varahramyan, K. & Witzmann, F. A., Nov 1 2013, In : Journal of Applied Toxicology. 33, 11, p. 1316-1329 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

Silver Nanoparticle Protein Corona Composition in Cell Culture Media

Shannahan, J. H., Lai, X., Ke, P. C., Podila, R., Brown, J. M. & Witzmann, F. A., Sep 9 2013, In : PloS one. 8, 9, e74001.

Research output: Contribution to journalArticle

129 Scopus citations
2012

Functional effects of nanoparticle exposure on calu-3 airway epithelial cells

Banga, A., Witzmann, F. A., Petrache, H. I. & Blazer-Yost, B. L., 2012, In : Cellular Physiology and Biochemistry. 29, 1-2, p. 197-212 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments

Rithidech, K. N., Lai, X., Honikel, L., Reungpatthanaphong, P. & Witzmann, F. A., Jan 1 2012, In : Health physics. 102, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Multi-walled carbon nanotube directed gene and protein expression in cultured human aortic endothelial cells is influenced by suspension medium

Vidanapathirana, A. K., Lai, X., Hilderbrand, S. C., Pitzer, J. E., Podila, R., Sumner, S. J., Fennell, T. R., Wingard, C. J., Witzmann, F. A. & Brown, J. M., 2012, In : Toxicology. 302, 2-3, p. 114-122 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Proteomic study of low-temperature responses in strawberry cultivars (Fragaria × ananassa) that differ in cold tolerance

Koehler, G., Wilson, R. C., Goodpaster, J. V., Sønsteby, A., Lai, X., Witzmann, F. A., You, J. S., Rohloff, J., Randall, S. K. & Alsheikh, M., Aug 1 2012, In : Plant Physiology. 159, 4, p. 1787-1805 19 p.

Research output: Contribution to journalArticle

60 Scopus citations

Size dependent aqueous dispersibility of carboxylated multiwall carbon nanotubes

Ntim, S. A., Sae-Khow, O., Desai, C., Witzmann, F. A. & Mitra, S., Oct 1 2012, In : Journal of Environmental Monitoring. 14, 10, p. 2772-2779 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011
42 Scopus citations

Differential expression of renal proteins in a rodent model of meckel syndrome

Mason, S. B., Lai, X., Ringham, H. N., Bacallao, R. L., Harris, P. C., Witzmann, F. A. & Gattone, V. H., Jan 1 2011, In : Nephron - Experimental Nephrology. 117, 2, p. e31-e38

Research output: Contribution to journalArticle

4 Scopus citations

Effect of carbon nanoparticles on renal epithelial cell structure, barrier function, and protein expression

Blazer-Yost, B. L., Banga, A., Amos, A., Chernoff, E., Lai, X., Li, C., Mitra, S. & Witzmann, F. A., Sep 1 2011, In : Nanotoxicology. 5, 3, p. 354-371 18 p.

Research output: Contribution to journalArticle

24 Scopus citations

Effects of polymer wrapping and covalent functionalization on the stability of MWCNT in aqueous dispersions

Ntim, S. A., Sae-Khow, O., Witzmann, F. A. & Mitra, S., Mar 15 2011, In : Journal of Colloid and Interface Science. 355, 2, p. 383-388 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Erratum: Tumor necrosis factor-α- and interleukin-1-induced cellular responses: Coupling proteomic and genomic information (Journal of Proteome Research (2007) 6 (2176-2185) DOI: 10.1021/pr060665l)

Ott, L. W., Resing, K. A., Sizemore, A. W., Heyen, J. W., Cocklin, R. R., Pedrick, N. M., Woods, H. C., Chen, J. Y., Goebl, M. G., Witzmann, F. A. & Harrington, M. A., Oct 7 2011, In : Journal of Proteome Research. 10, 10, 1 p.

Research output: Contribution to journalComment/debate

Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain

Zahr, N. M., Bell, R. L., Ringham, H. N., Sullivan, E. V., Witzmann, F. A. & Pfefferbaum, A., Sep 1 2011, In : Pharmacology Biochemistry and Behavior. 99, 3, p. 428-436 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy

Richardson, M. R., Segu, Z. M., Price, M. O., Lai, X., Witzmann, F. A., Mechref, Y., Yoder, M. C. & Price, F. W., Dec 1 2010, In : Molecular vision. 16, p. 2376-2383 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach

Basak, S. C., Gute, B. D., Monteiro-Riviere, N. A. & Witzmann, F. A., Dec 28 2010, Principles and Practice of Mixtures Toxicology. Wiley-VCH, p. 215-234 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Differential protein expression following JP-8 jet fuel exposure

Witzmann, F. & Witten, M. L., Jan 1 2010, Jet Fuel Toxicology. CRC Press, p. 73-102 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein changes in macrophages induced by plasma from rats exposed to 35 GHz millimeter waves

Sypniewska, R. K., Millenbaugh, N. J., Kiel, J. L., Blystone, R. V., Ringham, H. N., Mason, P. A. & Witzmann, F. A., Dec 1 2010, In : Bioelectromagnetics. 31, 8, p. 656-663 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
23 Scopus citations

Venous and arterial endothelial proteomics: Mining for markers and mechanisms of endothelial diversity

Richardson, M. R., Lai, X., Witzmann, F. A. & Yoder, M. C., Dec 1 2010, In : Expert Review of Proteomics. 7, 6, p. 823-831 9 p.

Research output: Contribution to journalReview article

19 Scopus citations
2009

A Pilot Study of Proteomic Profiles of Human Hepatocellular Carcinoma in the United States

Matos, J. M., Witzmann, F. A., Cummings, O. W. & Schmidt, C. M., Aug 1 2009, In : Journal of Surgical Research. 155, 2, p. 237-243 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS

Lai, X., Liangpunsakul, S., Crabb, D. W., Ringham, H. N. & Witzmann, F. A., Jun 1 2009, In : ELECTROPHORESIS. 30, 12, p. 2207-2214 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Diabetic dyslipidemia and exercise alter the plasma low-density lipoproteome in Yucatan pigs

Richardson, M. R., Lai, X., Dixon, J. L., Sturek, M. & Witzmann, F. A., May 1 2009, In : Proteomics. 9, 9, p. 2468-2483 16 p.

Research output: Contribution to journalArticle

13 Scopus citations