Frank Witzmann

  • 3918 Citations
  • 35 h-Index
1979 …2019
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Publications 1979 2019

  • 3918 Citations
  • 35 h-Index
  • 137 Article
  • 8 Chapter
  • 2 Editorial
  • 1 Conference contribution
2019
1 Citation (Scopus)

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

LaFavers, K. A., Macedo, E., Garimella, P. S., Lima, C., Khan, S., Myslinski, J., McClintick, J., Witzmann, F. A., Winfree, S., Phillips, C. L., Hato, T., Dagher, P. C., Wu, X. R., El-Achkar, T. M. & Micanovic, R., Oct 2 2019, In : Science translational medicine. 11, 512

Research output: Contribution to journalArticle

Uromodulin
Oxidative Stress
Acute Kidney Injury
Protein Deficiency
Reactive Oxygen Species
2018
1 Citation (Scopus)

A possible chemo-biodescriptor framework for the prediction of toxicity of nanosubstances: An integrated computational approach

Vracko, M., Witzmann, F. & Basak, S. C., Mar 1 2018, In : Current Computer-Aided Drug Design. 14, 1, p. 2-4 3 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation

Shugg, T., Johnson, D. E., Shao, M., Lai, X., Witzmann, F., Cummins, T., Rubart-von der Lohe, M., Hudmon, A. & Overholser, B. R., Jun 1 2018, In : Heart Rhythm. 15, 6, p. 895-904 10 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Adrenergic Receptors
Isoproterenol
Phosphorylation
1 Citation (Scopus)
Nanobelts
Carbon Nanotubes
Proteomics
Cluster Analysis
Carbon nanotubes
1 Citation (Scopus)

Exogenous gene transmission of isocitrate dehydrogenase 2 mimics ischemic preconditioning protection

Kolb, A. L., Corridon, P. R., Zhang, S., Xu, W., Witzmann, F., Collett, J. A., Rhodes, G. J., Winfree, S., Bready, D., Pfeffenberger, Z. J., Pomerantz, J. M., Hato, T., Nagami, G. T., Molitoris, B., Basile, D., Atkinson, S. J. & Bacallao, R., Apr 1 2018, In : Journal of the American Society of Nephrology. 29, 4, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Ischemic Preconditioning
Mitochondria
Cytoprotection
Wounds and Injuries
2017

Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes

Witzmann, F. & Monteiro-Riviere, N. A., Jan 1 2017, Nanomedicine in Cancer. Pan Stanford Publishing Pte. Ltd., p. 461-485 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbon Nanotubes
Keratinocytes
Carbon nanotubes
Proteins
2016
31 Citations (Scopus)

Cancer and chemotherapy contribute to muscle loss by activating common signaling pathways

Barreto, R., Mandili, G., Witzmann, F., Novelli, F., Zimmers, T. & Bonetto, A., Oct 19 2016, In : Frontiers in Physiology. 7, OCT, 472.

Research output: Contribution to journalArticle

Cachexia
Drug Therapy
Muscles
Colon
Neoplasms
5 Citations (Scopus)

Delineation of molecular pathways involved in cardiomyopathies caused by Troponin T Mutations

Gilda, J. E., Lai, X., Witzmann, F. & Gomes, A. V., Jun 1 2016, In : Molecular and Cellular Proteomics. 15, 6, p. 1962-1981 20 p.

Research output: Contribution to journalArticle

Troponin T
Familial Hypertrophic Cardiomyopathy
Cardiomyopathies
Mutation
Proteasome Endopeptidase Complex
1 Citation (Scopus)

Editorial

Basak, S. C., Vračko, M. & Witzmann, F., Dec 1 2016, In : Current Computer-Aided Drug Design. 12, 4, p. 253-254 2 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Label-free proteomic methodology for the analysis of human kidney stone matrix composition

Witzmann, F., Evan, A., Coe, F. L., Worcester, E. M., Lingeman, J. E. & Williams, J., 2016, In : Proteome Science. 14, 1, 4.

Research output: Contribution to journalArticle

Kidney Calculi
Proteomics
Labels
Proteome
Chemical analysis
6 Citations (Scopus)
Carbon Nanotubes
Proteomics
Nanoparticles
Poisons
Proteins
37 Citations (Scopus)

Proximal tubules have the capacity to regulate uptake of albumin

Wagner, M., Campos-Bilderback, S., Chowdhury, M., Flores, B., Lai, X., Myslinski, J., Pandit, S., Sandoval, R. M., Wean, S. E., Wei, Y., Satlin, L. M., Wiggins, R. C., Witzmann, F. & Molitoris, B., Feb 1 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 482-494 13 p.

Research output: Contribution to journalArticle

Albumins
Serum Albumin
Albumin Receptors
Proteins
Angiopoietin-2
2015
16 Citations (Scopus)

Distinctive and pervasive alterations in aqueous humor protein composition following different types of glaucoma surgery

Rosenfeld, C., Price, M. O., Lai, X., Witzmann, F. & Price, F. W., Aug 25 2015, In : Molecular Vision. 21, p. 911-918 8 p.

Research output: Contribution to journalArticle

Aqueous Humor
Glaucoma
Trabeculectomy
Glaucoma Drainage Implants
Proteins
105 Citations (Scopus)

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

Muscle Weakness
Transforming Growth Factors
Ryanodine Receptor Calcium Release Channel
Muscle
Bone
11 Citations (Scopus)

Novel serum biomarkers for detection of excessive alcohol use

Liangpunsakul, S., Lai, X., Ross, R. A., Yu, Z., Modlik, E., Westerhold, C., Heathers, L., Paul, R., O'Connor, S., Crabb, D. & Witzmann, F., Mar 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 3, p. 556-565 10 p.

Research output: Contribution to journalArticle

Biomarkers
Alcohols
Serum
Erythrocyte Indices
Alanine Transaminase
2 Citations (Scopus)

Proteomic profiling of hematopoietic stem/progenitor cells after a whole body exposure of CBA/CaJ mice to titanium (48Ti) ions

Rithidech, K. N., Tungjai, M., Jangiam, W., Honikel, L., Gordon, C., Lai, X. & Witzmann, F., Sep 1 2015, In : Proteomes. 3, 3, p. 132-159 28 p.

Research output: Contribution to journalArticle

Inbred CBA Mouse
Hematopoietic Stem Cells
Titanium
Stem cells
Proteomics
1 Citation (Scopus)

Proteomic profiling of human sera for discovery of potential biomarkers to monitor abstinence from alcohol abuse

Lai, X., Liangpunsakul, S., Li, K. & Witzmann, F., Feb 1 2015, In : Electrophoresis. 36, 4, p. 556-563 8 p.

Research output: Contribution to journalArticle

Biomarkers
Proteomics
Alcoholism
Alcohols
Serum
2014
4 Citations (Scopus)
alcohol consumption
Nonesterified Fatty Acids
Adipocytes
Alcohol Drinking
Adipose Tissue
27 Citations (Scopus)

Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice

Domenighetti, A. A., Chu, P. H., Wu, T., Sheikh, F., Gokhin, D. S., Guo, L. T., Cui, Z., Peter, A. K., Christodoulou, D. C., Parfenov, M. G., Gorham, J. M., Li, D. Y., Banerjee, I., Lai, X., Witzmann, F., Seidman, C. E., Seidman, J. G., Gomes, A. V., Shelton, G. D., Lieber, R. L. & 1 others, Chen, J., Jan 2014, In : Human Molecular Genetics. 23, 1, p. 209-225 17 p., ddt412.

Research output: Contribution to journalArticle

Muscular Diseases
Skeletal Muscle
Muscles
LIM Domain Proteins
Emery-Dreifuss Muscular Dystrophy
40 Citations (Scopus)

Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns

Tilton, S. C., Karin, N. J., Tolic, A., Xie, Y., Lai, X., Hamilton, R. F., Waters, K. M., Holian, A., Witzmann, F. & Orr, G., Aug 2014, In : Nanotoxicology. 8, 5, p. 533-548 16 p.

Research output: Contribution to journalArticle

Nanobelts
Carbon Nanotubes
Carbon Dioxide
Proteomics
Nanoparticles
2013
7 Citations (Scopus)

Bioinformatic analysis of differential protein expression in Calu-3 cells exposed to carbon nanotubes

Li, P., Lai, X., Witzmann, F. & Blazer-Yost, B. L., Dec 1 2013, In : Proteomes. 1, 3, p. 219-239 21 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Bioinformatics
Computational Biology
Proteins
Nanoparticles
83 Citations (Scopus)

Comparison of nanotube-protein corona composition in cell culture media

Shannahan, J. H., Brown, J. M., Chen, R., Ke, P. C., Lai, X., Mitra, S. & Witzmann, F., Jun 24 2013, In : Small. 9, 12, p. 2171-2181 11 p.

Research output: Contribution to journalArticle

Nanotubes
Cell culture
Culture Media
Cell Culture Techniques
Carbon Nanotubes
4 Citations (Scopus)

Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease

Prince, K. L., Colvin, S. C., Park, S., Lai, X., Witzmann, F. & Rhodes, S., Feb 1 2013, In : Endocrinology. 154, 2, p. 738-748 11 p.

Research output: Contribution to journalArticle

Deficiency Diseases
Adrenocorticotropic Hormone
Glycoproteins
Hormones
Endocrine System Diseases
114 Citations (Scopus)

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: The NIEHS Nano go consortium

Xia, T., Hamilton, R. F., Bonner, J. C., Crandall, E. D., Elder, A., Fazlollahi, F., Girtsman, T. A., Kim, K., Mitra, S., Ntim, S. A., Orr, G., Tagmount, M., Taylor, A. J., Telesca, D., Tolic, A., Vulpe, C. D., Walker, A. J., Wang, X., Witzmann, F., Wu, N. & 4 others, Xie, Y., Zink, J. I., Nel, A. & Holian, A., Jun 2013, In : Environmental Health Perspectives. 121, 6, p. 683-690 8 p.

Research output: Contribution to journalArticle

Nanostructures
National Institutes of Health (U.S.)
Interleukin-1
Carbon Nanotubes
Zinc Oxide
7 Citations (Scopus)

LHX3 Interacts with Inhibitor of Histone Acetyltransferase Complex Subunits LANP and TAF-1β to Modulate Pituitary Gene Regulation

Hunter, C. S., Malik, R. E., Witzmann, F. & Rhodes, S., Jul 4 2013, In : PLoS One. 8, 7, e68898.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Gene expression
Genes
Neurology
Chromatin
81 Citations (Scopus)

Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: Influence of obesity

Owen, M. K., Witzmann, F. A., Mckenney, M. L., Lai, X., Berwick, Z. C., Moberly, S. P., Alloosh, M., Sturek, M. & Tune, J. D., Jul 2 2013, In : Circulation. 128, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Adipose Tissue
Obesity
Swine
Proteome
17 Citations (Scopus)
Diabetic Cardiomyopathies
Epoxide Hydrolases
Proteomics
Medical problems
Type 1 Diabetes Mellitus
56 Citations (Scopus)

Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture

Lai, X., Agarwal, M., Lvov, Y. M., Pachpande, C., Varahramyan, K. & Witzmann, F., Nov 2013, In : Journal of Applied Toxicology. 33, 11, p. 1316-1329 14 p.

Research output: Contribution to journalArticle

Nanotubes
Coculture Techniques
Proteomics
Cell Culture Techniques
Biocompatibility
120 Citations (Scopus)

Silver Nanoparticle Protein Corona Composition in Cell Culture Media

Shannahan, J. H., Lai, X., Ke, P. C., Podila, R., Brown, J. M. & Witzmann, F., Sep 9 2013, In : PLoS One. 8, 9, e74001.

Research output: Contribution to journalArticle

Silver Proteins
nanosilver
protein composition
Silver
Cell culture
2012
19 Citations (Scopus)

Functional effects of nanoparticle exposure on calu-3 airway epithelial cells

Banga, A., Witzmann, F., Petrache, H. I. & Blazer-Yost, B. L., 2012, In : Cellular Physiology and Biochemistry. 29, 1-2, p. 197-212 16 p.

Research output: Contribution to journalArticle

Nanoparticles
Epithelial Cells
Electric Impedance
Fullerenes
Carbon Nanotubes
11 Citations (Scopus)

Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments

Rithidech, K. N., Lai, X., Honikel, L., Reungpatthanaphong, P. & Witzmann, F., Jan 2012, In : Health Physics. 102, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Lymphocytes
Radiation
Proteins
Proteomics
Airports
17 Citations (Scopus)

Multi-walled carbon nanotube directed gene and protein expression in cultured human aortic endothelial cells is influenced by suspension medium

Vidanapathirana, A. K., Lai, X., Hilderbrand, S. C., Pitzer, J. E., Podila, R., Sumner, S. J., Fennell, T. R., Wingard, C. J., Witzmann, F. & Brown, J. M., 2012, In : Toxicology. 302, 2-3, p. 114-122 9 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Endothelial cells
Suspensions
Endothelial Cells
Gene Expression
55 Citations (Scopus)

Proteomic study of low-temperature responses in strawberry cultivars (Fragaria × ananassa) that differ in cold tolerance

Koehler, G., Wilson, R. C., Goodpaster, J. V., Sønsteby, A., Lai, X., Witzmann, F., You, J. S., Rohloff, J., Randall, S. K. & Alsheikh, M., Aug 2012, In : Plant Physiology. 159, 4, p. 1787-1805 19 p.

Research output: Contribution to journalArticle

Fragaria
Fragaria ananassa
cold tolerance
Proteomics
proteomics
18 Citations (Scopus)

Size dependent aqueous dispersibility of carboxylated multiwall carbon nanotubes

Ntim, S. A., Sae-Khow, O., Desai, C., Witzmann, F. & Mitra, S., Oct 2012, In : Journal of Environmental Monitoring. 14, 10, p. 2772-2779 8 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Agglomeration
hydrophobicity
Zeta potential
Hydrophobicity
2011
42 Citations (Scopus)
Labels
Peptides
Proteins
Tissue
Kidney
4 Citations (Scopus)

Differential expression of renal proteins in a rodent model of meckel syndrome

Mason, S. B., Lai, X., Ringham, H. N., Bacallao, R., Harris, P. C., Witzmann, F. & Gattone, V. H., Jan 2011, In : Nephron - Experimental Nephrology. 117, 2

Research output: Contribution to journalArticle

Rodentia
Kidney
Proteins
Polycystic Kidney Diseases
Proteomics
23 Citations (Scopus)

Effect of carbon nanoparticles on renal epithelial cell structure, barrier function, and protein expression

Blazer-Yost, B. L., Banga, A., Amos, A., Chernoff, E., Lai, X., Li, C., Mitra, S. & Witzmann, F., Sep 2011, In : Nanotoxicology. 5, 3, p. 354-371 18 p.

Research output: Contribution to journalArticle

Nanoparticles
Carbon
Epithelial Cells
Proteins
Kidney
74 Citations (Scopus)

Effects of polymer wrapping and covalent functionalization on the stability of MWCNT in aqueous dispersions

Ntim, S. A., Sae-Khow, O., Witzmann, F. & Mitra, S., Mar 15 2011, In : Journal of Colloid and Interface Science. 355, 2, p. 383-388 6 p.

Research output: Contribution to journalArticle

Polyvinyls
Pyrrolidinones
Dispersions
Polymers
Agglomeration

Erratum: Tumor necrosis factor-α- and interleukin-1-induced cellular responses: Coupling proteomic and genomic information (Journal of Proteome Research (2007) 6 (2176-2185) DOI: 10.1021/pr060665l)

Ott, L. W., Resing, K. A., Sizemore, A. W., Heyen, J. W., Cocklin, R. R., Pedrick, N. M., Woods, H. C., Chen, J. Y., Goebl, M., Witzmann, F. & Harrington, M., Oct 7 2011, In : Journal of Proteome Research. 10, 10, p. 4886 1 p.

Research output: Contribution to journalArticle

Proteome
Interleukin-1
Tumor Necrosis Factor-alpha
Proteomics
9 Citations (Scopus)

Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain

Zahr, N. M., Bell, R., Ringham, H. N., Sullivan, E. V., Witzmann, F. & Pfefferbaum, A., Sep 2011, In : Pharmacology Biochemistry and Behavior. 99, 3, p. 428-436 9 p.

Research output: Contribution to journalArticle

Metabolism
Synaptic Transmission
Rats
Brain
Ethanol
2010
24 Citations (Scopus)

Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy

Richardson, M. R., Segu, Z. M., Price, M. O., Lai, X., Witzmann, F., Mechref, Y., Yoder, M. & Price, F. W., 2010, In : Molecular Vision. 16, p. 2376-2383 8 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Aqueous Humor
Proteome
Albumins
Proteins
4 Citations (Scopus)

Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach

Basak, S. C., Gute, B. D., Monteiro-Riviere, N. A. & Witzmann, F., Dec 28 2010, Principles and Practice of Mixtures Toxicology. Wiley-VCH, p. 215-234 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisome Proliferators
Proteomics

Differential protein expression following JP-8 jet fuel exposure

Witzmann, F. & Witten, M. L., Jan 1 2010, Jet Fuel Toxicology. CRC Press, p. 73-102 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jet fuel
Proteomics
Tissue
Proteins
Alveolar Epithelial Cells
8 Citations (Scopus)

Protein changes in macrophages induced by plasma from rats exposed to 35 GHz millimeter waves

Sypniewska, R. K., Millenbaugh, N. J., Kiel, J. L., Blystone, R. V., Ringham, H. N., Mason, P. A. & Witzmann, F., Dec 2010, In : Bioelectromagnetics. 31, 8, p. 656-663 8 p.

Research output: Contribution to journalArticle

Macrophages
Proteins
Hot Temperature
Peptide Mapping
Electrophoresis, Gel, Two-Dimensional
22 Citations (Scopus)
Erythrocyte Indices
gamma-Glutamyltransferase
Apolipoprotein A-I
Apolipoproteins B
Aspartate Aminotransferases
16 Citations (Scopus)

Venous and arterial endothelial proteomics: Mining for markers and mechanisms of endothelial diversity

Richardson, M. R., Lai, X., Witzmann, F. & Yoder, M., Dec 2010, In : Expert Review of Proteomics. 7, 6, p. 823-831 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Proteomics
Endothelial Cells
Blood Vessels
Publications
2009
26 Citations (Scopus)

A Pilot Study of Proteomic Profiles of Human Hepatocellular Carcinoma in the United States

Matos, J. M., Witzmann, F., Cummings, O. & Schmidt, C., Aug 2009, In : Journal of Surgical Research. 155, 2, p. 237-243 7 p.

Research output: Contribution to journalArticle

Proteomics
Hepatocellular Carcinoma
Proteins
Neoplasms
Biomarkers
18 Citations (Scopus)

A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS

Lai, X., Liangpunsakul, S., Crabb, D., Ringham, H. N. & Witzmann, F., Jun 2009, In : Electrophoresis. 30, 12, p. 2207-2214 8 p.

Research output: Contribution to journalArticle

Workflow
Biomarkers
Proteomics
Alcoholism
Blood Proteins
12 Citations (Scopus)

Diabetic dyslipidemia and exercise alter the plasma low-density lipoproteome in Yucatan pigs

Richardson, M. R., Lai, X., Dixon, J. L., Sturek, M. & Witzmann, F., May 2009, In : Proteomics. 9, 9, p. 2468-2483 16 p.

Research output: Contribution to journalArticle

Dyslipidemias
LDL Lipoproteins
Atherosclerosis
Swine
Plasmas
4 Citations (Scopus)

Protein composition of liver cyst fluid from the BALB/c-cpk/+ mouse model of autosomal recessive polycystic kidney disease

Lai, X., Blazer-Yost, B. L., Gattone, V. H., Muchatuta, M. N. & Witzmann, F., Jul 2009, In : Proteomics. 9, 14, p. 3775-3782 8 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Cyst Fluid
Liver
Common Hepatic Duct
Ducts