Fredrick Pavalko

  • 4214 Citations
  • 32 h-Index
1986 …2020

Research output per year

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Publications

2020

PIE-FLIM Measurements of Two Different FRET-Based Biosensor Activities in the Same Living Cells

Reissaus, C. A., Day, K. H., Mirmira, R. G., Dunn, K. W., Pavalko, F. M. & Day, R. N., Apr 21 2020, In : Biophysical journal. 118, 8, p. 1820-1829 10 p.

Research output: Contribution to journalArticle

Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/β-catenin suppression

Lim, K. E., Hoggatt, A. M., Bullock, W. A., Horan, D. J., Yokota, H., Pavalko, F. M. & Robling, A. G., 2020, (Accepted/In press) In : Journal of cellular physiology.

Research output: Contribution to journalArticle

2019

Expression of a Degradation-Resistant β-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting

Bullock, W. A., Hoggatt, A. M., Horan, D. J., Lewis, K. J., Yokota, H., Hann, S., Warman, M. L., Sebastian, A., Loots, G. G., Pavalko, F. M. & Robling, A. G., Oct 1 2019, In : Journal of Bone and Mineral Research. 34, 10, p. 1964-1975 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

Bullock, W. A., Hoggatt, A. M., Horan, D. J., Elmendorf, A. J., Sato, A. Y., Bellido, T., Loots, G. G., Pavalko, F. M. & Robling, A. G., Oct 25 2019, In : iScience. 20, p. 205-215 11 p.

Research output: Contribution to journalArticle

Open Access

Osteocytes and mechanical loading: The Wnt connection

Bullock, W. A., Pavalko, F. M. & Robling, A. G., May 2019, In : Orthodontics and Craniofacial Research. 22, S1, p. 175-179 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Mechanotransduction in bone formation and maintenance

Bullock, W. A., Plotkin, L. I., Robling, A. G. & Pavalko, F. M., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 75-83 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Hydroxy-Safflower Yellow A inhibits the TNFR1-Mediated Classical NF-κB Pathway by Inducing Shedding of TNFR1

Wang, H., Liu, J., Yang, Y., Cao, Q., Huo, X., Ma, S., Hu, J., Pavalko, F. M. & Liu, Q., May 1 2016, In : Phytotherapy Research. 30, 5, p. 790-796 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Genome-wide mapping and interrogation of the Nmp4 antianabolic bone axis

Childress, P., Stayrook, K. R., Alvarez, M. B., Wang, Z., Shao, Y., Hernandez-Buquer, S., Mack, J. K., Grese, Z. R., He, Y., Horan, D., Pavalko, F. M., Warden, S. J., Robling, A. G., Yang, F. C., Allen, M. R., Krishnan, V., Liu, Y. & Bidwell, J. P., Sep 1 2015, In : Molecular Endocrinology. 29, 9, p. 1269-1285 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Signaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells

Cheng, Y. H., Streicher, D. A., Waning, D. L., Chitteti, B. R., Gerard-O'Riley, R., Horowitz, M. C., Bidwell, J. P., Pavalko, F. M., Srour, E. F., Mayo, L. D. & Kacena, M. A., Mar 1 2015, In : Journal of cellular physiology. 230, 3, p. 578-586 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Estrogen receptor-β regulates mechanical signaling in primary osteoblasts

Castillo, A. B., Triplett, J. W., Pavalko, F. M. & Turner, C. H., Apr 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 8, p. E937-E944

Research output: Contribution to journalArticle

21 Scopus citations

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression

Hum, J. M., Day, R. N., Bidwell, J. P., Wang, Y. & Pavalko, F. M., May 19 2014, In : PLoS ONE. 9, 5, e97942.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation

Cheng, Y. H., Hooker, R. A., Nguyen, K., Gerard-O'Riley, R., Waning, D. L., Chitteti, B. R., Meijome, T. E., Chua, H. L., Plett, A. P., Orschell, C. M., Srour, E. F., Mayo, L. D., Pavalko, F. M., Bruzzaniti, A. & Kacena, M. A., Jun 2013, In : Journal of Bone and Mineral Research. 28, 6, p. 1434-1445 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012
12 Scopus citations

Monitoring biosensor activity in living cells with fluorescence lifetime imaging microscopy

Hum, J. M., Siegel, A. P., Pavalko, F. M. & Day, R. N., Jan 1 2012, In : International journal of molecular sciences. 13, 11, p. 14385-14400 16 p.

Research output: Contribution to journalReview article

15 Scopus citations

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J. P., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F. M., Kacena, M. A. & Yang, F. C., Nov 12 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Blockade of TNFR1 signaling: A role of oscillatory fluid shear stress in osteoblasts

Wang, H., Young, S. R., Gerard-O'Riley, R., Hum, J. M., Yang, Z., Bidwell, J. P. & Pavalko, F. M., Apr 1 2011, In : Journal of cellular physiology. 226, 4, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction

Young, S. R. L., Hum, J. M., Rodenberg, E., Turner, C. H. & Pavalko, F. M., 2011, In : PloS one. 6, 1, e16026.

Research output: Contribution to journalArticle

21 Scopus citations
2010

Activation of NF-κB by fluid shear stress, but not TNF-α, requires focal adhesion kinase in osteoblasts

Young, S. R. L., Gerard-O'Riley, R., Harrington, M. & Pavalko, F. M., Jul 1 2010, In : Bone. 47, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Mechanosomes carry a loaded message

Bidwell, J. P. & Pavalko, F. M., Dec 21 2010, In : Science Signaling. 3, 153

Research output: Contribution to journalReview article

14 Scopus citations

Nmp4/CIZ inhibits mechanically induced β-catenin signaling activity in osteoblasts

Yang, Z., Bidwell, J. P., Young, S. R., Gerard-O'Riley, R., Wang, H. & Pavalko, F. M., May 1 2010, In : Journal of cellular physiology. 223, 2, p. 435-441 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

The load-bearing mechanosome revisited

Bidwell, J. P. & Pavalko, F. M., Dec 1 2010, In : Clinical Reviews in Bone and Mineral Metabolism. 8, 4, p. 213-223 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Cytoskeletal interactions with leukocyte and endothelial cell adhesion molecules

Pavalko, F. M., 2009, In : Current Topics in Membranes. 64, 1, p. 133-156 24 p.

Research output: Contribution to journalArticle

1 Scopus citations

Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts

Young, S. R. L., Gerard-O'Riley, R., Kim, J. B. & Pavalko, F. M., Mar 1 2009, In : Journal of Bone and Mineral Research. 24, 3, p. 411-424 14 p.

Research output: Contribution to journalArticle

104 Scopus citations
2007

Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in A PKCζ-dependent manner

Triplett, J. W., O'Riley, R., Tekulve, K., Norvell, S. M. & Pavalko, F. M., Mar 1 2007, In : MCB Molecular and Cellular Biomechanics. 4, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts

Charoonpatrapong-Panyayong, K., Shah, R., Yang, J., Alvarez, M., Pavalko, F. M., Gerard-O'Riley, R., Robling, A. G., Templeton, E. & Bidwell, J. P., Dec 1 2007, In : Journal of Cellular Biochemistry. 102, 5, p. 1202-1213 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles

Ponik, S. M., Triplett, J. W. & Pavalko, F. M., Feb 15 2007, In : Journal of Cellular Biochemistry. 100, 3, p. 794-807 14 p.

Research output: Contribution to journalArticle

94 Scopus citations
22 Scopus citations
2006
38 Scopus citations

HMGB1 expression and release by bone cells

Charoonpatrapong, K., Shah, R., Robling, A. G., Alvarez, M., Clapp, D. W., Chen, S., Kopp, R. P., Pavalko, F. M., Yu, J. & Bidwell, J. P., May 1 2006, In : Journal of cellular physiology. 207, 2, p. 480-490 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2005

Adenoviral transgene expression enhanced by cotreatment with etoposide in cultured cells

Triplett, J. W., Herring, B. P. & Pavalko, F. M., 2005, In : BioTechniques. 39, 6, p. 826-829 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

Fluid shear stress induces β-catenin signaling in osteoblasts

Norvell, S. M., Alvarez, M., Bidwell, J. P. & Pavalko, F. M., Nov 1 2004, In : Calcified Tissue International. 75, 5, p. 396-404 9 p.

Research output: Contribution to journalArticle

116 Scopus citations

Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules

Norvell, S. M., Ponik, S. M., Bowen, D. K., Gerard, R. & Pavalko, F. M., Mar 1 2004, In : Journal of Applied Physiology. 96, 3, p. 957-966 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
76 Scopus citations

Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells

Woods, A. M., Rodenberg, E. J., Hiles, M. C. & Pavalko, F. M., Feb 2004, In : Biomaterials. 25, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts

Shah, R., Alvarez, M., Jones, D. R., Torrungruang, K., Watt, A. J., Selvamurugan, N., Partridge, N. C., Quinn, C. O., Pavalko, F. M., Rhodes, S. J. & Bidwell, J. P., Aug 1 2004, In : American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2, p. E289-E296

Research output: Contribution to journalArticle

35 Scopus citations
2003

A model for mechanotransduction in bone cells: The load-bearing mechanosomes

Pavalko, F. M., Norvell, S. M., Burr, D. B., Turner, C. H., Duncan, R. L. & Bidwell, J. P., Jan 1 2003, In : Journal of Cellular Biochemistry. 88, 1, p. 104-112 9 p.

Research output: Contribution to journalReview article

183 Scopus citations

Fluid shear-induced NFκB translocation in osteoblasts is mediated by intracellular calcium release

Chen, N. X., Geist, D. J., Genetos, D. C., Pavalko, F. M. & Duncan, R. L., Sep 1 2003, In : Bone. 33, 3, p. 399-410 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Fluid shear stress inhibits TNF-α-induced apoptosis in osteoblasts: A role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3

Pavalko, F. M., Gerard, R. L., Ponik, S. M., Gallagher, P. J., Jin, Y. & Norvell, S. M., Feb 1 2003, In : Journal of cellular physiology. 194, 2, p. 194-205 12 p.

Research output: Contribution to journalArticle

77 Scopus citations
2002

Osteoblast intracellular localization of Nmp4 proteins

Torrungruang, K., Shah, R., Alvarez, M., Bowen, D. K., Gerard, R., Pavalko, F. M., Elmendorf, J. S., Charoonpatrapong, K., Hock, J., Rhodes, S. J. & Bidwell, J. P., Jun 20 2002, In : Bone. 30, 6, p. 931-936 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2001

Peroxynitrite causes endothelial cell monolayer barrier dysfunction

Knepler, J. L., Taher, L. N., Gupta, M. P., Patterson, C., Pavalko, F., Ober, M. D. & Hart, C. M., Oct 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 3 50-3, p. C1064-C1075

Research output: Contribution to journalArticle

77 Scopus citations

Regulation of PGE2 and PGI2 release from human umbilical vein endothelial cells by actin cytoskeleton

Sawyer, S. J., Norvell, S. M., Ponik, S. M. & Pavalko, F. M., Oct 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 3 50-3, p. C1038-C1045

Research output: Contribution to journalArticle

20 Scopus citations
2000

Ca2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

Chen, N. X., Ryder, K. D., Pavalko, F. M., Turner, C. H., Burr, D. B., Qiu, J. & Duncan, R. L., Jun 22 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5, p. C989-C997

Research output: Contribution to journalArticle

243 Scopus citations
1999

Cellular mechanisms involved in mechanotransduction

Duncan, R., Brubaker, K., Chen, N., Ajubi, N., Ryder, K. & Pavalko, F., Dec 1 1999, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. IEEE, 1 p. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Structure-function studies of the eighth hydrophobic domain of a serotonin receptor

Hurley, J. H., Bloem, L. J., Pavalko, F., Liu, J., Tian, M., Simon, J. R. & Yu, L., Jan 11 1999, In : Journal of Neurochemistry. 72, 1, p. 413-421 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
1998

Cytoskeletal interactions with the leukocyte integrin cytoplasmic tail: Activation-dependent regulation of associations with talin and α-actinin

Sampath, R., Gallagher, P. J. & Pavalko, F. M., Dec 11 1998, In : Journal of Biological Chemistry. 273, 50, p. 33588-33594 7 p.

Research output: Contribution to journalArticle

194 Scopus citations

Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions

Pavalko, F. M., Chen, N. X., Turner, C. H., Burr, D. B., Atkinson, S., Hsieh, Y. F., Qiu, J. & Duncan, R. L., Dec 1 1998, In : American Journal of Physiology - Cell Physiology. 275, 6 44-6, p. C1591-C1601

Research output: Contribution to journalArticle

334 Scopus citations
254 Scopus citations