Fredrick Pavalko

  • 4120 Citations
  • 32 h-Index
1986 …2019
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Publications 1986 2019

  • 4120 Citations
  • 32 h-Index
  • 65 Article
  • 1 Book
  • 1 Chapter
  • 1 Conference contribution
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Article
2019
1 Citation (Scopus)

Expression of a Degradation-Resistant β-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting

Bullock, W. A., Hoggatt, A. M., Horan, D. J., Lewis, K. J., Yokota, H., Hann, S., Warman, M. L., Sebastian, A., Loots, G. G., Pavalko, F. & Robling, A., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteocytes
Catenins
Skeleton
Bone and Bones
Tail

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

Bullock, W. A., Hoggatt, A. M., Horan, D. J., Elmendorf, A. J., Sato, A. Y., Bellido, T., Loots, G. G., Pavalko, F. M. & Robling, A. G., Oct 25 2019, In : iScience. 20, p. 205-215 11 p.

Research output: Contribution to journalArticle

Open Access
Biological Science Disciplines
Cell Biology
Molecular Biology
Homeostasis
Bone and Bones

Osteocytes and mechanical loading: The Wnt connection

Bullock, W. A., Pavalko, F. & Robling, A., May 1 2019, In : Orthodontics and Craniofacial Research. 22, S1, p. 175-179 5 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Tooth Movement Techniques
Dentition
Gene Targeting
2016
3 Citations (Scopus)

Hydroxy-Safflower Yellow A inhibits the TNFR1-Mediated Classical Pathway by Inducing Shedding of TNFR1

Wang, H., Liu, J., Yang, Y., Cao, Q., Huo, X., Ma, S., Hu, J., Pavalko, F. & Liu, Q., 2016, (Accepted/In press) In : Phytotherapy Research.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
Endothelial Cells
Phosphorylation
Carthamus tinctorius
safflower yellow
2015
5 Citations (Scopus)

Genome-wide mapping and interrogation of the Nmp4 antianabolic bone axis

Childress, P., Stayrook, K. R., Alvarez, M. B., Wang, Z., Shao, Y., Hernandez-Buquer, S., Mack, J. K., Grese, Z. R., He, Y., Horan, D., Pavalko, F., Warden, S. J., Robling, A., Yang, F. C., Allen, M., Krishnan, V., Liu, Y. & Bidwell, J., Sep 1 2015, In : Molecular Endocrinology. 29, 9, p. 1269-1285 17 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Chromosome Mapping
Mesenchymal Stromal Cells
Bone and Bones
Osteoporosis
8 Citations (Scopus)

Signaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells

Cheng, Y. H., Streicher, D. A., Waning, D. L., Chitteti, B. R., Gerard-O'Riley, R., Horowitz, M. C., Bidwell, J., Pavalko, F., Srour, E., Mayo, L. & Kacena, M., Mar 1 2015, In : Journal of Cellular Physiology. 230, 3, p. 578-586 9 p.

Research output: Contribution to journalArticle

Megakaryocytes
Osteoblasts
Bone
CD29 Antigens
Cells
2014
18 Citations (Scopus)

Estrogen receptor-β regulates mechanical signaling in primary osteoblasts

Castillo, A. B., Triplett, J. W., Pavalko, F. & Turner, C. H., Apr 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 8

Research output: Contribution to journalArticle

Osteoblasts
Estrogen Receptors
Ligands
Response Elements
Mitogen-Activated Protein Kinases
7 Citations (Scopus)

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression

Hum, J. M., Day, R., Bidwell, J., Wang, Y. & Pavalko, F., May 19 2014, In : PLoS One. 9, 5, e97942.

Research output: Contribution to journalArticle

Osteocytes
Osteogenesis
Gene expression
shear stress
Bone
2013
Focal Adhesion Protein-Tyrosine Kinases
Osteoblasts
Minerals
Bone and Bones
Research
16 Citations (Scopus)

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation

Cheng, Y. H., Hooker, R. A., Nguyen, K., Gerard-O'Riley, R., Waning, D. L., Chitteti, B. R., Meijome, T. E., Chua, H. L., Plett, A. P., Orschell, C., Srour, E., Mayo, L., Pavalko, F., Bruzzaniti, A. & Kacena, M., Jun 2013, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 28, 6, p. 1434-1445 12 p.

Research output: Contribution to journalArticle

Megakaryocytes
Osteoblasts
Osteogenesis
Spleen
Integrins
2012
9 Citations (Scopus)

Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT)

Alvarez, M. B., Childress, P., Philip, B. K., Gerard-O'Riley, R., Hanlon, M., Herbert, B-S., Robling, A., Pavalko, F. & Bidwell, J., May 2012, In : Journal of Cellular Physiology. 227, 5, p. 1873-1882 10 p.

Research output: Contribution to journalArticle

Telomerase
Osteoblasts
Parathyroid Hormone
Mesenchymal Stromal Cells
Bone
13 Citations (Scopus)

Monitoring biosensor activity in living cells with fluorescence lifetime imaging microscopy

Hum, J. M., Siegel, A. P., Pavalko, F. & Day, R., 2012, In : International Journal of Molecular Sciences. 13, 11, p. 14385-14400 16 p.

Research output: Contribution to journalArticle

Optical Imaging
Biosensing Techniques
bioinstrumentation
Biosensors
Energy Transfer
5 Citations (Scopus)

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F., Kacena, M. & Yang, F. C., 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Zinc Fingers
Parathyroid Hormone
Proteins
Transcription Factors
2011
Receptors, Tumor Necrosis Factor, Type I
Osteoblasts
Signal Transduction
Cholesterol
Lipids
8 Citations (Scopus)

Blockade of TNFR1 signaling: A role of oscillatory fluid shear stress in osteoblasts

Wang, H., Young, S. R., Gerard-O'Riley, R., Hum, J. M., Yang, Z., Bidwell, J. & Pavalko, F., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Osteoblasts
Shear stress
Fluids
Apoptosis
19 Citations (Scopus)

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction

Young, S. R. L., Hum, J. M., Rodenberg, E., Turner, C. H. & Pavalko, F., 2011, In : PLoS One. 6, 1, e16026.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
non-specific protein-tyrosine kinase
Focal Adhesion Protein-Tyrosine Kinases
osteoblasts
Osteoblasts
2010
25 Citations (Scopus)

Activation of NF-κB by fluid shear stress, but not TNF-α, requires focal adhesion kinase in osteoblasts

Young, S. R. L., Gerard-O'Riley, R., Harrington, M. & Pavalko, F., Jul 2010, In : Bone. 47, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
NF-kappa B
Osteoblasts
Tumor Necrosis Factor-alpha
Bone and Bones
12 Citations (Scopus)

Mechanosomes carry a loaded message

Bidwell, J. & Pavalko, F., Dec 21 2010, In : Science Signaling. 3, 153

Research output: Contribution to journalArticle

Bone
Mechanical Phenomena
Adhesion
Genes
Guanylate Kinases
15 Citations (Scopus)

Nmp4/CIZ inhibits mechanically induced β-catenin signaling activity in osteoblasts

Yang, Z., Bidwell, J., Young, S. R., Gerard-O'Riley, R., Wang, H. & Pavalko, F., May 2010, In : Journal of Cellular Physiology. 223, 2, p. 435-441 7 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Catenins
Zinc Fingers
Osteoblasts
Zinc
21 Citations (Scopus)

The load-bearing mechanosome revisited

Bidwell, J. & Pavalko, F., Dec 2010, In : Clinical Reviews in Bone and Mineral Metabolism. 8, 4, p. 213-223 11 p.

Research output: Contribution to journalArticle

Weight-Bearing
Membranes
Bone and Bones
Genes
Physical Stimulation
2009
1 Citation (Scopus)

Cytoskeletal interactions with leukocyte and endothelial cell adhesion molecules

Pavalko, F., 2009, In : Current Topics in Membranes. 64, 1, p. 133-156 24 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Leukocytes
Endothelial Cells
101 Citations (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Osteoblasts
Bone and Bones
Focal Adhesions
Osteopontin
2007
34 Citations (Scopus)

Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in A PKCζ-dependent manner

Triplett, J. W., O'Riley, R., Tekulve, K., Norvell, S. M. & Pavalko, F., Mar 2007, In : MCB Molecular and Cellular Biomechanics. 4, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Osteoblasts
Insulin-Like Growth Factor I
Bone and Bones
Apoptosis
19 Citations (Scopus)

Nmp4/CIZ contributes to fluid shear stress induced MMP-13 gene induction in osteoblasts

Charoonpatrapong-Panyayong, K., Shah, R., Yang, J., Alvarez, M., Pavalko, F., Gerard-O'Riley, R., Robling, A., Templeton, E. & Bidwell, J., Dec 1 2007, In : Journal of Cellular Biochemistry. 102, 5, p. 1202-1213 12 p.

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Matrix Metalloproteinase 13
Zinc Fingers
Osteoblasts
Zinc
86 Citations (Scopus)

Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles

Ponik, S. M., Triplett, J. W. & Pavalko, F., Feb 15 2007, In : Journal of Cellular Biochemistry. 100, 3, p. 794-807 14 p.

Research output: Contribution to journalArticle

Osteocytes
Osteoblasts
Flow of fluids
Stress Fibers
Bone
20 Citations (Scopus)
Blood Vessel Prosthesis
Cell adhesion
Endothelial cells
Platelets
Fibronectins
2006
36 Citations (Scopus)
Actinin
Focal Adhesions
Osteoblasts
Integrins
Phosphorylation
51 Citations (Scopus)

HMGB1 expression and release by bone cells

Charoonpatrapong, K., Shah, R., Robling, A., Alvarez, M., Clapp, D., Chen, S., Kopp, R. P., Pavalko, F., Yu, J. & Bidwell, J., May 2006, In : Journal of Cellular Physiology. 207, 2, p. 480-490 11 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteoclasts
Bone
Bone and Bones
Bone Remodeling
2005
3 Citations (Scopus)

Adenoviral transgene expression enhanced by cotreatment with etoposide in cultured cells

Triplett, J. W., Herring, B. & Pavalko, F., 2005, In : BioTechniques. 39, 6, p. 826-829 4 p.

Research output: Contribution to journalArticle

Horizontal Gene Transfer
Etoposide
Green Fluorescent Proteins
Tumor Cell Line
Transgenes
2004
112 Citations (Scopus)

Fluid shear stress induces β-catenin signaling in osteoblasts

Norvell, S. M., Alvarez, M., Bidwell, J. & Pavalko, F., Nov 2004, In : Calcified Tissue International. 75, 5, p. 396-404 9 p.

Research output: Contribution to journalArticle

Catenins
Osteoblasts
Glycogen Synthase Kinase 3
Cyclooxygenase 2
TCF Transcription Factors
50 Citations (Scopus)

Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules

Norvell, S. M., Ponik, S. M., Bowen, D. K., Gerard, R. & Pavalko, F., Mar 2004, In : Journal of Applied Physiology. 96, 3, p. 957-966 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Osteoblasts
Actin Cytoskeleton
Intermediate Filaments
Microtubules
76 Citations (Scopus)
Focal Adhesions
arginyl-glycyl-aspartyl-serine
Cyclooxygenase 2
Osteoblasts
Fibronectins
33 Citations (Scopus)

Improved biocompatibility of small intestinal submucosa (SIS) following conditioning by human endothelial cells

Woods, A. M., Rodenberg, E. J., Hiles, M. C. & Pavalko, F., Feb 2004, In : Biomaterials. 25, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

Endothelial cells
Biocompatibility
Human Umbilical Vein Endothelial Cells
Endothelial Cells
Basement Membrane
33 Citations (Scopus)

Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts

Shah, R., Alvarez, M., Jones, D. R., Torrungruang, K., Watt, A. J., Selvamurugan, N., Partridge, N. C., Quinn, C. O., Pavalko, F., Rhodes, S. & Bidwell, J., Aug 2004, In : American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2

Research output: Contribution to journalArticle

Nuclear Matrix-Associated Proteins
Matrix Metalloproteinase 13
Zinc Fingers
Osteoblasts
Parathyroid Hormone
2003
177 Citations (Scopus)

A model for mechanotransduction in bone cells: The load-bearing mechanosomes

Pavalko, F., Norvell, S. M., Burr, D., Turner, C. H., Duncan, R. L. & Bidwell, J., Jan 1 2003, In : Journal of Cellular Biochemistry. 88, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Weight-Bearing
Bone
Genes
Bone and Bones
67 Citations (Scopus)

Fluid shear-induced NFκB translocation in osteoblasts is mediated by intracellular calcium release

Chen, X. N., Geist, D. J., Genetos, D. C., Pavalko, F. & Duncan, R. L., Sep 1 2003, In : Bone. 33, 3, p. 399-410 12 p.

Research output: Contribution to journalArticle

NF-kappa B
Osteoblasts
Calcium
Type C Phospholipases
Lysine
76 Citations (Scopus)

Fluid shear stress inhibits TNF-α-induced apoptosis in osteoblasts: A role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3

Pavalko, F., Gerard, R. L., Ponik, S. M., Gallagher, P., Jin, Y. & Norvell, S. M., Feb 1 2003, In : Journal of Cellular Physiology. 194, 2, p. 194-205 12 p.

Research output: Contribution to journalArticle

Osteoblasts
Phosphatidylinositol 3-Kinases
Caspase 3
Shear stress
Chemical activation
2002
7 Citations (Scopus)

Osteoblast intracellular localization of Nmp4 proteins

Torrungruang, K., Shah, R., Alvarez, M., Bowen, D. K., Gerard, R., Pavalko, F., Elmendorf, J., Charoonpatrapong, K., Hock, J., Rhodes, S. & Bidwell, J., 2002, In : Bone. 30, 6, p. 931-936 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Proteins
Protein Isoforms
Nuclear Matrix
Cytoplasm
2001
73 Citations (Scopus)

Peroxynitrite causes endothelial cell monolayer barrier dysfunction

Knepler, J. L., Taher, L. N., Gupta, M. P., Patterson, C., Pavalko, F., Ober, M. D. & Hart, C. M., 2001, In : American Journal of Physiology - Cell Physiology. 281, 3 50-3

Research output: Contribution to journalArticle

Peroxynitrous Acid
Endothelial cells
Pulmonary Artery
Monolayers
Endothelial Cells
19 Citations (Scopus)

Regulation of PGE2 and PGI2 release from human umbilical vein endothelial cells by actin cytoskeleton

Sawyer, S. J., Norvell, S. M., Ponik, S. M. & Pavalko, F., 2001, In : American Journal of Physiology - Cell Physiology. 281, 3 50-3

Research output: Contribution to journalArticle

Endothelial cells
Human Umbilical Vein Endothelial Cells
Epoprostenol
Actin Cytoskeleton
Dinoprostone
2000
239 Citations (Scopus)

Ca2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

Chen, X. N., Ryder, K. D., Pavalko, F., Turner, C. H., Burr, D., Qiu, J. & Duncan, R. L., 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

Osteoblasts
Gene expression
Gadolinium
Gene Expression
Stress Fibers
Cell Physiological Phenomena
Osteoblasts
Physiology
Gene expression
Gene Expression
1999
5 Citations (Scopus)

Structure-function studies of the eighth hydrophobic domain of a serotonin receptor

Hurley, J., Bloem, L. J., Pavalko, F., Liu, J., Tian, M., Simon, J. R. & Yu, L., 1999, In : Journal of Neurochemistry. 72, 1, p. 413-421 9 p.

Research output: Contribution to journalArticle

Serotonin Receptors
G-Protein-Coupled Receptors
Topology
Receptor, Serotonin, 5-HT2C
Membranes
1998
193 Citations (Scopus)

Cytoskeletal interactions with the leukocyte integrin cytoplasmic tail: Activation-dependent regulation of associations with talin and α-actinin

Sampath, R., Gallagher, P. & Pavalko, F., Dec 11 1998, In : Journal of Biological Chemistry. 273, 50, p. 33588-33594 7 p.

Research output: Contribution to journalArticle

Talin
Actinin
Integrins
Leukocytes
Chemical activation
326 Citations (Scopus)

Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions

Pavalko, F., Chen, X. N., Turner, C. H., Burr, D., Atkinson, S., Hsieh, Y. F., Qiu, J. & Duncan, R. L., 1998, In : American Journal of Physiology - Cell Physiology. 275, 6 44-6

Research output: Contribution to journalArticle

Osteoblasts
Actinin
Cytoskeleton
Stress Fibers
Integrins
247 Citations (Scopus)
Mechanics
Skeleton
Bone and Bones
Cellular Mechanotransduction
Osteocytes
1997
66 Citations (Scopus)

Thrombin-mediated Focal Adhesion Plaque Reorganization in Endothelium: Role of Protein Phosphorylation

Schaphorst, K. L., Pavalko, F., Patterson, C. E. & Garcia, J. G. N., 1997, In : American Journal of Respiratory Cell and Molecular Biology. 17, 4, p. 443-455 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Focal Adhesions
Endothelial cells
Thrombin
Endothelium
1996
29 Citations (Scopus)
Actinin
P-Selectin
E-Selectin
L-Selectin
Leukocytes
49 Citations (Scopus)
Paxillin
Phosphorylation
Muscle Contraction
Smooth Muscle
Tyrosine
1995
22 Citations (Scopus)

Immunodetection of α-Actinin in Focal Adhesions Is Limited by Antibody Inaccessibility

Pavalko, F., Schneider, G., Burridge, K. & Lim, S. S., Apr 1995, In : Experimental Cell Research. 217, 2, p. 534-540 7 p.

Research output: Contribution to journalArticle

Actinin
Focal Adhesions
Antibodies
Stress Fibers
Fluorescent Antibody Technique