G. David Roodman

  • 23998 Citations
  • 81 h-Index
1975 …2020

Research output per year

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Publications

2020

Juvenile Paget's Disease From Heterozygous Mutation of SP7 Encoding Osterix (Specificity Protein 7, Transcription Factor SP7)

Whyte, M. P., Campeau, P. M., McAlister, W. H., Roodman, G. D., Kurihara, N., Nenninger, A., Duan, S., Gottesman, G. S., Bijanki, V. N., Sedighi, H., Veis, D. J. & Mumm, S., Aug 2020, In : Bone. 137, 115364.

Research output: Contribution to journalArticle

Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo

Miyagawa, K., Ohata, Y., Delgado-Calle, J., Teramachi, J., Zhou, H., Dempster, D. D., Subler, M. A., Windle, J. J., Chirgwin, J. M., David Roodman, G. & Kurihara, N., Mar 26 2020, In : JCI Insight. 5, 6, e133113.

Research output: Contribution to journalArticle

Open Access
2019

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Paget’s disease of bone

Singer, F. R. & Roodman, G. D., Jan 1 2019, Principles of Bone Biology. Elsevier, p. 1601-1613 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Therapeutic targets in myeloma bone disease

Marino, S., Petrusca, D. N. & Roodman, G. D., 2019, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalReview article

2 Scopus citations

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, D. G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., May 4 2018, In : Journal of Medical Economics. 21, 5, p. 525-536 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bones in Multiple Myeloma: Imaging and Therapy

Zamagni, E., Cavo, M., Fakhri, B., Vij, R. & Roodman, D., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 638-646 9 p.

Research output: Contribution to journalReview article

9 Scopus citations

Cancer and bone

Guise, T. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 737-738 2 p.

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Mar 2018, In : The lancet oncology. 19, 3, p. 370-381 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Petrusca, D. N., Toscani, D., Wang, F. M., Park, C., Crean, C. D., Anderson, J. L., Marino, S., Mohammad, K. S., Zhou, D., Silbermann, R., Sun, Q., Kurihara, N., Galson, D. L., Giuliani, N. & Roodman, G. D., Oct 4 2018, In : Journal of Hematology and Oncology. 11, 1, 123.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanisms of osteolytic and osteoblastic skeletal lesions

Roodman, G. D. & Guise, T., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 739-742 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple myeloma and bone: The fatal interaction

Marino, S. & Roodman, G. D., Aug 1 2018, In : Cold Spring Harbor Perspectives in Medicine. 8, 8, a031286.

Research output: Contribution to journalArticle

6 Scopus citations

Osteoblast suppression in multiple myeloma bone disease

Adamik, J., Galson, D. L. & Roodman, G. D., Nov 2018, In : Journal of Bone Oncology. 13, p. 62-70 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Paget disease of bone

Charles, J. F., Siris, E. S. & Roodman, G. D., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, p. 713-720 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Primer on the metabolic bone diseases and disorders of mineral metabolism

Bilezikian, J. P., Bouillon, R., Clemens, T., Compston, J., Bauer, D. C., Ebeling, P. R., Engelke, K., Goltzman, D., Guise, T., Jan De Beur, S. M., Jüppner, H., Lyons, K., McCauley, L., McClung, M. R., Miller, P. D., Papapoulos, S. E., Roodman, G. D., Rosen, C. J., Seeman, E., Thakker, R. V. & 2 others, Whyte, M. P. & Zaidi, M., Jan 1 2018, wiley. 1105 p.

Research output: Book/ReportBook

1 Scopus citations

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Supportive care in multiple myeloma

Doshi, S. M., Noff, T. T. & David Roodman, G., Jan 1 2018, Neoplastic Diseases of the Blood. Springer International Publishing, p. 595-607 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

XRK3F2 inhibition of p62-ZZ domain signaling rescues myeloma-induced GFI1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression

Adamik, J., Silbermann, R., Marino, S., Sun, Q., Anderson, J. L., Zhou, D., Xie, X. Q., David Roodman, G. & Galson, D. L., Jun 29 2018, In : Frontiers in Endocrinology. 9, JUL, 344.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. A. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L. I., Bellido, T. & Roodman, G. D., Jan 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG

Hadji, P., Aapro, M. S., Body, J. J., Gnant, M., Brandi, M. L., Reginster, J. Y., Zillikens, M. C., Glüer, C. C., de Villiers, T., Baber, R., Roodman, G. D., Cooper, C., Langdahl, B., Palacios, S., Kanis, J., Al-Daghri, N., Nogues, X., Eriksen, E. F., Kurth, A., Rizzoli, R. & 1 others, Coleman, R. E., Jun 1 2017, In : Journal of Bone Oncology. 7, p. 1-12 12 p.

Research output: Contribution to journalReview article

68 Scopus citations

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma

Hao, M., Franqui-Machin, R., Xu, H., Shaughnessy, J., Barlogie, B., Roodman, D., Quelle, D. E., Janz, S., Tomasson, M. H., Sanderson, R. D., Qiu, L., Frech, I., Tricot, G. & Zhan, F., Jul 1 2017, In : Leukemia. 31, 7, p. 1648-1650 3 p.

Research output: Contribution to journalLetter

9 Scopus citations

Vitamin D and Paget's Disease

Kurihara, N. & Roodman, G. D., Dec 14 2017, Health, Disease and Therapeutics. Elsevier Inc., Vol. 2. p. 571-579 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma

Delgado-Calle, J., Anderson, J., Cregor, M. D., Hiasa, M., Chirgwin, J. M., Carlesso, N., Yoneda, T., Mohammad, K. S., Plotkin, L. I., Roodman, G. D. & Bellido, T., Mar 1 2016, In : Cancer Research. 76, 5, p. 1089-1100 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K. S., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Bone disease in multiple myeloma

Eda, H., Santo, L., Roodman, G. D. & Raje, N., Jan 1 2016, Cancer Treatment and Research. Kluwer Academic Publishers, p. 251-270 20 p. (Cancer Treatment and Research; vol. 169).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Current Controversies in the Management of Myeloma Bone Disease

Silbermann, R. & Roodman, G. D., Nov 1 2016, In : Journal of cellular physiology. 231, 11, p. 2374-2379 6 p.

Research output: Contribution to journalReview article

15 Scopus citations

Developmental Aspects of Pagetic Osteoclasts

Galson, D. L., Sun, Q. & Roodman, G. D., May 9 2016, Advances in Pathobiology and Management of Paget's Disease of Bone. Elsevier Inc., p. 37-53 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

34 Scopus citations

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

Storti, P., Marchica, V., Airoldi, I., Donofrio, G., Fiorini, E., Ferri, V., Guasco, D., Todoerti, K., Silbermann, R., Anderson, J. L., Zhao, W., Agnelli, L., Bolzoni, M., Martella, E., Mancini, C., Campanini, N., Noonan, D. M., Petronini, P. G., Neri, A., Aversa, F. & 2 others, Roodman, G. D. & Giuliani, N., Dec 1 2016, In : Leukemia. 30, 12, p. 2351-2363 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease

Teramachi, J., Nagata, Y., Mohammad, K., Inagaki, Y., Ohata, Y., Guise, T., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N. & Roodman, G. D., Mar 1 2016, In : Journal of Clinical Investigation. 126, 3, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

The Role of the Immune System in the Effects of Cancer on Bone

Silbermann, R. & David Roodman, G., Jan 1 2016, Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. Elsevier Inc., p. 311-324 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation

Girnius, S. K., Lee, S., Kambhampati, S., Rose, M. G., Mohiuddin, A., Houranieh, A., Zimelman, A., Grady, T., Mehta, P., Behler, C., Hayes, T. G., Efebera, Y. A., Prabhala, R. H., Han, A., Yellapragada, S. V., Klein, C. E., Roodman, G. D., Lichtenstein, A. & Munshi, N. C., Apr 1 2015, In : British journal of haematology. 169, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
10 Scopus citations

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K. S., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L. E., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F. A., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T. A., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

128 Scopus citations

Role of magnetic resonance imaging in the management of patients with multiple myeloma: A consensus statement

Dimopoulos, M. A., Hillengass, J., Usmani, S., Zamagni, E., Lentzsch, S., Davies, F. E., Raje, N., Sezer, O., Zweegman, S., Shah, J., Badros, A., Shimizu, K., Moreau, P., Chim, C. S., Lahuerta, J. J., Hou, J., Jurczyszyn, A., Goldschmidt, H., Sonneveld, P., Palumbo, A. & 8 others, Ludwig, H., Cavo, M., Barlogie, B., Anderson, K., Roodman, G. D., Rajkumar, S. V., Durie, B. G. M. & Terpos, E., Feb 20 2015, In : Journal of Clinical Oncology. 33, 6, p. 657-664 8 p.

Research output: Contribution to journalArticle

176 Scopus citations

Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption

Feng, R., Tong, Q., Xie, Z., Cheng, H., Wang, L., Lentzsch, S., Roodman, G. D. & Xie, X. Q., Dec 2015, In : Molecular Carcinogenesis. 54, 12, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Advances in supportive care for multiple myeloma

Raje, N. S., Yee, A. J. & Roodman, G. D., Jan 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 4, p. 502-511 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

Bon, J., Kahloon, R., Zhang, Y., Xue, J., Fuhrman, C. R., Tan, J., Burger, M., Kass, D. J., Csizmadia, E., Otterbein, L., Chandra, D., Bhargava, A., Pilewski, J. M., Roodman, G. D., Sciurba, F. C. & Duncan, S. R., Sep 2014, In : PloS one. 9, 9, e105066.

Research output: Contribution to journalArticle

7 Scopus citations

Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma

Silbermann, R., Bolzoni, M., Storti, P., Guasco, D., Bonomini, S., Zhou, D., Wu, J., Anderson, J. L., Windle, J. J., Aversa, F., David Roodman, G. & Giuliani, N., Apr 2014, In : Leukemia. 28, 4, p. 951-954 4 p.

Research output: Contribution to journalLetter

33 Scopus citations

CCN1: A sticky issue in myeloma

Roodman, G. D., Sep 25 2014, In : Blood. 124, 13, p. 2006-2008 3 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone

Teramachi, J., Zhou, H., Subler, M. A., Kitagawa, Y., Galson, D. L., Dempster, D. W., Windle, J. J., Kurihara, N. & Roodman, G. D., Jun 2014, In : Journal of Bone and Mineral Research. 29, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Management of bone disease in multiple myeloma

Terpos, E., Berenson, J., Raje, N. & Roodman, G. D., Feb 1 2014, In : Expert Review of Hematology. 7, 1, p. 113-125 13 p.

Research output: Contribution to journalReview article

55 Scopus citations

New drugs and novel mechanisms of action in multiple myeloma in 2013: A report from the International Myeloma Working Group (IMWG)

Ocio, E. M., Richardson, P. G., Rajkumar, S. V., Palumbo, A., Mateos, M. V., Orlowski, R., Kumar, S., Usmani, S., Roodman, D., Niesvizky, R., Einsele, H., Anderson, K. C., Dimopoulos, M. A., Avet-Loiseau, H., Mellqvist, U. H., Turesson, I., Merlini, G., Schots, R., Mccarthy, P., Bergsagel, L. & 14 others, Chim, C. S., Lahuerta, J. J., Shah, J., Reiman, A., Mikhael, J., Zweegman, S., Lonial, S., Comenzo, R., Chng, W. J., Moreau, P., Sonneveld, P., Ludwig, H., Durie, B. G. M. & Miguel, J. F. S., Mar 2014, In : Leukemia. 28, 3, p. 525-542 18 p.

Research output: Contribution to journalReview article

158 Scopus citations

Pathophysiology of Bone Metastases

Chirgwin, J. M. & Roodman, G. D., Mar 4 2014, Bone Metastases: A translational and Clinical Approach. Vassiliou, V., Chow, E. & Kardamakis, D. (eds.). 1 ed. p. 3-17 15 p. (Cancer Metastasis - Biology and Treatment; vol. 21, no. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (Bolus) infusion schedule of alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms

Holkova, B., Kmieciak, M., Perkins, E. B., Bose, P., Baz, R. C., Roodman, G. D., Stuart, R. K., Ramakrishnan, V., Wan, W., Peer, C. J., Dawson, J., Kang, L., Honeycutt, C., Tombes, M. B., Shrader, E., Weir-Wiggins, C., Wellons, M., Sankala, H., Hogan, K. T., Colevas, A. D. & 6 others, Doyle, L. A., Figg, W. D., Coppola, D., Roberts, J. D., Sullivan, D. & Grant, S., Nov 15 2014, In : Clinical Cancer Research. 20, 22, p. 5652-5662 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of osteocytes in multiple myeloma bone disease

Delgado-Calle, J., Bellido, T. & Roodman, G. D., Jan 1 2014, In : Current Opinion in Supportive and Palliative Care. 8, 4, p. 407-413 7 p.

Research output: Contribution to journalReview article

34 Scopus citations