G. David Roodman

  • 23995 Citations
  • 81 h-Index
1975 …2020

Research output per year

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Publications

2014

TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation

Sun, Q., Sammut, B., Wang, F. M., Kurihara, N., Windle, J. J., Roodman, G. D. & Galson, D. L., Jan 1 2014, In : Journal of Bone and Mineral Research. 29, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Whole-body low-dose computed tomography and advanced imaging techniques for multiple myeloma bone disease

Pianko, M. J., Terpos, E., Roodman, G. D., Divgi, C. R., Zweegman, S., Hillengass, J. & Lentzsch, S., Dec 1 2014, In : Clinical Cancer Research. 20, 23, p. 5888-5897 10 p.

Research output: Contribution to journalReview article

38 Scopus citations
2013

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Cao, H., Zhu, K., Qiu, L., Li, S., Niu, H., Hao, M., Yang, S., Zhao, Z., Lai, Y., Anderson, J. L., Fan, J., Im, H. J., Chen, D., Roodman, G. D. & Xiao, G., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30399-30410 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Hematologic Malignancies and Bone

Silbermann, R. & Roodman, G. D., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 694-701 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

Storti, P., Bolzoni, M., Donofrio, G., Airoldi, I., Guasco, D., Toscani, D., Martella, E., Lazzaretti, M., Mancini, C., Agnelli, L., Patrene, K., Maïga, S., Franceschi, V., Colla, S., Anderson, J., Neri, A., Amiot, M., Aversa, F., David Roodman, G. & Giuliani, N., Aug 1 2013, In : Leukemia. 27, 8, p. 1697-1706 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

International myeloma working group recommendations for the treatment of multiple myeloma-related bone disease

Terpos, E., Morgan, G., Dimopoulos, M. A., Drake, M. T., Lentzsch, S., Raje, N., Sezer, O., García-Sanz, R., Shimizu, K., Turesson, I., Reiman, T., Jurczyszyn, A., Merlini, G., Spencer, A., Leleu, X., Cavo, M., Munshi, N., Rajkumar, S. V., Durie, B. G. M. & Roodman, G. D., Jun 20 2013, In : Journal of Clinical Oncology. 31, 18, p. 2347-2357 11 p.

Research output: Contribution to journalArticle

201 Scopus citations

Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling

Wang, F. M., Sarmasik, A., Hiruma, Y., Sun, Q., Sammut, B., Windle, J. J., Roodman, G. D. & Galson, D. L., Mar 1 2013, In : Bone. 53, 1, p. 269-276 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mechanisms of Bone Destruction in Myeloma

Silbermann, R. & Roodman, G. D., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 1465-1478 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple myeloma surveillance counterpoint: USA

Modi, N., Roodman, G. D. & Lentzsch, S., Jan 1 2013, Patient Surveillance After Cancer Treatment. Humana Press Inc., p. 489-492 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Myeloma bone disease: Pathophysiology and management

Silbermann, R. & Roodman, G. D., Jun 2013, In : Journal of Bone Oncology. 2, 2, p. 59-69 11 p.

Research output: Contribution to journalReview article

35 Scopus citations

Optimal use of bisphosphonates in patients with multiple myeloma

Terpos, E., Roodman, G. D. & Dimopoulos, M. A., Apr 25 2013, In : Blood. 121, 17, p. 3325-3328 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Osteoclasts: Potential target for blocking microenvironmental support of myeloma

Galson, D. L., D'Souza, S. & Roodman, G. D., Jan 1 2013, Advances in Biology and Therapy of Multiple Myeloma: Volume 1: Basic Science. Springer New York, p. 169-185 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Paget's Disease of Bone

Siris, E. S. & Roodman, G. D., Jul 19 2013, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Eighth Edition. Wiley Blackwell, p. 659-668 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D. & Kurihara, N., Jun 1 2013, In : Journal of Bone and Mineral Research. 28, 6, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of bone disease in the pathogenesis of multiple myeloma

Roodman, G. D., May 1 2013, Genetic and Molecular Epidemiology of Multiple Myeloma. Springer New York, Vol. 9781461446606. p. 97-120 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment

D'Souza, S., Kurihara, N., Shiozawa, Y., Joseph, J., Taichman, R., Galson, D. L. & Roodman, G. D., Feb 23 2012, In : Blood. 119, 8, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

Kovacs, J. R., Li, C., Yang, Q., Li, G., Garcia, I. G., Ju, S., Roodman, D. G., Windle, J. J., Zhang, X. & Lu, B., Jan 1 2012, In : Cell Death and Differentiation. 19, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Combination of bendamustine, lenalidomide, anddexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: Results of phase 1/2 open-label, doseescalation study

Lentzsch, S., O'Sullivan, A., Kennedy, R. C., Abbas, M., Dai, L., Pregja, S. L., Burt, S., Boyiadzis, M., Roodman, G. D., Mapara, M. Y., Agha, M., Waas, J., Shuai, Y., Normolle, D. & Zonder, J. A., May 17 2012, In : Blood. 119, 20, p. 4608-4613 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation

Xu, G., Liu, K., Anderson, J., Patrene, K., Lentzsch, S., Roodman, G. D. & Ouyang, H., May 3 2012, In : Blood. 119, 18, p. 4205-4214 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Genes associate with abnormal bone cell activity in bone metastasis

Roodman, G. D., Dec 1 2012, In : Cancer and Metastasis Reviews. 31, 3-4, p. 569-578 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors

Yang, P., Myint, K. Z., Tong, Q., Feng, R., Cao, H., Almehizia, A. A., Alqarni, M. H., Wang, L., Bartlow, P., Gao, Y., Gertsch, J., Teramachi, J., Kurihara, N., Roodman, G. D., Cheng, T. & Xie, X. Q., Nov 26 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 9973-9987 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Paget's disease of bone: Pathogenesis and treatment

Singer, F. R. & Roodman, G. D., Jan 1 2012, Bone-Metabolic Functions and Modulators. Springer London, p. 197-215 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Vitamin E: Good for the heart, bad for the bones?

Roodman, G. D., Apr 1 2012, In : Nature Medicine. 18, 4, p. 491-492 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations
2011

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 1 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Advances in the biology and treatment of bone disease in multiple myeloma

Raje, N. & Roodman, G. D., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1278-1286 9 p.

Research output: Contribution to journalReview article

114 Scopus citations

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2, p. 151-166.e1

Research output: Contribution to journalArticle

33 Scopus citations

Bone effects of cancer therapies: Pros and cons

Silbermann, R. & Roodman, G. D., Sep 1 2011, In : Current Opinion in Supportive and Palliative Care. 5, 3, p. 251-257 7 p.

Research output: Contribution to journalReview article

14 Scopus citations

Bortezomib and osteoclasts and osteoblasts

Krauze, M. T. & Roodman, G. D., Dec 1 2011, Bortezomib in the Treatment of Multiple Myeloma. Ghobrial, I., Richardson, P. & Anderson, K. (eds.). p. 43-52 10 p. (Milestones in Drug Therapy; vol. 37).

Research output: Chapter in Book/Report/Conference proceedingChapter

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to paget's disease

Kurihara, N., Hiruma, Y., Yamana, K., Michou, L., Rousseau, C., Morissette, J., Galson, D. L., Teramachi, J., Zhou, H., Dempster, D. W., Windle, J. J., Brown, J. P. & Roodman, G. D., Jan 5 2011, In : Cell Metabolism. 13, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

D'Souza, S., Del Prete, D., Jin, S., Sun, Q., Huston, A. J., Kostov, F. E., Sammut, B., Hong, C. S., Anderson, J. L., Patrene, K. D., Yu, S., Velu, C. S., Xiao, G., Grimes, H. L., Roodman, G. D. & Galson, D. L., Dec 22 2011, In : Blood. 118, 26, p. 6871-6880 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Osteoblast function in myeloma

Roodman, G. D., Jan 1 2011, In : Bone. 48, 1, p. 135-140 6 p.

Research output: Contribution to journalReview article

46 Scopus citations

Paget's Disease of Bone

Roodman, G. D., Jul 1 2011, Goldman's Cecil Medicine: Twenty Fourth Edition. Elsevier Inc., Vol. 2. p. 1603-1605 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms

Holkova, B., Perkins, E. B., Ramakrishnan, V., Tombes, M. B., Shrader, E., Talreja, N., Wellons, M. D., Hogan, K. T., Roodman, G. D., Coppola, D., Kang, L., Dawson, J., Stuart, R. K., Peer, C., Figg, W. D., Kolla, S., Doyle, A., Wright, J., Sullivan, D. M., Roberts, J. D. & 1 others, Grant, S., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3388-3397 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 1 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2010

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D. & Xiao, G., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Bortezomib and osteoclasts and osteoblasts

Krauze, M. T. & Roodman, G. D., Dec 1 2010, Drugs for HER-2-positive Breast Cancer. Parnham, M. & Bruinvels, J. (eds.). p. 43-52 10 p. (Milestones in Drug Therapy).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia

Pal, R., Monaghan, S. A., Hassett, A. C., Mapara, M. Y., Schafer, P., Roodman, G. D., Ragni, M. V., Moscinski, L., List, A. & Lentzsch, S., Jan 21 2010, In : Blood. 115, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

Maes, K., Nemeth, E., Roodman, G. D., Huston, A., Esteve, F., Freytes, C., Callander, N., Katodritou, E., Tussing-Humphreys, L., Rivera, S., Vanderkerken, K., Lichtenstein, A. & Ganz, T., Nov 4 2010, In : Blood. 116, 18, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

Insights into the pathogenesis of Paget's disease

Roodman, G. D., Mar 2010, Skeletal Biology and Medicine. Blackwell Publishing Inc., p. 176-180 5 p. (Annals of the New York Academy of Sciences; vol. 1192).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

34 Scopus citations

Metastasis and bone loss: Advancing treatment and prevention

Coleman, R. E., Lipton, A., Roodman, G. D., Guise, T. A., Boyce, B. F., Brufsky, A. M., Clézardin, P., Croucher, P. I., Gralow, J. R., Hadji, P., Holen, I., Mundy, G. R., Smith, M. R. & Suva, L. J., Dec 1 2010, In : Cancer Treatment Reviews. 36, 8, p. 615-620 6 p.

Research output: Contribution to journalReview article

82 Scopus citations

Monoclonal gammopathy of undetermined significance: A consensus statement: Guideline

Berenson, J. R., Anderson, K. C., Audell, R. A., Boccia, R. V., Coleman, M., Dimopoulos, M. A., Drake, M. T., Fonseca, R., Harousseau, J. L., Joshua, D., Lonial, S., Niesvizky, R., Palumbo, A., Roodman, G. D., San-Miguel, J. F., Singhal, S., Weber, D. M., Zangari, M., Wirtschafter, E., Yellin, O. & 1 others, Kyle, R. A., Jul 1 2010, In : British journal of haematology. 150, 1, p. 28-38 11 p.

Research output: Contribution to journalReview article

81 Scopus citations

Osteoclasts are important for bone angiogenesis

Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C. & Roodman, G. D., Jan 7 2010, In : Blood. 115, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

105 Scopus citations

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Dossa, T., Arabian, A., Windle, J. J., Dedhar, S., Teitelbaum, S. L., Ross, F. P., Roodman, G. D. & St-Arnaud, R., Jul 1 2010, In : Journal of Cellular Biochemistry. 110, 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pathogenesis of myeloma bone disease

Roodman, G. D., Feb 1 2010, In : Journal of Cellular Biochemistry. 109, 2, p. 283-291 9 p.

Research output: Contribution to journalReview article

91 Scopus citations

Targeting the bone microenvironment in multiple myeloma

Roodman, G. D., May 1 2010, In : Journal of Bone and Mineral Metabolism. 28, 3, p. 244-250 7 p.

Research output: Contribution to journalReview article

36 Scopus citations

The use of biochemical markers of bone remodeling in multiple myeloma: A report of the International Myeloma Working Group

Terpos, E., Dimopoulos, M. A., Sezer, O., Roodman, D., Abildgaard, N., Vescio, R., Tosi, P., Garcia-Sanz, R., Davies, F., Chanan-Khan, A., Palumbo, A., Sonneveld, P., Drake, M. T., Harousseau, J. L., Anderson, K. C. & Durie, B. G. M., Oct 2010, In : Leukemia. 24, 10, p. 1700-1712 13 p.

Research output: Contribution to journalReview article

60 Scopus citations
2009

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells

Pal, R., Janz, M., Galson, D. L., Gries, M., Li, S., Jöhrens, K., Anagnostopoulos, I., Dörken, B., Mapara, M. Y., Borghesi, L., Kardava, L., David Roodman, G., Milcarek, C. & Lentzsch, S., Oct 29 2009, In : Blood. 114, 18, p. 3890-3898 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone

Yu, S., Franceschi, R. T., Luo, M., Fan, J., Jiang, D., Cao, H., Kwon, T. G., Lai, Y., Zhang, J., Patrene, K., Hankenson, K., Roodman, G. D. & Xiao, G., Oct 23 2009, In : PloS one. 4, 10, e7583.

Research output: Contribution to journalArticle

47 Scopus citations

Hematologic Malignancies and Bone

Mchayleh, W. M., Ellerman, J. & Roodman, G. D., Dec 23 2009, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 379-382 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations