G. David Roodman

  • 23995 Citations
  • 81 h-Index
1975 …2020

Research output per year

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Publications

2009

In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development

Choi, S. J., Roodman, G. D., Feng, J. Q., Song, I. S., Amin, K., Hart, P. S., Wright, J. T., Haruyama, N. & Hart, T. C., Jan 1 2009, In : Developmental Biology. 325, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

New opportunities for the management of cancer-related bone complications.

Lipton, A., Brown, G. A., Mundy, G. R., Roodman, G. D. & Smith, M. R., May 2009, In : Clinical advances in hematology & oncology : H&O. 7, 5 Suppl 11, p. 1-30; quiz 31

Research output: Contribution to journalArticle

1 Scopus citations

Osteoclasts Pump Iron

Roodman, G. D., May 6 2009, In : Cell Metabolism. 9, 5, p. 405-406 2 p.

Research output: Contribution to journalShort survey

11 Scopus citations

Paget's Disease of Bone

Siris, E. S. & Roodman, G. D., Dec 23 2009, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism: Seventh Edition. John Wiley & Sons, Inc., p. 335-343 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Pathogenesis of myeloma bone disease

Roodman, G. D., Jan 1 2009, In : Leukemia. 23, 3, p. 435-441 7 p.

Research output: Contribution to journalReview article

231 Scopus citations

The role of bisphosphonates in multiple myeloma

Levy, J. & Roodman, D. R., Apr 7 2009, In : Current Hematologic Malignancy Reports. 4, 2, p. 108-112 5 p.

Research output: Contribution to journalReview article

10 Scopus citations

The science and practice of bone health in oncology: Managing bone loss and metastasis in patients with solid tumors

Lipton, A., Uzzo, R., Amato, R. J., Ellis, G. K., Hakimian, B., Roodman, G. D. & Smith, M. R., Jan 1 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, SUPPL. 7, p. S1-S29

Research output: Contribution to journalReview article

59 Scopus citations
2008

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Ishizuka, S., Kurihara, N., Hiruma, Y., Miura, D., Namekawa, J. I., Tamura, A., Kato-Nakamura, Y., Nakano, Y., Takenouchi, K., Hashimoto, Y., Nagasawa, K. & Roodman, G. D., Jun 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 3-5, p. 269-277 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Advancing treatment for metastatic bone cancer: Consensus recommendations from the second cambridge conference

Coleman, R. E., Guise, T. A., Lipton, A., Roodman, G. D., Berenson, J. R., Body, J. J., Boyce, B. F., Calvi, L. M., Hadji, P., McCloskey, E. V., Saad, F., Smith, M. R., Suva, L. J., Taichman, R. S., Vessella, R. L. & Weilbaecher, K. N., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6387-6395 9 p.

Research output: Contribution to journalReview article

50 Scopus citations

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

Shiozawa, Y., Havens, A. M., Jung, Y., Ziegler, A. M., Pedersen, E. A., Wang, J., Wang, J., Lu, G., Roodman, G. D., Loberg, R. D., Pienta, K. J. & Taichman, R. S., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

159 Scopus citations

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment

Hiruma, Y., Kurihara, N., Subler, M. A., Zhou, H., Boykin, C. S., Zhang, H., Ishizuka, S., Dempster, D. W., Roodman, G. D. & Windle, J. J., Nov 19 2008, In : Human molecular genetics. 17, 23, p. 3708-3719 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Bone building with bortezomib

Roodman, G. D., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 462-464 3 p.

Research output: Contribution to journalComment/debate

30 Scopus citations

Diagnosis and treatment of myeloma bone disease

Roodman, G. D., Jan 1 2008, Treatment of Multiple Myeloma and Related Disorders. Cambridge University Press, p. 64-75 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Erratum: The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement (Leukemia (2008) 101038/leu.2008.127)

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, R. L., Roodman, D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., Jan 1 2008, In : Leukemia. 22, 8, 1 p.

Research output: Contribution to journalComment/debate

Involvement of hepcidin in the anemia of multiple myeloma

Sharma, S., Nemeth, E., Chen, Y. H., Goodnough, J., Huston, A., Roodman, G. D., Ganz, T. & Lichtenstein, A., Jun 1 2008, In : Clinical Cancer Research. 14, 11, p. 3262-3267 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Novel targets for myeloma bone disease

Roodman, G. D., Nov 1 2008, In : Expert Opinion on Therapeutic Targets. 12, 11, p. 1377-1387 11 p.

Research output: Contribution to journalReview article

22 Scopus citations

Paget's Disease of Bone

Singer, F. R. & Roodman, G. D., Dec 1 2008, Principles of Bone Biology, Two-Volume Set. Elsevier Inc., Vol. 2. p. 1599-1609 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

RANK ligand as a therapeutic target for bone metastases and multiple myeloma

Roodman, G. D. & Dougall, W. C., Feb 1 2008, In : Cancer Treatment Reviews. 34, 1, p. 92-101 10 p.

Research output: Contribution to journalReview article

87 Scopus citations
Open Access
40 Scopus citations

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

Huston, A., Leleu, X., Jia, X., Moreau, A. S., Ngo, H. T., Runnels, J., Anderson, J., Alsayed, Y., Roccaro, A., Vallet, S., Hatjiharissi, E., Tai, Y. T., Sportelli, P., Munshi, N., Richardson, P., Hideshima, T., Roodman, D. G., Anderson, K. C. & Ghobrial, I. M., Feb 1 2008, In : Clinical Cancer Research. 14, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, L., Roodman, D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., Jan 1 2008, In : Leukemia. 22, 8, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2007

American society of clinical oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, D. G., Twilde, P. & Anderson, K., Jun 10 2007, In : Journal of Clinical Oncology. 25, 17, p. 2464-2472 9 p.

Research output: Contribution to journalReview article

335 Scopus citations

ASCO 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma: Guideline summary

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, D. G., Twilde, P. & Anderson, K., Jul 1 2007, In : Journal of Oncology Practice. 3, 4, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bone-breaking cancer treatment

Roodman, G. D., Jan 1 2007, In : Nature Medicine. 13, 1, p. 25-26 2 p.

Research output: Contribution to journalShort survey

11 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1

Garcia-Palacios, V., Yeon Chung, H., Jin Choi, S., Sarmasik, A., Kurihara, N., Won Lee, J., Galson, D. L., Collins, R. & Roodman, G. D., Feb 1 2007, In : Bone. 40, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Experimental models of Paget's disease

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, SUPPL. 2, p. P55-P57

Research output: Contribution to journalArticle

11 Scopus citations

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

Alsayed, Y., Ngo, H., Runnels, J., Leleu, X., Singha, U. K., Pitsillides, C. M., Spencer, J. A., Kimlinger, T., Ghobrial, J. M., Jia, X., Lu, G., Timm, M., Kumar, A., Côté, D., Veilleux, I., Hedin, K. E., Roodman, G. D., Witzig, T. E., Kung, A. L., Hideshima, T. & 3 others, Anderson, K. C., Lin, C. P. & Ghobrial, I. M., Apr 1 2007, In : Blood. 109, 7, p. 2708-2717 10 p.

Research output: Contribution to journalArticle

324 Scopus citations

Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption

Lu, Y., Cai, Z., Xiao, G., Keller, E. T., Mizokami, A., Yao, Z., Roodman, G. D. & Zhang, J., Apr 15 2007, In : Cancer Research. 67, 8, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Kurihara, N., Hiruma, Y., Zhou, H., Subler, M. A., Dempster, D. W., Singer, F. R., Reddy, S. V., Gruber, H. E., Windle, J. J. & Roodman, G. D., Jan 4 2007, In : Journal of Clinical Investigation. 117, 1, p. 133-142 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Myeloma bone disease

Huston, A. & Roodman, G. D., Jan 1 2007, Multiple Myeloma: Translational and Emerging Therapies. CRC Press, p. 45-60 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Pathophysiology of Multiple Myeloma Bone Disease

Lentzsch, S., Ehrlich, L. A. & Roodman, G. D., Dec 1 2007, In : Hematology/Oncology Clinics of North America. 21, 6, p. 1035-1049 15 p.

Research output: Contribution to journalReview article

35 Scopus citations

Pathophysiology of myeloma bone disease

Esteve, F. R. & Roodman, G. D., Dec 1 2007, In : Best Practice and Research: Clinical Haematology. 20, 4, p. 613-624 12 p.

Research output: Contribution to journalReview article

55 Scopus citations

Perspective on the osteoclast: An angiogenic cell?

Cackowski, F. C. & Roodman, G. D., Nov 2007, In : Annals of the New York Academy of Sciences. 1117, p. 12-25 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Feng, R., Anderson, G., Xiao, G., Elliott, G., Leoni, L., Mapara, M. Y., Roodman, G. D. & Lentzsch, S., Mar 1 2007, In : Blood. 109, 5, p. 2130-2138 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma

Lentzsch, S., Elliott, G. & Roodman, G. D., Oct 1 2007, In : Archiv der Pharmazie. 340, 10, p. 511-516 6 p.

Research output: Contribution to journalReview article

12 Scopus citations

Treatment strategies for bone disease

Roodman, G. D., Dec 1 2007, In : Bone marrow transplantation. 40, 12, p. 1139-1146 8 p.

Research output: Contribution to journalReview article

30 Scopus citations

Ultrastructure of bone cells in Paget's disease of bone

Singer, F. R., Mills, B. G., Gruber, H. E., Windle, J. J. & Roodman, G. D., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, SUPPL. 2, p. P51-P54

Research output: Contribution to journalArticle

17 Scopus citations
2006

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T. A., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6209s-6212s

Research output: Contribution to journalArticle

11 Scopus citations

Chemokines in multiple myeloma

Aggarwal, R., Ghobrial, I. M. & Roodman, G. D., Oct 1 2006, In : Experimental Hematology. 34, 10, p. 1289-1295 7 p.

Research output: Contribution to journalReview article

106 Scopus citations

Cloning and characterization of the annexin II receptor on human marrow stromal cells

Lu, G., Maeda, H., Reddy, S. V., Kurihara, N., Leach, R., Anderson, J. L. & Roodman, G. D., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30542-30550 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma

Francis, L. K., Alsayed, Y., Leleu, X., Jia, X., Singha, U. K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L. A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Nov 15 2006, In : Clinical Cancer Research. 12, 22, p. 6826-6835 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing ICAM-1 expression

Palacios, V. G., Chung, H. Y., Choi, S. J., Kurihara, N., Lee, J. W., Ehrlich, L. A., Collins, R. & Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 240-243 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression of measles virus nucleocapsid protein in osteoclasts induces Paget's disease-like bone lesions in mice

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Mar 1 2006, In : Journal of Bone and Mineral Research. 21, 3, p. 446-455 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Masih-Khan, E., Trudel, S., Heise, C., Li, Z., Paterson, J., Nadeem, V., Wei, E., Roodman, D., Claudio, J. O., Bergsagel, P. L. & Stewart, A. K., Nov 15 2006, In : Blood. 108, 10, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition

Giuliani, N., Rizzoli, V. & Roodman, G. D., Dec 15 2006, In : Blood. 108, 13, p. 3992-3996 5 p.

Research output: Contribution to journalReview article

214 Scopus citations

New potential targets for treating myeloma bone disease

Roodman, G. D., Berenson, Clohisy, Bruland, Suva & Weilbaecher, Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6270s-6273s

Research output: Contribution to journalArticle

30 Scopus citations

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

Nguyen, A. N., Stebbins, E. G., Henson, M., O'Young, G., Choi, S. J., Quon, D., Damm, D., Reddy, M., Ma, J. Y., Haghnazari, E., Kapoun, A. M., Medicherla, S., Protter, A., Schreiner, G. F., Kurihara, N., Anderson, J., Roodman, G. D., Navas, T. A. & Higgins, L. S., Jun 10 2006, In : Experimental Cell Research. 312, 10, p. 1909-1923 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Novel approaches in the management of myeloma-related skeletal complications

Reddy, G. K., Mughal, T. I. & Roodman, G. D., Oct 2006, In : Supportive Cancer Therapy. 4, 1, p. 15-18 4 p.

Research output: Contribution to journalReview article

7 Scopus citations

Regulation of osteoclast differentiation

Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

137 Scopus citations

Role of the microenvironment in multiple myeloma bone disease

Huston, A. & Roodman, G. D., Jun 1 2006, In : Future Oncology. 2, 3, p. 371-378 8 p.

Research output: Contribution to journalReview article

12 Scopus citations