G. David Roodman

  • 23776 Citations
  • 81 h-Index
1975 …2020

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Publications

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1992

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone

Ohsaki, Y., Takahashi, S., Scarcez, T., Demulder, A., Nishihara, T., Williams, R. & Roodman, G. D., Nov 1992, In : Endocrinology. 131, 5, p. 2229-2234 6 p.

Research output: Contribution to journalArticle

146 Scopus citations

Interleukin 6: A potential autocrine/paracrine factor in Paget's disease of bone

Roodman, G. D., Kurihara, N., Ohsaki, Y., Kukita, A., Hosking, D., Demulder, A., Smith, J. F. & Singer, F. R., Jan 1 1992, In : Journal of Clinical Investigation. 89, 1, p. 46-52 7 p.

Research output: Contribution to journalArticle

Open Access
308 Scopus citations

Perspectives: Interleukin‐6: An osteotropic factor?

Roodman, G. D., May 1992, In : Journal of Bone and Mineral Research. 7, 5, p. 475-478 4 p.

Research output: Contribution to journalArticle

279 Scopus citations
1993

5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices

Gallwitz, W. E., Mundy, G. R., Lee, C. H., Qiao, M., Roodman, G. D., Raftery, M., Gaskell, S. J. & Bonewald, L. F., Jan 1 1993, In : Journal of Biological Chemistry. 268, 14, p. 10087-10094 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Abnormalities in osteoclast precursors and marrow accessory cells in paget’s disease

Demulder, A., Takahashi, S., Singer, F. R., Hosking, D. J. & Roodman, G. D., Nov 1993, In : Endocrinology. 133, 5, p. 1978-1982 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors

Adkins, D. R., Irvin, R., Kuhn, J., Boldt, D. H., Roodman, G. D., Salzman, D., Freytes, C., Von Hoff, D. D. & LeMaistre, C. F., Jun 1 1993, In : Investigational New Drugs. 11, 2-3, p. 169-179 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Assignment of the mouse tartrate-resistant acid phosphatase gene (acp5) to chromosome 9

Grimes, R., Reddy, S. V., Leach, R. J., Scarcez, T., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A. & Windle, J. J., Feb 1993, In : Genomics. 15, 2, p. 421-422 2 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cloning and characterization of the 5′‐flanking region of the mouse tartrate‐resistant acid phosphatase gene

Reddy, S. V., Scarcez, T., Windle, J. J., Leach, R. J., Hundley, J. E., Chirgwin, J. M., Chou, J. Y. & Roodman, G. D., Oct 1993, In : Journal of Bone and Mineral Research. 8, 10, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Comparison of engraftment and acute GVHD in patients undergoing cryopreserved or fresh allogeneic BMT

Eckardt, J. R., Roodman, G. D., Boldt, D. H., Clark, G. M., Alvarez, R., Page, C., Gaskill, H. & LeMaistre, C. F., Jan 1 1993, In : Bone marrow transplantation. 11, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

In vitro cytotoxicity of hepsulfam against human tumor cell lines and primary human tumor colony forming units

Marshall, M. V., Marshall, M. H., Degen, D. R., Roodman, G. D., Kuhn, J. G., Ross, M. E. & Von Hoff, D. D., 1993, In : STEM CELLS. 11, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nutritional parameters observed during 28-day infusion of recombinant human tumor necrosis factor-α

Hardin, T. C., Koeller, J. M., Kuhn, J. G., Roodman, G. D. & Von Hoff, D. D., Jan 1 1993, In : Journal of Parenteral and Enteral Nutrition. 17, 6, p. 541-545 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of cytokines in the regulation of bone resorption

Roodman, G. D., Feb 1 1993, In : Calcified Tissue International. 53, 1 Supplement, p. S94-S98

Research output: Contribution to journalArticle

145 Scopus citations

Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures

Reddy, S. V., Takahashi, S., Haipek, C., Chirgwin, J. M. & Roodman, G. D., Jan 1 1993, In : BioTechniques. 15, 3, p. 444-446 3 p.

Research output: Contribution to journalArticle

7 Scopus citations
1994

Biology of the osteoclast in Paget's disease

Roodman, G. D., Feb 1994, In : Seminars in Arthritis and Rheumatism. 23, 4, p. 235-236 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption

Takahashi, S., Reddy, S. V., Chirgwin, J. M., Devlin, R., Haipek, C., Anderson, J. & Roodman, G. D., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28696-28701 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Interleukin‐6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone

Reddy, S. V., Takahashi, S., Dallas, M., Williams, R. E., Neckers, L. & Roodman, G. D., May 1994, In : Journal of Bone and Mineral Research. 9, 5, p. 753-757 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens

Mills, B. G., Frausto, A., Singer, F. R., Ohsaki, Y., Demulder, A. & Roodman, G. D., Jan 1 1994, In : Bone. 15, 4, p. 443-448 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma

Adkins, D. R., Salzman, D., Boldt, D., Kuhn, J., Irvin, R., Roodman, G. D., Lyons, R., Smith, L., Freytes, C. O. & LeMaistre, C. F., Sep 1994, In : Journal of Clinical Oncology. 12, 9, p. 1890-1901 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron

Alcantara, O., Reddy, S. V., Roodman, G. D. & Boldt, D. H., Jan 1 1994, In : Biochemical Journal. 298, 2, p. 421-425 5 p.

Research output: Contribution to journalArticle

35 Scopus citations
1995

An in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Jan 1 1995, In : STEM CELLS. 13, SUPPL. 2, p. 48-50 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, D. G., Mundy, G. R. & Boyce, B. F., Oct 1995, In : Journal of Bone and Mineral Research. 10, 10, p. 1478-1487 10 p.

Research output: Contribution to journalArticle

861 Scopus citations
101 Scopus citations

Characterization of the 5′-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene

Reddy, S. V., Kuzhandaivelu, N., Acosta, L. G. & Roodman, G. D., May 1995, In : Bone. 16, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Characterization of the mouse tartrate‐resistant acid phosphatase (trap) gene promoter

Reddy, S. V., Hundley, J. E., Windle, J. J., Alcantara, O., Linn, R., Leach, R. J., Boldt, D. H. & Roodman, G. D., Apr 1995, In : Journal of Bone and Mineral Research. 10, 4, p. 601-606 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Characterization of the osteoclast vacuolar H+-ATPase B-subunit

Bartkiewicz, M., Hernando, N., Reddy, S. V., Roodman, G. D. & Baron, R., 1995, In : Gene. 160, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation

Takahashi, S., Reddy, S. V., Dallas, M., Devlin, R., Chou, J. Y. & Roodman, G. D., Apr 1995, In : Endocrinology. 136, 4, p. 1441-1449 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast-like cell differentiation

Takahashi, S., Goldring, S., Katz, M., Hilsenbeck, S., Williams, R. & Roodman, G. D., Jan 1 1995, In : Journal of Clinical Investigation. 95, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

106 Scopus citations

Effects of parathyroid hormone (pth)-related protein and pth on osteoclasts and osteoclast precursors in vivo

Uy, H. L., Guise, T. A., Mata, J. D. L., Taylor, S. D., Story, B. M., Dallas, M. R., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Aug 1995, In : Endocrinology. 136, 8, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo

De La Mata, J., Uy, H. L., Guise, T. A., Story, B., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Jun 1995, In : Journal of Clinical Investigation. 95, 6, p. 2846-2852 7 p.

Research output: Contribution to journalArticle

Open Access
214 Scopus citations

Osteoclast function in Paget's disease and multiple myeloma

Roodman, G. D., Aug 1995, In : Bone. 17, 2 SUPPL. 1, p. S57-S61

Research output: Contribution to journalArticle

39 Scopus citations

Targeting simian virus 40 t antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts

Boyce, B. F., Wright, K., Reddy, S. V., Koop, B. A., Story, B., Devlin, R., Leach, R. J., Roodman, G. D. & Windle, J. J., Apr 1995, In : Endocrinology. 136, 12, p. 5751-5759 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Use of an in vivo model to determine the effects of interleukin‐1 on cells at different stages in the osteoclast lineage

Uy, H. L., Dallas, M., Calland, J. W., Boyce, B. F., Mundy, G. R. & Roodman, D. G., Feb 1995, In : Journal of Bone and Mineral Research. 10, 2, p. 295-301 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
1996

Assignment of matrix metalloproteinase 9 (Mmp9) to mouse Chromosome 2 bands H1-H2

DuPont, B. R., Linn, R., Knight, C. B., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A., Fournier, R. E. K. & Leach, R. J., Jan 1 1996, In : Cytogenetic and Genome Research. 74, 1-2, p. 118-119 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Detection of measles virus nucleocapsid transcripts in circulating blood cells from patients with paget disease

Reddy, S. V., Singer, F. R., Mallette, L. & Roodman, G. D., Nov 1 1996, In : Journal of Bone and Mineral Research. 11, 11, p. 1602-1607 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Development of an in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B., Devlin, R. D., Anderson, J. L., Craig, F., Mundy, G. R. & Roodman, G. D., Feb 15 1996, In : Blood. 87, 4, p. 1495-1501 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Inhibition of tartrate-resistant acid phosphatase gene expression by hemin and protoporphyrin IX. Identification of a hemin-responsive inhibitor of transcription

Reddy, S. V., Alcantara, O., Roodman, G. D. & Boldt, D. H., Sep 15 1996, In : Blood. 88, 6, p. 2288-2297 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Interleukin-6: A potential mediator of the massive osteolysis in patients with Gorham-Stout disease

Devlin, R. D., Bone, H. G. & Roodman, G. D., May 21 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 5, p. 1893-1897 5 p.

Research output: Contribution to journalArticle

153 Scopus citations

Rutologous hematopoietic stem cell transplantation for poof prognosis low grade lymphoka

Frevets, C. O., Vukelia, S., Castro, D. J., Boldt, D., Roodman, G. D., Hilesbeck, S., Adkins, D., Bachier, C., Craig, F., Clare, N., Weismare, A. & Lemaistre, C. F., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

1997

Cokeromyces recurvatus infection in a bone marrow transplant recipient

Tsai, T. W., Hammond, L. A., Rinaldi, M., Martin, K., Tio, F., Maples, J., Freytes, C. O. & Roodman, G. D., Feb 1 1997, In : Bone Marrow Transplantation. 19, 3, p. 301-302 2 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Genetic linkage of Paget disease of the bone to chromosome 18q

Cody, J. D., Singer, F. R., Roodman, G. D., Otterund, B., Lewis, T. B., Leppert, M. & Leach, R. J., Nov 1997, In : American Journal of Human Genetics. 61, 5, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Mechanisms of bone lesions in multiple myeloma and lymphoma

Roodman, G. D., Oct 15 1997, In : Cancer. 80, 8 SUPPL., p. 1557-1563 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Uy, H. L., Mundy, G. R., Boyce, B. F., Story, B. M., Dunstan, C. R., Yin, J. J., Roodman, G. D. & Guise, T. A., Sep 2 1997, In : Cancer Research. 57, 15, p. 3194-3199 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
1998

Animal models of bone disease

David Roodman, G., Dec 1 1998, In : Cancer Research Therapy and Control. 6, 1-4, p. 89-90 2 p.

Research output: Contribution to journalArticle

Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma

Gao, S. J., Alsina, M., Deng, J. H., Harrison, C. R., Montalvo, E. A., Leach, C. T., David Roodman, G. & Jenson, H. B., Jan 1 1998, In : Journal of Infectious Diseases. 178, 3, p. 846-849 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation

Mbalaviele, G., Nishimura, R., Myoi, A., Niewolna, M., Reddy, S. V., Chen, D., Feng, J., Roodman, D., Mundy, G. R. & Yoneda, T., Jun 15 1998, In : Journal of Cell Biology. 141, 6, p. 1467-1476 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Devlin, R. D., Menaa, C., Chung, H., Roodman, G. D. & Reddy, S. V., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Cloning and identification of human stem cell antigen as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Davlin, R., Baddy, S. V. & Roodman, G. D., Dec 1 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

Epitope mapping of recombinant human procathepsin D

Sachdev, D., Ohsaki, Y., Roodman, G. D. & Chirgwin, J. M., Dec 1 1998, In : Advances in experimental medicine and biology. 436, p. 185-189 5 p.

Research output: Contribution to journalArticle

Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone

Nellissery, M. J., Padalecki, S. S., Brkanac, Z., Singer, F. R., Roodman, G. D., Unni, K. K., Leach, R. J. & Hansen, M. F., Sep 1998, In : American Journal of Human Genetics. 63, 3, p. 817-824 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Further characterization of the murine collagenase (type IVB) gene promoter and analysis of mRNA expression in murine tissues

Roach, J., Jin Choi, S., L. Schaub, R., Leach, R. J., David Roodman, G. & Reddy, S. V., Feb 22 1998, In : Gene. 208, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

7 Scopus citations