G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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1997
46 Citations (Scopus)

Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Uy, H. L., Mundy, G. R., Boyce, B. F., Story, B. M., Dunstan, C. R., Yin, J. J., Roodman, G. D. & Guise, T., 1997, In : Cancer Research. 57, 15, p. 3194-3199 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Bone Resorption
Osteogenesis
Cricetulus
1998

Animal models of bone disease

Roodman, G. D., 1998, In : Cancer Research Therapy and Control. 6, 1-4, p. 89-90 2 p.

Research output: Contribution to journalArticle

Bone Diseases
Animal Models
50 Citations (Scopus)

Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma

Gao, S. J., Alsina, M., Deng, J. H., Harrison, C. R., Montalvo, E. A., Leach, C. T., Roodman, G. D. & Jenson, H. B., 1998, In : Journal of Infectious Diseases. 178, 3, p. 846-849 4 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Multiple Myeloma
Antibodies
Blood Donors
Neoplasms
42 Citations (Scopus)

Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation

Mbalaviele, G., Nishimura, R., Myoi, A., Niewolna, M., Reddy, S. V., Chen, D., Feng, J., Roodman, G. D., Mundy, G. R. & Yoneda, T., Jun 15 1998, In : Journal of Cell Biology. 141, 6, p. 1467-1476 10 p.

Research output: Contribution to journalArticle

Cell Lineage
Osteoclasts
Stromal Cells
Cadherins
Protein Isoforms
23 Citations (Scopus)

Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Devlin, R. D., Menaa, C., Chung, H., Roodman, G. D. & Reddy, S. V., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Osteoclasts
Bone Resorption
Organism Cloning
Peptides

Cloning and identification of human stem cell antigen as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Davlin, R., Baddy, S. V. & Roodman, G. D., 1998, In : Experimental Hematology. 26, 8, p. 729 1 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Osteoclasts
Bone Resorption
Organism Cloning
Stem Cells
58 Citations (Scopus)

Control of osteoclast differentiation

Reddy, S. V. & Roodman, G. D., 1998, In : Critical Reviews in Eukaryotic Gene Expression. 8, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Stromal Cells
Osteoblasts
Macrophages

Epitope mapping of recombinant human procathepsin D

Sachdev, D., Ohsaki, Y., Roodman, G. D. & Chirgwin, J., 1998, In : Advances in Experimental Medicine and Biology. 436, p. 185-190 6 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Cultured Tumor Cells
Recombinant Fusion Proteins
B-Lymphocyte Epitopes
Epitope Mapping
79 Citations (Scopus)

Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone

Nellissery, M. J., Padalecki, S. S., Brkanac, Z., Singer, F. R., Roodman, G. D., Unni, K. K., Leach, R. J. & Hansen, M. F., Sep 1998, In : American Journal of Human Genetics. 63, 3, p. 817-824 8 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Chromosomes, Human, Pair 18
Osteosarcoma
Tumor Suppressor Genes
Loss of Heterozygosity
7 Citations (Scopus)

Further characterization of the murine collagenase (type IVB) gene promoter and analysis of mRNA expression in murine tissues

Roach, J., Jin Choi, S., L. Schaub, R., Leach, R. J., Roodman, G. D. & Reddy, S. V., Feb 22 1998, In : Gene. 208, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Collagenases
Osteoclasts
Messenger RNA
Genes
Gene Expression
77 Citations (Scopus)
Parathyroid Hormone-Related Protein
Osteoclasts
Interleukin-1
Interleukin-6
Bone Marrow
44 Citations (Scopus)

Immortalization of osteoclast precursors by targeting bcl-X(L) and Simian Virus 40 large T antigen to the osteoclast lineage in transgenic mice

Hentunen, T. A., Reddy, S. V., Boyce, B. F., Devlin, R., Park, H. R., Chung, H., Selander, K. S., Dallas, M., Kurihara, N., Galson, D. L., Goldring, S. R., Koop, B. A., Windle, J. J. & Roodman, G. D., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Osteoclasts
Transgenic Mice
Bone and Bones
40 Citations (Scopus)

Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption

Reddy, S., Devlin, R., Menaa, C., Nishimura, R., Choi, S. J., Dallas, M., Yoneda, T. & Roodman, G. D., Dec 1998, In : Journal of Cellular Physiology. 177, 4, p. 636-645 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Bone
Complementary DNA
Clone Cells
5 Citations (Scopus)

Osteoclast differentiation and activity

Roodman, G. D., 1998, In : Biochemical Society Transactions. 26, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

Osteoclasts
2 Citations (Scopus)

Pagetic osteoclasts formed in vitro: Absence of paracrystalline inclusions

Roodman, G. D., Ohsaki, Y., Miller, M. M., Demulder, A., Hosking, D., Singer, F. R. & McManus, L. M., Apr 1998, In : Journal of Submicroscopic Cytology and Pathology. 30, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Nucleocapsid
Distemper
Bone and Bones
Intranuclear Inclusion Bodies
1 Citation (Scopus)

Paget's Disease of Bone

Roodman, G. D., 1998, In : Advances in Organ Biology. 5, C, p. 661-675 15 p.

Research output: Contribution to journalArticle

Osteitis Deformans
1999
81 Citations (Scopus)

Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures

Menaa, C., Devlin, R. D., Reddy, S. V., Gazitt, Y., Choi, S. J. & Roodman, G. D., Jun 1999, In : Journal of Clinical Investigation. 103, 11, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

Annexin A2
Osteoclasts
Bone Marrow
Granulocyte-Macrophage Colony-Stimulating Factor
T-Lymphocytes
46 Citations (Scopus)

Cell biology of Paget's disease

Reddy, S. V., Menaa, C., Singer, F. R., Demulder, A. & Roodman, G. D., 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, SUPPL. 2, p. 3-8 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Cell Biology
Bone Marrow
Interleukin-6
Calcitriol Receptors
400 Citations (Scopus)

Cell biology of the osteoclast

Roodman, G. D., Aug 1999, In : Experimental Hematology. 27, 8, p. 1229-1241 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Cell Biology
RANK Ligand
Bone Marrow
Bone Resorption
22 Citations (Scopus)

Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen

Hentunen, T. A., Jackson, S. H., Chung, H., Reddy, S. V., Lorenzo, J., Choi, S. J. & Roodman, G. D., 1999, In : Endocrinology. 140, 7, p. 2954-2961 8 p.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Osteoclasts
Transgenic Mice
RANK Ligand

Effects of alendronate on cytokine production and osteoclast formation induced by human marrow stromal cells

Moore, J., Anderson, J. A., Roodman, G. D. & Reddy, S. V., Feb 1999, In : Journal of Investigative Medicine. 47, 2

Research output: Contribution to journalArticle

Alendronate
Osteoclasts
Stromal Cells
Bone Marrow
Cytokines
75 Citations (Scopus)

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

Choi, S. J., Reddy, S. V., Devlin, R. D., Menaa, C., Chung, H., Boyce, B. F. & Roodman, G. D., Sep 24 1999, In : Journal of Biological Chemistry. 274, 39, p. 27747-27753 7 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Forensic Anthropology
Osteoclasts
Bone Resorption
Bone
183 Citations (Scopus)

Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase

Halleen, J. M., Räisänen, S., Salo, J. J., Reddy, S. V., Roodman, G. D., Hentunen, T. A., Lehenkari, P. P., Kaija, H., Vihko, P. & Väänänen, H. K., Aug 13 1999, In : Journal of Biological Chemistry. 274, 33, p. 22907-22910 4 p.

Research output: Contribution to journalArticle

Bone Resorption
Acid Phosphatase
Reactive Oxygen Species
Bone
Iron
33 Citations (Scopus)

Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone

Reddy, S. V., Menaa, C., Singer, F. R., Cundy, T., Cornish, J., Whyte, M. P. & Roodman, G. D., Oct 1999, In : Experimental Hematology. 27, 10, p. 1528-1532 5 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Nucleocapsid
Measles virus
Osteoclasts
Viruses
10 Citations (Scopus)

Mechanisms of abnormal bone turnover in Paget's disease

Roodman, G. D., May 1999, In : Bone. 24, 5 SUPPL.

Research output: Contribution to journalArticle

Morbillivirus Infections
Morbillivirus
Osteitis Deformans
Bone Remodeling
Viral RNA
1 Citation (Scopus)

Osteoclast function in healthy subjects and in patients with Paget's disease

Wirfel, K. L., Bruder, J. M., Vardag, A. & Roodman, G. D., 1999, In : Endocrinologist. 9, 4, p. 263-269 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Healthy Volunteers
Osteoporosis
Bone Resorption
Osteogenesis
17 Citations (Scopus)
Genes
Age of Onset
Chromosomes, Human, Pair 18
Bone and Bones
Intranuclear Inclusion Bodies
2000
80 Citations (Scopus)
Calcitriol
Osteoclasts
Hypersensitivity
Stromal Cells
RANK Ligand
27 Citations (Scopus)

A murine model of inflammatory bone disease

Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L. & Roodman, G. D., Feb 2000, In : Bone. 26, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone Marrow
Osteoclasts
Chromosomes, Human, Pair 18
Bone and Bones
3 Citations (Scopus)

A phase I-II clinical trial with a combination of gemcitabine (GEMZAR) and paclitaxel (TAXOL) for the treatment of refractory multiple myeloma (MM) patients

Gazitt, Y., Roodman, G. D., Freytes, C., Shaughnessy, P., Callander, N., Traynor, A. & Rothenberg, M., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

gemcitabine
Phase II Clinical Trials
Clinical Trials, Phase I
Paclitaxel
Multiple Myeloma
3 Citations (Scopus)

Assignment of OSTF1 to human chromosome bands 12q24.1 → q24.2 by in situ hybridization

Schaub, R., Dupont, B., Roodman, G. D., Leach, R. J. & Reddy, S. V., 2000, In : Cytogenetics and Cell Genetics. 88, 1-2, p. 87-88 2 p.

Research output: Contribution to journalArticle

Physical Chromosome Mapping
Chromosome Banding
Chromosomes, Human, Pair 12
Hybrid Cells
Human Chromosomes
48 Citations (Scopus)

CFU-GM-derived cells form osteoclasts at a very high efficiency

Menaa, C., Kurihara, N. & Roodman, G. D., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 943-946 4 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Progenitor Cells
Osteoclasts
Macrophages
RANK Ligand
Macrophage Colony-Stimulating Factor

Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas

Callander, N. S., Galvez, J., Cortes, R., Aisina, M. & Roodman, G. D., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Epidemiology
Multiple Myeloma
Hispanic Americans
Immunoglobulin G
Cells
65 Citations (Scopus)

Effect of telomere and telomerase interactive agents on human tumor and normal cell lines

Rha, S. Y., Izbicka, E., Lawrence, R., Davidson, K., Sun, D., Moyer, M. P., Roodman, G. D., Hurley, L. & Von Hoff, D., Mar 2000, In : Clinical Cancer Research. 6, 3, p. 987-993 7 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Tumor Cell Line
Inhibitory Concentration 50
Zidovudine
129 Citations (Scopus)

Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone

Menaa, C., Reddy, S. V., Kurihara, N., Maeda, H., Anderson, D., Cundy, T., Cornish, J., Singer, F. R., Bruder, J. M. & Roodman, G. D., 2000, In : Journal of Clinical Investigation. 105, 12, p. 1833-1838 6 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteitis Deformans
Bone Marrow Cells
Bone Marrow
Osteoclasts
55 Citations (Scopus)

Expansile skeletal hyperphosphatasia: A new familial metabolic bone disease

Whyte, M. P., Mills, B. G., Reinus, W. R., Podgornik, M. N., Roodman, G. D., Gannon, F. H., Eddy, M. C. & McAlister, W. H., 2000, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 15, 12, p. 2330-2344 15 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Hypercalcemia
Bone and Bones
Finger Phalanges
Osteosclerosis
323 Citations (Scopus)

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

Choi, S. J., Cruz, J. C., Craig, F., Chung, H., Devlin, R. D., Roodman, G. D. & Alsina, M., Jul 15 2000, In : Blood. 96, 2, p. 671-675 5 p.

Research output: Contribution to journalArticle

Chemokine CCL3
Macrophages
Osteoclasts
Multiple Myeloma
Bone Marrow
104 Citations (Scopus)

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Kurihara, N., Reddy, S. V., Menaa, C., Anderson, D. & Roodman, G. D., Mar 2000, In : Journal of Clinical Investigation. 105, 5, p. 607-614 8 p.

Research output: Contribution to journalArticle

Nucleocapsid
Measles virus
Osteoclasts
Phenotype
Genes
2001
87 Citations (Scopus)

ADAM8: A novel osteoclast stimulating factor

Sun Jin Choi, J. C., Han, J. H. & Roodman, G. D., 2001, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16, 5, p. 814-822 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Disintegrins
Conditioned Culture Medium
Complementary DNA
Bone Marrow
180 Citations (Scopus)

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

Choi, S. J., Oba, Y., Gazitt, Y., Alsina, M., Cruz, J., Anderson, J. & Roodman, G. D., 2001, In : Journal of Clinical Investigation. 108, 12, p. 1833-1841 9 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Bone Diseases
Multiple Myeloma
Bone and Bones
Osteoclasts
238 Citations (Scopus)

Biology of osteoclast activation in cancer

Roodman, G. D., Aug 1 2001, In : Journal of Clinical Oncology. 19, 15, p. 3562-3571 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Receptor Activator of Nuclear Factor-kappa B
Bone and Bones
Neoplasms
Osteogenesis
36 Citations (Scopus)

Genetics of endocrine disease: The genetics of paget's disease of the bone

Leach, R. J., Singer, F. R. & Roodman, G. D., 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma

Cruz, J. C., Alsina, M., Craig, F., Yoneda, T., Anderson, J. L., Dallas, M. & Roodman, G. D., 2001, In : Experimental Hematology. 29, 4, p. 441-447 7 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone Development
Osteoclasts
Paraplegia
Bone Marrow
256 Citations (Scopus)

Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

Man, J. H., Choi, S. J., Kurihara, N., Koide, M., Oba, Y. & Roodman, G. D., Jun 1 2001, In : Blood. 97, 11, p. 3349-3353 5 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Cytoplasmic and Nuclear Receptors
Osteoclasts
Ligands
Bone Marrow
123 Citations (Scopus)

Myeloma bone disease

Callander, N. S. & Roodman, G. D., 2001, In : Seminars in Hematology. 38, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Bone Diseases
RANK Ligand
Chemokine CCL3
Stromal Cells
Interleukin-6
27 Citations (Scopus)
Osteoclasts
Peptides
asparaginylendopeptidase
RANK Ligand
Enzymes
61 Citations (Scopus)

Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts

Reddy, S. V., Kurihara, N., Menaa, C., Landucci, G., Forthal, D., Koop, B. A., Windle, J. J. & Roodman, G. D., 2001, In : Endocrinology. 142, 7, p. 2898-2905 8 p.

Research output: Contribution to journalArticle

Measles virus
Osteoclasts
Transgenic Mice
Virus Diseases
Bone Marrow
37 Citations (Scopus)

Paget's Disease of Bone: A Disease of the Osteoclast

Reddy, S. V., Kurihara, N., Menaa, C. & Roodman, G. D., 2001, In : Reviews in Endocrine and Metabolic Disorders. 2, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Bone Diseases
Osteoclasts
RANK Ligand
Chromosomes, Human, Pair 21
121 Citations (Scopus)

Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: Results of United States intergroup trial (Southwest Oncology Group S9003)

Dhodapkar, M. V., Jacobson, J. L., Gertz, M. A., Rivkin, S. E., Roodman, G. D., Tuscano, J. M., Shurafa, M., Kyle, R. A., Crowley, J. J. & Barlogie, B., Jul 1 2001, In : Blood. 98, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Oncology
Hemoglobins
Purine Nucleosides
Immunoglobulin M
22 Citations (Scopus)

Studies in Paget's disease and their relevance to oncology

Roodman, G. D., 2001, In : Seminars in Oncology. 28, 4 SUPPL. 11, p. 15-21 7 p.

Research output: Contribution to journalArticle

RANK Ligand
Interleukin-6
Diphosphonates
Osteoclasts
Osteitis Deformans