G. David Roodman

  • 23776 Citations
  • 81 h-Index
1975 …2020

Research output per year

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Publications

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Article
1998

IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures

Devlin, R. D., Reddy, S. V., Savino, R., Ciliberto, G. & Roodman, G. D., Apr 14 1998, In : Journal of Bone and Mineral Research. 13, 3, p. 393-399 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Immortalization of osteoclast precursors by targeting bcl-X(L) and Simian Virus 40 large T antigen to the osteoclast lineage in transgenic mice

Hentunen, T. A., Reddy, S. V., Boyce, B. F., Devlin, R., Park, H. R., Chung, H., Selander, K. S., Dallas, M., Kurihara, N., Galson, D. L., Goldring, S. R., Koop, B. A., Windle, J. J. & Roodman, G. D., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption

Reddy, S., Devlin, R., Menaa, C., Nishimura, R., Choi, S. J., Dallas, M., Yoneda, T. & Roodman, G. D., Dec 1998, In : Journal of cellular physiology. 177, 4, p. 636-645 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Osteoclast differentiation and activity

Roodman, G. D., Jan 1 1998, In : Biochemical Society transactions. 26, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pagetic osteoclasts formed in vitro: Absence of paracrystalline inclusions

Roodman, G. D., Ohsaki, Y., Miller, M. M., Demulder, A., Hosking, D., Singer, F. R. & McManus, L. M., Apr 1 1998, In : Journal of Submicroscopic Cytology and Pathology. 30, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Paget's Disease of Bone

Roodman, G. D., Dec 1 1998, In : Advances in Organ Biology. 5, C, p. 661-675 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
1999

Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures

Menaa, C., Devlin, R. D., Reddy, S. V., Gazitt, Y., Choi, S. J. & Roodman, G. D., Jun 1999, In : Journal of Clinical Investigation. 103, 11, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Cell biology of Paget's disease

Reddy, S. V., Menaa, C., Singer, F. R., Demulder, A. & Roodman, G. D., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, SUPPL. 2, p. 3-8 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen

Hentunen, T. A., Jackson, S. H., Chung, H., Reddy, S. V., Lorenzo, J., Choi, S. J. & David Roodman, G., Jan 1 1999, In : Endocrinology. 140, 7, p. 2954-2961 8 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Effects of alendronate on cytokine production and osteoclast formation induced by human marrow stromal cells

Moore, J., Anderson, J. A., Roodman, G. D. & Reddy, S. V., Feb 1999, In : Journal of Investigative Medicine. 47, 2, p. 132A

Research output: Contribution to journalArticle

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

Choi, S. J., Reddy, S. V., Devlin, R. D., Menaa, C., Chung, H., Boyce, B. F. & Roodman, G. D., Sep 24 1999, In : Journal of Biological Chemistry. 274, 39, p. 27747-27753 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase

Halleen, J. M., Räisänen, S., Salo, J. J., Reddy, S. V., Roodman, G. D., Hentunen, T. A., Lehenkari, P. P., Kaija, H., Vihko, P. & Väänänen, H. K., Aug 13 1999, In : Journal of Biological Chemistry. 274, 33, p. 22907-22910 4 p.

Research output: Contribution to journalArticle

185 Scopus citations

Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone

Reddy, S. V., Menaa, C., Singer, F. R., Cundy, T., Cornish, J., Whyte, M. P. & Roodman, G. D., Oct 1 1999, In : Experimental Hematology. 27, 10, p. 1528-1532 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mechanisms of abnormal bone turnover in Paget's disease

Roodman, G. D., May 1999, In : Bone. 24, 5 SUPPL., p. 39S-40S

Research output: Contribution to journalArticle

10 Scopus citations

Variable disease severity associated with a Paget's disease predisposition gene

Leach, R. J., Singer, F. R., Cody, J. D. & Roodman, G. D., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, SUPPL. 2, p. 17-20 4 p.

Research output: Contribution to journalArticle

18 Scopus citations
2000

1,25-dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease

Menaa, C., Barsony, J., Reddy, S. V., Cornish, J., Cundy, T. & Roodman, G. D., Jan 1 2000, In : Journal of Bone and Mineral Research. 15, 2, p. 228-236 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

A murine model of inflammatory bone disease

Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L. & Roodman, G. D., Feb 1 2000, In : Bone. 26, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

A phase I-II clinical trial with a combination of gemcitabine (GEMZAR) and paclitaxel (TAXOL) for the treatment of refractory multiple myeloma (MM) patients

Gazitt, Y., Roodman, D., Freytes, C., Shaughnessy, P., Callander, N., Traynor, A. & Rothenberg, M., Dec 1 2000, In : Blood. 96, 11 PART II, p. 287b

Research output: Contribution to journalArticle

3 Scopus citations

Assignment of OSTF1 to human chromosome bands 12q24.1 → q24.2 by in situ hybridization

Schaub, R., Dupont, B., Roodman, G. D., Leach, R. J. & Reddy, S. V., Apr 11 2000, In : Cytogenetics and Cell Genetics. 88, 1-2, p. 87-88 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

CFU-GM-derived cells form osteoclasts at a very high efficiency

Menaa, C., Kurihara, N. & Roodman, G. D., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 943-946 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas

Callander, N. S., Galvez, J., Cortes, R., Aisina, M. & Roodman, G. D., Dec 1 2000, In : Blood. 96, 11 PART II, p. 271b

Research output: Contribution to journalArticle

Effect of telomere and telomerase interactive agents on human tumor and normal cell lines

Rha, S. Y., Izbicka, E., Lawrence, R., Davidson, K., Sun, D., Moyer, M. P., Roodman, G. D., Hurley, L. & Von Hoff, D., Mar 1 2000, In : Clinical Cancer Research. 6, 3, p. 987-993 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone

Menaa, C., Reddy, S. V., Kurihara, N., Maeda, H., Anderson, D., Cundy, T., Cornish, J., Singer, F. R., Bruder, J. M. & Roodman, G. D., Jan 1 2000, In : Journal of Clinical Investigation. 105, 12, p. 1833-1838 6 p.

Research output: Contribution to journalArticle

Open Access
132 Scopus citations

Expansile skeletal hyperphosphatasia: A new familial metabolic bone disease

Whyte, M. P., Mills, B. G., Reinus, W. R., Podgornik, M. N., Roodman, G. D., Gannon, F. H., Eddy, M. C. & Mcalister, W. H., Jan 1 2000, In : Journal of Bone and Mineral Research. 15, 12, p. 2330-2344 15 p.

Research output: Contribution to journalArticle

57 Scopus citations

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

Choi, S. J., Cruz, J. C., Craig, F., Chung, H., Devlin, R. D., Roodman, G. D. & Alsina, M., Jul 15 2000, In : Blood. 96, 2, p. 671-675 5 p.

Research output: Contribution to journalArticle

329 Scopus citations

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Kurihara, N., Reddy, S. V., Menaa, C., Anderson, D. & Roodman, G. D., Mar 2000, In : Journal of Clinical Investigation. 105, 5, p. 607-614 8 p.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations
2001

ADAM8: A novel osteoclast stimulating factor

Choi, S. J., Han, J. H. & Roodman, G. D., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 5, p. 814-822 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

Choi, S. J., Oba, Y., Gazitt, Y., Alsina, M., Cruz, J., Anderson, J. & David Roodman, G., Dec 1 2001, In : Journal of Clinical Investigation. 108, 12, p. 1833-1841 9 p.

Research output: Contribution to journalArticle

184 Scopus citations

Biology of osteoclast activation in cancer

Roodman, G. D., Aug 1 2001, In : Journal of Clinical Oncology. 19, 15, p. 3562-3571 10 p.

Research output: Contribution to journalArticle

239 Scopus citations

Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma

Cruz, J. C., Alsina, M., Craig, F., Yoneda, T., Anderson, J. L., Dallas, M. & Roodman, G. D., Apr 26 2001, In : Experimental Hematology. 29, 4, p. 441-447 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

Man, J. H., Choi, S. J., Kurihara, N., Koide, M., Oba, Y. & David Roodman, G., Jun 1 2001, In : Blood. 97, 11, p. 3349-3353 5 p.

Research output: Contribution to journalArticle

258 Scopus citations

Myeloma bone disease

Callander, N. S. & Roodman, G. D., Jan 1 2001, In : Seminars in Hematology. 38, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

123 Scopus citations

Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its c-terminal fragment

Choi, S. J., Kurihara, N., Oba, Y. & Roodman, G. D., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 10, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts

Reddy, S. V., Kurihara, N., Menaa, C., Landucci, G., Forthal, D., Koop, B. A., Windle, J. J. & Roodman, G. D., Jan 1 2001, In : Endocrinology. 142, 7, p. 2898-2905 8 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Paget's Disease of Bone: A Disease of the Osteoclast

Reddy, S. V., Kurihara, N., Menaa, C. & Roodman, G. D., Jan 1 2001, In : Reviews in Endocrine and Metabolic Disorders. 2, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: Results of United States intergroup trial (Southwest Oncology Group S9003)

Dhodapkar, M. V., Jacobson, J. L., Gertz, M. A., Rivkin, S. E., David Roodman, G., Tuscano, J. M., Shurafa, M., Kyle, R. A., Crowley, J. J. & Barlogie, B., Jul 1 2001, In : Blood. 98, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

Studies in Paget's disease and their relevance to oncology

Roodman, G. D., Jan 1 2001, In : Seminars in oncology. 28, 4 SUPPL. 11, p. 15-21 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2002

Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease

Friedrichs, W. E., Reddy, S. V., Bruder, J. M., Cundy, T., Cornish, J., Singer, F. R. & Roodman, G. D., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 1, p. 145-151 7 p.

Research output: Contribution to journalArticle

82 Scopus citations

SV40 T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype

Darimont, C., Avanti, O., Tromvoukis, Y., Vautravers-Leone, P., Kurihara, N., Roodman, G. D., Colgin, L. M., Tullberg-Reinert, H., Pfeifer, A. M. A., Offord, E. A. & Mace, K., Mar 19 2002, In : Cell Growth and Differentiation. 13, 2, p. 59-67 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2003

AML-1A and AML-1B regulation of MIP-1α expression in multiple myeloma

Choi, S. J., Oba, T., Callander, N. S., Jelinek, D. F. & Roodman, G. D., May 15 2003, In : Blood. 101, 10, p. 3778-3783 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Eosinophil Chemotactic Factor-L (ECF-L): A Novel Osteoclast Stimulating Factor

Oba, Y., Chung, H. Y., Choi, S. J. & Roodman, G. D., Jul 1 2003, In : Journal of Bone and Mineral Research. 18, 7, p. 1332-1341 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mechanisms of bone resorption in myeloma

Roodman, G. D., Dec 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 271-272 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of stromal-derived cytokines and growth factors in bone metastasis

Roodman, G. D., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 733-738 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Summary - Bone resorption session

Roodman, G. D., Dec 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 292-294 3 p.

Research output: Contribution to journalArticle

2004

Functional Role for Heat Shock Factors in the Transcriptional Regulation of Human RANK Ligand Gene Expression in Stromal/Osteoblast Cells

Roccisana, J. L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G. D. & Reddy, S. V., Mar 12 2004, In : Journal of Biological Chemistry. 279, 11, p. 10500-10507 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells

Lee, J. W., Chung, H. Y., Ehrlich, L. A., Jelinek, D. F., Callander, N. S., Roodman, G. D. & Choi, S. J., Mar 15 2004, In : Blood. 103, 6, p. 2308-2315 8 p.

Research output: Contribution to journalArticle

174 Scopus citations

Paget's disease - A VDR coactivator disease?

Kurihara, N., Ishizuka, S., Demulder, A., Menaa, C. & Roodman, G. D., May 1 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 321-325 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pathogenesis of myeloma bone disease

Roodman, G. D., Jan 1 2004, In : Blood Cells, Molecules, and Diseases. 32, 2, p. 290-292 3 p.

Research output: Contribution to journalArticle

111 Scopus citations

Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease

Kurihara, N., Reddy, S. V., Araki, N., Ishizuka, S., Ozono, K., Cornish, J., Cundy, T., Singer, F. R. & Roodman, G. D., Jul 1 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D3 from pagetic bone marrow cells

Ishizuka, S., Kurihara, N., Miura, D., Takenouchi, K., Cornish, J., Cundy, T., Reddy, S. V. & Roodman, G. D., May 1 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 331-334 4 p.

Research output: Contribution to journalArticle

34 Scopus citations