G. David Roodman

  • 23639 Citations
  • 80 h-Index
1975 …2020

Research output per year

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Publications

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2005
45 Scopus citations

Annexin II stimulates RANKL expression through MAPK

Li, F., Chung, H. Y., Reddy, S. V., Lu, G., Kurihara, N., Zhao, A. Z. & Roodman, G. D., Jul 1 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1161-1167 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

EL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma

Ehrlich, L. A., Chung, H. Y., Ghobrial, I., Choi, S. J., Morandi, F., Colla, S., Rizzoli, V., Roodman, G. D. & Giuliani, N., Aug 15 2005, In : Blood. 106, 4, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

156 Scopus citations

Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer

Murthy, R. V., Arbman, G., Gao, J., Roodman, G. D. & Sun, X. F., Mar 15 2005, In : Clinical Cancer Research. 11, 6, p. 2293-2299 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells

Oba, Y., Lee, J. W., Ehrlich, L. A., Chung, H. Y., Jelinek, D. F., Callander, N. S., Horuk, R., Choi, S. J. & Roodman, G. D., Mar 2005, In : Experimental Hematology. 33, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

114 Scopus citations
2006

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T. A., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6209s-6212s

Research output: Contribution to journalArticle

11 Scopus citations

Cloning and characterization of the annexin II receptor on human marrow stromal cells

Lu, G., Maeda, H., Reddy, S. V., Kurihara, N., Leach, R., Anderson, J. L. & Roodman, G. D., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30542-30550 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma

Francis, L. K., Alsayed, Y., Leleu, X., Jia, X., Singha, U. K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L. A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Nov 15 2006, In : Clinical Cancer Research. 12, 22, p. 6826-6835 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing ICAM-1 expression

Palacios, V. G., Chung, H. Y., Choi, S. J., Kurihara, N., Lee, J. W., Ehrlich, L. A., Collins, R. & Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 240-243 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Expression of measles virus nucleocapsid protein in osteoclasts induces Paget's disease-like bone lesions in mice

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Mar 1 2006, In : Journal of Bone and Mineral Research. 21, 3, p. 446-455 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Masih-Khan, E., Trudel, S., Heise, C., Li, Z., Paterson, J., Nadeem, V., Wei, E., Roodman, D., Claudio, J. O., Bergsagel, P. L. & Stewart, A. K., Nov 15 2006, In : Blood. 108, 10, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

New potential targets for treating myeloma bone disease

Roodman, G. D., Berenson, Clohisy, Bruland, Suva & Weilbaecher, Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6270s-6273s

Research output: Contribution to journalArticle

29 Scopus citations

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

Nguyen, A. N., Stebbins, E. G., Henson, M., O'Young, G., Choi, S. J., Quon, D., Damm, D., Reddy, M., Ma, J. Y., Haghnazari, E., Kapoun, A. M., Medicherla, S., Protter, A., Schreiner, G. F., Kurihara, N., Anderson, J., Roodman, G. D., Navas, T. A. & Higgins, L. S., Jun 10 2006, In : Experimental Cell Research. 312, 10, p. 1909-1923 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Regulation of osteoclast differentiation

Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

136 Scopus citations

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1

Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V., Donnenberg, A., Ghobrial, I., Mapara, M. Y., Stirling, D., Roodman, D. & Lentzsch, S., Apr 15 2006, In : Blood. 107, 8, p. 3098-3105 8 p.

Research output: Contribution to journalArticle

142 Scopus citations

α9β1: A novel osteoclast integrin that regulates osteoclast formation and function

Rao, H., Lu, G., Kajiya, H., Garcia-Palacios, V., Kurihara, N., Anderson, J., Patrene, K., Sheppard, D., Blair, H. C., Windle, J. J., Choi, S. J. & Roodman, G. D., Oct 1 2006, In : Journal of Bone and Mineral Research. 21, 10, p. 1657-1665 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
2007

ASCO 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma: Guideline summary

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, D. G., Twilde, P. & Anderson, K., Jul 1 2007, In : Journal of Oncology Practice. 3, 4, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1

Garcia-Palacios, V., Yeon Chung, H., Jin Choi, S., Sarmasik, A., Kurihara, N., Won Lee, J., Galson, D. L., Collins, R. & Roodman, G. D., Feb 1 2007, In : Bone. 40, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Experimental models of Paget's disease

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, SUPPL. 2, p. P55-P57

Research output: Contribution to journalArticle

11 Scopus citations

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

Alsayed, Y., Ngo, H., Runnels, J., Leleu, X., Singha, U. K., Pitsillides, C. M., Spencer, J. A., Kimlinger, T., Ghobrial, J. M., Jia, X., Lu, G., Timm, M., Kumar, A., Côté, D., Veilleux, I., Hedin, K. E., Roodman, G. D., Witzig, T. E., Kung, A. L., Hideshima, T. & 3 others, Anderson, K. C., Lin, C. P. & Ghobrial, I. M., Apr 1 2007, In : Blood. 109, 7, p. 2708-2717 10 p.

Research output: Contribution to journalArticle

320 Scopus citations

Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption

Lu, Y., Cai, Z., Xiao, G., Keller, E. T., Mizokami, A., Yao, Z., Roodman, G. D. & Zhang, J., Apr 15 2007, In : Cancer Research. 67, 8, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Kurihara, N., Hiruma, Y., Zhou, H., Subler, M. A., Dempster, D. W., Singer, F. R., Reddy, S. V., Gruber, H. E., Windle, J. J. & Roodman, G. D., Jan 4 2007, In : Journal of Clinical Investigation. 117, 1, p. 133-142 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Perspective on the osteoclast: An angiogenic cell?

Cackowski, F. C. & Roodman, G. D., Nov 2007, In : Annals of the New York Academy of Sciences. 1117, p. 12-25 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Feng, R., Anderson, G., Xiao, G., Elliott, G., Leoni, L., Mapara, M. Y., Roodman, G. D. & Lentzsch, S., Mar 1 2007, In : Blood. 109, 5, p. 2130-2138 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Ultrastructure of bone cells in Paget's disease of bone

Singer, F. R., Mills, B. G., Gruber, H. E., Windle, J. J. & Roodman, G. D., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, SUPPL. 2, p. P51-P54

Research output: Contribution to journalArticle

16 Scopus citations
2008

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Ishizuka, S., Kurihara, N., Hiruma, Y., Miura, D., Namekawa, J. I., Tamura, A., Kato-Nakamura, Y., Nakano, Y., Takenouchi, K., Hashimoto, Y., Nagasawa, K. & Roodman, G. D., Jun 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 3-5, p. 269-277 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

Shiozawa, Y., Havens, A. M., Jung, Y., Ziegler, A. M., Pedersen, E. A., Wang, J., Wang, J., Lu, G., Roodman, G. D., Loberg, R. D., Pienta, K. J. & Taichman, R. S., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

151 Scopus citations

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment

Hiruma, Y., Kurihara, N., Subler, M. A., Zhou, H., Boykin, C. S., Zhang, H., Ishizuka, S., Dempster, D. W., Roodman, G. D. & Windle, J. J., Nov 19 2008, In : Human molecular genetics. 17, 23, p. 3708-3719 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Involvement of hepcidin in the anemia of multiple myeloma

Sharma, S., Nemeth, E., Chen, Y. H., Goodnough, J., Huston, A., Roodman, G. D., Ganz, T. & Lichtenstein, A., Jun 1 2008, In : Clinical Cancer Research. 14, 11, p. 3262-3267 6 p.

Research output: Contribution to journalArticle

77 Scopus citations
Open Access
40 Scopus citations

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

Huston, A., Leleu, X., Jia, X., Moreau, A. S., Ngo, H. T., Runnels, J., Anderson, J., Alsayed, Y., Roccaro, A., Vallet, S., Hatjiharissi, E., Tai, Y. T., Sportelli, P., Munshi, N., Richardson, P., Hideshima, T., Roodman, D. G., Anderson, K. C. & Ghobrial, I. M., Feb 1 2008, In : Clinical Cancer Research. 14, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, L., Roodman, D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., Jan 1 2008, In : Leukemia. 22, 8, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2009

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells

Pal, R., Janz, M., Galson, D. L., Gries, M., Li, S., Jöhrens, K., Anagnostopoulos, I., Dörken, B., Mapara, M. Y., Borghesi, L., Kardava, L., David Roodman, G., Milcarek, C. & Lentzsch, S., Oct 29 2009, In : Blood. 114, 18, p. 3890-3898 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone

Yu, S., Franceschi, R. T., Luo, M., Fan, J., Jiang, D., Cao, H., Kwon, T. G., Lai, Y., Zhang, J., Patrene, K., Hankenson, K., Roodman, G. D. & Xiao, G., Oct 23 2009, In : PLoS ONE. 4, 10, e7583.

Research output: Contribution to journalArticle

46 Scopus citations

Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

Hiruma, Y., Honjo, T., Jelinek, D. F., Windle, J. J., Shin, J., Roodman, G. D. & Kurihara, N., Nov 17 2009, In : Blood. 113, 20, p. 4894-4902 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development

Choi, S. J., Roodman, G. D., Feng, J. Q., Song, I. S., Amin, K., Hart, P. S., Wright, J. T., Haruyama, N. & Hart, T. C., Jan 1 2009, In : Developmental Biology. 325, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

New opportunities for the management of cancer-related bone complications.

Lipton, A., Brown, G. A., Mundy, G. R., Roodman, G. D. & Smith, M. R., May 2009, In : Clinical advances in hematology & oncology : H&O. 7, 5 Suppl 11, p. 1-30; quiz 31

Research output: Contribution to journalArticle

2010

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D. & Xiao, G., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia

Pal, R., Monaghan, S. A., Hassett, A. C., Mapara, M. Y., Schafer, P., Roodman, G. D., Ragni, M. V., Moscinski, L., List, A. & Lentzsch, S., Jan 21 2010, In : Blood. 115, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

Maes, K., Nemeth, E., Roodman, G. D., Huston, A., Esteve, F., Freytes, C., Callander, N., Katodritou, E., Tussing-Humphreys, L., Rivera, S., Vanderkerken, K., Lichtenstein, A. & Ganz, T., Nov 4 2010, In : Blood. 116, 18, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Osteoclasts are important for bone angiogenesis

Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C. & Roodman, G. D., Jan 7 2010, In : Blood. 115, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

104 Scopus citations

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Dossa, T., Arabian, A., Windle, J. J., Dedhar, S., Teitelbaum, S. L., Ross, F. P., Roodman, G. D. & St-Arnaud, R., Jul 1 2010, In : Journal of Cellular Biochemistry. 110, 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 1 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2, p. 151-166.e1

Research output: Contribution to journalArticle

31 Scopus citations

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to paget's disease

Kurihara, N., Hiruma, Y., Yamana, K., Michou, L., Rousseau, C., Morissette, J., Galson, D. L., Teramachi, J., Zhou, H., Dempster, D. W., Windle, J. J., Brown, J. P. & Roodman, G. D., Jan 5 2011, In : Cell Metabolism. 13, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

D'Souza, S., Del Prete, D., Jin, S., Sun, Q., Huston, A. J., Kostov, F. E., Sammut, B., Hong, C. S., Anderson, J. L., Patrene, K. D., Yu, S., Velu, C. S., Xiao, G., Grimes, H. L., Roodman, G. D. & Galson, D. L., Dec 22 2011, In : Blood. 118, 26, p. 6871-6880 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms

Holkova, B., Perkins, E. B., Ramakrishnan, V., Tombes, M. B., Shrader, E., Talreja, N., Wellons, M. D., Hogan, K. T., Roodman, G. D., Coppola, D., Kang, L., Dawson, J., Stuart, R. K., Peer, C., Figg, W. D., Kolla, S., Doyle, A., Wright, J., Sullivan, D. M., Roberts, J. D. & 1 others, Grant, S., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3388-3397 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 1 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2012

Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment

D'Souza, S., Kurihara, N., Shiozawa, Y., Joseph, J., Taichman, R., Galson, D. L. & Roodman, G. D., Feb 23 2012, In : Blood. 119, 8, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

43 Scopus citations