G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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2019

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Dexamethasone
Bone Development
Osteoblasts
2 Citations (Scopus)

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journalArticle

Open Access
Kyphoplasty
Compression Fractures
Multiple Myeloma
Consensus
Pain
2018
3 Citations (Scopus)

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., Mar 6 2018, (Accepted/In press) In : Journal of Medical Economics. p. 1-12 12 p.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Cost-Benefit Analysis
Costs and Cost Analysis
Disease-Free Survival
56 Citations (Scopus)

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: An international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Jan 1 2018, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
Therapeutics
Safety
1 Citation (Scopus)

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Petrusca, D., Toscani, D., Wang, F. M., Park, C., Crean, C. D., Anderson, J. L., Marino, S., Mohammad, K., Zhou, D., Silbermann, R., Sun, Q., Kurihara, N., Galson, D. L., Giuliani, N. & Roodman, G. D., Oct 4 2018, In : Journal of Hematology and Oncology. 11, 1, 123.

Research output: Contribution to journalArticle

Multiple Myeloma
Osteogenesis
Intercellular Signaling Peptides and Proteins
Survival
Growth
3 Citations (Scopus)

Multiple myeloma and bone: The fatal interaction

Marino, S. & Roodman, G. D., Aug 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 8, a031286.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone
Bone and Bones
Bone Diseases
Spontaneous Fractures
27 Citations (Scopus)

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

zoledronic acid
pamidronate
Medical Oncology
Multiple Myeloma
Practice Guidelines
2 Citations (Scopus)

XRK3F2 inhibition of p62-ZZ domain signaling rescues myeloma-induced GFI1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression

Adamik, J., Silbermann, R., Marino, S., Sun, Q., Anderson, J. L., Zhou, D., Xie, X. Q., Roodman, G. D. & Galson, D. L., Jun 29 2018, In : Frontiers in Endocrinology. 9, JUL, 344.

Research output: Contribution to journalArticle

Epigenetic Repression
Osteoblasts
Mesenchymal Stromal Cells
Histone Deacetylase 1
Tissue Donors
2017
19 Citations (Scopus)

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Adenosine Triphosphatases
zoledronic acid
Bone and Bones
Pain
21 Citations (Scopus)

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 1 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Multiple Myeloma
Epigenomics
Chromatin
Histones
22 Citations (Scopus)

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L., Bellido, T. & Roodman, G. D., Dec 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Pharmacology
Growth
Neoplasms
2016
61 Citations (Scopus)
Osteocytes
Tumor Microenvironment
Multiple Myeloma
Bone Marrow
Cell Proliferation
16 Citations (Scopus)

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Osteogenesis
Bone and Bones
Growth
30 Citations (Scopus)

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Confidence Intervals
Survival
Lost to Follow-Up
15 Citations (Scopus)

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

Storti, P., Marchica, V., Airoldi, I., Donofrio, G., Fiorini, E., Ferri, V., Guasco, D., Todoerti, K., Silbermann, R., Anderson, J. L., Zhao, W., Agnelli, L., Bolzoni, M., Martella, E., Mancini, C., Campanini, N., Noonan, D. M., Petronini, P. G., Neri, A., Aversa, F. & 2 others, Roodman, G. D. & Giuliani, N., Jun 17 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Galectin 1
Multiple Myeloma
Growth
Small Interfering RNA
Down-Regulation
15 Citations (Scopus)

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease

Teramachi, J., Nagata, Y., Mohammad, K., Inagaki, Y., Ohata, Y., Guise, T., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N. & Roodman, G. D., Mar 1 2016, In : Journal of Clinical Investigation. 126, 3, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Bone Resorption
Osteogenesis
Interleukin-6
25 Citations (Scopus)

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Matrix Metalloproteinases
Multiple Myeloma
Bone Diseases
Matrix Metalloproteinase 13
2015
7 Citations (Scopus)

A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation

Girnius, S. K., Lee, S., Kambhampati, S., Rose, M. G., Mohiuddin, A., Houranieh, A., Zimelman, A., Grady, T., Mehta, P., Behler, C., Hayes, T. G., Efebera, Y. A., Prabhala, R. H., Han, A., Yellapragada, S. V., Klein, C. E., Roodman, G. D., Lichtenstein, A. & Munshi, N. C., Apr 1 2015, In : British Journal of Haematology. 169, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Veterans
Multiple Myeloma
Dexamethasone
Peripheral Nervous System Diseases
10 Citations (Scopus)
Osteitis Deformans
Osteoclasts
Bone Marrow Cells
Cultured Cells
Interleukin-6
103 Citations (Scopus)

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

Muscle Weakness
Transforming Growth Factors
Ryanodine Receptor Calcium Release Channel
Muscle
Bone
154 Citations (Scopus)

Role of magnetic resonance imaging in the management of patients with multiple myeloma: A consensus statement

Dimopoulos, M. A., Hillengass, J., Usmani, S., Zamagni, E., Lentzsch, S., Davies, F. E., Raje, N., Sezer, O., Zweegman, S., Shah, J., Badros, A., Shimizu, K., Moreau, P., Chim, C. S., Lahuerta, J. J., Hou, J., Jurczyszyn, A., Goldschmidt, H., Sonneveld, P., Palumbo, A. & 8 others, Ludwig, H., Cavo, M., Barlogie, B., Anderson, K., Roodman, G. D., Rajkumar, S. V., Durie, B. G. M. & Terpos, E., Feb 20 2015, In : Journal of Clinical Oncology. 33, 6, p. 657-664 8 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Magnetic Resonance Imaging
Bone and Bones
Spinal Nerves
Osteoporotic Fractures
4 Citations (Scopus)

Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption

Feng, R., Tong, Q., Xie, Z., Cheng, H., Wang, L., Lentzsch, S., Roodman, G. D. & Xie, X. Q., Dec 1 2015, In : Molecular Carcinogenesis. 54, 12, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cytoskeleton
Multiple Myeloma
rimonabant
Transcription Factor CHOP
2014
11 Citations (Scopus)

Advances in supportive care for multiple myeloma

Raje, N. S., Yee, A. J. & Roodman, G. D., 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 4, p. 502-511 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Diseases
Diphosphonates
Peripheral Nervous System Diseases
Appointments and Schedules
6 Citations (Scopus)

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

Bon, J., Kahloon, R., Zhang, Y., Xue, J., Fuhrman, C. R., Tan, J., Burger, M., Kass, D. J., Csizmadia, E., Otterbein, L., Chandra, D., Bhargava, A., Pilewski, J. M., Roodman, G. D., Sciurba, F. C. & Duncan, S. R., 2014, In : PLoS One. 9, 9, p. e105066

Research output: Contribution to journalArticle

osteoporosis
Emphysema
Osteoporosis
glucose
autoantibodies
32 Citations (Scopus)

Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma

Silbermann, R., Bolzoni, M., Storti, P., Guasco, D., Bonomini, S., Zhou, D., Wu, J., Anderson, J. L., Windle, J. J., Aversa, F., Roodman, G. D. & Giuliani, N., 2014, In : Leukemia. 28, 4, p. 951-954 4 p.

Research output: Contribution to journalArticle

RANK Ligand
Activins
Interleukin-3
Bone Diseases
Osteoclasts
2 Citations (Scopus)

CCN1: A sticky issue in myeloma

Roodman, G. D., Sep 25 2014, In : Blood. 124, 13, p. 2006-2008 3 p.

Research output: Contribution to journalArticle

Blood
Disease-Free Survival
Bone Marrow
Survival
Therapeutics
12 Citations (Scopus)

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone

Teramachi, J., Zhou, H., Subler, M. A., Kitagawa, Y., Galson, D. L., Dempster, D. W., Windle, J. J., Kurihara, N. & Roodman, G. D., 2014, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Osteoclasts
Interleukin-6
Bone and Bones
Transgenic Mice
49 Citations (Scopus)

Management of bone disease in multiple myeloma

Terpos, E., Berenson, J., Raje, N. & Roodman, G. D., Feb 2014, In : Expert Review of Hematology. 7, 1, p. 113-125 13 p.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
pamidronate
Diphosphonates
150 Citations (Scopus)

New drugs and novel mechanisms of action in multiple myeloma in 2013: A report from the International Myeloma Working Group (IMWG)

Ocio, E. M., Richardson, P. G., Rajkumar, S. V., Palumbo, A., Mateos, M. V., Orlowski, R., Kumar, S., Usmani, S., Roodman, G. D., Niesvizky, R., Einsele, H., Anderson, K. C., Dimopoulos, M. A., Avet-Loiseau, H., Mellqvist, U. H., Turesson, I., Merlini, G., Schots, R., Mccarthy, P., Bergsagel, L. & 14 others, Chim, C. S., Lahuerta, J. J., Shah, J., Reiman, A., Mikhael, J., Zweegman, S., Lonial, S., Comenzo, R., Chng, W. J., Moreau, P., Sonneveld, P., Ludwig, H., Durie, B. G. M. & Miguel, J. F. S., 2014, In : Leukemia. 28, 3, p. 525-542 18 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Pharmaceutical Preparations
Dexamethasone
Unfolded Protein Response
Kinesin
19 Citations (Scopus)

Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (Bolus) infusion schedule of alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms

Holkova, B., Kmieciak, M., Perkins, E. B., Bose, P., Baz, R. C., Roodman, G. D., Stuart, R. K., Ramakrishnan, V., Wan, W., Peer, C. J., Dawson, J., Kang, L., Honeycutt, C., Tombes, M. B., Shrader, E., Weir-Wiggins, C., Wellons, M., Sankala, H., Hogan, K. T., Colevas, A. D. & 6 others, Doyle, L. A., Figg, W. D., Coppola, D., Roberts, J. D., Sullivan, D. & Grant, S., Nov 15 2014, In : Clinical Cancer Research. 20, 22, p. 5652-5662 11 p.

Research output: Contribution to journalArticle

alvocidib
Appointments and Schedules
B-Lymphocytes
Maximum Tolerated Dose
Neoplasms
30 Citations (Scopus)
Osteocytes
Bone Diseases
Multiple Myeloma
Osteogenesis
Bone and Bones
14 Citations (Scopus)
Osteoclasts
Phosphotransferases
Monocytes
Interleukin-6
Bone Marrow
34 Citations (Scopus)

Whole-body low-dose computed tomography and advanced imaging techniques for multiple myeloma bone disease

Pianko, M. J., Terpos, E., Roodman, G. D., Divgi, C. R., Zweegman, S., Hillengass, J. & Lentzsch, S., Dec 1 2014, In : Clinical Cancer Research. 20, 23, p. 5888-5897 10 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Tomography
X-Rays
Radiography
2013
30 Citations (Scopus)

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Cao, H., Zhu, K., Qiu, L., Li, S., Niu, H., Hao, M., Yang, S., Zhao, Z., Lai, Y., Anderson, J. L., Fan, J., Im, H. J., Chen, D., Roodman, G. D. & Xiao, G., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30399-30410 12 p.

Research output: Contribution to journalArticle

Myeloma Proteins
Osteolysis
Osteoclasts
Bone
Proteins
55 Citations (Scopus)

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

Storti, P., Bolzoni, M., Donofrio, G., Airoldi, I., Guasco, D., Toscani, D., Martella, E., Lazzaretti, M., Mancini, C., Agnelli, L., Patrene, K., Maïga, S., Franceschi, V., Colla, S., Anderson, J., Neri, A., Amiot, M., Aversa, F., Roodman, G. D. & Giuliani, N., Aug 2013, In : Leukemia. 27, 8, p. 1697-1706 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Multiple Myeloma
Bone and Bones
Growth
Vascular Endothelial Growth Factors
187 Citations (Scopus)

International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease.

Terpos, E., Morgan, G., Dimopoulos, M. A., Drake, M. T., Lentzsch, S., Raje, N., Sezer, O., García-Sanz, R., Shimizu, K., Turesson, I., Reiman, T., Jurczyszyn, A., Merlini, G., Spencer, A., Leleu, X., Cavo, M., Munshi, N., Rajkumar, S. V., Durie, B. G. M. & Roodman, G. D., Jun 20 2013, In : Journal of Clinical Oncology. 31, 18, p. 2347-2357 11 p.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
pamidronate
Diphosphonates
13 Citations (Scopus)

Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling

Wang, F. M., Sarmasik, A., Hiruma, Y., Sun, Q., Sammut, B., Windle, J. J., Roodman, G. D. & Galson, D. L., Mar 2013, In : Bone. 53, 1, p. 269-276 8 p.

Research output: Contribution to journalArticle

Interleukin-6
Down-Regulation
Osteoclasts
measles virus nucleocapsid protein
Messenger RNA
26 Citations (Scopus)

Myeloma bone disease: Pathophysiology and management

Silbermann, R. & Roodman, G. D., Jun 2013, In : Journal of Bone Oncology. 2, 2, p. 59-69 11 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoclasts
Disease Management
Osteoblasts
Bone and Bones
24 Citations (Scopus)

Optimal use of bisphosphonates in patients with multiple myeloma.

Terpos, E., Roodman, G. D. & Dimopoulos, M. A., Apr 25 2013, In : Blood. 121, 17, p. 3325-3328 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D. & Kurihara, N., Jun 2013, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 28, 6, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Activating Transcription Factors
Osteoclasts
Vitamin D
Hypersensitivity
2012
43 Citations (Scopus)

Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment

D'Souza, S., Kurihara, N., Shiozawa, Y., Joseph, J., Taichman, R., Galson, D. L. & Roodman, G. D., Feb 23 2012, In : Blood. 119, 8, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

Annexin A2
Cell adhesion
Cell growth
Multiple Myeloma
Cell Adhesion
103 Citations (Scopus)

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

Kovacs, J. R., Li, C., Yang, Q., Li, G., Garcia, I. G., Ju, S., Roodman, G. D., Windle, J. J., Zhang, X. & Lu, B., Jan 2012, In : Cell Death and Differentiation. 19, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

Autophagy
Proteolysis
Cell Survival
Cell Death
T-Lymphocytes
88 Citations (Scopus)

Combination of bendamustine, lenalidomide, anddexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: Results of phase 1/2 open-label, doseescalation study

Lentzsch, S., O'Sullivan, A., Kennedy, R. C., Abbas, M., Dai, L., Pregja, S. L., Burt, S., Boyiadzis, M., Roodman, G. D., Mapara, M. Y., Agha, M., Waas, J., Shuai, Y., Normolle, D. & Zonder, J. A., May 17 2012, In : Blood. 119, 20, p. 4608-4613 6 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Multiple Myeloma
Refractory materials
Dexamethasone
Disease-Free Survival
41 Citations (Scopus)

Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation

Xu, G., Liu, K., Anderson, J., Patrene, K., Lentzsch, S., Roodman, G. D. & Ouyang, H., May 3 2012, In : Blood. 119, 18, p. 4205-4214 10 p.

Research output: Contribution to journalArticle

Cell growth
Osteoclasts
Multiple Myeloma
Mesenchymal Stromal Cells
Stromal Cells
40 Citations (Scopus)

Genes associate with abnormal bone cell activity in bone metastasis

Roodman, G. D., Dec 2012, In : Cancer and Metastasis Reviews. 31, 3-4, p. 569-578 10 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Genes
Neoplasms
Breast Neoplasms
28 Citations (Scopus)

Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors

Yang, P., Myint, K. Z., Tong, Q., Feng, R., Cao, H., Almehizia, A. A., Alqarni, M. H., Wang, L., Bartlow, P., Gao, Y., Gertsch, J., Teramachi, J., Kurihara, N., Roodman, G. D., Cheng, T. & Xie, X. Q., Nov 26 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 9973-9987 15 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Osteoclasts
Osteogenesis
Biological Assay
Databases
4 Citations (Scopus)

Vitamin E: Good for the heart, bad for the bones?

Roodman, G. D., Apr 2012, In : Nature Medicine. 18, 4, p. 491-492 2 p.

Research output: Contribution to journalArticle

Vitamin E Deficiency
Osteoclasts
Bone Resorption
Vitamin E
Vitamins
2011
25 Citations (Scopus)

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 2011, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone and Bones
Knockout Mice
Tumor Necrosis Factor-alpha
TNF Receptor-Associated Factor 6
108 Citations (Scopus)

Advances in the biology and treatment of bone disease in multiple myeloma

Raje, N. & Roodman, G. D., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Diseases
Osteoclasts
Osteoblasts
Multiple Myeloma
29 Citations (Scopus)

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2

Research output: Contribution to journalArticle

Stem Cell Niche
Annexins
Chemokine CXCL12
Hematopoietic Stem Cells
Stem Cells