G. David Roodman

  • 23363 Citations
  • 80 h-Index
1975 …2020
If you made any changes in Pure, your changes will be visible here soon.

Publications 1975 2019

Filter
Article
44 Citations (Scopus)
Calcitriol Receptors
Osteoclasts
Bone Resorption
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
232 Citations (Scopus)

1,25-dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow

Roodman, G. D., Ibbotson, K. J., MacDonald, B. R., Kuehl, T. J. & Mundy, G. R., Dec 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 23, p. 8213-8217 5 p.

Research output: Contribution to journalArticle

Calcitriol
Osteoclasts
Primates
Bone Marrow
Calcitonin
80 Citations (Scopus)

1,25-dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease

Menaa, C., Barsony, J., Reddy, S. V., Cornish, J., Cundy, T. & Roodman, G. D., Feb 24 2000, In : Journal of Bone and Mineral Research. 15, 2, p. 228-236 9 p.

Research output: Contribution to journalArticle

Calcitriol
Osteoclasts
Hypersensitivity
Stromal Cells
RANK Ligand
13 Citations (Scopus)

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Ishizuka, S., Kurihara, N., Hiruma, Y., Miura, D., Namekawa, J. I., Tamura, A., Kato-Nakamura, Y., Nakano, Y., Takenouchi, K., Hashimoto, Y., Nagasawa, K. & Roodman, G. D., Jun 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 3-5, p. 269-277 9 p.

Research output: Contribution to journalArticle

Lactams
Calcitriol Receptors
Calcitriol
Rodentia
HL-60 Cells
76 Citations (Scopus)

5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices

Gallwitz, W. E., Mundy, G. R., Lee, C. H., Qiao, M., Roodman, G. D., Raftery, M., Gaskell, S. J. & Bonewald, L. F., Jan 1 1993, In : Journal of Biological Chemistry. 268, 14, p. 10087-10094 8 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Osteoclasts
Metabolites
Arachidonic Acid
Bone
64 Citations (Scopus)

Abnormalities in osteoclast precursors and marrow accessory cells in paget’s disease

Demulder, A., Takahashi, S., Singer, F. R., Hosking, D. J. & Roodman, G. D., Nov 1993, In : Endocrinology. 133, 5, p. 1978-1982 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
Calcitriol
CD34 Antigens
3 Citations (Scopus)

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., Mar 6 2018, (Accepted/In press) In : Journal of Medical Economics. p. 1-12 12 p.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Cost-Benefit Analysis
Costs and Cost Analysis
Disease-Free Survival
46 Citations (Scopus)

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D. & Xiao, G., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
Osteoclasts
Macrophage Colony-Stimulating Factor
Osteogenesis
Transcription Factors
87 Citations (Scopus)

ADAM8: A novel osteoclast stimulating factor

Choi, S. J., Han, J. H. & Roodman, G. D., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 5, p. 814-822 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Disintegrins
Conditioned Culture Medium
Complementary DNA
Bone Marrow
25 Citations (Scopus)

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 1 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone and Bones
Knockout Mice
Tumor Necrosis Factor-alpha
TNF Receptor-Associated Factor 6
11 Citations (Scopus)

Advances in supportive care for multiple myeloma

Raje, N. S., Yee, A. J. & Roodman, G. D., Jan 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 4, p. 502-511 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Diseases
Diphosphonates
Peripheral Nervous System Diseases
Appointments and Schedules
11 Citations (Scopus)

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T. A., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6209s-6212s

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Natural History
Neoplasm Metastasis
Research
36 Citations (Scopus)

AML-1A and AML-1B regulation of MIP-1α expression in multiple myeloma

Choi, S. J., Oba, T., Callander, N. S., Jelinek, D. F. & Roodman, G. D., May 15 2003, In : Blood. 101, 10, p. 3778-3783 6 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Multiple Myeloma
Acute Myeloid Leukemia
Messenger RNA
Bone
27 Citations (Scopus)

A murine model of inflammatory bone disease

Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L. & Roodman, G. D., Feb 1 2000, In : Bone. 26, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone Marrow
Osteoclasts
Chromosomes, Human, Pair 18
Bone and Bones

Animal models of bone disease

David Roodman, G., Dec 1 1998, In : Cancer Research Therapy and Control. 6, 1-4, p. 89-90 2 p.

Research output: Contribution to journalArticle

Bone Diseases
Animal Models
8 Citations (Scopus)

An in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Jan 1 1995, In : STEM CELLS. 13, SUPPL. 2, p. 48-50 3 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Hypercalcemia
Bone and Bones
Severe Combined Immunodeficiency
31 Citations (Scopus)

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2, p. 151-166.e1

Research output: Contribution to journalArticle

Stem Cell Niche
Annexins
Chemokine CXCL12
Hematopoietic Stem Cells
Stem Cells
147 Citations (Scopus)

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

Shiozawa, Y., Havens, A. M., Jung, Y., Ziegler, A. M., Pedersen, E. A., Wang, J., Wang, J., Lu, G., Roodman, G. D., Loberg, R. D., Pienta, K. J. & Taichman, R. S., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

Annexin A2
Prostatic Neoplasms
Adhesion
Growth
Osteoblasts
81 Citations (Scopus)

Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures

Menaa, C., Devlin, R. D., Reddy, S. V., Gazitt, Y., Choi, S. J. & Roodman, G. D., Jun 1999, In : Journal of Clinical Investigation. 103, 11, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

Open Access
Annexin A2
Osteoclasts
Bone Marrow
Granulocyte-Macrophage Colony-Stimulating Factor
T-Lymphocytes
43 Citations (Scopus)

Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment

D'Souza, S., Kurihara, N., Shiozawa, Y., Joseph, J., Taichman, R., Galson, D. L. & Roodman, G. D., Feb 23 2012, In : Blood. 119, 8, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

Annexin A2
Cell adhesion
Cell growth
Multiple Myeloma
Cell Adhesion
44 Citations (Scopus)

Annexin II stimulates RANKL expression through MAPK

Li, F., Chung, H. Y., Reddy, S. V., Lu, G., Kurihara, N., Zhao, A. Z. & Roodman, G. D., Jul 1 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1161-1167 7 p.

Research output: Contribution to journalArticle

Annexin A2
Granulocyte-Macrophage Colony-Stimulating Factor
Osteoclasts
Osteoprotegerin
Bone Marrow Cells
113 Citations (Scopus)

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

Lymphocytes
Interleukin-17
Bone Diseases
Multiple Myeloma
Bone
50 Citations (Scopus)

Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma

Gao, S. J., Alsina, M., Deng, J. H., Harrison, C. R., Montalvo, E. A., Leach, C. T., David Roodman, G. & Jenson, H. B., Jan 1 1998, In : Journal of Infectious Diseases. 178, 3, p. 846-849 4 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Multiple Myeloma
Antibodies
Blood Donors
Neoplasms
183 Citations (Scopus)

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

Choi, S. J., Oba, Y., Gazitt, Y., Alsina, M., Cruz, J., Anderson, J. & David Roodman, G., Dec 1 2001, In : Journal of Clinical Investigation. 108, 12, p. 1833-1841 9 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Bone Diseases
Multiple Myeloma
Bone and Bones
Osteoclasts
7 Citations (Scopus)

A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors

Adkins, D. R., Irvin, R., Kuhn, J., Boldt, D. H., Roodman, G. D., Salzman, D., Freytes, C., Von Hoff, D. D. & LeMaistre, C. F., Jun 1 1993, In : Investigational New Drugs. 11, 2-3, p. 169-179 11 p.

Research output: Contribution to journalArticle

Dacarbazine
Autologous Transplantation
Bone Marrow Transplantation
Pharmacology
Neoplasms
3 Citations (Scopus)

A phase I-II clinical trial with a combination of gemcitabine (GEMZAR) and paclitaxel (TAXOL) for the treatment of refractory multiple myeloma (MM) patients

Gazitt, Y., Roodman, D., Freytes, C., Shaughnessy, P., Callander, N., Traynor, A. & Rothenberg, M., Dec 1 2000, In : Blood. 96, 11 PART II, p. 287b

Research output: Contribution to journalArticle

gemcitabine
Phase II Clinical Trials
Clinical Trials, Phase I
Paclitaxel
Multiple Myeloma
8 Citations (Scopus)

A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation

Girnius, S. K., Lee, S., Kambhampati, S., Rose, M. G., Mohiuddin, A., Houranieh, A., Zimelman, A., Grady, T., Mehta, P., Behler, C., Hayes, T. G., Efebera, Y. A., Prabhala, R. H., Han, A., Yellapragada, S. V., Klein, C. E., Roodman, G. D., Lichtenstein, A. & Munshi, N. C., Apr 1 2015, In : British journal of haematology. 169, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Veterans
Multiple Myeloma
Dexamethasone
Peripheral Nervous System Diseases
1 Citation (Scopus)

Aplastic Anemia Associated With Rubber Cement Used by a Marathon Runner

Roodman, G. D., Reese, E. P. & Cardamone, J. M., May 1980, In : Archives of Internal Medicine. 140, 5, 1 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Rubber
Foot
Benzene
Adhesives

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Dexamethasone
Bone Development
Osteoblasts
10 Citations (Scopus)
Osteitis Deformans
Osteoclasts
Bone Marrow Cells
Cultured Cells
Interleukin-6
1 Citation (Scopus)

ASCO 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma: Guideline summary

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, D. G., Twilde, P. & Anderson, K., Jul 1 2007, In : Journal of Oncology Practice. 3, 4, 1 p.

Research output: Contribution to journalArticle

Diphosphonates
Multiple Myeloma
Practice Guidelines
Guidelines
62 Citations (Scopus)

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment

Hiruma, Y., Kurihara, N., Subler, M. A., Zhou, H., Boykin, C. S., Zhang, H., Ishizuka, S., Dempster, D. W., Roodman, G. D. & Windle, J. J., Nov 19 2008, In : Human molecular genetics. 17, 23, p. 3708-3719 12 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Osteoclasts
Stromal Cells
Bone and Bones
Mutation
10 Citations (Scopus)

Assays for Bone Resorption and Bone Formation

Mundy, G. R., Roodman, G. D., Bonewald, L. F., Oreffo, R. O. C. & Boyce, B. F., Jan 1 1991, In : Methods in Enzymology. 198, C, p. 502-510 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Assignment of matrix metalloproteinase 9 (Mmp9) to mouse Chromosome 2 bands H1-H2

DuPont, B. R., Linn, R., Knight, C. B., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A., Fournier, R. E. K. & Leach, R. J., Jan 1 1996, In : Cytogenetic and Genome Research. 74, 1-2, p. 118-119 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Assignment of OSTF1 to human chromosome bands 12q24.1 → q24.2 by in situ hybridization

Schaub, R., Dupont, B., Roodman, G. D., Leach, R. J. & Reddy, S. V., Apr 11 2000, In : Cytogenetics and Cell Genetics. 88, 1-2, p. 87-88 2 p.

Research output: Contribution to journalArticle

Physical Chromosome Mapping
Chromosome Banding
Chromosomes, Human, Pair 12
Hybrid Cells
Human Chromosomes
14 Citations (Scopus)

Assignment of the mouse tartrate-resistant acid phosphatase gene (acp5) to chromosome 9

Grimes, R., Reddy, S. V., Leach, R. J., Scarcez, T., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A. & Windle, J. J., Feb 1993, In : Genomics. 15, 2, p. 421-422 2 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Hybrid Cells
Human Chromosomes
Osteoclasts
Bone Resorption
67 Citations (Scopus)

Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease

Kukita, A., Chenu, C., McManus, L. M., Mundy, G. R. & Roodman, G. D., Jan 1 1990, In : Journal of Clinical Investigation. 85, 4, p. 1280-1286 7 p.

Research output: Contribution to journalArticle

Open Access
Osteoclasts
Bone Marrow
Ergocalciferols
Bone and Bones
Cell Nucleus
7 Citations (Scopus)

Autoimmune pancytopenia: Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro

David Roodman, G., Ascensao, J. L., Banisadre, M., Bloom, P. M. & Zanjani, E. D., Jan 1 1980, In : American Journal of Medicine. 69, 2, p. 325-328 4 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Pancytopenia
Bone Development
Bone Marrow
Lymphocytes
107 Citations (Scopus)

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

Kovacs, J. R., Li, C., Yang, Q., Li, G., Garcia, I. G., Ju, S., Roodman, D. G., Windle, J. J., Zhang, X. & Lu, B., Jan 1 2012, In : Cell Death and Differentiation. 19, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

Autophagy
Proteolysis
Cell Survival
Cell Death
T-Lymphocytes
6 Citations (Scopus)

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

Bon, J., Kahloon, R., Zhang, Y., Xue, J., Fuhrman, C. R., Tan, J., Burger, M., Kass, D. J., Csizmadia, E., Otterbein, L., Chandra, D., Bhargava, A., Pilewski, J. M., Roodman, G. D., Sciurba, F. C. & Duncan, S. R., Sep 2014, In : PLoS ONE. 9, 9, e105066.

Research output: Contribution to journalArticle

osteoporosis
Emphysema
Osteoporosis
glucose
autoantibodies
64 Citations (Scopus)
Osteocytes
Tumor Microenvironment
Multiple Myeloma
Bone Marrow
Cell Proliferation
238 Citations (Scopus)

Biology of osteoclast activation in cancer

Roodman, G. D., Aug 1 2001, In : Journal of Clinical Oncology. 19, 15, p. 3562-3571 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Receptor Activator of Nuclear Factor-kappa B
Bone and Bones
Neoplasms
Osteogenesis
4 Citations (Scopus)

Biology of the osteoclast in Paget's disease

Roodman, G. D., Feb 1994, In : Seminars in Arthritis and Rheumatism. 23, 4, p. 235-236 2 p.

Research output: Contribution to journalArticle

Viral Inclusion Bodies
Osteitis Deformans
Osteoclasts
Cell Division
Interleukin-6
856 Citations (Scopus)

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, D. G., Mundy, G. R. & Boyce, B. F., Oct 1995, In : Journal of Bone and Mineral Research. 10, 10, p. 1478-1487 10 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoclasts
Apoptosis
Bone Resorption
pamidronate
16 Citations (Scopus)

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Osteogenesis
Bone and Bones
Growth
99 Citations (Scopus)
Nucleocapsid
Measles virus
Viruses
Bone Marrow Cells
Osteoclasts
21 Citations (Scopus)

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Adenosine Triphosphatases
zoledronic acid
Bone and Bones
Pain
47 Citations (Scopus)

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells

Pal, R., Janz, M., Galson, D. L., Gries, M., Li, S., Jöhrens, K., Anagnostopoulos, I., Dörken, B., Mapara, M. Y., Borghesi, L., Kardava, L., David Roodman, G., Milcarek, C. & Lentzsch, S., Oct 29 2009, In : Blood. 114, 18, p. 3890-3898 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Multiple Myeloma
Transcription Factors
Cells
B-Cell Lymphoma
42 Citations (Scopus)

Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation

Mbalaviele, G., Nishimura, R., Myoi, A., Niewolna, M., Reddy, S. V., Chen, D., Feng, J., Roodman, D., Mundy, G. R. & Yoneda, T., Jun 15 1998, In : Journal of Cell Biology. 141, 6, p. 1467-1476 10 p.

Research output: Contribution to journalArticle

Cell Lineage
Osteoclasts
Stromal Cells
Cadherins
Protein Isoforms
47 Citations (Scopus)

Cell biology of Paget's disease

Reddy, S. V., Menaa, C., Singer, F. R., Demulder, A. & Roodman, G. D., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, SUPPL. 2, p. 3-8 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Cell Biology
Bone Marrow
Interleukin-6
Calcitriol Receptors