G. David Roodman

  • 23998 Citations
  • 81 h-Index
1975 …2020

Research output per year

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Publications

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48 Scopus citations

1,25-dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow

Roodman, G. D., Ibbotson, K. J., MacDonald, B. R., Kuehl, T. J. & Mundy, G. R., Dec 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 23, p. 8213-8217 5 p.

Research output: Contribution to journalArticle

232 Scopus citations

1,25-dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease

Menaa, C., Barsony, J., Reddy, S. V., Cornish, J., Cundy, T. & Roodman, G. D., Jan 1 2000, In : Journal of Bone and Mineral Research. 15, 2, p. 228-236 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Ishizuka, S., Kurihara, N., Hiruma, Y., Miura, D., Namekawa, J. I., Tamura, A., Kato-Nakamura, Y., Nakano, Y., Takenouchi, K., Hashimoto, Y., Nagasawa, K. & Roodman, G. D., Jun 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 3-5, p. 269-277 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices

Gallwitz, W. E., Mundy, G. R., Lee, C. H., Qiao, M., Roodman, G. D., Raftery, M., Gaskell, S. J. & Bonewald, L. F., Jan 1 1993, In : Journal of Biological Chemistry. 268, 14, p. 10087-10094 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Abnormalities in osteoclast precursors and marrow accessory cells in paget’s disease

Demulder, A., Takahashi, S., Singer, F. R., Hosking, D. J. & Roodman, G. D., Nov 1993, In : Endocrinology. 133, 5, p. 1978-1982 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., May 4 2018, In : Journal of Medical Economics. 21, 5, p. 525-536 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D. & Xiao, G., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

ADAM8: A novel osteoclast stimulating factor

Choi, S. J., Han, J. H. & Roodman, G. D., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 5, p. 814-822 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Advances in supportive care for multiple myeloma

Raje, N. S., Yee, A. J. & Roodman, G. D., Jan 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 4, p. 502-511 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T. A., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6209s-6212s

Research output: Contribution to journalArticle

11 Scopus citations

AML-1A and AML-1B regulation of MIP-1α expression in multiple myeloma

Choi, S. J., Oba, T., Callander, N. S., Jelinek, D. F. & Roodman, G. D., May 15 2003, In : Blood. 101, 10, p. 3778-3783 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

A murine model of inflammatory bone disease

Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L. & Roodman, G. D., Feb 1 2000, In : Bone. 26, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Animal models of bone disease

David Roodman, G., Dec 1 1998, In : Cancer Research Therapy and Control. 6, 1-4, p. 89-90 2 p.

Research output: Contribution to journalArticle

An in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Jan 1 1995, In : STEM CELLS. 13, SUPPL. 2, p. 48-50 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2, p. 151-166.e1

Research output: Contribution to journalArticle

33 Scopus citations

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

Shiozawa, Y., Havens, A. M., Jung, Y., Ziegler, A. M., Pedersen, E. A., Wang, J., Wang, J., Lu, G., Roodman, G. D., Loberg, R. D., Pienta, K. J. & Taichman, R. S., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

159 Scopus citations

Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures

Menaa, C., Devlin, R. D., Reddy, S. V., Gazitt, Y., Choi, S. J. & Roodman, G. D., Jun 1999, In : Journal of Clinical Investigation. 103, 11, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment

D'Souza, S., Kurihara, N., Shiozawa, Y., Joseph, J., Taichman, R., Galson, D. L. & Roodman, G. D., Feb 23 2012, In : Blood. 119, 8, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Annexin II stimulates RANKL expression through MAPK

Li, F., Chung, H. Y., Reddy, S. V., Lu, G., Kurihara, N., Zhao, A. Z. & Roodman, G. D., Jul 1 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1161-1167 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma

Gao, S. J., Alsina, M., Deng, J. H., Harrison, C. R., Montalvo, E. A., Leach, C. T., David Roodman, G. & Jenson, H. B., Jan 1 1998, In : Journal of Infectious Diseases. 178, 3, p. 846-849 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

Choi, S. J., Oba, Y., Gazitt, Y., Alsina, M., Cruz, J., Anderson, J. & David Roodman, G., Dec 1 2001, In : Journal of Clinical Investigation. 108, 12, p. 1833-1841 9 p.

Research output: Contribution to journalArticle

184 Scopus citations

A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors

Adkins, D. R., Irvin, R., Kuhn, J., Boldt, D. H., Roodman, G. D., Salzman, D., Freytes, C., Von Hoff, D. D. & LeMaistre, C. F., Jun 1 1993, In : Investigational New Drugs. 11, 2-3, p. 169-179 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

A phase I-II clinical trial with a combination of gemcitabine (GEMZAR) and paclitaxel (TAXOL) for the treatment of refractory multiple myeloma (MM) patients

Gazitt, Y., Roodman, D., Freytes, C., Shaughnessy, P., Callander, N., Traynor, A. & Rothenberg, M., Dec 1 2000, In : Blood. 96, 11 PART II, p. 287b

Research output: Contribution to journalArticle

3 Scopus citations

A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation

Girnius, S. K., Lee, S., Kambhampati, S., Rose, M. G., Mohiuddin, A., Houranieh, A., Zimelman, A., Grady, T., Mehta, P., Behler, C., Hayes, T. G., Efebera, Y. A., Prabhala, R. H., Han, A., Yellapragada, S. V., Klein, C. E., Roodman, G. D., Lichtenstein, A. & Munshi, N. C., Apr 1 2015, In : British journal of haematology. 169, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Aplastic Anemia Associated With Rubber Cement Used by a Marathon Runner

Roodman, G. D., Reese, E. P. & Cardamone, J. M., May 1980, In : Archives of Internal Medicine. 140, 5, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
10 Scopus citations

ASCO 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma: Guideline summary

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, D. G., Twilde, P. & Anderson, K., Jul 1 2007, In : Journal of Oncology Practice. 3, 4, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment

Hiruma, Y., Kurihara, N., Subler, M. A., Zhou, H., Boykin, C. S., Zhang, H., Ishizuka, S., Dempster, D. W., Roodman, G. D. & Windle, J. J., Nov 19 2008, In : Human molecular genetics. 17, 23, p. 3708-3719 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Assays for Bone Resorption and Bone Formation

Mundy, G. R., Roodman, G. D., Bonewald, L. F., Oreffo, R. O. C. & Boyce, B. F., Jan 1 1991, In : Methods in Enzymology. 198, C, p. 502-510 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Assignment of matrix metalloproteinase 9 (Mmp9) to mouse Chromosome 2 bands H1-H2

DuPont, B. R., Linn, R., Knight, C. B., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A., Fournier, R. E. K. & Leach, R. J., Jan 1 1996, In : Cytogenetic and Genome Research. 74, 1-2, p. 118-119 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Assignment of OSTF1 to human chromosome bands 12q24.1 → q24.2 by in situ hybridization

Schaub, R., Dupont, B., Roodman, G. D., Leach, R. J. & Reddy, S. V., Apr 11 2000, In : Cytogenetics and Cell Genetics. 88, 1-2, p. 87-88 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Assignment of the mouse tartrate-resistant acid phosphatase gene (acp5) to chromosome 9

Grimes, R., Reddy, S. V., Leach, R. J., Scarcez, T., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A. & Windle, J. J., Feb 1993, In : Genomics. 15, 2, p. 421-422 2 p.

Research output: Contribution to journalArticle

14 Scopus citations

Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease

Kukita, A., Chenu, C., McManus, L. M., Mundy, G. R. & Roodman, G. D., 1990, In : Journal of Clinical Investigation. 85, 4, p. 1280-1286 7 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Autoimmune pancytopenia: Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro

David Roodman, G., Ascensao, J. L., Banisadre, M., Bloom, P. M. & Zanjani, E. D., Jan 1 1980, In : American Journal of Medicine. 69, 2, p. 325-328 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

Kovacs, J. R., Li, C., Yang, Q., Li, G., Garcia, I. G., Ju, S., Roodman, D. G., Windle, J. J., Zhang, X. & Lu, B., Jan 2012, In : Cell Death and Differentiation. 19, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

Bon, J., Kahloon, R., Zhang, Y., Xue, J., Fuhrman, C. R., Tan, J., Burger, M., Kass, D. J., Csizmadia, E., Otterbein, L., Chandra, D., Bhargava, A., Pilewski, J. M., Roodman, G. D., Sciurba, F. C. & Duncan, S. R., Sep 2014, In : PloS one. 9, 9, e105066.

Research output: Contribution to journalArticle

7 Scopus citations

Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma

Delgado-Calle, J., Anderson, J., Cregor, M. D., Hiasa, M., Chirgwin, J. M., Carlesso, N., Yoneda, T., Mohammad, K. S., Plotkin, L. I., Roodman, G. D. & Bellido, T., Mar 1 2016, In : Cancer Research. 76, 5, p. 1089-1100 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Biology of osteoclast activation in cancer

Roodman, G. D., Aug 1 2001, In : Journal of Clinical Oncology. 19, 15, p. 3562-3571 10 p.

Research output: Contribution to journalArticle

240 Scopus citations

Biology of the osteoclast in Paget's disease

Roodman, G. D., Feb 1994, In : Seminars in Arthritis and Rheumatism. 23, 4, p. 235-236 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, D. G., Mundy, G. R. & Boyce, B. F., Oct 1995, In : Journal of Bone and Mineral Research. 10, 10, p. 1478-1487 10 p.

Research output: Contribution to journalArticle

864 Scopus citations

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K. S., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
101 Scopus citations

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. A. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells

Pal, R., Janz, M., Galson, D. L., Gries, M., Li, S., Jöhrens, K., Anagnostopoulos, I., Dörken, B., Mapara, M. Y., Borghesi, L., Kardava, L., David Roodman, G., Milcarek, C. & Lentzsch, S., Oct 29 2009, In : Blood. 114, 18, p. 3890-3898 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation

Mbalaviele, G., Nishimura, R., Myoi, A., Niewolna, M., Reddy, S. V., Chen, D., Feng, J., Roodman, D., Mundy, G. R. & Yoneda, T., Jun 15 1998, In : Journal of Cell Biology. 141, 6, p. 1467-1476 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cell biology of Paget's disease

Reddy, S. V., Menaa, C., Singer, F. R., Demulder, A. & Roodman, G. D., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, SUPPL. 2, p. 3-8 6 p.

Research output: Contribution to journalArticle

48 Scopus citations