G. David Roodman

  • 24196 Citations
  • 81 h-Index
1975 …2020

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International myeloma working group recommendations for the treatment of multiple myeloma-related bone disease

Terpos, E., Morgan, G., Dimopoulos, M. A., Drake, M. T., Lentzsch, S., Raje, N., Sezer, O., García-Sanz, R., Shimizu, K., Turesson, I., Reiman, T., Jurczyszyn, A., Merlini, G., Spencer, A., Leleu, X., Cavo, M., Munshi, N., Rajkumar, S. V., Durie, B. G. M. & Roodman, G. D., Jun 20 2013, In : Journal of Clinical Oncology. 31, 18, p. 2347-2357 11 p.

Research output: Contribution to journalArticle

205 Scopus citations

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo

De La Mata, J., Uy, H. L., Guise, T. A., Story, B., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Jun 1995, In : Journal of Clinical Investigation. 95, 6, p. 2846-2852 7 p.

Research output: Contribution to journalArticle

Open Access
215 Scopus citations

Interleukin‐6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone

Reddy, S. V., Takahashi, S., Dallas, M., Williams, R. E., Neckers, L. & Roodman, G. D., May 1994, In : Journal of Bone and Mineral Research. 9, 5, p. 753-757 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

Interleukin-6: A potential mediator of the massive osteolysis in patients with Gorham-Stout disease

Devlin, R. D., Bone, H. G. & Roodman, G. D., May 21 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 5, p. 1893-1897 5 p.

Research output: Contribution to journalArticle

153 Scopus citations

Interleukin 6: A potential autocrine/paracrine factor in Paget's disease of bone

Roodman, G. D., Kurihara, N., Ohsaki, Y., Kukita, A., Hosking, D., Demulder, A., Smith, J. F. & Singer, F. R., 1992, In : Journal of Clinical Investigation. 89, 1, p. 46-52 7 p.

Research output: Contribution to journalArticle

Open Access
311 Scopus citations

Interleukin-3: Its biology and potential uses in pediatric hematology/oncology

Sunderland, M. C. & Roodman, G. D., Jan 1 1991, In : Journal of Pediatric Hematology/Oncology. 13, 4, p. 414-425 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interleukin‐1 and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro

Pfeilschifter, J., Chenu, C., Bird, A., Mundy, G. R. & Roodman, D. G., Feb 1989, In : Journal of Bone and Mineral Research. 4, 1, p. 113-118 6 p.

Research output: Contribution to journalArticle

373 Scopus citations
40 Scopus citations

Inhibition of tartrate-resistant acid phosphatase gene expression by hemin and protoporphyrin IX. Identification of a hemin-responsive inhibitor of transcription

Reddy, S. V., Alcantara, O., Roodman, G. D. & Boldt, D. H., Sep 15 1996, In : Blood. 88, 6, p. 2288-2297 10 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Inhibition of erythroid colony formation by autologous bone marrow adherent cells from patients with the anemia of chronic disease

Roodman, G. D., Horadam, V. W. & Wright, T. L., 1983, In : Blood. 62, 2, p. 406-412 7 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

Hiruma, Y., Honjo, T., Jelinek, D. F., Windle, J. J., Shin, J., Roodman, G. D. & Kurihara, N., Nov 17 2009, In : Blood. 113, 20, p. 4894-4902 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone

Teramachi, J., Zhou, H., Subler, M. A., Kitagawa, Y., Galson, D. L., Dempster, D. W., Windle, J. J., Kurihara, N. & Roodman, G. D., Jun 2014, In : Journal of Bone and Mineral Research. 29, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

Maes, K., Nemeth, E., Roodman, G. D., Huston, A., Esteve, F., Freytes, C., Callander, N., Katodritou, E., Tussing-Humphreys, L., Rivera, S., Vanderkerken, K., Lichtenstein, A. & Ganz, T., Nov 4 2010, In : Blood. 116, 18, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

92 Scopus citations

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia

Pal, R., Monaghan, S. A., Hassett, A. C., Mapara, M. Y., Schafer, P., Roodman, G. D., Ragni, M. V., Moscinski, L., List, A. & Lentzsch, S., Jan 21 2010, In : Blood. 115, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Immortalization of osteoclast precursors by targeting bcl-X(L) and Simian Virus 40 large T antigen to the osteoclast lineage in transgenic mice

Hentunen, T. A., Reddy, S. V., Boyce, B. F., Devlin, R., Park, H. R., Chung, H., Selander, K. S., Dallas, M., Kurihara, N., Galson, D. L., Goldring, S. R., Koop, B. A., Windle, J. J. & Roodman, G. D., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release

Kurihara, N., Bertolini, D., Suda, T., Akiyama, Y. & Roodman, G. D., Jan 1 1990, In : Journal of Immunology. 144, 11, p. 4226-4230 5 p.

Research output: Contribution to journalArticle

365 Scopus citations

IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures

Devlin, R. D., Reddy, S. V., Savino, R., Ciliberto, G. & Roodman, G. D., Apr 14 1998, In : Journal of Bone and Mineral Research. 13, 3, p. 393-399 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells

Lee, J. W., Chung, H. Y., Ehrlich, L. A., Jelinek, D. F., Callander, N. S., Roodman, G. D. & Choi, S. J., Mar 15 2004, In : Blood. 103, 6, p. 2308-2315 8 p.

Research output: Contribution to journalArticle

175 Scopus citations

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

Choi, S. J., Reddy, S. V., Devlin, R. D., Menaa, C., Chung, H., Boyce, B. F. & Roodman, G. D., Sep 24 1999, In : Journal of Biological Chemistry. 274, 39, p. 27747-27753 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures

Kurihara, N., Chenu, C., Miller, M., Civin, C. & Roodman, G. D., May 1990, In : Endocrinology. 126, 5, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

191 Scopus citations

Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells

Ibbotson, K. J., Roodman, G. D., McManus, L. M. & Mundy, G. R., 1984, In : Journal of Cell Biology. 99, 2, p. 471-480 10 p.

Research output: Contribution to journalArticle

Open Access
177 Scopus citations

Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma

Cruz, J. C., Alsina, M., Craig, F., Yoneda, T., Anderson, J. L., Dallas, M. & Roodman, G. D., Apr 26 2001, In : Experimental Hematology. 29, 4, p. 441-447 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

Storti, P., Bolzoni, M., Donofrio, G., Airoldi, I., Guasco, D., Toscani, D., Martella, E., Lazzaretti, M., Mancini, C., Agnelli, L., Patrene, K., Maïga, S., Franceschi, V., Colla, S., Anderson, J., Neri, A., Amiot, M., Aversa, F., David Roodman, G. & Giuliani, N., Aug 1 2013, In : Leukemia. 27, 8, p. 1697-1706 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Hemin-induced erythroid differentiation changes the sensitivity of K562 cells to tumor necrosis factor-α

Li, X. F., Anderson, J., Hutzler, D. & Roodman, G. D., Dec 1 1989, In : Experimental Hematology. 17, 11, p. 1059-1062 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Hematology-oncology. Hematology-Oncology Workgroup, Legislative Task Force on Cancer in Texas.

Gardner, F. H., Alperin, J. B., Belli, J. A., Farley, P. C., Frenkel, E. P., Redman, J. R., Roodman, G. D., Sears, D. A. & Trowbridge, A. A., Sep 1 1987, In : Texas Medicine. 83, 9 Pt 2, p. 59-71 13 p.

Research output: Contribution to journalArticle

Hematologic manifestations of malignancy

Johnson, R. A. & Roodman, G. D., Nov 1989, In : Disease-a-Month. 35, 11, p. 726-768 43 p.

Research output: Contribution to journalArticle

35 Scopus citations

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Petrusca, D. N., Toscani, D., Wang, F. M., Park, C., Crean, C. D., Anderson, J. L., Marino, S., Mohammad, K. S., Zhou, D., Silbermann, R., Sun, Q., Kurihara, N., Galson, D. L., Giuliani, N. & Roodman, G. D., Oct 4 2018, In : Journal of Hematology and Oncology. 11, 1, 123.

Research output: Contribution to journalArticle

2 Scopus citations

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

D'Souza, S., Del Prete, D., Jin, S., Sun, Q., Huston, A. J., Kostov, F. E., Sammut, B., Hong, C. S., Anderson, J. L., Patrene, K. D., Yu, S., Velu, C. S., Xiao, G., Grimes, H. L., Roodman, G. D. & Galson, D. L., Dec 22 2011, In : Blood. 118, 26, p. 6871-6880 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Genetic linkage of Paget disease of the bone to chromosome 18q

Cody, J. D., Singer, F. R., Roodman, G. D., Otterund, B., Lewis, T. B., Leppert, M. & Leach, R. J., Nov 1997, In : American Journal of Human Genetics. 61, 5, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L. I., Bellido, T. & Roodman, G. D., Jan 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Genes associate with abnormal bone cell activity in bone metastasis

Roodman, G. D., Dec 1 2012, In : Cancer and Metastasis Reviews. 31, 3-4, p. 569-578 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

Storti, P., Marchica, V., Airoldi, I., Donofrio, G., Fiorini, E., Ferri, V., Guasco, D., Todoerti, K., Silbermann, R., Anderson, J. L., Zhao, W., Agnelli, L., Bolzoni, M., Martella, E., Mancini, C., Campanini, N., Noonan, D. M., Petronini, P. G., Neri, A., Aversa, F. & 2 others, Roodman, G. D. & Giuliani, N., Dec 1 2016, In : Leukemia. 30, 12, p. 2351-2363 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Further characterization of the murine collagenase (type IVB) gene promoter and analysis of mRNA expression in murine tissues

Roach, J., Jin Choi, S., L. Schaub, R., Leach, R. J., David Roodman, G. & Reddy, S. V., Feb 22 1998, In : Gene. 208, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Functional Role for Heat Shock Factors in the Transcriptional Regulation of Human RANK Ligand Gene Expression in Stromal/Osteoblast Cells

Roccisana, J. L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G. D. & Reddy, S. V., Mar 12 2004, In : Journal of Biological Chemistry. 279, 11, p. 10500-10507 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures

Macdonald, B. R., Takahashi, N., McManus, L. M., Holahan, J., Mundy, G. R. & Roodman, G. D., Jun 1987, In : Endocrinology. 120, 6, p. 2326-2333 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation

Xu, G., Liu, K., Anderson, J., Patrene, K., Lentzsch, S., Roodman, G. D. & Ouyang, H., May 3 2012, In : Blood. 119, 18, p. 4205-4214 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Expression of measles virus nucleocapsid protein in osteoclasts induces Paget's disease-like bone lesions in mice

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Mar 2006, In : Journal of Bone and Mineral Research. 21, 3, p. 446-455 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Expression of latent hematopoietic progenitor cells in cultures of newborn and adult baboon liver

Roodman, G. D., VandeBerg, J. L. & Kuehl, T. J., 1985, In : Blood. 65, 6, p. 1518-1525 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Experimental models of Paget's disease

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Feb 2007, In : Journal of Bone and Mineral Research. 22, SUPPL. 2, p. P55-P57

Research output: Contribution to journalArticle

11 Scopus citations

Expansile skeletal hyperphosphatasia: A new familial metabolic bone disease

Whyte, M. P., Mills, B. G., Reinus, W. R., Podgornik, M. N., Roodman, G. D., Gannon, F. H., Eddy, M. C. & Mcalister, W. H., Jan 1 2000, In : Journal of Bone and Mineral Research. 15, 12, p. 2330-2344 15 p.

Research output: Contribution to journalArticle

57 Scopus citations

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K. S., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L. E., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F. A., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T. A., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

133 Scopus citations

Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone

Nellissery, M. J., Padalecki, S. S., Brkanac, Z., Singer, F. R., Roodman, G. D., Unni, K. K., Leach, R. J. & Hansen, M. F., Sep 1998, In : American Journal of Human Genetics. 63, 3, p. 817-824 8 p.

Research output: Contribution to journalArticle

80 Scopus citations

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone

Ohsaki, Y., Takahashi, S., Scarcez, T., Demulder, A., Nishihara, T., Williams, R. & Roodman, G. D., Nov 1992, In : Endocrinology. 131, 5, p. 2229-2234 6 p.

Research output: Contribution to journalArticle

147 Scopus citations

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

37 Scopus citations

Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor necrosis factor-alpha in vivo

Clibon, U., Bonewald, L., Caro, J. & Roodman, G. D., Jul 2 1990, In : Experimental Hematology. 18, 5, p. 438-441 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Epitope mapping of recombinant human procathepsin D

Sachdev, D., Ohsaki, Y., Roodman, G. D. & Chirgwin, J. M., 1998, In : Advances in experimental medicine and biology. 436, p. 185-189 5 p.

Research output: Contribution to journalArticle

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1

Garcia-Palacios, V., Yeon Chung, H., Jin Choi, S., Sarmasik, A., Kurihara, N., Won Lee, J., Galson, D. L., Collins, R. & Roodman, G. D., Feb 2007, In : Bone. 40, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing ICAM-1 expression

Palacios, V. G., Chung, H. Y., Choi, S. J., Kurihara, N., Lee, J. W., Ehrlich, L. A., Collins, R. & Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 240-243 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Eosinophil Chemotactic Factor-L (ECF-L): A Novel Osteoclast Stimulating Factor

Oba, Y., Chung, H. Y., Choi, S. J. & Roodman, G. D., Jul 1 2003, In : Journal of Bone and Mineral Research. 18, 7, p. 1332-1341 10 p.

Research output: Contribution to journalArticle

15 Scopus citations