G. David Roodman

  • 23000 Citations
  • 79 h-Index
1975 …2020
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Publications 1975 2019

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44 Citations (Scopus)
Calcitriol Receptors
Osteoclasts
Bone Resorption
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
232 Citations (Scopus)

1,25-dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow

Roodman, G. D., Ibbotson, K. J., MacDonald, B. R., Kuehl, T. J. & Mundy, G. R., 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 23, p. 8213-8217 5 p.

Research output: Contribution to journalArticle

Calcitriol
Osteoclasts
Primates
Bone Marrow
Calcitonin
80 Citations (Scopus)
Calcitriol
Osteoclasts
Hypersensitivity
Stromal Cells
RANK Ligand
13 Citations (Scopus)

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Ishizuka, S., Kurihara, N., Hiruma, Y., Miura, D., Namekawa, J. I., Tamura, A., Kato-Nakamura, Y., Nakano, Y., Takenouchi, K., Hashimoto, Y., Nagasawa, K. & Roodman, G. D., Jun 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 3-5, p. 269-277 9 p.

Research output: Contribution to journalArticle

Lactams
Calcitriol Receptors
Calcitriol
Rodentia
HL-60 Cells
76 Citations (Scopus)

5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices

Gallwitz, W. E., Mundy, G. R., Lee, C. H., Qiao, M., Roodman, G. D., Raftery, M., Gaskell, S. J. & Bonewald, L., May 15 1993, In : Journal of Biological Chemistry. 268, 14, p. 10087-10094 8 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Osteoclasts
Metabolites
Arachidonic Acid
Bone
63 Citations (Scopus)

Abnormalities in osteoclast precursors and marrow accessory cells in Paget's disease

Demulder, A., Takahashi, S., Singer, F. R., Hosking, D. J. & Roodman, G. D., Nov 1993, In : Endocrinology. 133, 5, p. 1978-1982 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
Calcitriol
CD34 Antigens
8 Citations (Scopus)

Absence of paramyxo virus transcripts in juvenile Paget bone disease.

Whyte, M. P., Leelawattana, R., Reddy, S. V. & Roodman, G. D., Jul 1996, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 11, 7, p. 1041 1 p.

Research output: Contribution to journalArticle

Respirovirus
Osteitis Deformans
Viral RNA
Viruses
Bone and Bones
3 Citations (Scopus)

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America

Raje, N., Roodman, G. D., Willenbacher, W., Shimizu, K., García-Sanz, R., Terpos, E., Kennedy, L., Sabatelli, L., Intorcia, M. & Hechmati, G., Mar 6 2018, (Accepted/In press) In : Journal of Medical Economics. p. 1-12 12 p.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Cost-Benefit Analysis
Costs and Cost Analysis
Disease-Free Survival
43 Citations (Scopus)

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D. & Xiao, G., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
Osteoclasts
Macrophage Colony-Stimulating Factor
Osteogenesis
Transcription Factors
86 Citations (Scopus)

ADAM8: A novel osteoclast stimulating factor

Sun Jin Choi, J. C., Han, J. H. & Roodman, G. D., 2001, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16, 5, p. 814-822 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Disintegrins
Conditioned Culture Medium
Complementary DNA
Bone Marrow
24 Citations (Scopus)

ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo

Ishizuka, H., García-Palacios, V., Lu, G., Subler, M. A., Zhang, H., Boykin, C. S., Choi, S. J., Zhao, L., Patrene, K., Galson, D. L., Blair, H. C., Hadi, T. M., Windle, J. J., Kurihara, N. & Roodman, G. D., Jan 2011, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 26, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone and Bones
Knockout Mice
Tumor Necrosis Factor-alpha
TNF Receptor-Associated Factor 6
438 Citations (Scopus)

Advances in bone biology: The osteoclast

Roodman, G. D., 1996, In : Endocrine Reviews. 17, 4, p. 308-332 25 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone and Bones
Bone Resorption
Hormones
Cytokines
10 Citations (Scopus)

Advances in supportive care for multiple myeloma

Raje, N. S., Yee, A. J. & Roodman, G. D., 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 4, p. 502-511 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Diseases
Diphosphonates
Peripheral Nervous System Diseases
Appointments and Schedules
106 Citations (Scopus)

Advances in the biology and treatment of bone disease in multiple myeloma

Raje, N. & Roodman, G. D., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1278-1286 9 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Diseases
Osteoclasts
Osteoblasts
Multiple Myeloma
10 Citations (Scopus)

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Natural History
Neoplasm Metastasis
Research
50 Citations (Scopus)

Advancing treatment for metastatic bone cancer: Consensus recommendations from the second cambridge conference

Coleman, R. E., Guise, T., Lipton, A., Roodman, G. D., Berenson, J. R., Body, J. J., Boyce, B. F., Calvi, L. M., Hadji, P., McCloskey, E. V., Saad, F., Smith, M. R., Suva, L. J., Taichman, R. S., Vessella, R. L. & Weilbaecher, K. N., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6387-6395 9 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Therapeutics
Neoplasm Metastasis
Research
329 Citations (Scopus)

American society of clinical oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, G. D., Twilde, P. & Anderson, K., Jun 10 2007, In : Journal of Clinical Oncology. 25, 17, p. 2464-2472 9 p.

Research output: Contribution to journalArticle

zoledronic acid
pamidronate
Medical Oncology
Diphosphonates
Multiple Myeloma
36 Citations (Scopus)

AML-1A and AML-1B regulation of MIP-1α expression in multiple myeloma

Choi, S. J., Oba, T., Callander, N. S., Jelinek, D. F. & Roodman, G. D., May 15 2003, In : Blood. 101, 10, p. 3778-3783 6 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Multiple Myeloma
Acute Myeloid Leukemia
Messenger RNA
Bone
26 Citations (Scopus)

A murine model of inflammatory bone disease

Hentunen, T. A., Choi, S. J., Boyce, B. F., Dallas, M. R., Dallas, S. L., Shen-Ong, G. L. & Roodman, G. D., Feb 2000, In : Bone. 26, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone Marrow
Osteoclasts
Chromosomes, Human, Pair 18
Bone and Bones
266 Citations (Scopus)
Biological Models
Bone Remodeling
Diphosphonates
Calcitonin
Osteoclasts

Animal models of bone disease

Roodman, G. D., 1998, In : Cancer Research Therapy and Control. 6, 1-4, p. 89-90 2 p.

Research output: Contribution to journalArticle

Bone Diseases
Animal Models
8 Citations (Scopus)

An in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1995, In : Stem Cells. 13, SUPPL. 2, p. 48-50 3 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Hypercalcemia
Bone and Bones
Severe Combined Immunodeficiency
29 Citations (Scopus)

Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche

Jung, Y., Shiozawa, Y., Wang, J., Patel, L. R., Havens, A. M., Song, J., Krebsbach, P. H., Roodman, G. D. & Taichman, R. S., Feb 2011, In : Experimental Hematology. 39, 2

Research output: Contribution to journalArticle

Stem Cell Niche
Annexins
Chemokine CXCL12
Hematopoietic Stem Cells
Stem Cells
144 Citations (Scopus)

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

Shiozawa, Y., Havens, A. M., Jung, Y., Ziegler, A. M., Pedersen, E. A., Wang, J., Wang, J., Lu, G., Roodman, G. D., Loberg, R. D., Pienta, K. J. & Taichman, R. S., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

Annexin A2
Prostatic Neoplasms
Adhesion
Growth
Osteoblasts
81 Citations (Scopus)

Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures

Menaa, C., Devlin, R. D., Reddy, S. V., Gazitt, Y., Choi, S. J. & Roodman, G. D., Jun 1999, In : Journal of Clinical Investigation. 103, 11, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

Annexin A2
Osteoclasts
Bone Marrow
Granulocyte-Macrophage Colony-Stimulating Factor
T-Lymphocytes
41 Citations (Scopus)

Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment

D'Souza, S., Kurihara, N., Shiozawa, Y., Joseph, J., Taichman, R., Galson, D. L. & Roodman, G. D., Feb 23 2012, In : Blood. 119, 8, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

Annexin A2
Cell adhesion
Cell growth
Multiple Myeloma
Cell Adhesion
43 Citations (Scopus)

Annexin II stimulates RANKL expression through MAPK

Li, F., Chung, H. Y., Reddy, S. V., Lu, G., Kurihara, N., Zhao, A. Z. & Roodman, G. D., Jul 2005, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 20, 7, p. 1161-1167 7 p.

Research output: Contribution to journalArticle

Annexin A2
Granulocyte-Macrophage Colony-Stimulating Factor
Osteoclasts
Osteoprotegerin
Bone Marrow Cells
112 Citations (Scopus)

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

Lymphocytes
Interleukin-17
Bone Diseases
Multiple Myeloma
Bone
50 Citations (Scopus)

Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma

Gao, S. J., Alsina, M., Deng, J. H., Harrison, C. R., Montalvo, E. A., Leach, C. T., Roodman, G. D. & Jenson, H. B., 1998, In : Journal of Infectious Diseases. 178, 3, p. 846-849 4 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Multiple Myeloma
Antibodies
Blood Donors
Neoplasms
180 Citations (Scopus)

Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease

Choi, S. J., Oba, Y., Gazitt, Y., Alsina, M., Cruz, J., Anderson, J. & Roodman, G. D., 2001, In : Journal of Clinical Investigation. 108, 12, p. 1833-1841 9 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Bone Diseases
Multiple Myeloma
Bone and Bones
Osteoclasts
7 Citations (Scopus)

A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors

Adkins, D. R., Irvin, R., Kuhn, J., Boldt, D. H., Roodman, G. D., Salzman, D., Freytes, C., Von Hoff, D. D. & LeMaistre, C. F., Jun 1993, In : Investigational New Drugs. 11, 2-3, p. 169-179 11 p.

Research output: Contribution to journalArticle

Dacarbazine
Autologous Transplantation
Bone Marrow Transplantation
Pharmacology
Neoplasms
3 Citations (Scopus)

A phase I-II clinical trial with a combination of gemcitabine (GEMZAR) and paclitaxel (TAXOL) for the treatment of refractory multiple myeloma (MM) patients

Gazitt, Y., Roodman, G. D., Freytes, C., Shaughnessy, P., Callander, N., Traynor, A. & Rothenberg, M., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

gemcitabine
Phase II Clinical Trials
Clinical Trials, Phase I
Paclitaxel
Multiple Myeloma
7 Citations (Scopus)

A Phase II trial of weekly bortezomib and dexamethasone in veterans with newly diagnosed multiple myeloma not eligible for or who deferred autologous stem cell transplantation

Girnius, S. K., Lee, S., Kambhampati, S., Rose, M. G., Mohiuddin, A., Houranieh, A., Zimelman, A., Grady, T., Mehta, P., Behler, C., Hayes, T. G., Efebera, Y. A., Prabhala, R. H., Han, A., Yellapragada, S. V., Klein, C. E., Roodman, G. D., Lichtenstein, A. & Munshi, N. C., Apr 1 2015, In : British Journal of Haematology. 169, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Veterans
Multiple Myeloma
Dexamethasone
Peripheral Nervous System Diseases
1 Citation (Scopus)

Aplastic Anemia Associated With Rubber Cement Used by a Marathon Runner

Roodman, G. D., Reese, E. P. & Cardamone, J. M., 1980, In : Archives of Internal Medicine. 140, 5, p. 703 1 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Rubber
Foot
Benzene
Adhesives

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Dexamethasone
Bone Development
Osteoblasts
10 Citations (Scopus)
Osteitis Deformans
Osteoclasts
Bone Marrow Cells
Cultured Cells
Interleukin-6
1 Citation (Scopus)

ASCO 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma: Guideline summary

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, G. D., Twilde, P. & Anderson, K., Jul 2007, In : Journal of Oncology Practice. 3, 4, p. 236 1 p.

Research output: Contribution to journalArticle

Diphosphonates
Multiple Myeloma
Practice Guidelines
Guidelines
62 Citations (Scopus)

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment

Hiruma, Y., Kurihara, N., Subler, M. A., Zhou, H., Boykin, C. S., Zhang, H., Ishizuka, S., Dempster, D. W., Roodman, G. D. & Windle, J. J., 2008, In : Human Molecular Genetics. 17, 23, p. 3708-3719 12 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Osteoclasts
Stromal Cells
Bone and Bones
Mutation
10 Citations (Scopus)

Assays for bone resorption and bone formation

Mundy, G. R., Roodman, G. D., Bonewald, L., Oreffo, R. O. C. & Boyce, B. F., 1991, In : Methods in Enzymology. 198, p. 502-510 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Assignment of matrix metalloproteinase 9 (Mmp9) to mouse Chromosome 2 bands H1-H2

DuPont, B. R., Linn, R., Knight, C. B., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A., Fournier, R. E. K. & Leach, R. J., 1996, In : Cytogenetics and Cell Genetics. 74, 1-2, p. 118-119 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Assignment of OSTF1 to human chromosome bands 12q24.1 → q24.2 by in situ hybridization

Schaub, R., Dupont, B., Roodman, G. D., Leach, R. J. & Reddy, S. V., 2000, In : Cytogenetics and Cell Genetics. 88, 1-2, p. 87-88 2 p.

Research output: Contribution to journalArticle

Physical Chromosome Mapping
Chromosome Banding
Chromosomes, Human, Pair 12
Hybrid Cells
Human Chromosomes
14 Citations (Scopus)

Assignment of the Mouse Tartrate-Resistant Acid Phosphatase Gene (Acp5) to Chromosome 9

Grimes, R., Reddy, S. V., Leach, R. J., Scarcez, T., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A. & Windle, J. J., Feb 1993, In : Genomics. 15, 2, p. 421-422 2 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Hybrid Cells
Human Chromosomes
Osteoclasts
Bone Resorption
65 Citations (Scopus)

Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease

Kukita, A., Chenu, C., McManus, L. M., Mundy, G. R. & Roodman, G. D., Apr 1990, In : Journal of Clinical Investigation. 85, 4, p. 1280-1286 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Ergocalciferols
Bone and Bones
Cell Nucleus
7 Citations (Scopus)

Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro

Roodman, G. D., Ascensao, J. L., Banisadre, M., Bloom, P. M. & Zanjani, E. D., 1980, In : The American Journal of Medicine. 69, 2, p. 325-328 4 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Pancytopenia
Bone Development
Bone Marrow
Lymphocytes
99 Citations (Scopus)

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

Kovacs, J. R., Li, C., Yang, Q., Li, G., Garcia, I. G., Ju, S., Roodman, G. D., Windle, J. J., Zhang, X. & Lu, B., Jan 2012, In : Cell Death and Differentiation. 19, 1, p. 144-152 9 p.

Research output: Contribution to journalArticle

Autophagy
Proteolysis
Cell Survival
Cell Death
T-Lymphocytes
6 Citations (Scopus)

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers

Bon, J., Kahloon, R., Zhang, Y., Xue, J., Fuhrman, C. R., Tan, J., Burger, M., Kass, D. J., Csizmadia, E., Otterbein, L., Chandra, D., Bhargava, A., Pilewski, J. M., Roodman, G. D., Sciurba, F. C. & Duncan, S. R., 2014, In : PLoS One. 9, 9, p. e105066

Research output: Contribution to journalArticle

osteoporosis
Emphysema
Osteoporosis
glucose
autoantibodies
57 Citations (Scopus)
Osteocytes
Tumor Microenvironment
Multiple Myeloma
Bone Marrow
Cell Proliferation
237 Citations (Scopus)

Biology of osteoclast activation in cancer

Roodman, G. D., Aug 1 2001, In : Journal of Clinical Oncology. 19, 15, p. 3562-3571 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Receptor Activator of Nuclear Factor-kappa B
Bone and Bones
Neoplasms
Osteogenesis
4 Citations (Scopus)

Biology of the osteoclast in Paget's disease

Roodman, G. D., 1994, In : Seminars in Arthritis and Rheumatism. 23, 4, p. 235-236 2 p.

Research output: Contribution to journalArticle

Viral Inclusion Bodies
Osteitis Deformans
Osteoclasts
Cell Division
Interleukin-6
853 Citations (Scopus)

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, G. D., Mundy, G. R. & Boyce, B. F., 1995, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 10, 10, p. 1478-1487 10 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoclasts
Apoptosis
Bone Resorption
pamidronate