G. David Roodman

  • 24303 Citations
  • 82 h-Index
1975 …2020

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Publications

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CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan chemotherapy.

Roodman, G. D., LeMaistre, C. F., Clark, G. M., Page, C. P., Newcomb, T. F. & Knight, W. A., Aug 1987, In : Bone marrow transplantation. 2, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

CFU-GM-derived cells form osteoclasts at a very high efficiency

Menaa, C., Kurihara, N. & Roodman, G. D., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 943-946 4 p.

Research output: Contribution to journalArticle

49 Scopus citations

Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen

Hentunen, T. A., Jackson, S. H., Chung, H., Reddy, S. V., Lorenzo, J., Choi, S. J. & David Roodman, G., Jan 1 1999, In : Endocrinology. 140, 7, p. 2954-2961 8 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Characterization of the 5′-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene

Reddy, S. V., Kuzhandaivelu, N., Acosta, L. G. & Roodman, G. D., May 1995, In : Bone. 16, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Characterization of the mouse tartrate‐resistant acid phosphatase (trap) gene promoter

Reddy, S. V., Hundley, J. E., Windle, J. J., Alcantara, O., Linn, R., Leach, R. J., Boldt, D. H. & Roodman, G. D., Apr 1995, In : Journal of Bone and Mineral Research. 10, 4, p. 601-606 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Characterization of the osteoclast vacuolar H+-ATPase B-subunit

Bartkiewicz, M., Hernando, N., Reddy, S. V., Roodman, G. D. & Baron, R., 1995, In : Gene. 160, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice

Johnson, R. A., Waddelow, T. A., Caro, J., Oliff, A. & Roodman, G. D., 1989, In : Blood. 74, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Open Access
142 Scopus citations

Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas

Callander, N. S., Galvez, J., Cortes, R., Aisina, M. & Roodman, G. D., Dec 1 2000, In : Blood. 96, 11 PART II, p. 271b

Research output: Contribution to journalArticle

Cloning and characterization of the 5′‐flanking region of the mouse tartrate‐resistant acid phosphatase gene

Reddy, S. V., Scarcez, T., Windle, J. J., Leach, R. J., Hundley, J. E., Chirgwin, J. M., Chou, J. Y. & Roodman, G. D., Oct 1993, In : Journal of Bone and Mineral Research. 8, 10, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cloning and characterization of the annexin II receptor on human marrow stromal cells

Lu, G., Maeda, H., Reddy, S. V., Kurihara, N., Leach, R., Anderson, J. L. & Roodman, G. D., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30542-30550 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption

Takahashi, S., Reddy, S. V., Chirgwin, J. M., Devlin, R., Haipek, C., Anderson, J. & Roodman, G. D., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28696-28701 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Devlin, R. D., Menaa, C., Chung, H., Roodman, G. D. & Reddy, S. V., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Cloning and identification of human stem cell antigen as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Davlin, R., Baddy, S. V. & Roodman, G. D., Dec 1 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

Cokeromyces recurvatus infection in a bone marrow transplant recipient

Tsai, T. W., Hammond, L. A., Rinaldi, M., Martin, K., Tio, F., Maples, J., Freytes, C. O. & Roodman, G. D., Feb 1 1997, In : Bone Marrow Transplantation. 19, 3, p. 301-302 2 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma

Francis, L. K., Alsayed, Y., Leleu, X., Jia, X., Singha, U. K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L. A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Nov 15 2006, In : Clinical Cancer Research. 12, 22, p. 6826-6835 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Combination of bendamustine, lenalidomide, anddexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: Results of phase 1/2 open-label, doseescalation study

Lentzsch, S., O'Sullivan, A., Kennedy, R. C., Abbas, M., Dai, L., Pregja, S. L., Burt, S., Boyiadzis, M., Roodman, G. D., Mapara, M. Y., Agha, M., Waas, J., Shuai, Y., Normolle, D. & Zonder, J. A., May 17 2012, In : Blood. 119, 20, p. 4608-4613 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

Comparison of engraftment and acute GVHD in patients undergoing cryopreserved or fresh allogeneic BMT

Eckardt, J. R., Roodman, G. D., Boldt, D. H., Clark, G. M., Alvarez, R., Page, C., Gaskill, H. & LeMaistre, C. F., Jan 1 1993, In : Bone marrow transplantation. 11, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
7 Scopus citations

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to paget's disease

Kurihara, N., Hiruma, Y., Yamana, K., Michou, L., Rousseau, C., Morissette, J., Galson, D. L., Teramachi, J., Zhou, H., Dempster, D. W., Windle, J. J., Brown, J. P. & Roodman, G. D., Jan 5 2011, In : Cell Metabolism. 13, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

86 Scopus citations

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone

Yu, S., Franceschi, R. T., Luo, M., Fan, J., Jiang, D., Cao, H., Kwon, T. G., Lai, Y., Zhang, J., Patrene, K., Hankenson, K., Roodman, G. D. & Xiao, G., Oct 23 2009, In : PloS one. 4, 10, e7583.

Research output: Contribution to journalArticle

48 Scopus citations

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Cao, H., Zhu, K., Qiu, L., Li, S., Niu, H., Hao, M., Yang, S., Zhao, Z., Lai, Y., Anderson, J. L., Fan, J., Im, H. J., Chen, D., Roodman, G. D. & Xiao, G., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30399-30410 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Mar 2018, In : The lancet oncology. 19, 3, p. 370-381 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Detection of measles virus nucleocapsid transcripts in circulating blood cells from patients with paget disease

Reddy, S. V., Singer, F. R., Mallette, L. & Roodman, G. D., Nov 1996, In : Journal of Bone and Mineral Research. 11, 11, p. 1602-1607 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Developmental changes in membrane proteins from baboon erythrocytes

Lee, J. C., Kuehl, T. J. & Roodman, G. D., 1987, In : Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 88, 1, p. 233-236 4 p.

Research output: Contribution to journalArticle

Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation

Takahashi, S., Reddy, S. V., Dallas, M., Devlin, R., Chou, J. Y. & Roodman, G. D., Apr 1995, In : Endocrinology. 136, 4, p. 1441-1449 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
17 Scopus citations

Development of an in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B., Devlin, R. D., Anderson, J. L., Craig, F., Mundy, G. R. & Roodman, G. D., Feb 15 1996, In : Blood. 87, 4, p. 1495-1501 7 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations
19 Scopus citations

DNA polymerase activities during erythropoiesis. Effects of erythropoietin, vinblastine, colcemid, and daunomycin

Roodman, G. D., Hutton, J. J. & Bollum, F. J., Mar 15 1975, In : Experimental Cell Research. 91, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast-like cell differentiation

Takahashi, S., Goldring, S., Katz, M., Hilsenbeck, S., Williams, R. & Roodman, G. D., Jan 1995, In : Journal of Clinical Investigation. 95, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Effect of telomere and telomerase interactive agents on human tumor and normal cell lines

Rha, S. Y., Izbicka, E., Lawrence, R., Davidson, K., Sun, D., Moyer, M. P., Roodman, G. D., Hurley, L. & Von Hoff, D., Mar 2000, In : Clinical Cancer Research. 6, 3, p. 987-993 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Effects of alendronate on cytokine production and osteoclast formation induced by human marrow stromal cells

Moore, J., Anderson, J. A., Roodman, G. D. & Reddy, S. V., Feb 1999, In : Journal of Investigative Medicine. 47, 2, p. 132A

Research output: Contribution to journalArticle

Effects of dexamethasone on erythroid colony and burst formation from human fetal liver and adult marrow

Roodman, G. D., Lee, J. & Gidari, A. S., Apr 1983, In : British journal of haematology. 53, 4, p. 621-628 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Effects of human recombinant CSF‐GM and highly purified CSF‐1 on the formation of multinucleated cells with osteoclast characteristics in long‐term bone marrow cultures

MacDonald, B. R., Mundy, G. R., Clark, S., Wang, E. A., Kuehl, T. J., Stanley, E. R. & Roodman, G. D., Apr 1986, In : Journal of Bone and Mineral Research. 1, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

169 Scopus citations

Effects of parathyroid hormone (pth)-related protein and pth on osteoclasts and osteoclast precursors in vivo

Uy, H. L., Guise, T. A., Mata, J. D. L., Taylor, S. D., Story, B. M., Dallas, M. R., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Aug 1995, In : Endocrinology. 136, 8, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Effects of Shortened Erythropoietin Exposure on Sheep Marrow Cultures

Roodman, G. D., Kaplan, J. M., Kaplan, M. E. & Zanjani, E. D., Feb 1981, In : British journal of haematology. 47, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of stem cell factor on osteoclast‐like cell formation in long‐term human marrow cultures

Demulder, A., Suggs, S. V., Zsebo, K. M., Scarcez, T. & Roodman, G. D., Nov 1992, In : Journal of Bone and Mineral Research. 7, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

EL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma

Ehrlich, L. A., Chung, H. Y., Ghobrial, I., Choi, S. J., Morandi, F., Colla, S., Rizzoli, V., Roodman, G. D. & Giuliani, N., Aug 15 2005, In : Blood. 106, 4, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

157 Scopus citations

Endogenous erythroid colony-forming cells in fetal and newborn sheep

Roodman, G. D. & Zanjani, E. D., Dec 1 1979, In : Journal of Laboratory and Clinical Medicine. 94, 5, p. 699-707 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone

Menaa, C., Reddy, S. V., Kurihara, N., Maeda, H., Anderson, D., Cundy, T., Cornish, J., Singer, F. R., Bruder, J. M. & Roodman, G. D., 2000, In : Journal of Clinical Investigation. 105, 12, p. 1833-1838 6 p.

Research output: Contribution to journalArticle

Open Access
132 Scopus citations

Eosinophil Chemotactic Factor-L (ECF-L): A Novel Osteoclast Stimulating Factor

Oba, Y., Chung, H. Y., Choi, S. J. & Roodman, G. D., Jul 1 2003, In : Journal of Bone and Mineral Research. 18, 7, p. 1332-1341 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing ICAM-1 expression

Palacios, V. G., Chung, H. Y., Choi, S. J., Kurihara, N., Lee, J. W., Ehrlich, L. A., Collins, R. & Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 240-243 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1

Garcia-Palacios, V., Yeon Chung, H., Jin Choi, S., Sarmasik, A., Kurihara, N., Won Lee, J., Galson, D. L., Collins, R. & Roodman, G. D., Feb 2007, In : Bone. 40, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Epitope mapping of recombinant human procathepsin D

Sachdev, D., Ohsaki, Y., Roodman, G. D. & Chirgwin, J. M., 1998, In : Advances in experimental medicine and biology. 436, p. 185-189 5 p.

Research output: Contribution to journalArticle

Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor necrosis factor-alpha in vivo

Clibon, U., Bonewald, L., Caro, J. & Roodman, G. D., 1990, In : Experimental Hematology. 18, 5, p. 438-441 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

38 Scopus citations

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone

Ohsaki, Y., Takahashi, S., Scarcez, T., Demulder, A., Nishihara, T., Williams, R. & Roodman, G. D., Nov 1992, In : Endocrinology. 131, 5, p. 2229-2234 6 p.

Research output: Contribution to journalArticle

147 Scopus citations

Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone

Nellissery, M. J., Padalecki, S. S., Brkanac, Z., Singer, F. R., Roodman, G. D., Unni, K. K., Leach, R. J. & Hansen, M. F., Sep 1998, In : American Journal of Human Genetics. 63, 3, p. 817-824 8 p.

Research output: Contribution to journalArticle

80 Scopus citations

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K. S., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L. E., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F. A., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T. A., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

135 Scopus citations