G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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16 Citations (Scopus)

Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo

Teramachi, J., Silbermann, R., Yang, P., Zhao, W., Mohammad, K., Guo, J., Anderson, J. L., Zhou, D., Feng, R., Myint, K. Z., Maertz, N., Beumer, J. H., Eiseman, J. L., Windle, J. J., Xie, X. Q., Roodman, G. D. & Kurihara, N., Feb 1 2016, In : Leukemia. 30, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Osteogenesis
Bone and Bones
Growth
11 Citations (Scopus)

Bone-breaking cancer treatment

Roodman, G. D., Jan 2007, In : Nature Medicine. 13, 1, p. 25-26 2 p.

Research output: Contribution to journalArticle

Experimental Mammary Neoplasms
Xenograft Model Antitumor Assays
Biological Models
Bone Neoplasms
NF-kappa B
29 Citations (Scopus)

Bone building with bortezomib

Roodman, G. D., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 462-464 3 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone and Bones
Osteogenesis
Postmenopausal Osteoporosis
Proteasome Inhibitors
12 Citations (Scopus)

Bone effects of cancer therapies: Pros and cons

Silbermann, R. & Roodman, G. D., Sep 2011, In : Current Opinion in Supportive and Palliative Care. 5, 3, p. 251-257 7 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Bone Remodeling
Physiologic Monitoring
Osteoclasts
32 Citations (Scopus)

Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma

Silbermann, R., Bolzoni, M., Storti, P., Guasco, D., Bonomini, S., Zhou, D., Wu, J., Anderson, J. L., Windle, J. J., Aversa, F., Roodman, G. D. & Giuliani, N., 2014, In : Leukemia. 28, 4, p. 951-954 4 p.

Research output: Contribution to journalArticle

RANK Ligand
Activins
Interleukin-3
Bone Diseases
Osteoclasts
99 Citations (Scopus)
Nucleocapsid
Measles virus
Viruses
Bone Marrow Cells
Osteoclasts
3 Citations (Scopus)

Bone metastasis [5] (multiple letters)

Hall, F. M. & Roodman, G. D., Jul 8 2004, In : New England Journal of Medicine. 351, 2, p. 195-196 2 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone Remodeling
Osteoclasts
Osteoblasts
Neoplasm Metastasis
19 Citations (Scopus)

Bone pain induced by multiple myeloma is reduced by targeting V-ATPase and ASIC3

Hiasa, M., Okui, T., Allette, Y. M., Ripsch, M. S., Sun-Wada, G. H., Wakabayashi, H., Roodman, G. D., White, F. & Yoneda, T., Mar 15 2017, In : Cancer Research. 77, 6, p. 1283-1295 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Adenosine Triphosphatases
zoledronic acid
Bone and Bones
Pain
47 Citations (Scopus)

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells

Pal, R., Janz, M., Galson, D. L., Gries, M., Li, S., Jöhrens, K., Anagnostopoulos, I., Dörken, B., Mapara, M. Y., Borghesi, L., Kardava, L., Roodman, G. D., Milcarek, C. & Lentzsch, S., Oct 29 2009, In : Blood. 114, 18, p. 3890-3898 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Multiple Myeloma
Transcription Factors
Cells
B-Cell Lymphoma
42 Citations (Scopus)

Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation

Mbalaviele, G., Nishimura, R., Myoi, A., Niewolna, M., Reddy, S. V., Chen, D., Feng, J., Roodman, G. D., Mundy, G. R. & Yoneda, T., Jun 15 1998, In : Journal of Cell Biology. 141, 6, p. 1467-1476 10 p.

Research output: Contribution to journalArticle

Cell Lineage
Osteoclasts
Stromal Cells
Cadherins
Protein Isoforms
2 Citations (Scopus)

CCN1: A sticky issue in myeloma

Roodman, G. D., Sep 25 2014, In : Blood. 124, 13, p. 2006-2008 3 p.

Research output: Contribution to journalArticle

Blood
Disease-Free Survival
Bone Marrow
Survival
Therapeutics
46 Citations (Scopus)

Cell biology of Paget's disease

Reddy, S. V., Menaa, C., Singer, F. R., Demulder, A. & Roodman, G. D., 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, SUPPL. 2, p. 3-8 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Cell Biology
Bone Marrow
Interleukin-6
Calcitriol Receptors
400 Citations (Scopus)

Cell biology of the osteoclast

Roodman, G. D., Aug 1999, In : Experimental Hematology. 27, 8, p. 1229-1241 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Cell Biology
RANK Ligand
Bone Marrow
Bone Resorption
13 Citations (Scopus)

Cellular interactions in hemopoietic progenitor cell homing: A review

Hardy, C. L., Minguell, J. J., Roodman, G. D., Greenberger, J. S. & Allen, T. D., Mar 1993, In : Scanning Microscopy. 7, 1, p. 333-341 9 p.

Research output: Contribution to journalArticle

homing
Stem cells
stem cells
Bone
cells
12 Citations (Scopus)

CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan chemotherapy.

Roodman, G. D., LeMaistre, C. F., Clark, G. M., Page, C. P., Newcomb, T. F. & Knight, W. A., Aug 1987, In : Bone Marrow Transplantation. 2, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Erythroid Precursor Cells
Melphalan
Autologous Transplantation
Neutrophils
48 Citations (Scopus)

CFU-GM-derived cells form osteoclasts at a very high efficiency

Menaa, C., Kurihara, N. & Roodman, G. D., Jan 27 2000, In : Biochemical and Biophysical Research Communications. 267, 3, p. 943-946 4 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Progenitor Cells
Osteoclasts
Macrophages
RANK Ligand
Macrophage Colony-Stimulating Factor
Newborn Animals
Papio
Hematopoietic Stem Cells
Bone Marrow Cells
Bone Marrow
22 Citations (Scopus)

Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen

Hentunen, T. A., Jackson, S. H., Chung, H., Reddy, S. V., Lorenzo, J., Choi, S. J. & Roodman, G. D., 1999, In : Endocrinology. 140, 7, p. 2954-2961 8 p.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Osteoclasts
Transgenic Mice
RANK Ligand
15 Citations (Scopus)

Characterization of the 5′-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene

Reddy, S. V., Kuzhandaivelu, N., Acosta, L. G. & Roodman, G. D., 1995, In : Bone. 16, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Genes
Introns
Gene Expression
Tartrate-Resistant Acid Phosphatase
71 Citations (Scopus)

Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter

Reddy, S. V., Hundley, J. E., Windle, J. J., Alcantara, O., Linn, R., Leach, R. J., Boldt, D. H. & Roodman, G. D., 1995, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 10, 4, p. 601-606 6 p.

Research output: Contribution to journalArticle

Genes
Iron
Iron-Binding Proteins
5' Flanking Region
Heroin
19 Citations (Scopus)

Characterization of the osteoclast vacuolar H+-ATPase B-subunit

Bartkiewicz, M., Hernando, N., Reddy, S. V., Roodman, G. D. & Baron, R., 1995, In : Gene. 160, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Osteoclasts
Protein Isoforms
Chickens
Messenger RNA
97 Citations (Scopus)

Chemokines in multiple myeloma

Aggarwal, R., Ghobrial, I. M. & Roodman, G. D., Oct 2006, In : Experimental Hematology. 34, 10, p. 1289-1295 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Chemokines
Chemokine Receptors
Bone Development
Osteoclasts
136 Citations (Scopus)

Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice

Johnson, R. A., Waddelow, T. A., Caro, J., Oliff, A. & Roodman, G. D., 1989, In : Blood. 74, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Erythropoiesis
Nude Mice
Erythroid Precursor Cells
Tumor Necrosis Factor-alpha
Anemia

Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas

Callander, N. S., Galvez, J., Cortes, R., Aisina, M. & Roodman, G. D., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Epidemiology
Multiple Myeloma
Hispanic Americans
Immunoglobulin G
Cells
37 Citations (Scopus)

Cloning and characterization of the 5′-flanking region of the mouse tartrate-resistant acid phosphatase gene

Reddy, S. V., Scarcez, T., Windle, J. J., Leach, R. J., Hundley, J. E., Chirgwin, J., Chou, J. Y. & Roodman, G. D., Oct 1993, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 8, 10, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

5' Flanking Region
Organism Cloning
Osteoclasts
Genes
Bone Resorption
22 Citations (Scopus)

Cloning and characterization of the annexin II receptor on human marrow stromal cells

Lu, G., Maeda, H., Reddy, S. V., Kurihara, N., Leach, R., Anderson, J. L. & Roodman, G. D., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30542-30550 9 p.

Research output: Contribution to journalArticle

Annexin A2
Cloning
Stromal Cells
Organism Cloning
Bone Marrow
84 Citations (Scopus)

Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption

Takahashi, S., Reddy, S. V., Chirgwin, J., Devlin, R., Haipek, C., Anderson, J. & Roodman, G. D., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28696-28701 6 p.

Research output: Contribution to journalArticle

Annexin A2
Cloning
Osteoclasts
Bone Resorption
Organism Cloning
23 Citations (Scopus)

Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Devlin, R. D., Menaa, C., Chung, H., Roodman, G. D. & Reddy, S. V., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1360-1368 9 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Osteoclasts
Bone Resorption
Organism Cloning
Peptides

Cloning and identification of human stem cell antigen as a novel inhibitor of osteoclast formation and bone resorption

Choi, S. J., Davlin, R., Baddy, S. V. & Roodman, G. D., 1998, In : Experimental Hematology. 26, 8, p. 729 1 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Osteoclasts
Bone Resorption
Organism Cloning
Stem Cells
12 Citations (Scopus)

Cokeromyces recurvatus infection in a bone marrow transplant recipient

Tsai, T. W., Hammond, L. A., Rinaldi, M., Martin, K., Tio, F., Maples, J., Freytes, C. O. & Roodman, G. D., Feb 1 1997, In : Bone Marrow Transplantation. 19, 3, p. 301-302 2 p.

Research output: Contribution to journalArticle

Diarrhea
Bone Marrow
Infection
Transplants
Transplant Recipients
87 Citations (Scopus)

Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma

Francis, L. K., Alsayed, Y., Leleu, X., Jia, X., Singha, U. K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L. A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Nov 15 2006, In : Clinical Cancer Research. 12, 22, p. 6826-6835 10 p.

Research output: Contribution to journalArticle

tanespimycin
Sirolimus
Multiple Myeloma
Phosphatidylinositol 3-Kinase
Retinoblastoma
88 Citations (Scopus)

Combination of bendamustine, lenalidomide, anddexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: Results of phase 1/2 open-label, doseescalation study

Lentzsch, S., O'Sullivan, A., Kennedy, R. C., Abbas, M., Dai, L., Pregja, S. L., Burt, S., Boyiadzis, M., Roodman, G. D., Mapara, M. Y., Agha, M., Waas, J., Shuai, Y., Normolle, D. & Zonder, J. A., May 17 2012, In : Blood. 119, 20, p. 4608-4613 6 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Multiple Myeloma
Refractory materials
Dexamethasone
Disease-Free Survival
25 Citations (Scopus)

Comparison of engraftment and acute GVHD in patients undergoing cryopreserved or fresh allogeneic BMT

Eckardt, J. R., Roodman, G. D., Boldt, D. H., Clark, G. M., Alvarez, R., Page, C., Gaskill, H. & LeMaistre, C. F., 1993, In : Bone Marrow Transplantation. 11, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

Bone Marrow
Tissue Donors
Platelet Transfusion
Granulocytes
Recurrence
7 Citations (Scopus)
Congenital Dyserythropoietic Anemia
Chromosome Banding
Erythroid Precursor Cells
Bone Marrow
Erythroblasts
77 Citations (Scopus)

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to paget's disease

Kurihara, N., Hiruma, Y., Yamana, K., Michou, L., Rousseau, C., Morissette, J., Galson, D. L., Teramachi, J., Zhou, H., Dempster, D. W., Windle, J. J., Brown, J. P. & Roodman, G. D., Jan 5 2011, In : Cell Metabolism. 13, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Nucleocapsid
Measles virus
Osteoclasts
Mutation
Genes
58 Citations (Scopus)

Control of osteoclast differentiation

Reddy, S. V. & Roodman, G. D., 1998, In : Critical Reviews in Eukaryotic Gene Expression. 8, 1, p. 1-17 17 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Stromal Cells
Osteoblasts
Macrophages
1665 Citations (Scopus)

Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group

Kyle, R. A., Child, J. A., Anderson, K., Barlogie, B., Bataille, R., Bensinger, W., Bladé, J., Boccadoro, M., Dalton, W., Dimopoulos, M., Djulbegovic, B., Drayson, M., Durie, B., Facon, T., Fonseca, R., Gahrton, G., Greipp, P., Harousseau, J. L., Harrington, D., Hussein, M. & 19 others, Joshua, D., Ludwig, H., Morgan, G., Oken, M., Powles, R., Richardson, P., Roodman, G. D., San Miguel, J., Shimizu, K., Shustik, C., Sirohi, B., Sonneveld, P., Tricot, G., Turesson, I., Van Ness, B., Vesole, D., Weber, D., Westin, J. & Wheatley, K., Jun 2003, In : British Journal of Haematology. 121, 5, p. 749-757 9 p.

Research output: Contribution to journalArticle

Paraproteinemias
Plasmacytoma
Multiple Myeloma
Plasma Cells
Bone Marrow Cells
45 Citations (Scopus)

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone

Yu, S., Franceschi, R. T., Luo, M., Fan, J., Jiang, D., Cao, H., Kwon, T. G., Lai, Y., Zhang, J., Patrene, K., Hankenson, K., Roodman, G. D. & Xiao, G., Oct 23 2009, In : PLoS One. 4, 10, e7583.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
parathyroid hormone
Parathyroid Hormone
Bone
transcription factors
30 Citations (Scopus)

Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis

Cao, H., Zhu, K., Qiu, L., Li, S., Niu, H., Hao, M., Yang, S., Zhao, Z., Lai, Y., Anderson, J. L., Fan, J., Im, H. J., Chen, D., Roodman, G. D. & Xiao, G., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30399-30410 12 p.

Research output: Contribution to journalArticle

Myeloma Proteins
Osteolysis
Osteoclasts
Bone
Proteins
29 Citations (Scopus)

Cytokine Regulation of Bone Cell Differentiation

Alsina, M., Guise, T. & Roodman, G. D., 1996, In : Vitamins and Hormones. 52, C, p. 63-98 36 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Cell Division
Cell Differentiation
Cytokines
56 Citations (Scopus)

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: An international, double-blind, double-dummy, randomised, controlled, phase 3 study

Raje, N., Terpos, E., Willenbacher, W., Shimizu, K., García-Sanz, R., Durie, B., Legieć, W., Krejčí, M., Laribi, K., Zhu, L., Cheng, P., Warner, D. & Roodman, G. D., Jan 1 2018, (Accepted/In press) In : The Lancet Oncology.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
Therapeutics
Safety
77 Citations (Scopus)
Nucleocapsid
Measles virus
Osteoclasts
Blood Cells
Granulocyte-Macrophage Progenitor Cells

Developmental changes in membrane proteins from baboon erythrocytes

Lee, J. C., Kuehl, T. J. & Roodman, G. D., 1987, In : Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 88, 1, p. 233-236 4 p.

Research output: Contribution to journalArticle

Papio
Membrane Proteins
Erythrocytes
Electrophoresis
Glycoproteins
37 Citations (Scopus)

Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation

Takahashi, S., Reddy, S. V., Dallas, M., Devlin, R., Chou, J. Y. & Roodman, G. D., 1995, In : Endocrinology. 136, 4, p. 1441-1449 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Stromal Cells
Bone Marrow
Cell Line
Simian virus 40
17 Citations (Scopus)
Osteoclasts
Bone Marrow
Monoclonal Antibodies
Calcitonin
In Vitro Techniques
81 Citations (Scopus)

Development of an in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B., Devlin, R. D., Anderson, J. L., Craig, F., Mundy, G. R. & Roodman, G. D., Feb 15 1996, In : Blood. 87, 4, p. 1495-1501 7 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone
Bone and Bones
Hypercalcemia
19 Citations (Scopus)
Thymidine Kinase
DNA-Directed DNA Polymerase
Bovine Serum Albumin
Spleen
DNA
22 Citations (Scopus)

DNA polymerase activities during erythropoiesis. Effects of erythropoietin, vinblastine, colcemid, and daunomycin

Roodman, G. D., Hutton, J. J. & Bollum, F. J., Mar 15 1975, In : Experimental Cell Research. 91, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

Demecolcine
Daunorubicin
Vinblastine
Erythropoiesis
DNA-Directed DNA Polymerase
105 Citations (Scopus)

Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast-like cell differentiation

Takahashi, S., Goldring, S., Katz, M., Hilsenbeck, S., Williams, R. & Roodman, G. D., Jan 1995, In : Journal of Clinical Investigation. 95, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

Calcitonin Receptors
Calcitonin
Osteoclasts
Cell Differentiation
Down-Regulation
65 Citations (Scopus)

Effect of telomere and telomerase interactive agents on human tumor and normal cell lines

Rha, S. Y., Izbicka, E., Lawrence, R., Davidson, K., Sun, D., Moyer, M. P., Roodman, G. D., Hurley, L. & Von Hoff, D., Mar 2000, In : Clinical Cancer Research. 6, 3, p. 987-993 7 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Tumor Cell Line
Inhibitory Concentration 50
Zidovudine