G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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Effects of alendronate on cytokine production and osteoclast formation induced by human marrow stromal cells

Moore, J., Anderson, J. A., Roodman, G. D. & Reddy, S. V., Feb 1999, In : Journal of Investigative Medicine. 47, 2

Research output: Contribution to journalArticle

Alendronate
Osteoclasts
Stromal Cells
Bone Marrow
Cytokines
13 Citations (Scopus)

Effects of dexamethasone on erythroid colony and burst formation from human fetal liver and adult marrow

Roodman, G. D., Lee, J. & Gidari, A. S., 1983, In : British Journal of Haematology. 53, 4, p. 621-628 8 p.

Research output: Contribution to journalArticle

Dexamethasone
Bone Marrow
Liver
Erythroid Precursor Cells
Erythropoietin
167 Citations (Scopus)
Macrophage Colony-Stimulating Factor
Osteoclasts
Granulocyte-Macrophage Colony-Stimulating Factor
Bone Marrow
Colony-Stimulating Factors
33 Citations (Scopus)

Effects of parathyroid hormone (PTH)-related protein and PTH on osteoclasts and osteoclast precursors in vivo

Uy, H. L., Guise, T., De La Mata, J., Taylor, S. D., Story, B. M., Dallas, M. R., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Aug 1995, In : Endocrinology. 136, 8, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Osteoclasts
Parathyroid Hormone
Granulocyte-Macrophage Progenitor Cells
Hypercalcemia
2 Citations (Scopus)

Effects of shortened erythropoietin exposure on sheep marrow cultures

Roodman, G. D., Kaplan, J. M., Kaplan, M. E. & Zanjani, E. D., 1981, In : British Journal of Haematology. 47, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Erythroid Precursor Cells
Sheep
Bone Marrow
Erythrocytes
34 Citations (Scopus)

Effects of stem cell factor on osteoclast-like cell formation in long-term human marrow cultures

Demulder, A., Suggs, S. V., Zsebo, K. M., Scarcez, T. & Roodman, G. D., Nov 1992, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 7, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Osteoclasts
Bone Marrow
Hematopoietic Stem Cells
Mast Cells
6 Citations (Scopus)

Effects of TNF and lymphotoxin on bone cells.

Mundy, G. R., Roodman, G. D., Bonewald, L., Yoneda, T. & Sabatini, M., 1992, In : Immunology series. 56, p. 483-498 16 p.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Bone Remodeling
Bone Diseases
Osteoclasts
Multiple Myeloma
153 Citations (Scopus)

EL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma

Ehrlich, L. A., Chung, H. Y., Ghobrial, I., Choi, S. J., Morandi, F., Colla, S., Rizzoli, V., Roodman, G. D. & Giuliani, N., Aug 15 2005, In : Blood. 106, 4, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

Interleukin-3
Osteoblasts
Multiple Myeloma
Bone
Bone and Bones
13 Citations (Scopus)

Endogenous erythroid colony-forming cells in fetal and newborn sheep

Roodman, G. D. & Zanjani, E. D., 1979, In : Journal of Laboratory and Clinical Medicine. 94, 5, p. 699-707 9 p.

Research output: Contribution to journalArticle

Sheep
Cells
European Union
Culture Media
Newborn Infant
129 Citations (Scopus)

Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone

Menaa, C., Reddy, S. V., Kurihara, N., Maeda, H., Anderson, D., Cundy, T., Cornish, J., Singer, F. R., Bruder, J. M. & Roodman, G. D., 2000, In : Journal of Clinical Investigation. 105, 12, p. 1833-1838 6 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteitis Deformans
Bone Marrow Cells
Bone Marrow
Osteoclasts
15 Citations (Scopus)
Eosinophil Chemotactic Factors
Osteoclasts
Bone Marrow
Conditioned Culture Medium
Osteogenesis
1 Citation (Scopus)

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing ICAM-1 expression

Palacios, V. G., Chung, H. Y., Choi, S. J., Kurihara, N., Lee, J. W., Ehrlich, L. A., Collins, R. & Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 240-243 4 p.

Research output: Contribution to journalArticle

Eosinophil Chemotactic Factors
Osteoclasts
Intercellular Adhesion Molecule-1
RANK Ligand
Lymphocyte Function-Associated Antigen-1
13 Citations (Scopus)

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1

Garcia-Palacios, V., Yeon Chung, H., Jin Choi, S., Sarmasik, A., Kurihara, N., Won Lee, J., Galson, D. L., Collins, R. & Roodman, G. D., Feb 2007, In : Bone. 40, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

Eosinophil Chemotactic Factors
Lymphocyte Function-Associated Antigen-1
Osteoclasts
Intercellular Adhesion Molecule-1
RANK Ligand

Epitope mapping of recombinant human procathepsin D

Sachdev, D., Ohsaki, Y., Roodman, G. D. & Chirgwin, J., 1998, In : Advances in Experimental Medicine and Biology. 436, p. 185-190 6 p.

Research output: Contribution to journalArticle

Inbred BALB C Mouse
Cultured Tumor Cells
Recombinant Fusion Proteins
B-Lymphocyte Epitopes
Epitope Mapping
8 Citations (Scopus)

Erratum: Myeloma management guidelines: A consensus report from the scientific advisors of the international myeloma foundation (The Hematology Journal (2003) vol, 4 (379-398) 10.1038/sj.thj.6200312)

Durie, B. G. M., Kyle, R. A., Belch, A., Bensinger, W., Blade, J., Boccadoro, M., Child, J. A., Comenzo, R., Djulbegovic, B., Fantl, D., Gahrton, G., Harousseau, J. L., Hungria, V., Joshua, D., Ludwig, H., Mehta, J., Morales, A. R., Morgan, G., Nouel, A., Oken, M. & 9 others, Powles, R., Roodman, G. D., San Miguel, J., Shimizu, K., Singhal, S., Sirohi, B., Sonneveld, P., Tricot, G. & Van Ness, B., 2004, In : Hematology Journal. 5, 3, p. 285 1 p.

Research output: Contribution to journalArticle

Hematologic Diseases
Bone Diseases
Blood Cells

Erratum: The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement (Leukemia (2008) 101038/leu.2008.127)

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, R. L., Roodman, G. D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., 2008, In : Leukemia. 22, 8, p. 1649 1 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor necrosis factor-alpha in vivo

Clibon, U., Bonewald, L., Caro, J. & Roodman, G. D., 1990, In : Experimental Hematology. 18, 5, p. 438-441 4 p.

Research output: Contribution to journalArticle

Erythropoietin
Erythroid Precursor Cells
Anemia
Tumor Necrosis Factor-alpha
Neoplasms
30 Citations (Scopus)

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., Jan 8 2016, In : Blood Cancer Journal. 6, e378.

Research output: Contribution to journalArticle

zoledronic acid
Multiple Myeloma
Confidence Intervals
Survival
Lost to Follow-Up
146 Citations (Scopus)

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone

Ohsaki, Y., Takahashi, S., Scarcez, T., Demulder, A., Nishihara, T., Williams, R. & Roodman, G. D., Nov 1992, In : Endocrinology. 131, 5, p. 2229-2234 6 p.

Research output: Contribution to journalArticle

Giant Cell Tumor of Bone
Giant Cells
Bone Resorption
Interleukin-6
Osteoclasts
79 Citations (Scopus)

Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone

Nellissery, M. J., Padalecki, S. S., Brkanac, Z., Singer, F. R., Roodman, G. D., Unni, K. K., Leach, R. J. & Hansen, M. F., Sep 1998, In : American Journal of Human Genetics. 63, 3, p. 817-824 8 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Chromosomes, Human, Pair 18
Osteosarcoma
Tumor Suppressor Genes
Loss of Heterozygosity
103 Citations (Scopus)

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Waning, D. L., Mohammad, K., Reiken, S., Xie, W., Andersson, D. C., John, S., Chiechi, A., Wright, L., Umanskaya, A., Niewolna, M., Trivedi, T., Charkhzarrin, S., Khatiwada, P., Wronska, A., Haynes, A., Benassi, M. S., Witzmann, F., Zhen, G., Wang, X., Cao, X. & 3 others, Roodman, G. D., Marks, A. R. & Guise, T., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1262-1271 10 p.

Research output: Contribution to journalArticle

Muscle Weakness
Transforming Growth Factors
Ryanodine Receptor Calcium Release Channel
Muscle
Bone
55 Citations (Scopus)

Expansile skeletal hyperphosphatasia: A new familial metabolic bone disease

Whyte, M. P., Mills, B. G., Reinus, W. R., Podgornik, M. N., Roodman, G. D., Gannon, F. H., Eddy, M. C. & McAlister, W. H., 2000, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 15, 12, p. 2330-2344 15 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Hypercalcemia
Bone and Bones
Finger Phalanges
Osteosclerosis
11 Citations (Scopus)

Experimental models of Paget's disease

Kurihara, N., Zhou, H., Reddy, S. V., Garcia Palacios, V., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Dec 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, SUPPL. 2

Research output: Contribution to journalArticle

Osteoclasts
Nucleocapsid
Measles virus
Theoretical Models
Bone and Bones
3 Citations (Scopus)

Expression of latent hematopoietic progenitor cells in cultures of newborn and adult baboon liver

Roodman, G. D., VandeBerg, J. L. & Kuehl, T. J., 1985, In : Blood. 65, 6, p. 1518-1525 8 p.

Research output: Contribution to journalArticle

Papio
Hematopoietic Stem Cells
Liver
Cell Culture Techniques
Erythroid Precursor Cells
84 Citations (Scopus)

Expression of measles virus nucleocapsid protein in osteoclasts induces Paget's disease-like bone lesions in mice

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Mar 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, 3, p. 446-455 10 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Measles virus
Osteoclasts
Nucleocapsid
Bone and Bones
41 Citations (Scopus)

Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation

Xu, G., Liu, K., Anderson, J., Patrene, K., Lentzsch, S., Roodman, G. D. & Ouyang, H., May 3 2012, In : Blood. 119, 18, p. 4205-4214 10 p.

Research output: Contribution to journalArticle

Cell growth
Osteoclasts
Multiple Myeloma
Mesenchymal Stromal Cells
Stromal Cells
21 Citations (Scopus)

EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation

Adamik, J., Jin, S., Sun, Q., Zhang, P., Weiss, K. R., Anderson, J. L., Silbermann, R., Roodman, G. D. & Galson, D. L., Apr 1 2017, In : Molecular Cancer Research. 15, 4, p. 405-417 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Multiple Myeloma
Epigenomics
Chromatin
Histones
143 Citations (Scopus)

Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures

MacDonald, B. R., Takahashi, N., McManus, L. M., Holahan, J., Mundy, G. R. & Roodman, G. D., 1987, In : Endocrinology. 120, 6, p. 2326-2336 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Hormones
Biopsy
Parathyroidectomy
36 Citations (Scopus)

Functional Role for Heat Shock Factors in the Transcriptional Regulation of Human RANK Ligand Gene Expression in Stromal/Osteoblast Cells

Roccisana, J. L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G. D. & Reddy, S. V., Mar 12 2004, In : Journal of Biological Chemistry. 279, 11, p. 10500-10507 8 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoblasts
Stromal Cells
Gene expression
Shock
7 Citations (Scopus)

Further characterization of the murine collagenase (type IVB) gene promoter and analysis of mRNA expression in murine tissues

Roach, J., Jin Choi, S., L. Schaub, R., Leach, R. J., Roodman, G. D. & Reddy, S. V., Feb 22 1998, In : Gene. 208, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Collagenases
Osteoclasts
Messenger RNA
Genes
Gene Expression
15 Citations (Scopus)

Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo

Storti, P., Marchica, V., Airoldi, I., Donofrio, G., Fiorini, E., Ferri, V., Guasco, D., Todoerti, K., Silbermann, R., Anderson, J. L., Zhao, W., Agnelli, L., Bolzoni, M., Martella, E., Mancini, C., Campanini, N., Noonan, D. M., Petronini, P. G., Neri, A., Aversa, F. & 2 others, Roodman, G. D. & Giuliani, N., Jun 17 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Galectin 1
Multiple Myeloma
Growth
Small Interfering RNA
Down-Regulation
40 Citations (Scopus)

Genes associate with abnormal bone cell activity in bone metastasis

Roodman, G. D., Dec 2012, In : Cancer and Metastasis Reviews. 31, 3-4, p. 569-578 10 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Genes
Neoplasms
Breast Neoplasms
22 Citations (Scopus)

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L., Bellido, T. & Roodman, G. D., Dec 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Pharmacology
Growth
Neoplasms
131 Citations (Scopus)

Genetic linkage of Paget disease of the bone to chromosome 18q

Cody, J. D., Singer, F. R., Roodman, G. D., Otterund, B., Lewis, T. B., Leppert, M. & Leach, R. J., Nov 1997, In : American Journal of Human Genetics. 61, 5, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Genetic Linkage
Chromosomes
Osteoclasts
Intranuclear Inclusion Bodies
36 Citations (Scopus)

Genetics of endocrine disease: The genetics of paget's disease of the bone

Leach, R. J., Singer, F. R. & Roodman, G. D., 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

D'Souza, S., Del Prete, D., Jin, S., Sun, Q., Huston, A. J., Kostov, F. E., Sammut, B., Hong, C. S., Anderson, J. L., Patrene, K. D., Yu, S., Velu, C. S., Xiao, G., Grimes, H. L., Roodman, G. D. & Galson, D. L., Dec 22 2011, In : Blood. 118, 26, p. 6871-6880 10 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Multiple Myeloma
Mesenchymal Stromal Cells
Bone
1 Citation (Scopus)

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Petrusca, D., Toscani, D., Wang, F. M., Park, C., Crean, C. D., Anderson, J. L., Marino, S., Mohammad, K., Zhou, D., Silbermann, R., Sun, Q., Kurihara, N., Galson, D. L., Giuliani, N. & Roodman, G. D., Oct 4 2018, In : Journal of Hematology and Oncology. 11, 1, 123.

Research output: Contribution to journalArticle

Multiple Myeloma
Osteogenesis
Intercellular Signaling Peptides and Proteins
Survival
Growth
35 Citations (Scopus)

Hematologic manifestations of malignancy

Johnson, R. A. & Roodman, G. D., 1989, In : Disease-a-Month. 35, 11, p. 726-768 43 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Bone Marrow
Neoplasms
Embolism
Anemia

Hematology-oncology. Hematology-Oncology Workgroup, Legislative Task Force on Cancer in Texas.

Gardner, F. H., Alperin, J. B., Belli, J. A., Farley, P. C., Frenkel, E. P., Redman, J. R., Roodman, G. D., Sears, D. A. & Trowbridge, A. A., Sep 1987, In : Texas Medicine. 83, 9 Pt 2, p. 59-71 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hemin-induced erythroid differentiation changes the sensitivity of K562 cells to tumor necrosis factor-α

Li, X. F., Anderson, J., Hutzler, D. & Roodman, G. D., 1989, In : Experimental Hematology. 17, 11, p. 1059-1062 4 p.

Research output: Contribution to journalArticle

Hemin
K562 Cells
Tumor Necrosis Factor Receptors
Erythroid Precursor Cells
Tumor Necrosis Factor-alpha
13 Citations (Scopus)

High bone turnover markers predict poor outcome in patients with bone metastasis

Roodman, G. D., 2005, In : Journal of Clinical Oncology. 23, 22, p. 4821-4822 2 p.

Research output: Contribution to journalArticle

Predictive Value of Tests
Bone Neoplasms
Bone Remodeling
Bone Resorption
Neoplasm Metastasis
80 Citations (Scopus)

Human bone marrow myeloma cells express RANKL [2] (multiple letters)

Sezer, O., Heider, U., Jakob, C., Eucker, J., Possinger, K. & Roodman, G. D., Jan 1 2002, In : Journal of Clinical Oncology. 20, 1, p. 353-354 2 p.

Research output: Contribution to journalArticle

Receptor Activator of Nuclear Factor-kappa B
RANK Ligand
Myeloma Proteins
Membrane Glycoproteins
Multiple Myeloma
55 Citations (Scopus)

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

Storti, P., Bolzoni, M., Donofrio, G., Airoldi, I., Guasco, D., Toscani, D., Martella, E., Lazzaretti, M., Mancini, C., Agnelli, L., Patrene, K., Maïga, S., Franceschi, V., Colla, S., Anderson, J., Neri, A., Amiot, M., Aversa, F., Roodman, G. D. & Giuliani, N., Aug 2013, In : Leukemia. 27, 8, p. 1697-1706 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Multiple Myeloma
Bone and Bones
Growth
Vascular Endothelial Growth Factors
42 Citations (Scopus)

Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma

Cruz, J. C., Alsina, M., Craig, F., Yoneda, T., Anderson, J. L., Dallas, M. & Roodman, G. D., 2001, In : Experimental Hematology. 29, 4, p. 441-447 7 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone Development
Osteoclasts
Paraplegia
Bone Marrow
176 Citations (Scopus)

Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells

Ibbotson, K. J., Roodman, G. D., McManus, L. M. & Mundy, G. R., 1984, In : Journal of Cell Biology. 99, 2, p. 471-480 10 p.

Research output: Contribution to journalArticle

Felidae
Osteoclasts
Stem Cells
Bone Marrow
Parathyroid Hormone
190 Citations (Scopus)

Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures

Kurihara, N., Chenu, C., Miller, M., Civin, C. & Roodman, G. D., May 1990, In : Endocrinology. 126, 5, p. 2733-2741 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Monoclonal Antibodies
Macrophages
Granulocyte-Macrophage Progenitor Cells
75 Citations (Scopus)

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

Choi, S. J., Reddy, S. V., Devlin, R. D., Menaa, C., Chung, H., Boyce, B. F. & Roodman, G. D., Sep 24 1999, In : Journal of Biological Chemistry. 274, 39, p. 27747-27753 7 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Forensic Anthropology
Osteoclasts
Bone Resorption
Bone
171 Citations (Scopus)

IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells

Lee, J. W., Chung, H. Y., Ehrlich, L. A., Jelinek, D. F., Callander, N. S., Roodman, G. D. & Choi, S. J., Mar 15 2004, In : Blood. 103, 6, p. 2308-2315 8 p.

Research output: Contribution to journalArticle

Interleukin-3
Osteoclasts
Macrophage Inflammatory Proteins
Multiple Myeloma
Acute Myeloid Leukemia
77 Citations (Scopus)
Parathyroid Hormone-Related Protein
Osteoclasts
Interleukin-1
Interleukin-6
Bone Marrow